BR0013281A - Derivados de arilmetil-carbonilamino-tiazol, processo para sua preparação e seu uso como agentes antitumorais - Google Patents

Derivados de arilmetil-carbonilamino-tiazol, processo para sua preparação e seu uso como agentes antitumorais

Info

Publication number: BR0013281A
Authority: BR; Brazil
Prior art keywords: preparation; arylmethyl; carbonylamino; thiazole derivatives; antitumor agents
Prior art date: 1999-08-12

Application number

BR0013281-0A

Other languages

English (en)

Portuguese (pt)

Inventor

Paolo Pevarello

Raffaella Amici

Mario Varasi

Manuela Villa

Anna Vulpetti

Original Assignee

Pharmacia Italia Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-12

Filing date

2000-08-11

Publication date

2002-06-18

2000-08-11 Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa

2002-06-18 Publication of BR0013281A publication Critical patent/BR0013281A/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Oncology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Psychiatry (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)

BR0013281-0A 1999-08-12 2000-08-11 Derivados de arilmetil-carbonilamino-tiazol, processo para sua preparação e seu uso como agentes antitumorais BR0013281A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/372,832 US6114365A (en)	1999-08-12	1999-08-12	Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
PCT/IB2000/001423 WO2001014353A1 (fr)	1999-08-12	2000-08-11	Derives d'arylmethyl-carbonylamino-thiazole utilisation de ceux-ci comme agents antitumoraux

Publications (1)

Publication Number	Publication Date
BR0013281A true BR0013281A (pt)	2002-06-18

Family

ID=23469806

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR0013281-0A BR0013281A (pt)	1999-08-12	2000-08-11	Derivados de arilmetil-carbonilamino-tiazol, processo para sua preparação e seu uso como agentes antitumorais

Country Status (36)

Country	Link
US (3)	US6114365A (fr)
EP (1)	EP1204649B1 (fr)
JP (1)	JP4864260B2 (fr)
KR (2)	KR100773709B1 (fr)
CN (1)	CN100410245C (fr)
AP (1)	AP1853A (fr)
AT (1)	ATE375987T1 (fr)
AU (1)	AU782882B2 (fr)
BG (1)	BG65484B1 (fr)
BR (1)	BR0013281A (fr)
CA (1)	CA2381097C (fr)
CY (1)	CY1107108T1 (fr)
CZ (1)	CZ303138B6 (fr)
DE (1)	DE60036803T2 (fr)
DK (1)	DK1204649T3 (fr)
EA (1)	EA005375B1 (fr)
EE (1)	EE04939B1 (fr)
ES (1)	ES2295056T3 (fr)
GE (1)	GEP20053475B (fr)
HK (1)	HK1054233B (fr)
HR (1)	HRP20020127B1 (fr)
HU (1)	HUP0202492A3 (fr)
IL (2)	IL147924A0 (fr)
IS (1)	IS2594B (fr)
MA (1)	MA25433A1 (fr)
MX (1)	MXPA02001508A (fr)
NO (1)	NO323576B1 (fr)
NZ (1)	NZ517236A (fr)
OA (1)	OA12047A (fr)
PT (1)	PT1204649E (fr)
RS (1)	RS50300B (fr)
SI (1)	SI1204649T1 (fr)
SK (1)	SK287373B6 (fr)
UA (1)	UA72538C2 (fr)
WO (1)	WO2001014353A1 (fr)
ZA (1)	ZA200201117B (fr)

