AP2004003190A0 - Broaspectrum substituted benzisoxazole sulfonamideHIV protease inhibitors. - Google Patents

Broaspectrum substituted benzisoxazole sulfonamideHIV protease inhibitors.

Info

Publication number: AP2004003190A0
Authority: AP; ARIPO
Prior art keywords: sulfonamidehiv; broaspectrum; protease inhibitors; substituted benzisoxazole; benzisoxazole
Prior art date: 2002-05-17

Application number

AP2004003190A

Other languages

English (en)

Original Assignee

Tibotec Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-17

Filing date

2003-05-16

Publication date

2004-12-31

2003-05-16 Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd

2004-12-31 Publication of AP2004003190A0 publication Critical patent/AP2004003190A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Virology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AP2004003190A 2002-05-17 2003-05-16 Broaspectrum substituted benzisoxazole sulfonamideHIV protease inhibitors. AP2004003190A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02076957		2002-05-17
PCT/EP2003/050173 WO2003097616A1 (en)	2002-05-17	2003-05-16	Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors

Publications (1)

Publication Number	Publication Date
AP2004003190A0 true AP2004003190A0 (en)	2004-12-31

Family

ID=29433159

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2004003190A AP2004003190A0 (en)	2002-05-17	2003-05-16	Broaspectrum substituted benzisoxazole sulfonamideHIV protease inhibitors.

Country Status (28)

Country	Link
US (1)	US7462636B2 (pt)
EP (1)	EP1517899B1 (pt)
JP (2)	JP4674084B2 (pt)
KR (2)	KR20100130234A (pt)
CN (1)	CN100582097C (pt)
AP (1)	AP2004003190A0 (pt)
AR (1)	AR039887A1 (pt)
AT (1)	ATE371652T1 (pt)
AU (1)	AU2003238074B2 (pt)
BR (1)	BR0310089A (pt)
CA (1)	CA2485903C (pt)
CY (1)	CY1107040T1 (pt)
DE (1)	DE60315984T2 (pt)
DK (1)	DK1517899T3 (pt)
EA (1)	EA010908B1 (pt)
ES (1)	ES2292976T3 (pt)
HR (1)	HRP20050607B1 (pt)
IL (1)	IL165043A0 (pt)
MX (1)	MXPA04011466A (pt)
MY (1)	MY135226A (pt)
NO (1)	NO330184B1 (pt)
NZ (1)	NZ536496A (pt)
PL (1)	PL373425A1 (pt)
PT (1)	PT1517899E (pt)
SI (1)	SI1517899T1 (pt)
TW (1)	TWI356700B (pt)
WO (1)	WO2003097616A1 (pt)
ZA (1)	ZA200410156B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1517899E (pt) *	2002-05-17	2007-11-16	Tibotec Pharm Ltd	¿inibidores da protease do hiv de largo espectro benzisoxazolossulfonamidas substituídas¿
CN1953964A (zh) *	2004-03-11	2007-04-25	塞阔伊亚药品公司	抗耐药性反转录病毒蛋白酶抑制剂
WO2005110428A2 (en) *	2004-05-07	2005-11-24	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
CA2595295C (en)	2005-02-25	2014-07-08	Tibotec Pharmaceuticals Ltd.	Protease inhibitor precursor synthesis
CN101702908A (zh) *	2007-03-23	2010-05-05	麻萨诸塞州大学	Hiv-1蛋白酶抑制剂
WO2009118356A2 (en) *	2008-03-25	2009-10-01	Formac Pharmaceuticals N.V.	Preparation method for solid disupersions
WO2011061590A1 (en)	2009-11-17	2011-05-26	Hetero Research Foundation	Novel carboxamide derivatives as hiv inhibitors
DE102010004957A1 (de) *	2010-01-14	2011-07-21	Universitätsklinikum Jena, 07743	Biologisch wirksame Moleküle zur Beeinflussung von Virus-, Bakterien-, Parasiten-infizierten Zellen und/oder Tumorzellen und Verfahren zu deren Anwendung
JP2016503395A (ja)	2012-10-31	2016-02-04	バイエル・クロップサイエンス・アクチェンゲゼルシャフト	病害生物防除剤としての複素環化合物
EP2964204B1 (en)	2013-03-07	2017-01-04	Dow Global Technologies LLC	Novel esterified cellulose ethers of very low viscosity

