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AR110244A1 - Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética - Google Patents

Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética

Info

Publication number
AR110244A1
AR110244A1 ARP170103297A ARP170103297A AR110244A1 AR 110244 A1 AR110244 A1 AR 110244A1 AR P170103297 A ARP170103297 A AR P170103297A AR P170103297 A ARP170103297 A AR P170103297A AR 110244 A1 AR110244 A1 AR 110244A1
Authority
AR
Argentina
Prior art keywords
alkyl
group
identically
alkoxy
optionally substituted
Prior art date
Application number
ARP170103297A
Other languages
English (en)
Inventor
Berger Markus Dr
Lohrke Jessica Dra
Hilger Christoph Dr
- Dr Jost Gregor Stephan
Frenzel Thomas Dr
Panknin Olaf Dr
Pietsch Hubertus Dr
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of AR110244A1 publication Critical patent/AR110244A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

La presente se refiere a una clase de complejos de quelato de gadolinio extracelular de alta relaxividad, a métodos de preparación de dichos compuestos y al uso de dichos compuestos como agentes de contraste para MRI. Reivindicación 1: Un compuesto de la fórmula general (1), caracterizado porque: R¹ representa, independientemente uno de otro, un átomo de hidrógeno o un grupo metilo; R² representa, independientemente uno de otro, un grupo seleccionado de: C₁₋₆-alquilo, C₃₋₆-cicloalquilo, C₂₋₆-hidroxialquilo, (C₁₋₃-alcoxi)-(C₂₋₄-alquil)-, 2-(2-metoxietoxi)etilo, 2-(2-etoxietoxi)etilo, oxetan-3-ilo, tetrahidro-2H-piran-4-ilo y fenilo, donde dicho grupo C₁₋₆-alquilo está opcionalmente sustituido, de manera idéntica o diferente, con un grupo fenilo, cuyo grupo fenilo está opcionalmente sustituido una, dos o tres veces, de manera idéntica o diferente, con un átomo de halógeno o un grupo seleccionado de: C₁₋₃-alquilo, C₁₋₃-haloalquilo y C₁₋₃-alcoxi, y donde dicho grupo fenilo, cuyo grupo fenilo está opcionalmente sustituido una, dos o tres veces, de manera idéntica o diferente, con un átomo de halógeno o un grupo seleccionado de: C₁₋₃-alquilo, C₁₋₃-haloalquilo y C₁₋₃-alcoxi; o un estereoisómero, un tautómero, un N-óxido, un hidrato, un solvato o una sal de los anteriores, o una mezcla de los mismos.
ARP170103297A 2016-11-28 2017-11-28 Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética AR110244A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16200932 2016-11-28

Publications (1)

Publication Number Publication Date
AR110244A1 true AR110244A1 (es) 2019-03-13

Family

ID=57406168

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170103297A AR110244A1 (es) 2016-11-28 2017-11-28 Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética

Country Status (12)

Country Link
US (2) US10975060B2 (es)
EP (1) EP3544964B1 (es)
JP (1) JP7034160B2 (es)
KR (1) KR102464647B1 (es)
CN (1) CN110035996B (es)
AR (1) AR110244A1 (es)
CA (1) CA3044877A1 (es)
ES (1) ES2814555T3 (es)
RU (1) RU2755181C2 (es)
TW (1) TW201825480A (es)
UY (1) UY37500A (es)
WO (1) WO2018096082A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3101012A1 (en) * 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
CA3044877A1 (en) 2016-11-28 2018-05-31 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
EP3883613A1 (en) * 2018-11-23 2021-09-29 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof
GB201919073D0 (en) * 2019-12-20 2020-02-05 Ge Healthcare As Novel manufacturing process
EP4335461A1 (en) 2022-09-09 2024-03-13 Bayer AG Combinations of contrast agents

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