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US6610846B1 (en) *	1999-03-29	2003-08-26	Hoffman-La Roche Inc.	Heteroaromatic glucokinase activators
CN101481359A (zh)	1999-04-15	2009-07-15	布里斯托尔-迈尔斯斯奎布公司	环状蛋白酪氨酸激酶抑制剂
US7125875B2 (en) *	1999-04-15	2006-10-24	Bristol-Myers Squibb Company	Cyclic protein tyrosine kinase inhibitors
US6114365A (en)	1999-08-12	2000-09-05	Pharmacia & Upjohn S.P.A.	Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
AU775373B2 (en)	1999-10-01	2004-07-29	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US20040048844A1 (en) *	1999-10-20	2004-03-11	Bristol-Myers Squibb Pharma Company	Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
US6291504B1 (en)	1999-10-20	2001-09-18	Dupont Pharmaceuticals Company	Acylsemicarbazides and their uses
CA2430151A1 (fr) *	2000-11-27	2002-06-20	Pharmacia Italia S.P.A.	Derives phenylacetamido-pyrazole et leur utilisation comme agents antitumoraux
WO2002044174A2 (fr) *	2000-12-01	2002-06-06	Bristol-Myers Squibb Pharma Company	Derives de 3-(2,4-dimethylthiazol-5-yl)indeno[1,2-c]pyrazol-4-one et leur utilisation
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EP1458382A1 (fr) *	2001-12-21	2004-09-22	Novo Nordisk A/S	Derives amide utiles en tant qu'activateurs de la glucokinase
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US8232402B2 (en)	2008-03-12	2012-07-31	Link Medicine Corporation	Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
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EP2112152A1 (fr)	2008-04-22	2009-10-28	GPC Biotech AG	Dihydropteridinones comme inhibiteurs Plk
US8343996B2 (en)	2008-11-13	2013-01-01	Astrazeneca Ab	Azaquinolinone derivatives and uses thereof
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TWI504598B (zh) *	2009-03-20	2015-10-21	Onyx Therapeutics Inc	結晶性三肽環氧酮蛋白酶抑制劑
EP2440556A1 (fr) *	2009-06-10	2012-04-18	Vertex Pharmaceuticals Incorporated	Inhibiteurs de la phosphatidylinositol 3-kinase
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EP2325185A1 (fr)	2009-10-28	2011-05-25	GPC Biotech AG	Inhibiteur de Plk
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US8883793B2 (en)	2010-12-29	2014-11-11	Development Center For Biotechnology	Tubulin inhibitors and methods of using the same
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1999
- 1999-08-12 US US09/372,832 patent/US6114365A/en not_active Expired - Lifetime
2000
- 2000-08-11 KR KR1020027001844A patent/KR100773709B1/ko not_active IP Right Cessation
- 2000-08-11 JP JP2001518441A patent/JP4864260B2/ja not_active Expired - Fee Related
- 2000-08-11 OA OA1200200052A patent/OA12047A/en unknown
- 2000-08-11 EP EP00962760A patent/EP1204649B1/fr not_active Expired - Lifetime
- 2000-08-11 EA EA200200247A patent/EA005375B1/ru not_active IP Right Cessation
- 2000-08-11 CN CNB008127336A patent/CN100410245C/zh not_active Expired - Fee Related
- 2000-08-11 WO PCT/IB2000/001423 patent/WO2001014353A1/fr active IP Right Grant
- 2000-08-11 AU AU74400/00A patent/AU782882B2/en not_active Ceased
- 2000-08-11 GE GE4757A patent/GEP20053475B/en unknown
- 2000-08-11 AP APAP/P/2002/002441A patent/AP1853A/en active
- 2000-08-11 DK DK00962760T patent/DK1204649T3/da active
- 2000-08-11 SI SI200030974T patent/SI1204649T1/sl unknown
- 2000-08-11 AT AT00962760T patent/ATE375987T1/de active
- 2000-08-11 PT PT00962760T patent/PT1204649E/pt unknown
- 2000-08-11 US US10/048,474 patent/US6784198B1/en not_active Expired - Fee Related
- 2000-08-11 BR BR0013281-0A patent/BR0013281A/pt not_active IP Right Cessation
- 2000-08-11 KR KR1020077014635A patent/KR100827563B1/ko not_active IP Right Cessation
- 2000-08-11 ES ES00962760T patent/ES2295056T3/es not_active Expired - Lifetime
- 2000-08-11 NZ NZ517236A patent/NZ517236A/en not_active IP Right Cessation
- 2000-08-11 DE DE60036803T patent/DE60036803T2/de not_active Expired - Lifetime
- 2000-08-11 CZ CZ20020486A patent/CZ303138B6/cs not_active IP Right Cessation
- 2000-08-11 HU HU0202492A patent/HUP0202492A3/hu unknown
- 2000-08-11 EE EEP200200064A patent/EE04939B1/xx not_active IP Right Cessation
- 2000-08-11 CA CA002381097A patent/CA2381097C/fr not_active Expired - Fee Related
- 2000-08-11 SK SK180-2002A patent/SK287373B6/sk not_active IP Right Cessation
- 2000-08-11 IL IL14792400A patent/IL147924A0/xx active IP Right Grant
- 2000-08-11 RS YUP-97/02A patent/RS50300B/sr unknown
- 2000-08-11 MX MXPA02001508A patent/MXPA02001508A/es active IP Right Grant
- 2000-11-08 UA UA2002031948A patent/UA72538C2/uk unknown
2002
- 2002-01-31 IL IL147924A patent/IL147924A/en not_active IP Right Cessation
- 2002-02-08 ZA ZA200201117A patent/ZA200201117B/en unknown
- 2002-02-11 IS IS6264A patent/IS2594B/is unknown
- 2002-02-11 NO NO20020683A patent/NO323576B1/no not_active IP Right Cessation
- 2002-02-12 HR HR20020127A patent/HRP20020127B1/xx not_active IP Right Cessation
- 2002-03-05 BG BG106481A patent/BG65484B1/bg unknown
- 2002-03-11 MA MA26547A patent/MA25433A1/fr unknown
2003
- 2003-09-11 HK HK03106484.7A patent/HK1054233B/zh not_active IP Right Cessation
2004
- 2004-07-29 US US10/902,326 patent/US20050004120A1/en not_active Abandoned
2007
- 2007-12-20 CY CY20071101629T patent/CY1107108T1/el unknown

