SI1517899T1 - Substituirani benzoksazol sulfonamidi sirokega spektra, ki so HIV proteazni inhibitorji - Google Patents

Substituirani benzoksazol sulfonamidi sirokega spektra, ki so HIV proteazni inhibitorji

Info

Publication number: SI1517899T1
Authority: SI; Slovenia
Prior art keywords: protease inhibitors; hiv protease; substituted benzisoxazole; sulfonamide hiv; broadspectrum
Prior art date: 2002-05-17

Application number

SI200331012T

Other languages

English (en)

Inventor

Dominique Louis Nest Surleraux

Bernhard Joanna Bern Vergouwen

Kock Herman Augustinus De

Original Assignee

Tibotec Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-17

Filing date

2003-05-16

Publication date

2008-02-29

2003-05-16 Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd

2008-02-29 Publication of SI1517899T1 publication Critical patent/SI1517899T1/sl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SI200331012T 2002-05-17 2003-05-16 Substituirani benzoksazol sulfonamidi sirokega spektra, ki so HIV proteazni inhibitorji SI1517899T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP02076957		2002-05-17
EP03735707A EP1517899B1 (en)	2002-05-17	2003-05-16	Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
PCT/EP2003/050173 WO2003097616A1 (en)	2002-05-17	2003-05-16	Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors

Publications (1)

Publication Number	Publication Date
SI1517899T1 true SI1517899T1 (sl)	2008-02-29

Family

ID=29433159

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200331012T SI1517899T1 (sl)	2002-05-17	2003-05-16	Substituirani benzoksazol sulfonamidi sirokega spektra, ki so HIV proteazni inhibitorji

Country Status (28)

Country	Link
US (1)	US7462636B2 (sl)
EP (1)	EP1517899B1 (sl)
JP (2)	JP4674084B2 (sl)
KR (2)	KR20100130234A (sl)
CN (1)	CN100582097C (sl)
AP (1)	AP2004003190A0 (sl)
AR (1)	AR039887A1 (sl)
AT (1)	ATE371652T1 (sl)
AU (1)	AU2003238074B2 (sl)
BR (1)	BR0310089A (sl)
CA (1)	CA2485903C (sl)
CY (1)	CY1107040T1 (sl)
DE (1)	DE60315984T2 (sl)
DK (1)	DK1517899T3 (sl)
EA (1)	EA010908B1 (sl)
ES (1)	ES2292976T3 (sl)
HR (1)	HRP20050607B1 (sl)
IL (1)	IL165043A0 (sl)
MX (1)	MXPA04011466A (sl)
MY (1)	MY135226A (sl)
NO (1)	NO330184B1 (sl)
NZ (1)	NZ536496A (sl)
PL (1)	PL373425A1 (sl)
PT (1)	PT1517899E (sl)
SI (1)	SI1517899T1 (sl)
TW (1)	TWI356700B (sl)
WO (1)	WO2003097616A1 (sl)
ZA (1)	ZA200410156B (sl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1517899T1 (sl) *	2002-05-17	2008-02-29	Tibotec Pharm Ltd	Substituirani benzoksazol sulfonamidi sirokega spektra, ki so HIV proteazni inhibitorji
MXPA06010365A (es) *	2004-03-11	2007-05-04	Sequoia Pharmaceuticals Inc	Inhibidores de proteasa retrovirales repelentes a la resistencia.
AU2005244121B2 (en) *	2004-05-07	2012-01-19	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
DK1856125T3 (da)	2005-02-25	2009-12-07	Tibotec Pharm Ltd	Syntese af proteasehæmmerforstadie
CN101702908A (zh) *	2007-03-23	2010-05-05	麻萨诸塞州大学	Hiv-1蛋白酶抑制剂
ATE545411T1 (de) *	2008-03-25	2012-03-15	Formac Pharmaceuticals N V	Herstellungsverfahren für feststoffdispersionen
WO2011061590A1 (en)	2009-11-17	2011-05-26	Hetero Research Foundation	Novel carboxamide derivatives as hiv inhibitors
DE102010004957A1 (de) *	2010-01-14	2011-07-21	Universitätsklinikum Jena, 07743	Biologisch wirksame Moleküle zur Beeinflussung von Virus-, Bakterien-, Parasiten-infizierten Zellen und/oder Tumorzellen und Verfahren zu deren Anwendung
US20150284380A1 (en)	2012-10-31	2015-10-08	Bayer Cropscience Ag	Novel heterocyclic compounds as pest control agents
CN105025887B (zh) *	2013-03-07	2017-07-28	陶氏环球技术有限责任公司	新颖极低粘度酯化纤维素醚