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US5004751A (en) *	1987-08-28	1991-04-02	Mochida Pharmaceutical Co., Ltd.	Hydantoin derivatives
US5145684A (en)	1991-01-25	1992-09-08	Sterling Drug Inc.	Surface modified drug nanoparticles
KR100296463B1 (ko) *	1992-08-25	2001-10-24	죤 에이치. 뷰센	레트로바이러스프로테아제저해제로서유용한히드록시에틸아미노술폰아미드
PH30929A (en)	1992-09-03	1997-12-23	Janssen Pharmaceutica Nv	Beads having a core coated with an antifungal and a polymer.
IS2334B (is) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
DK0715618T3 (da)	1993-08-24	1999-08-23	Searle & Co	Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser
DK0721331T3 (da)	1993-10-01	2002-02-11	Astrazeneca Ab	Fremgangsmåde
EP1586558A3 (en) *	1995-01-20	2005-10-26	G.D. Searle LLC.	Bis-sulfonamide hydroxyethylamino retroviral protease inhinitors
US5756533A (en) *	1995-03-10	1998-05-26	G.D. Searle & Co.	Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5705500A (en) *	1995-03-10	1998-01-06	G.D. Searle & Co.	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en)	1995-03-10	2000-11-21	G. D. Dearle & Co.	Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
CN1149223C (zh) *	1995-03-10	2004-05-12	G·D·瑟尔公司	杂环羰基氨基酸羟乙氨基磺酰胺逆转录病毒蛋白酶抑制剂
US5753660A (en)	1995-11-15	1998-05-19	G. D. Searle & Co.	Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
CZ293841B6 (cs)	1996-05-20	2004-08-18	Janssenápharmaceuticaán@Áv	Částice s obsahem itrakonazolu
ID21477A (id)	1997-03-26	1999-06-17	Janssen Pharmaceutica Nv	Pelet-pelet yang mempunyai inti yang dilapisi dengan suatu anti jamur dan suatu polimer
US6436989B1 (en)	1997-12-24	2002-08-20	Vertex Pharmaceuticals, Incorporated	Prodrugs of aspartyl protease inhibitors
TR200002402T2 (tr)	1997-12-24	2001-01-22	Vertex Pharmaceuticals Incorporated	Aspartil proteaz inhibitörü ön-ilaçlar.
AU2010299A (en)	1997-12-24	1999-07-19	Vertex Pharmaceuticals Incorporated	Prodrugs os aspartyl protease inhibitors
WO1999033795A1 (en)	1997-12-24	1999-07-08	Vertex Pharmaceuticals Incorporated	Prodrugs of aspartyl protease inhibitors
WO1999067254A2 (en)	1998-06-23	1999-12-29	The United States Of America Represented By The Secretary, Department Of Health And Human Services	Multi-drug resistant retroviral protease inhibitors and use thereof
DK1088098T4 (en) *	1998-06-23	2015-09-14	Us Of America Represented By The Secretary Dept Of Health And Human Services	Fitnessassay and methods for reducing HIV resistance to therapy
WO2001025240A1 (en)	1999-10-06	2001-04-12	Tibotec Pharmaceuticals Ltd.	HEXAHYDROFURO'2,3-B&excl;FURAN-3-YL-N- {3'(1,3-BENZODIOXOL -5- YLSULFONYL) (ISOBUTYL) AMINO&excl; -1-BENZYL-2-HYDROXYPROPYL} CARBAMATE AS RETROVIRAL PROTEASE INHIBITOR
US7244752B2 (en) *	2001-04-09	2007-07-17	Tibotec Pharmaceuticals Ltd.	Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors
PT1517899E (pt) *	2002-05-17	2007-11-16	Tibotec Pharm Ltd	¿inibidores da protease do hiv de largo espectro benzisoxazolossulfonamidas substituídas¿

2003
- 2003-05-16 PT PT03735707T patent/PT1517899E/pt unknown
- 2003-05-16 TW TW092113367A patent/TWI356700B/zh not_active IP Right Cessation
- 2003-05-16 AU AU2003238074A patent/AU2003238074B2/en not_active Ceased
- 2003-05-16 JP JP2004505349A patent/JP4674084B2/ja not_active Expired - Fee Related
- 2003-05-16 CN CN03816458A patent/CN100582097C/zh not_active Expired - Fee Related
- 2003-05-16 IL IL16504303A patent/IL165043A0/xx not_active IP Right Cessation
- 2003-05-16 SI SI200331012T patent/SI1517899T1/sl unknown
- 2003-05-16 US US10/514,539 patent/US7462636B2/en not_active Expired - Fee Related
- 2003-05-16 WO PCT/EP2003/050173 patent/WO2003097616A1/en active IP Right Grant
- 2003-05-16 PL PL03373425A patent/PL373425A1/xx unknown
- 2003-05-16 BR BR0310089-8A patent/BR0310089A/pt not_active IP Right Cessation
- 2003-05-16 AP AP2004003190A patent/AP2004003190A0/xx unknown
- 2003-05-16 MX MXPA04011466A patent/MXPA04011466A/es active IP Right Grant
- 2003-05-16 HR HRP20050607AA patent/HRP20050607B1/hr not_active IP Right Cessation
- 2003-05-16 MY MYPI20031819A patent/MY135226A/en unknown
- 2003-05-16 NZ NZ536496A patent/NZ536496A/en not_active IP Right Cessation
- 2003-05-16 KR KR1020107025714A patent/KR20100130234A/ko not_active Withdrawn
- 2003-05-16 DK DK03735707T patent/DK1517899T3/da active
- 2003-05-16 CA CA2485903A patent/CA2485903C/en not_active Expired - Fee Related
- 2003-05-16 DE DE60315984T patent/DE60315984T2/de not_active Expired - Lifetime
- 2003-05-16 ES ES03735707T patent/ES2292976T3/es not_active Expired - Lifetime
- 2003-05-16 EP EP03735707A patent/EP1517899B1/en not_active Expired - Lifetime
- 2003-05-16 AT AT03735707T patent/ATE371652T1/de active
- 2003-05-16 AR ARP030101725A patent/AR039887A1/es active IP Right Grant
- 2003-05-16 KR KR1020047018261A patent/KR101019648B1/ko not_active Expired - Fee Related
- 2003-05-16 EA EA200401524A patent/EA010908B1/ru not_active IP Right Cessation
2004
- 2004-12-14 NO NO20045444A patent/NO330184B1/no not_active IP Right Cessation
- 2004-12-15 ZA ZA2004/10156A patent/ZA200410156B/en unknown
2007
- 2007-11-29 CY CY20071101524T patent/CY1107040T1/el unknown
2010
- 2010-10-25 JP JP2010238833A patent/JP2011051999A/ja active Pending