Also Published As

Publication number	Publication date
EP1204649B1 (fr)	2007-10-17
CY1107108T1 (el)	2012-10-24
NZ517236A (en)	2004-11-26
NO20020683D0 (no)	2002-02-11
DE60036803T2 (de)	2008-07-24
US6114365A (en)	2000-09-05
KR100827563B1 (ko)	2008-05-07
SI1204649T1 (sl)	2008-02-29
CA2381097A1 (fr)	2001-03-01
OA12047A (en)	2006-05-02
JP2003507461A (ja)	2003-02-25
HUP0202492A2 (hu)	2002-11-28
DK1204649T3 (da)	2007-12-03
AP2002002441A0 (en)	2002-03-31
EE200200064A (et)	2003-04-15
PL353588A1 (en)	2003-12-01
US6784198B1 (en)	2004-08-31
BG106481A (en)	2002-09-30
KR100773709B1 (ko)	2007-11-09
HRP20020127B1 (en)	2010-08-31
AU782882B2 (en)	2005-09-08
US20050004120A1 (en)	2005-01-06
IS2594B (is)	2010-03-15
BG65484B1 (bg)	2008-09-30
WO2001014353A1 (fr)	2001-03-01
SK1802002A3 (en)	2003-05-02
NO20020683L (no)	2002-04-10
EP1204649A1 (fr)	2002-05-15
GEP20053475B (en)	2005-03-25
KR20070074003A (ko)	2007-07-10
CN1425009A (zh)	2003-06-18
HK1054233A1 (en)	2003-11-21
ATE375987T1 (de)	2007-11-15
EA200200247A1 (ru)	2002-08-29
IL147924A (en)	2008-03-20
SK287373B6 (sk)	2010-08-09
EA005375B1 (ru)	2005-02-24
RS50300B (sr)	2009-09-08
YU9702A (sh)	2004-11-25
UA72538C2 (en)	2005-03-15
AU7440000A (en)	2001-03-19
CA2381097C (fr)	2009-06-16
IL147924A0 (en)	2002-08-14
HUP0202492A3 (en)	2004-12-28
DE60036803D1 (de)	2007-11-29
CZ303138B6 (cs)	2012-04-25
JP4864260B2 (ja)	2012-02-01
ES2295056T3 (es)	2008-04-16
KR20020060159A (ko)	2002-07-16
CN100410245C (zh)	2008-08-13
CZ2002486A3 (cs)	2002-11-13
AP1853A (en)	2008-05-29
NO323576B1 (no)	2007-06-11
PT1204649E (pt)	2008-01-10
MXPA02001508A (es)	2003-07-21
EE04939B1 (et)	2007-12-17
ZA200201117B (en)	2003-04-30
HRP20020127A2 (en)	2003-04-30
HK1054233B (zh)	2009-05-29
IS6264A (is)	2002-02-11
MA25433A1 (fr)	2002-04-01