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5004751A (en) *	1987-08-28	1991-04-02	Mochida Pharmaceutical Co., Ltd.	Hydantoin derivatives
US5145684A (en)	1991-01-25	1992-09-08	Sterling Drug Inc.	Surface modified drug nanoparticles
JP3657002B2 (ja) *	1992-08-25	2005-06-08	ジー．ディー．サールアンドカンパニー	レトロウイルスプロテアーゼ阻害剤として有用なα−およびβ−アミノ酸ヒドロキシエチルアミノスルホンアミド
PH30929A (en)	1992-09-03	1997-12-23	Janssen Pharmaceutica Nv	Beads having a core coated with an antifungal and a polymer.
IS2334B (is) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
DK0715618T3 (da)	1993-08-24	1999-08-23	Searle & Co	Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser
CN1110300C (zh)	1993-10-01	2003-06-04	阿斯特拉公司	工艺技术ⅰ
EP0804428B1 (en) *	1995-01-20	2007-12-26	G.D. Searle LLC.	Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
US5756533A (en)	1995-03-10	1998-05-26	G.D. Searle & Co.	Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en)	1995-03-10	2000-11-21	G. D. Dearle & Co.	Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5705500A (en) *	1995-03-10	1998-01-06	G.D. Searle & Co.	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
WO1996028465A1 (en) *	1995-03-10	1996-09-19	G.D. Searle & Co.	Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
AU7722296A (en)	1995-11-15	1997-06-05	G.D. Searle & Co.	Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
ATE255883T1 (de)	1996-05-20	2003-12-15	Janssen Pharmaceutica Nv	Fungizide mittel mit verbesserter bioverfügbarkeit
AP1227A (en)	1997-03-26	2003-11-24	Janssen Pharmaceutica Nv	Pellets having a core coated with an antifungal and a polymer.
WO1999033792A2 (en)	1997-12-24	1999-07-08	Vertex Pharmaceuticals Incorporated	Prodrugs os aspartyl protease inhibitors
AU2012199A (en)	1997-12-24	1999-07-19	Vertex Pharmaceuticals Incorporated	Prodrugs of aspartyl protease inhibitors
US6436989B1 (en)	1997-12-24	2002-08-20	Vertex Pharmaceuticals, Incorporated	Prodrugs of aspartyl protease inhibitors
AP2000001856A0 (en)	1997-12-24	2000-09-30	Vertex Pharma	Prodrugs of aspartyl protease inhibitors.
ES2362404T5 (es) *	1998-06-23	2015-11-25	The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Ensayo de aptitud y métodos para reducir la resistencia del VIH a terapia
WO1999067254A2 (en)	1998-06-23	1999-12-29	The United States Of America Represented By The Secretary, Department Of Health And Human Services	Multi-drug resistant retroviral protease inhibitors and use thereof
KR100792391B1 (ko)	1999-10-06	2008-01-08	티보텍 파마슈티칼즈 리미티드	레트로바이러스 프로테아제 저해제로서의헥사하이드로푸로[2,3-ｂ]푸란-3-일-Ｎ-[3-[(1,3-벤조디옥솔-5-일설포닐)(이소부틸)아미노]-1-벤질-2-하이드록시프로필]카바메이트
MXPA03009179A (es) *	2001-04-09	2004-11-22	Tibotec Pharm Ltd	2-(amino sustituido)-benzoxazol sunfonamidas, inhibidores de amplio espectro de la vih proteasa.
SI1517899T1 (sl) *	2002-05-17	2008-02-29	Tibotec Pharm Ltd	Substituirani benzoksazol sulfonamidi sirokega spektra, ki so HIV proteazni inhibitorji

