MXPA04011466A - Inhibidores de la proteasa de hiv de benzisoxazol sulfonamida sustituida de amplio espectro. - Google Patents
Inhibidores de la proteasa de hiv de benzisoxazol sulfonamida sustituida de amplio espectro.Info
- Publication number
- MXPA04011466A MXPA04011466A MXPA04011466A MXPA04011466A MXPA04011466A MX PA04011466 A MXPA04011466 A MX PA04011466A MX PA04011466 A MXPA04011466 A MX PA04011466A MX PA04011466 A MXPA04011466 A MX PA04011466A MX PA04011466 A MXPA04011466 A MX PA04011466A
- Authority
- MX
- Mexico
- Prior art keywords
- protease inhibitors
- hiv protease
- broadspectrum
- substituted benzisoxazole
- sulfonamide hiv
- Prior art date
Links
- 239000004030 hiv protease inhibitor Substances 0.000 title abstract 2
- OIFAKIJHBGJKLD-UHFFFAOYSA-N 1,2-benzoxazole-3-sulfonamide Chemical class C1=CC=C2C(S(=O)(=O)N)=NOC2=C1 OIFAKIJHBGJKLD-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 229940124522 antiretrovirals Drugs 0.000 abstract 1
- 239000003903 antiretrovirus agent Substances 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invencion se refiere a los compuestos que tiene la formula (I)(ver formula I)N-oxidos, sales, formas estereoisomericas, mezclas racemicas, esteres profarmacos y metabolitos de los mismos; ademas se refiere a su uso como inhibidores de la proteasa de HIV de amplio espectro, procedimiento para su preparacion, asi como composiciones farmaceuticas y equipos de diagnostico que los comprenden; tambien se refiere a combinaciones de los mismos con otro agente anti-retroviral y su uso en ensayos como compuestos d referencia o como reactivos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02076957 | 2002-05-17 | ||
| PCT/EP2003/050173 WO2003097616A1 (en) | 2002-05-17 | 2003-05-16 | Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04011466A true MXPA04011466A (es) | 2005-02-14 |
Family
ID=29433159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04011466A MXPA04011466A (es) | 2002-05-17 | 2003-05-16 | Inhibidores de la proteasa de hiv de benzisoxazol sulfonamida sustituida de amplio espectro. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7462636B2 (es) |
| EP (1) | EP1517899B1 (es) |
| JP (2) | JP4674084B2 (es) |
| KR (2) | KR20100130234A (es) |
| CN (1) | CN100582097C (es) |
| AP (1) | AP2004003190A0 (es) |
| AR (1) | AR039887A1 (es) |
| AT (1) | ATE371652T1 (es) |
| AU (1) | AU2003238074B2 (es) |
| BR (1) | BR0310089A (es) |
| CA (1) | CA2485903C (es) |
| CY (1) | CY1107040T1 (es) |
| DE (1) | DE60315984T2 (es) |
| DK (1) | DK1517899T3 (es) |
| EA (1) | EA010908B1 (es) |
| ES (1) | ES2292976T3 (es) |
| HR (1) | HRP20050607B1 (es) |
| IL (1) | IL165043A0 (es) |
| MX (1) | MXPA04011466A (es) |
| MY (1) | MY135226A (es) |
| NO (1) | NO330184B1 (es) |
| NZ (1) | NZ536496A (es) |
| PL (1) | PL373425A1 (es) |
| PT (1) | PT1517899E (es) |
| SI (1) | SI1517899T1 (es) |
| TW (1) | TWI356700B (es) |
| WO (1) | WO2003097616A1 (es) |
| ZA (1) | ZA200410156B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1517899E (pt) * | 2002-05-17 | 2007-11-16 | Tibotec Pharm Ltd | ¿inibidores da protease do hiv de largo espectro benzisoxazolossulfonamidas substituídas¿ |