Publication	Publication Date	Title
BR0013281A (pt)	2002-06-18	Derivados de arilmetil-carbonilamino-tiazol, processo para sua preparação e seu uso como agentes antitumorais
BR0013277A (pt)	2002-06-18	Derivados de 3(5) ureido-pirazol, processo para sua preparação e uso dos mesmos como agentes antitumorais
BR0013143A (pt)	2002-06-11	Derivados de 3 (5) amino pirazol, processo para sua preparação e uso dos mesmos como agentes antitumorais
GB0102687D0 (en)	2001-03-21	Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them
AU2003218989A1 (en)	2003-09-09	Tricyclic pyrazole derivatives, process for their preparation and their use as antitumor agents
NO20040547L (no)	2004-03-03	Amino-ftalazinonderivater aktive som kinaseinhibitorer, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende disse.
BR0212841A (pt)	2004-08-03	Derivado ativo de aminoindazole como inibidores de cinase, processo para sua preparação e composições farmacêuticas que os contém
MXPA02012164A (es)	2003-04-25	Derivados de tiofeno activos como inhibidores de cinasa, proceso para su preparacion y composiciones farmaceuticas que los comprenden.
MXPA04000920A (es)	2004-04-02	Derivados de aminoisoxazol activos como inhibidores de la cinasa.
BRPI0410563B8 (pt)	2021-05-25	compostos de pirazol-quinazolina, seus processos de preparação e composições farmacêuticas
BRPI0418184A (pt)	2007-04-27	derivados de pirrol[2,3-b]piridina ativos como inibidores de quinase, processo para seu preparo e composições farmacêuticas compreendendo os mesmos
BR0316234A (pt)	2005-10-11	Hidroxiindóis, seu uso como inibidores de fosfodiesterase 4 e processos para a preparação dos mesmos
BR0008840A (pt)	2002-01-08	Derivados de camptotecina tendo atividade antitumoral
BRPI0414330A (pt)	2006-11-07	composto, processo para preparação do mesmo, métodos para produção de um efeito antibacteriano, para inibição de dna girase bacteriana, e para tratamento de uma infecção bacteriana em um animal de sangue quente, uso de um composto, e, composição farmacêutica
MXPA05009719A (es)	2005-10-18	Derivados de biciclo-pirazol activos como inhibidores de cinasa, procedimiento para su preparacion y composiciones farmaceuticas que los comprenden.
EA199901031A1 (ru)	2000-06-26	Производные бензимидазола
DE602004014163D1 (de)	2008-07-10	Pyrimidylpyrrolderivate, die als kinaseinhibitoren wirken
BR0314195A (pt)	2005-07-26	Derivados de piridina substituìda como agentes antitumorais

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2014-08-05	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2256 DE 01/04/2014.