[go: up one dir, main page]

CY1107108T1 - Παραγωγα αρυλομεθυλο-καρβονυλαμινο-θειαζολης και χρησις των ως αντινεοπλασματικοι παραγοντες - Google Patents

Παραγωγα αρυλομεθυλο-καρβονυλαμινο-θειαζολης και χρησις των ως αντινεοπλασματικοι παραγοντες

Info

Publication number
CY1107108T1
CY1107108T1 CY20071101629T CY071101629T CY1107108T1 CY 1107108 T1 CY1107108 T1 CY 1107108T1 CY 20071101629 T CY20071101629 T CY 20071101629T CY 071101629 T CY071101629 T CY 071101629T CY 1107108 T1 CY1107108 T1 CY 1107108T1
Authority
CY
Cyprus
Prior art keywords
thiazolis
arylomethyl
carbonylamine
producers
factors
Prior art date
Application number
CY20071101629T
Other languages
English (en)
Inventor
Paolo Pevarello
Raffaella Amici
Manuela Villa
Barbara Salom
Anna Vulpetti
Mario Varasi
Original Assignee
Pfizer Italia S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Italia S.R.L. filed Critical Pfizer Italia S.R.L.
Publication of CY1107108T1 publication Critical patent/CY1107108T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Παράγωγα 2-αμινο-1,3-θειαζόλης παριστώμενα υπό του τύπου (Ι) ή (II): ένθα τα R, R1, R2 και R3 είναι ως καθορίζονται ενταύθα, ή φαρμακευτικώς αποδεκτά άλατα αυτών, είναι χρήσιμα χρήσιμοι, επί παραδείγματι, εις την θεραπείαν καρκίνου, κύτταρο-βλαστικών (εκφυτικών) διαταραχών, νόσου Alzheimer, ιώσεων, αυτο-ανόσων νόσων ή νευροεκφυλιστικών νόσων.
CY20071101629T 1999-08-12 2007-12-20 Παραγωγα αρυλομεθυλο-καρβονυλαμινο-θειαζολης και χρησις των ως αντινεοπλασματικοι παραγοντες CY1107108T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/372,832 US6114365A (en) 1999-08-12 1999-08-12 Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
EP00962760A EP1204649B1 (en) 1999-08-12 2000-08-11 Arylmethyl-carbonylamino-thiazole derivatives and their use as antitumor agents

Publications (1)

Publication Number Publication Date
CY1107108T1 true CY1107108T1 (el) 2012-10-24

Family

ID=23469806

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071101629T CY1107108T1 (el) 1999-08-12 2007-12-20 Παραγωγα αρυλομεθυλο-καρβονυλαμινο-θειαζολης και χρησις των ως αντινεοπλασματικοι παραγοντες

Country Status (36)

