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BR0111230A - Composto, e, uso e processo para a preparação do mesmo - Google Patents

Composto, e, uso e processo para a preparação do mesmo

Info

Publication number
BR0111230A
BR0111230A BR0111230-9A BR0111230A BR0111230A BR 0111230 A BR0111230 A BR 0111230A BR 0111230 A BR0111230 A BR 0111230A BR 0111230 A BR0111230 A BR 0111230A
Authority
BR
Brazil
Prior art keywords
group
hydrogen
integer
formula
independently selected
Prior art date
Application number
BR0111230-9A
Other languages
English (en)
Inventor
Jean-Claude Arnould
Thomas Geoffrey Bird
Francis Thomas Boyle
David Charles Blakey
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0111230A publication Critical patent/BR0111230A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

"COMPOSTO, E, USO E PROCESSO PARA A PREPARAçãO DO MESMO". A invenção fornece um composto de Fórmula (I) em que: R^ 1^ e R^ 2^ são independentemente selecionados de hidrogênio, halogênio, -CN, um grupo hidrocarbila ou um grupo de Fórmula (II); em que W é arila ou um grupo heterocíclico, R^ 4^ é independentemente selecionado de hidrogênio, halogênio, -OH, amino, alcanoilamino, -OPO~ 3~H~ 2~, ou um grupo hidrocarbila, em que o grupo amino é opcionalmente substituído por um resíduo de aminoácido e o grupo hidróxi é opcionalmente esterificado ou dois grupos R^ 4^ juntos formam um grupo cíclico ou heterocíclico opcionalmente substituido; X é selecionado de $M(y) S+-, +-O-+, -+S(O)+- e -+NH--; p é um número inteiro de 0 a 4; e q é um número inteiro de 1 a 4; R^ 3^ e R^ 10^ são independentemente selecionados de hidrogênio, alquila inferior ou um grupo de Fórmula (IV): em que Y é selecionado de +NH+-, -$M(Y)O$M(Y)- ou uma ligação; Z é selecionado de +NH+-, -+O<sym>-, -+C(O)+- ou uma ligação; r é um número inteiro de 0 a 4; t é um número inteiro de 0 a 1; R^ 6^ é hidrogênio, um grupo hidrocarbila ou um grupo de Fórmula (V): em que n é um número inteiro de 1 a 6, e; R ^ 7^ e R ^ 8^ são independentemente selecionados de hidrogênio ou um grupo hidrocarbila; e R^ 11^ hidrogênio ou alquila inferior; ou um sal ou solvato destes; contanto que: I) quando R^ 1^ for um grupo feniltio não substituído (Ph-S-), R^ 2^ for H, R^ 10^ for H e R^ 11^ for H, então R^ 3^ nem é H nem -C(O)-O-CH~ 2~CH~ 3~; e ii) R^ 1^, R^ 2^ e R^ 3^ não são todos hidrogênio. Tais compostos são preditos de causarem a destruição seletiva da vasculatura tumoral. Eles podem portanto ser usados para inibir e/ou reverter, e/ou aliviar os sintomas da angiogênese e/ou qualquer estado doentio associado com a angiogênese.
BR0111230-9A 2000-05-31 2001-05-25 Composto, e, uso e processo para a preparação do mesmo BR0111230A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00401551 2000-05-31
EP00402956 2000-10-25
PCT/GB2001/002335 WO2001092224A1 (en) 2000-05-31 2001-05-25 Indole derivatives with vascular damaging activity

Publications (1)

Publication Number Publication Date
BR0111230A true BR0111230A (pt) 2003-06-10

Family

ID=26073503

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0111230-9A BR0111230A (pt) 2000-05-31 2001-05-25 Composto, e, uso e processo para a preparação do mesmo

Country Status (13)

Country Link
US (1) US7030123B2 (pt)
EP (1) EP1289952A1 (pt)
JP (1) JP2003535078A (pt)
KR (1) KR20030013433A (pt)
CN (1) CN1431999A (pt)
AU (1) AU2001258628A1 (pt)
BR (1) BR0111230A (pt)
CA (1) CA2406979A1 (pt)
IL (1) IL152682A0 (pt)
MX (1) MXPA02011770A (pt)
NO (1) NO20025696L (pt)
NZ (1) NZ522074A (pt)
WO (1) WO2001092224A1 (pt)

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