| CN1953964A (zh) * | 2004-03-11 | 2007-04-25 | 塞阔伊亚药品公司 | 抗耐药性反转录病毒蛋白酶抑制剂 |
| WO2005110428A2 (en) * | 2004-05-07 | 2005-11-24 | Sequoia Pharmaceuticals, Inc. | Resistance-repellent retroviral protease inhibitors |
| CA2595295C (en) | 2005-02-25 | 2014-07-08 | Tibotec Pharmaceuticals Ltd. | Protease inhibitor precursor synthesis |
| CN101702908A (zh) * | 2007-03-23 | 2010-05-05 | 麻萨诸塞州大学 | Hiv-1蛋白酶抑制剂 |
| WO2009118356A2 (en) * | 2008-03-25 | 2009-10-01 | Formac Pharmaceuticals N.V. | Preparation method for solid disupersions |
| WO2011061590A1 (en) | 2009-11-17 | 2011-05-26 | Hetero Research Foundation | Novel carboxamide derivatives as hiv inhibitors |
| DE102010004957A1 (de) * | 2010-01-14 | 2011-07-21 | Universitätsklinikum Jena, 07743 | Biologisch wirksame Moleküle zur Beeinflussung von Virus-, Bakterien-, Parasiten-infizierten Zellen und/oder Tumorzellen und Verfahren zu deren Anwendung |
| JP2016503395A (ja) | 2012-10-31 | 2016-02-04 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 病害生物防除剤としての複素環化合物 |
| EP2964204B1 (en) | 2013-03-07 | 2017-01-04 | Dow Global Technologies LLC | Novel esterified cellulose ethers of very low viscosity |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5004751A (en) * | 1987-08-28 | 1991-04-02 | Mochida Pharmaceutical Co., Ltd. | Hydantoin derivatives |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| KR100296463B1 (ko) * | 1992-08-25 | 2001-10-24 | 죤 에이치. 뷰센 | 레트로바이러스프로테아제저해제로서유용한히드록시에틸아미노술폰아미드 |
| PH30929A (en) | 1992-09-03 | 1997-12-23 | Janssen Pharmaceutica Nv | Beads having a core coated with an antifungal and a polymer. |
| IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| DK0715618T3 (da) | 1993-08-24 | 1999-08-23 | Searle & Co | Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser |
| DK0721331T3 (da) | 1993-10-01 | 2002-02-11 | Astrazeneca Ab | Fremgangsmåde |
| EP1586558A3 (en) * | 1995-01-20 | 2005-10-26 | G.D. Searle LLC. | Bis-sulfonamide hydroxyethylamino retroviral protease inhinitors |
| US5756533A (en) * | 1995-03-10 | 1998-05-26 | G.D. Searle & Co. | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US5705500A (en) * | 1995-03-10 | 1998-01-06 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US6150556A (en) | 1995-03-10 | 2000-11-21 | G. D. Dearle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| CN1149223C (zh) * | 1995-03-10 | 2004-05-12 | G·D·瑟尔公司 | 杂环羰基氨基酸羟乙氨基磺酰胺逆转录病毒蛋白酶抑制剂 |
| US5753660A (en) | 1995-11-15 | 1998-05-19 | G. D. Searle & Co. | Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| CZ293841B6 (cs) | 1996-05-20 | 2004-08-18 | Janssenápharmaceuticaán@Áv | Částice s obsahem itrakonazolu |
| ID21477A (id) | 1997-03-26 | 1999-06-17 | Janssen Pharmaceutica Nv | Pelet-pelet yang mempunyai inti yang dilapisi dengan suatu anti jamur dan suatu polimer |
| US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| TR200002402T2 (tr) | 1997-12-24 | 2001-01-22 | Vertex Pharmaceuticals Incorporated | Aspartil proteaz inhibitörü ön-ilaçlar. |
| AU2010299A (en) | 1997-12-24 | 1999-07-19 | Vertex Pharmaceuticals Incorporated | Prodrugs os aspartyl protease inhibitors |
| WO1999033795A1 (en) | 1997-12-24 | 1999-07-08 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