Country Link
US (3) US6114365A (el)
EP (1) EP1204649B1 (el)
JP (1) JP4864260B2 (el)
KR (2) KR100773709B1 (el)
CN (1) CN100410245C (el)
AP (1) AP1853A (el)
AT (1) ATE375987T1 (el)
AU (1) AU782882B2 (el)
BG (1) BG65484B1 (el)
BR (1) BR0013281A (el)
CA (1) CA2381097C (el)
CY (1) CY1107108T1 (el)
CZ (1) CZ303138B6 (el)
DE (1) DE60036803T2 (el)
DK (1) DK1204649T3 (el)
EA (1) EA005375B1 (el)
EE (1) EE04939B1 (el)
ES (1) ES2295056T3 (el)
GE (1) GEP20053475B (el)
HK (1) HK1054233B (el)
HR (1) HRP20020127B1 (el)
HU (1) HUP0202492A3 (el)
IL (2) IL147924A0 (el)
IS (1) IS2594B (el)
MA (1) MA25433A1 (el)
MX (1) MXPA02001508A (el)
NO (1) NO323576B1 (el)
NZ (1) NZ517236A (el)
OA (1) OA12047A (el)
PT (1) PT1204649E (el)
RS (1) RS50300B (el)
SI (1) SI1204649T1 (el)
SK (1) SK287373B6 (el)
UA (1) UA72538C2 (el)
WO (1) WO2001014353A1 (el)
ZA (1) ZA200201117B (el)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020150921A1 (en) * 1996-02-09 2002-10-17 Francis Barany Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6407103B2 (en) 1998-04-21 2002-06-18 Bristol-Myers Squibb Pharma Company Indeno [1,2-c] pyrazol-4-ones and their uses
US6320050B1 (en) * 1999-03-29 2001-11-20 Hoffmann-La Roche Inc. Heteroaromatic glucokinase activators
US6610846B1 (en) * 1999-03-29 2003-08-26 Hoffman-La Roche Inc. Heteroaromatic glucokinase activators
CN101481359A (zh) 1999-04-15 2009-07-15 布里斯托尔-迈尔斯斯奎布公司 环状蛋白酪氨酸激酶抑制剂
US7125875B2 (en) * 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
US6114365A (en) 1999-08-12 2000-09-05 Pharmacia & Upjohn S.P.A. Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US20040048844A1 (en) * 1999-10-20 2004-03-11 Bristol-Myers Squibb Pharma Company Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
US6291504B1 (en) 1999-10-20 2001-09-18 Dupont Pharmaceuticals Company Acylsemicarbazides and their uses
CA2430151A1 (en) * 2000-11-27 2002-06-20 Pharmacia Italia S.P.A. Phenylacetamido- pyrazole derivatives and their use as antitumor agents
WO2002044174A2 (en) * 2000-12-01 2002-06-06 Bristol-Myers Squibb Pharma Company 3-(2,4-dimethylthiazol-5-yl) indeno[1,2-c]pyrazol-4-one derivatives as cdk inhibitors
CA2430376A1 (en) 2000-12-08 2002-06-13 David J. Carini Semicarbazides and their uses as cyclin dependent kinase inhibitors
AU3113902A (en) * 2000-12-21 2002-07-01 Bristol Myers Squibb Co Thiazolyl inhibitors of tec family tyrosine kinases
DE60208630T2 (de) * 2001-05-11 2006-08-17 Pfizer Products Inc., Groton Thiazolderivate und ihre Verwendung als cdk-Inhibitoren
GEP20105095B (en) * 2001-07-19 2010-10-25 Pfizer Italia Srl Phenylacetamido-thiazole derivatives, process for their preparation and their use as antitumor agents
EP1724270A3 (en) 2001-07-19 2007-01-03 Pfizer Italia S.r.l. Phenylacetamido-thiazole derivatives, process for their preparation and their use as antitumor agents
EP1436286B1 (en) * 2001-09-27 2009-08-19 Equispharm Co., Ltd. Fumagillol derivatives and preparing method thereof
EP1458382A1 (en) * 2001-12-21 2004-09-22 Novo Nordisk A/S Amide derivatives as gk activators
WO2004002481A1 (en) * 2002-06-27 2004-01-08 Novo Nordisk A/S Aryl carbonyl derivatives as therapeutic agents
JP2006517577A (ja) * 2003-02-12 2006-07-27 ファイザー・インク 抗増殖性の２−（スルホ−フェニル）−アミノチアゾール誘導体
MXPA05008878A (es) * 2003-02-21 2005-10-05 Pfizer Derivados de aminotiazol sustituidos con cicloalquilo que contiene n y composiciones farmaceuticas para inhibir la proliferacion celular, y metodos para su uso.
CA2520957C (en) * 2003-03-31 2013-08-06 Sucampo Ag Method for treating vascular hyperpermeable disease
WO2005014591A1 (en) * 2003-07-15 2005-02-17 L'oreal 2-acylamino or 2-sulfonylamino-1, 3-thiazoles as couplers for the oxidation dyeing of keratin fibres
FR2857664B1 (fr) * 2003-07-15 2007-12-14 Oreal Nouveaux derives thiazoles et utilisation de ces derives pour la teinture des fibres keratiniques
US7351727B2 (en) * 2003-09-02 2008-04-01 Bristol-Myers Squibb Company Inhibitors of 15-lipoxygenase
US20050074424A1 (en) * 2003-10-03 2005-04-07 Lev Salnikov Using polyion polymers with glucose infusion for a cancer selective chemotherapy compound and method
US20070196395A1 (en) * 2003-12-12 2007-08-23 Mackerell Alexander Immunomodulatory compounds that target and inhibit the py'binding site of tyrosene kinase p56 lck sh2 domain
AU2005203930C1 (en) * 2004-01-06 2012-02-23 Vtv Therapeutics Llc Heteroaryl-ureas and their use as glucokinase activators
WO2006002119A2 (en) 2004-06-18 2006-01-05 Gpc Biotech, Inc. Kinase inhibitors for treating cancers
EP1621539A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Heterocycle -substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621536A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Amino cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP2620150A3 (en) * 2004-08-13 2014-01-08 Genentech, Inc. 2-amido thiazole based inhibitors of ATP-utilizing enyzmes