Also Published As

Publication number	Publication date
AU2003238074B2 (en)	2009-04-30
PT1517899E (pt)	2007-11-16
ATE371652T1 (de)	2007-09-15
EP1517899B1 (en)	2007-08-29
EA010908B1 (ru)	2008-12-30
US20050171173A1 (en)	2005-08-04
ES2292976T3 (es)	2008-03-16
NO330184B1 (no)	2011-02-28
JP4674084B2 (ja)	2011-04-20
JP2005527607A (ja)	2005-09-15
HK1076099A1 (en)	2006-01-06
PL373425A1 (en)	2005-08-22
NZ536496A (en)	2006-06-30
TWI356700B (en)	2012-01-21
AR039887A1 (es)	2005-03-09
DK1517899T3 (da)	2007-12-03
IL165043A0 (en)	2005-12-18
EP1517899A1 (en)	2005-03-30
WO2003097616A1 (en)	2003-11-27
JP2011051999A (ja)	2011-03-17
CY1107040T1 (el)	2012-09-26
HRP20050607A2 (en)	2006-02-28
TW200404538A (en)	2004-04-01
EA200401524A1 (ru)	2005-06-30
KR20100130234A (ko)	2010-12-10
MY135226A (en)	2008-02-29
DE60315984D1 (de)	2007-10-11
AU2003238074A1 (en)	2003-12-02
HRP20050607B1 (hr)	2014-07-04
DE60315984T2 (de)	2008-05-29
US7462636B2 (en)	2008-12-09
KR101019648B1 (ko)	2011-03-07
CN1668605A (zh)	2005-09-14
SI1517899T1 (sl)	2008-02-29
NO20045444L (no)	2005-02-16
MXPA04011466A (es)	2005-02-14
ZA200410156B (en)	2005-11-30
KR20050013549A (ko)	2005-02-04
BR0310089A (pt)	2005-02-15
CA2485903A1 (en)	2003-11-27
CA2485903C (en)	2011-08-16
CN100582097C (zh)	2010-01-20

Publication	Publication Date	Title
EG25482A (en)	2012-01-15	Inhibitors
GB0125445D0 (en)	2001-12-12	Protease Inhibitors
MXPA03008191A (es)	2004-01-29	Inhibidores de metaloproteinasa.
MXPA03008180A (es)	2003-12-12	Inhibidores de metaloproteinasa.
MXPA03001780A (es)	2003-06-04	Inhibidores de proteasa peptidomimeticos.
MXPA03008183A (es)	2003-12-12	Inhibidores de metaloproteinasa.
EP1483254A4 (en)	2005-06-08	INHIBITORS OF ANTI-RESISTANCE RETROVIRAL PROTEASE
EP1532133A4 (en)	2006-11-15	NF-: B INHIBITORS
AP2004003156A0 (en)	2004-12-31	Peptide deformylase inhibitors.
EP1663279A4 (en)	2009-02-18	MODIFIED PROTEASE INHIBITORS
EP1704142A4 (en)	2008-08-20	PROTEASE INHIBITORS
AU2003234630A1 (en)	2003-12-02	Cysteine protease inhibitors
AP2004003190A0 (en)	2004-12-31	Broaspectrum substituted benzisoxazole sulfonamideHIV protease inhibitors.
MX263097B (es)	2008-12-15	Inhibidores de entrada a moleculas pequenas.
AU2003269984A8 (en)	2004-03-11	Protease inhibitors
ZA200408511B (en)	2005-11-04	Plasma carboxypeptidase B inhibitors.
MXPA03000512A (es)	2003-10-06	Oxiguanidina-pirazinonas ciclicas como inhibidores de proteasas.
EP1401453A4 (en)	2005-04-06	PROTEASE INHIBITORS
AU2003263738A8 (en)	2003-12-02	Protease inhibitors
MXPA03004542A (es)	2003-09-10	Inhibidores de proteasa.
AU2003287325A8 (en)	2004-06-03	N-cycloalkylglycines as hiv protease inhibitors
AU2003304496A8 (en)	2005-04-27	Protease inhibitors
AU2003233642A8 (en)	2003-12-12	Protease inhibitors
AU2003265240A8 (en)	2003-12-22	Protease inhibitors
AU2003269878A8 (en)	2003-12-22	Protease inhibitors