| WO1999067254A2 (en) | 1998-06-23 | 1999-12-29 | The United States Of America Represented By The Secretary, Department Of Health And Human Services | Multi-drug resistant retroviral protease inhibitors and use thereof |
| DK1088098T4 (en) * | 1998-06-23 | 2015-09-14 | Us Of America Represented By The Secretary Dept Of Health And Human Services | Fitnessassay and methods for reducing HIV resistance to therapy |
| WO2001025240A1 (en) | 1999-10-06 | 2001-04-12 | Tibotec Pharmaceuticals Ltd. | HEXAHYDROFURO'2,3-B!FURAN-3-YL-N- {3'(1,3-BENZODIOXOL -5- YLSULFONYL) (ISOBUTYL) AMINO! -1-BENZYL-2-HYDROXYPROPYL} CARBAMATE AS RETROVIRAL PROTEASE INHIBITOR |
| US7244752B2 (en) * | 2001-04-09 | 2007-07-17 | Tibotec Pharmaceuticals Ltd. | Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors |
| PT1517899E (pt) * | 2002-05-17 | 2007-11-16 | Tibotec Pharm Ltd | ¿inibidores da protease do hiv de largo espectro benzisoxazolossulfonamidas substituídas¿ |
-
2003
- 2003-05-16 PT PT03735707T patent/PT1517899E/pt unknown
- 2003-05-16 TW TW092113367A patent/TWI356700B/zh not_active IP Right Cessation
- 2003-05-16 AU AU2003238074A patent/AU2003238074B2/en not_active Ceased
- 2003-05-16 JP JP2004505349A patent/JP4674084B2/ja not_active Expired - Fee Related
- 2003-05-16 CN CN03816458A patent/CN100582097C/zh not_active Expired - Fee Related
- 2003-05-16 IL IL16504303A patent/IL165043A0/xx not_active IP Right Cessation
- 2003-05-16 SI SI200331012T patent/SI1517899T1/sl unknown
- 2003-05-16 US US10/514,539 patent/US7462636B2/en not_active Expired - Fee Related
- 2003-05-16 WO PCT/EP2003/050173 patent/WO2003097616A1/en active IP Right Grant
- 2003-05-16 PL PL03373425A patent/PL373425A1/xx unknown
- 2003-05-16 BR BR0310089-8A patent/BR0310089A/pt not_active IP Right Cessation
- 2003-05-16 AP AP2004003190A patent/AP2004003190A0/xx unknown
- 2003-05-16 MX MXPA04011466A patent/MXPA04011466A/es active IP Right Grant
- 2003-05-16 HR HRP20050607AA patent/HRP20050607B1/hr not_active IP Right Cessation
- 2003-05-16 MY MYPI20031819A patent/MY135226A/en unknown
- 2003-05-16 NZ NZ536496A patent/NZ536496A/en not_active IP Right Cessation
- 2003-05-16 KR KR1020107025714A patent/KR20100130234A/ko not_active Withdrawn
- 2003-05-16 DK DK03735707T patent/DK1517899T3/da active
- 2003-05-16 CA CA2485903A patent/CA2485903C/en not_active Expired - Fee Related
- 2003-05-16 DE DE60315984T patent/DE60315984T2/de not_active Expired - Lifetime
- 2003-05-16 ES ES03735707T patent/ES2292976T3/es not_active Expired - Lifetime
- 2003-05-16 EP EP03735707A patent/EP1517899B1/en not_active Expired - Lifetime
- 2003-05-16 AT AT03735707T patent/ATE371652T1/de active
- 2003-05-16 AR ARP030101725A patent/AR039887A1/es active IP Right Grant
- 2003-05-16 KR KR1020047018261A patent/KR101019648B1/ko not_active Expired - Fee Related
- 2003-05-16 EA EA200401524A patent/EA010908B1/ru not_active IP Right Cessation
-
2004
- 2004-12-14 NO NO20045444A patent/NO330184B1/no not_active IP Right Cessation
- 2004-12-15 ZA ZA2004/10156A patent/ZA200410156B/en unknown
-
2007
- 2007-11-29 CY CY20071101524T patent/CY1107040T1/el unknown
-
2010
- 2010-10-25 JP JP2010238833A patent/JP2011051999A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |