DE60315984D1 - Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung - Google Patents

Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung

Info

Publication number: DE60315984D1
Authority: DE; Germany
Prior art keywords: hammender; benzoxoxolsulfonamides; protease; broad; substituted
Prior art date: 2002-05-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60315984T

Other languages

English (en)

Other versions

DE60315984T2 (de

Inventor

Dominique Louis Surleraux

Bernhard Joanna Vergouwen

Kock Herman Augustinus De

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen R&D Ireland ULC

Original Assignee

Tibotec Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-17

Filing date

2003-05-16

Publication date

2007-10-11

2003-05-16 Application filed by Tibotec Pharmaceuticals Ltd filed Critical Tibotec Pharmaceuticals Ltd

2007-10-11 Application granted granted Critical

2007-10-11 Publication of DE60315984D1 publication Critical patent/DE60315984D1/de

2008-05-29 Publication of DE60315984T2 publication Critical patent/DE60315984T2/de

2023-05-17 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE60315984T 2002-05-17 2003-05-16 Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung Expired - Lifetime DE60315984T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP02076957		2002-05-17
EP02076957		2002-05-17
PCT/EP2003/050173 WO2003097616A1 (en)	2002-05-17	2003-05-16	Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors

Publications (2)

Publication Number	Publication Date
DE60315984D1 true DE60315984D1 (de)	2007-10-11
DE60315984T2 DE60315984T2 (de)	2008-05-29

Family

ID=29433159

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60315984T Expired - Lifetime DE60315984T2 (de)	2002-05-17	2003-05-16	Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung

Country Status (29)

Country	Link
US (1)	US7462636B2 (de)
EP (1)	EP1517899B1 (de)
JP (2)	JP4674084B2 (de)
KR (2)	KR20100130234A (de)
CN (1)	CN100582097C (de)
AP (1)	AP2004003190A0 (de)
AR (1)	AR039887A1 (de)
AT (1)	ATE371652T1 (de)
AU (1)	AU2003238074B2 (de)
BR (1)	BR0310089A (de)
CA (1)	CA2485903C (de)
CY (1)	CY1107040T1 (de)
DE (1)	DE60315984T2 (de)
DK (1)	DK1517899T3 (de)
EA (1)	EA010908B1 (de)
ES (1)	ES2292976T3 (de)
HK (1)	HK1076099A1 (de)
HR (1)	HRP20050607B1 (de)
IL (1)	IL165043A0 (de)
MX (1)	MXPA04011466A (de)
MY (1)	MY135226A (de)
NO (1)	NO330184B1 (de)
NZ (1)	NZ536496A (de)
PL (1)	PL373425A1 (de)
PT (1)	PT1517899E (de)
SI (1)	SI1517899T1 (de)
TW (1)	TWI356700B (de)
WO (1)	WO2003097616A1 (de)
ZA (1)	ZA200410156B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EA010908B1 (ru) *	2002-05-17	2008-12-30	Тиботек Фармасьютикалз Лтд.	Ингибиторы вич-протеазы на основе замещённых бензизоксазолсульфонамидов широкого спектра действия
WO2005087728A1 (en) *	2004-03-11	2005-09-22	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
MXPA06012909A (es) *	2004-05-07	2007-09-06	Sequoia Pharmaceuticals Inc	Inhibidores de proteasa retroviral repelente de resistencia.
KR101333627B1 (ko)	2005-02-25	2013-11-27	얀센 알 앤드 디 아일랜드	프로테아제 저해제 전구체 합성
CN101702908A (zh) *	2007-03-23	2010-05-05	麻萨诸塞州大学	Hiv-1蛋白酶抑制剂
WO2009118356A2 (en) *	2008-03-25	2009-10-01	Formac Pharmaceuticals N.V.	Preparation method for solid disupersions
WO2011061590A1 (en)	2009-11-17	2011-05-26	Hetero Research Foundation	Novel carboxamide derivatives as hiv inhibitors
DE102010004957A1 (de) *	2010-01-14	2011-07-21	Universitätsklinikum Jena, 07743	Biologisch wirksame Moleküle zur Beeinflussung von Virus-, Bakterien-, Parasiten-infizierten Zellen und/oder Tumorzellen und Verfahren zu deren Anwendung
US20150284380A1 (en)	2012-10-31	2015-10-08	Bayer Cropscience Ag	Novel heterocyclic compounds as pest control agents
EP2964204B1 (de)	2013-03-07	2017-01-04	Dow Global Technologies LLC	Neuartige veresterte celluloseether von sehr geringer viskosität

Family Cites Families (24)