EP2096107A1 (en) 2004-12-23 2009-09-02 GPC Biotech AG Derivatives of squaric acid with anti-proliferative activity
CA2618646A1 (en) * 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
JP2009500378A (ja) * 2005-07-08 2009-01-08 ノボ・ノルデイスク・エー／エス グルコキナーゼ活性化剤としてのジシクロアルキルカルバモイル尿素
EP1904467B1 (en) 2005-07-14 2013-05-01 Novo Nordisk A/S Urea glucokinase activators
EP1914234A1 (en) * 2006-10-16 2008-04-23 GPC Biotech Inc. Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
US8138185B2 (en) * 2007-01-09 2012-03-20 Novo Nordisk A/S Urea glucokinase activators
AU2008204530B2 (en) * 2007-01-11 2013-08-01 Vtv Therapeutics Llc Urea glucokinase activators
WO2008098949A2 (en) * 2007-02-13 2008-08-21 Ab Science Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors
US8450348B2 (en) * 2007-02-21 2013-05-28 Forma Tm, Llc Derivatives of squaric acid with anti-proliferative activity
TWI437986B (zh) * 2008-01-31 2014-05-21 R Tech Ueno Ltd 噻唑衍生物及使用該衍生物作為ｖａｐ－１抑制劑之用途
US8232402B2 (en) 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
EP2112150B1 (en) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Improved raf inhibitors
EP2112152A1 (en) 2008-04-22 2009-10-28 GPC Biotech AG Dihydropteridinones as Plk Inhibitors
US8343996B2 (en) 2008-11-13 2013-01-01 Astrazeneca Ab Azaquinolinone derivatives and uses thereof
UA103918C2 (en) * 2009-03-02 2013-12-10 Айерем Элелси N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
TWI504598B (zh) * 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
EP2440556A1 (en) * 2009-06-10 2012-04-18 Vertex Pharmaceuticals Incorporated Inhibitors of phosphatidylinositol 3-kinase
DE102009043260A1 (de) * 2009-09-28 2011-04-28 Merck Patent Gmbh Pyridinyl-imidazolonderivate
EP2325185A1 (en) 2009-10-28 2011-05-25 GPC Biotech AG Plk inhibitor
HU0900798D0 (en) 2009-12-21 2010-03-01 Vichem Chemie Kutato Kft 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity
US8883793B2 (en) 2010-12-29 2014-11-11 Development Center For Biotechnology Tubulin inhibitors and methods of using the same
RU2011122942A (ru) 2011-06-08 2012-12-20 Общество С Ограниченной Ответственностью "Асинэкс Медхим" Новые ингибиторы киназ
CN103387551B (zh) 2012-05-11 2015-05-20 中国人民解放军军事医学科学院毒物药物研究所 噻唑类化合物及其用途
SG11201501041VA (en) 2012-08-23 2015-03-30 Virostatics Srl Novel 4,6-disubstituted aminopyrimidine derivatives
DK3777855T3 (da) 2016-04-11 2023-01-09 Genfit Fremgangsmåder til behandling af fibrotiske sygdomme
KR20200104873A (ko) 2017-12-06 2020-09-04 린 바이오사이언스, 피티와이 엘티디. 튜불린 억제제
JP7184383B2 (ja) * 2018-02-01 2022-12-06 ザ・ユニバーシティ・オブ・シドニー 抗癌性化合物
JP2021526130A (ja) 2018-06-12 2021-09-30 ブイティーブイ・セラピューティクス・エルエルシー インスリンまたはインスリン類似体と組み合わせたグルコキナーゼ活性化薬の治療的使用
EP3941900A1 (en) 2019-03-22 2022-01-26 Deutsches Krebsforschungszentrum Novel inhibitors of histone deacetylase 10
EP3712127A1 (en) 2019-03-22 2020-09-23 Deutsches Krebsforschungszentrum Novel inhibitors of histone deacetylase 10
EP4015506A4 (en) * 2019-09-25 2023-08-30 Korea Institute of Radiological & Medical Sciences COMPOSITION FOR PREVENTING OR TREATING CANCER, CONTAINING A DERIVATIVE BASED ON TRIFLUOROMETHYLPHENYL PYRAZOLE AS ACTIVE PRINCIPLE
WO2021162054A1 (ja) * 2020-02-10 2021-08-19 学校法人順天堂 ２型リアノジン受容体活性抑制剤
CN115322208B (zh) * 2021-05-10 2023-04-11 中国药科大学 2-氨基噻唑类衍生物及其制备方法和医药用途
AU2023239988A1 (en) * 2022-03-22 2024-10-10 Autotelic Bio Inc. Thiazole derivative compound and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL125062C (el) * 1960-04-20
JPH1095777A (ja) * 1996-07-31 1998-04-14 Otsuka Pharmaceut Co Ltd チアゾール誘導体
TW513418B (en) * 1996-07-31 2002-12-11 Otsuka Pharma Co Ltd Thiazole derivatives, their production and use
US6794392B1 (en) * 1996-09-30 2004-09-21 Schering Aktiengesellschaft Cell differentiation inducer
YU22400A (sh) * 1997-10-27 2003-08-29 Agouron Pharmaceuticals Inc. Supstituisana 4-amino-tiazol-2-i jedinjenja kao cdks inhibitori
US6040321A (en) * 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
JP2002518380A (ja) * 1998-06-18 2002-06-25 ブリストル−マイヤーズ スクイブ カンパニー サイクリン依存キナーゼの炭素置換アミノチアゾール抑制剤
GB9823871D0 (en) * 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
CN101481359A (zh) * 1999-04-15 2009-07-15 布里斯托尔-迈尔斯斯奎布公司 环状蛋白酪氨酸激酶抑制剂
US6114365A (en) 1999-08-12 2000-09-05 Pharmacia & Upjohn S.P.A. Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
US6992081B2 (en) * 2000-03-23 2006-01-31 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
SE0102440D0 (sv) * 2001-07-05 2001-07-05 Astrazeneca Ab New compound
US6936629B2 (en) * 2001-12-21 2005-08-30 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of flavivirus infections
JP4650412B2 (ja) * 2003-01-27 2011-03-16 アステラス製薬株式会社 チアゾール誘導体およびｖａｐ−１阻害剤としてのその使用

Also Published As

Publication number Publication date
EP1204649B1 (en) 2007-10-17
NZ517236A (en) 2004-11-26
NO20020683D0 (no) 2002-02-11
DE60036803T2 (de) 2008-07-24
US6114365A (en) 2000-09-05
KR100827563B1 (ko) 2008-05-07
SI1204649T1 (sl) 2008-02-29
CA2381097A1 (en) 2001-03-01
OA12047A (en) 2006-05-02
JP2003507461A (ja) 2003-02-25
HUP0202492A2 (hu) 2002-11-28
DK1204649T3 (da) 2007-12-03
AP2002002441A0 (en) 2002-03-31
EE200200064A (et) 2003-04-15
PL353588A1 (en) 2003-12-01
US6784198B1 (en) 2004-08-31
BG106481A (en) 2002-09-30
KR100773709B1 (ko) 2007-11-09
HRP20020127B1 (en) 2010-08-31
AU782882B2 (en) 2005-09-08
US20050004120A1 (en) 2005-01-06
IS2594B (is) 2010-03-15
BG65484B1 (bg) 2008-09-30
WO2001014353A1 (en) 2001-03-01
SK1802002A3 (en) 2003-05-02
NO20020683L (no) 2002-04-10
EP1204649A1 (en) 2002-05-15
GEP20053475B (en) 2005-03-25
KR20070074003A (ko) 2007-07-10
CN1425009A (zh) 2003-06-18
HK1054233A1 (en) 2003-11-21
ATE375987T1 (de) 2007-11-15
BR0013281A (pt) 2002-06-18
EA200200247A1 (ru) 2002-08-29
IL147924A (en) 2008-03-20
SK287373B6 (sk) 2010-08-09
EA005375B1 (ru) 2005-02-24
RS50300B (sr) 2009-09-08
YU9702A (sh) 2004-11-25
UA72538C2 (en) 2005-03-15
AU7440000A (en) 2001-03-19
CA2381097C (en) 2009-06-16
IL147924A0 (en) 2002-08-14
HUP0202492A3 (en) 2004-12-28
DE60036803D1 (de) 2007-11-29
CZ303138B6 (cs) 2012-04-25
JP4864260B2 (ja) 2012-02-01
ES2295056T3 (es) 2008-04-16
KR20020060159A (ko) 2002-07-16
CN100410245C (zh) 2008-08-13
CZ2002486A3 (cs) 2002-11-13
AP1853A (en) 2008-05-29
NO323576B1 (no) 2007-06-11
PT1204649E (pt) 2008-01-10
MXPA02001508A (es) 2003-07-21
EE04939B1 (et) 2007-12-17
ZA200201117B (en) 2003-04-30
HRP20020127A2 (en) 2003-04-30
HK1054233B (zh) 2009-05-29
IS6264A (is) 2002-02-11
MA25433A1 (fr) 2002-04-01