2003
- 2003-05-16 SI SI200331012T patent/SI1517899T1/sl unknown
- 2003-05-16 WO PCT/EP2003/050173 patent/WO2003097616A1/en not_active Ceased
- 2003-05-16 ES ES03735707T patent/ES2292976T3/es not_active Expired - Lifetime
- 2003-05-16 HR HRP20050607AA patent/HRP20050607B1/hr not_active IP Right Cessation
- 2003-05-16 AR ARP030101725A patent/AR039887A1/es active IP Right Grant
- 2003-05-16 CN CN03816458A patent/CN100582097C/zh not_active Expired - Fee Related
- 2003-05-16 IL IL16504303A patent/IL165043A0/xx not_active IP Right Cessation
- 2003-05-16 KR KR1020107025714A patent/KR20100130234A/ko not_active Withdrawn
- 2003-05-16 DK DK03735707T patent/DK1517899T3/da active
- 2003-05-16 MX MXPA04011466A patent/MXPA04011466A/es active IP Right Grant
- 2003-05-16 TW TW092113367A patent/TWI356700B/zh not_active IP Right Cessation
- 2003-05-16 CA CA2485903A patent/CA2485903C/en not_active Expired - Fee Related
- 2003-05-16 PL PL03373425A patent/PL373425A1/xx unknown
- 2003-05-16 PT PT03735707T patent/PT1517899E/pt unknown
- 2003-05-16 KR KR1020047018261A patent/KR101019648B1/ko not_active Expired - Fee Related
- 2003-05-16 BR BR0310089-8A patent/BR0310089A/pt not_active IP Right Cessation
- 2003-05-16 AP AP2004003190A patent/AP2004003190A0/xx unknown
- 2003-05-16 AT AT03735707T patent/ATE371652T1/de active
- 2003-05-16 US US10/514,539 patent/US7462636B2/en not_active Expired - Fee Related
- 2003-05-16 DE DE60315984T patent/DE60315984T2/de not_active Expired - Lifetime
- 2003-05-16 MY MYPI20031819A patent/MY135226A/en unknown
- 2003-05-16 EP EP03735707A patent/EP1517899B1/en not_active Expired - Lifetime
- 2003-05-16 JP JP2004505349A patent/JP4674084B2/ja not_active Expired - Fee Related
- 2003-05-16 EA EA200401524A patent/EA010908B1/ru not_active IP Right Cessation
- 2003-05-16 NZ NZ536496A patent/NZ536496A/en not_active IP Right Cessation
- 2003-05-16 AU AU2003238074A patent/AU2003238074B2/en not_active Ceased
2004
- 2004-12-14 NO NO20045444A patent/NO330184B1/no not_active IP Right Cessation
- 2004-12-15 ZA ZA2004/10156A patent/ZA200410156B/en unknown
2007
- 2007-11-29 CY CY20071101524T patent/CY1107040T1/el unknown
2010
- 2010-10-25 JP JP2010238833A patent/JP2011051999A/ja active Pending

Also Published As

Publication number	Publication date
CA2485903A1 (en)	2003-11-27
AU2003238074B2 (en)	2009-04-30
KR101019648B1 (ko)	2011-03-07
DK1517899T3 (da)	2007-12-03
CY1107040T1 (el)	2012-09-26
IL165043A0 (en)	2005-12-18
HRP20050607B1 (hr)	2014-07-04
JP2005527607A (ja)	2005-09-15
JP2011051999A (ja)	2011-03-17
NO20045444L (no)	2005-02-16
KR20050013549A (ko)	2005-02-04
NO330184B1 (no)	2011-02-28
ATE371652T1 (de)	2007-09-15
TW200404538A (en)	2004-04-01
DE60315984D1 (de)	2007-10-11
AR039887A1 (es)	2005-03-09
PL373425A1 (en)	2005-08-22
BR0310089A (pt)	2005-02-15
TWI356700B (en)	2012-01-21
ZA200410156B (en)	2005-11-30
AU2003238074A1 (en)	2003-12-02
MY135226A (en)	2008-02-29
CA2485903C (en)	2011-08-16
HK1076099A1 (en)	2006-01-06
MXPA04011466A (es)	2005-02-14
DE60315984T2 (de)	2008-05-29
NZ536496A (en)	2006-06-30
US20050171173A1 (en)	2005-08-04
EA010908B1 (ru)	2008-12-30
ES2292976T3 (es)	2008-03-16
EP1517899B1 (en)	2007-08-29
PT1517899E (pt)	2007-11-16
CN1668605A (zh)	2005-09-14
CN100582097C (zh)	2010-01-20
HRP20050607A2 (en)	2006-02-28
WO2003097616A1 (en)	2003-11-27
AP2004003190A0 (en)	2004-12-31
EA200401524A1 (ru)	2005-06-30
US7462636B2 (en)	2008-12-09
JP4674084B2 (ja)	2011-04-20
KR20100130234A (ko)	2010-12-10
EP1517899A1 (en)	2005-03-30

Publication	Publication Date	Title
EP1499336A4 (en)	2005-06-01	PROTEASE INHIBITORS
EP1483254A4 (en)	2005-06-08	INHIBITORS OF ANTI-RESISTANCE RETROVIRAL PROTEASE
AP2003002856A0 (en)	2003-09-30	Broadspectrum 2-(substitutted-amino)-benzothiazolesulphonamide HIV protease inhibitors.
IL179056A0 (en)	2007-03-08	An hiv protease inhibitor
IL158093A0 (en)	2004-03-28	Broadspectrum 2-amino-benzoxazole sulfonamide hiv protease inhibitors
EP1704142A4 (en)	2008-08-20	PROTEASE INHIBITORS
IL165043A0 (en)	2005-12-18	broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
PL375307A1 (en)	2005-11-28	Broadspectrum substituted oxindole sulfonamide hiv protease inhibitors
AP1878A (en)	2008-08-13	Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors.
AU2003269984A8 (en)	2004-03-11	Protease inhibitors
AP2003002882A0 (en)	2003-12-31	Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors.
AP2004003083A0 (en)	2004-09-30	Broadspectrum heterocyclic substituted phenyl containing sulfonamide HIV protease inhibitors
HRP20040936A2 (en)	2005-10-31	Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
AU2003263738A8 (en)	2003-12-02	Protease inhibitors
AU2003287325A8 (en)	2004-06-03	N-cycloalkylglycines as hiv protease inhibitors
ZA200500926B (en)	2006-03-29	Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors
AU2003304496A8 (en)	2005-04-27	Protease inhibitors
HK1079769A (zh)	2006-04-13	取代的羟吲哚磺酰胺类广谱hiv蛋白酶抑制剂
AU2003233642A8 (en)	2003-12-12	Protease inhibitors
HK1079684A (en)	2006-04-13	Broadspectrum 2-amino-benzothiazole sulfonamide hiv protease inhibitors
AU2003265240A8 (en)	2003-12-22	Protease inhibitors
AU2003269878A8 (en)	2003-12-22	Protease inhibitors
AU2002255485A8 (en)	2008-01-10	Hiv/fiv protease inhibitors
TWI340135B (en)	2011-04-11	Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors
HK1071573A (en)	2005-07-22	Resistance-repellent retroviral protease inhibitors