Similar Documents

Publication Publication Date Title
CY1107108T1 (el) Παραγωγα αρυλομεθυλο-καρβονυλαμινο-θειαζολης και χρησις των ως αντινεοπλασματικοι παραγοντες
EA200200249A1 (ru) Производные 3(5)-уреидопиразола, способ их получения и их применение в качестве противоопухолевых агентов
CY1105441T1 (el) Ετepοκυκλικοι σουλφοναμιδικοι αναστολεις της παραγωγης βητα αμυλοειδους
CY1105948T1 (el) Παραγωγα φαινυλακεταμιδο-θειαζολης, διepγασια για την παρασκευη τους και η χρηση τους ως παραγοντων κατα των ογκων
NZ527123A (en) Oxazolyl-pyrazole derivatives as kinase inhibitors
CY1114708T1 (el) Παραγωγα πυραζολο-κιναζολινης, διαδικασια για την παρασκευη τους και η χρηση τους ως αναστολεων κινασης
ATE407928T1 (de) Amino-phtalazinon derivate, anwendung als kinase inhibitoren, herstellung und pharmazeutische zusammensetzung
CY1107815T1 (el) 1,3 - διϋποκατεστημεναι και 1,3,3 -τριϋποκατεστημεναι πυρρολιδιναι ως συνδεσμικα μεσα υποδοχεως ισταμινης -3, και θεραπευτικαι εφαρμογαι των
CY1108339T1 (el) Παραγωγα spiro(2h-1-benzopyran-2,4´-piperidine) ως αναστολεις της μεταφορας γλυκινης
ATE248837T1 (de) Chinuclidin-acrylamide
JO2503B1 (en) Benzathiazole derivatives
CY1108094T1 (el) Κινολινικα παραγωγα ως αναστολεις φωσφοδιεστερασης
PT1029853E (pt) Derivados biciclicos heteroaromaticos uteis como agentes anticancerigenos
CY1108129T1 (el) Παραγωγα 4-αμινο-6-φαινυλ-πυρρολο[2,3-δ]πυριμιδινης
ZA200401848B (en) Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them.
EA200500853A1 (ru) 2,4,6-тризамещённые пиримидины, являющиеся ингибиторами фосфотидилинозитол(pi)-3-киназы, и их применение при лечении рака
CY1110332T1 (el) Παραγωγα βενζιμιδαζολης, συνθεσεις που τα περιεχουν, παρασκευη αυτων και χρηση τους
BR0109703A (pt) Derivados de piperazina
AU2002314914A1 (en) Hydroxy alkyl amine derivatives as beta-secretase inhibitors and their use for the treatment of alzheimer's disease and similar diseases
NO20023486D0 (no) Forbindelser av pyrroltypen, perapater inneholdende forbindelser samt deres anvendelse for behandling av cancer- ogvirale sykdommer
PT992509E (pt) Novos derivados macrolidos
DE60108626D1 (de) Verwendung von 5-thio, sulfinyl- und sulfonylpyrazolo 3,4-b] pyridinen als cyclin-abhängige kinase-hemmer
DK1268472T3 (da) 3-aminopyrazolinhibitorer af cyclinafhængige kinaser
NO20021337D0 (no) 4-benzylaminoquinolinkonjugater med gallesyre og deres heteroanaloger, fremgangsmåte for deres fremstilling, legemidlersom inneholder disse forbindelser og deres anvendelse
BR9902049A (pt) Derivados 9a,11b-desidro de 9-oxima-3-ceto-6-o-metileritromicina.