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US5004751A (en) *	1987-08-28	1991-04-02	Mochida Pharmaceutical Co., Ltd.	Hydantoin derivatives
US5145684A (en)	1991-01-25	1992-09-08	Sterling Drug Inc.	Surface modified drug nanoparticles
KR100296463B1 (ko) *	1992-08-25	2001-10-24	죤 에이치. 뷰센	레트로바이러스프로테아제저해제로서유용한히드록시에틸아미노술폰아미드
PH30929A (en)	1992-09-03	1997-12-23	Janssen Pharmaceutica Nv	Beads having a core coated with an antifungal and a polymer.
IS2334B (is) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
EP0715618B1 (de)	1993-08-24	1998-12-16	G.D. Searle & Co.	Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
DE69429357T2 (de)	1993-10-01	2002-08-14	Astrazeneca Ab, Soedertaelje	Verfahren i
CA2210889C (en) *	1995-01-20	2007-08-28	G.D. Searle & Co.	Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
US5756533A (en)	1995-03-10	1998-05-26	G.D. Searle & Co.	Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
JP4124818B2 (ja) *	1995-03-10	2008-07-23	ジー．ディー．サールアンドカンパニー	ヘテロシクロカルボニルアミノ酸ヒドロキシエチルアミノスルホンアミドレトロウイルスプロテアーゼインヒビター
US5705500A (en)	1995-03-10	1998-01-06	G.D. Searle & Co.	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en)	1995-03-10	2000-11-21	G. D. Dearle & Co.	Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5753660A (en)	1995-11-15	1998-05-19	G. D. Searle & Co.	Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
BR9706897B1 (pt)	1996-05-20	2010-09-21		forma de dosagem farmacêutica.
CZ295502B6 (cs)	1997-03-26	2005-08-17	Janssen Pharmaceutica N. V.	Antifungální peleta, způsob její přípravy a farmaceutická dávková forma s obsahem těchto pelet
AU2012199A (en)	1997-12-24	1999-07-19	Vertex Pharmaceuticals Incorporated	Prodrugs of aspartyl protease inhibitors
US6436989B1 (en)	1997-12-24	2002-08-20	Vertex Pharmaceuticals, Incorporated	Prodrugs of aspartyl protease inhibitors
AP2000001856A0 (en)	1997-12-24	2000-09-30	Vertex Pharma	Prodrugs of aspartyl protease inhibitors.
WO1999033792A2 (en)	1997-12-24	1999-07-08	Vertex Pharmaceuticals Incorporated	Prodrugs os aspartyl protease inhibitors
DE69943266D1 (de) *	1998-06-23	2011-04-21	Trustees For The University Of Illinois Board Of	Arzneimittel zur behandlung von hiv-infizierten säugetieren
AU4828199A (en)	1998-06-23	2000-01-10	Board Of Trustees Of The University Of Illinois, The	Multi-drug resistant retroviral protease inhibitors and associated methods
CA2386850C (en)	1999-10-06	2010-03-30	Piet Tom Bert Paul Wigerinck	Hexahydrofuro[2,3-b]furan-3-yl-n-{3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl} carbamate as retroviral protease inhibitor
MXPA03009179A (es) *	2001-04-09	2004-11-22	Tibotec Pharm Ltd	2-(amino sustituido)-benzoxazol sunfonamidas, inhibidores de amplio espectro de la vih proteasa.
EA010908B1 (ru) *	2002-05-17	2008-12-30	Тиботек Фармасьютикалз Лтд.	Ингибиторы вич-протеазы на основе замещённых бензизоксазолсульфонамидов широкого спектра действия

2003
- 2003-05-16 EA EA200401524A patent/EA010908B1/ru not_active IP Right Cessation
- 2003-05-16 AU AU2003238074A patent/AU2003238074B2/en not_active Ceased
- 2003-05-16 PT PT03735707T patent/PT1517899E/pt unknown
- 2003-05-16 EP EP03735707A patent/EP1517899B1/de not_active Expired - Lifetime
- 2003-05-16 KR KR1020107025714A patent/KR20100130234A/ko not_active Withdrawn
- 2003-05-16 NZ NZ536496A patent/NZ536496A/en not_active IP Right Cessation
- 2003-05-16 PL PL03373425A patent/PL373425A1/xx unknown
- 2003-05-16 WO PCT/EP2003/050173 patent/WO2003097616A1/en active IP Right Grant
- 2003-05-16 CN CN03816458A patent/CN100582097C/zh not_active Expired - Fee Related
- 2003-05-16 AR ARP030101725A patent/AR039887A1/es active IP Right Grant
- 2003-05-16 JP JP2004505349A patent/JP4674084B2/ja not_active Expired - Fee Related
- 2003-05-16 BR BR0310089-8A patent/BR0310089A/pt not_active IP Right Cessation
- 2003-05-16 MX MXPA04011466A patent/MXPA04011466A/es active IP Right Grant
- 2003-05-16 CA CA2485903A patent/CA2485903C/en not_active Expired - Fee Related
- 2003-05-16 ES ES03735707T patent/ES2292976T3/es not_active Expired - Lifetime
- 2003-05-16 MY MYPI20031819A patent/MY135226A/en unknown
- 2003-05-16 AT AT03735707T patent/ATE371652T1/de active
- 2003-05-16 KR KR1020047018261A patent/KR101019648B1/ko not_active Expired - Fee Related
- 2003-05-16 US US10/514,539 patent/US7462636B2/en not_active Expired - Fee Related
- 2003-05-16 SI SI200331012T patent/SI1517899T1/sl unknown
- 2003-05-16 IL IL16504303A patent/IL165043A0/xx not_active IP Right Cessation
- 2003-05-16 DK DK03735707T patent/DK1517899T3/da active
- 2003-05-16 TW TW092113367A patent/TWI356700B/zh not_active IP Right Cessation
- 2003-05-16 DE DE60315984T patent/DE60315984T2/de not_active Expired - Lifetime
- 2003-05-16 AP AP2004003190A patent/AP2004003190A0/xx unknown
2004
- 2004-12-14 NO NO20045444A patent/NO330184B1/no not_active IP Right Cessation
- 2004-12-15 ZA ZA2004/10156A patent/ZA200410156B/en unknown
2005
- 2005-06-29 HR HRP20050607AA patent/HRP20050607B1/hr not_active IP Right Cessation
- 2005-09-14 HK HK05108052A patent/HK1076099A1/xx not_active IP Right Cessation
2007
- 2007-11-29 CY CY20071101524T patent/CY1107040T1/el unknown
2010
- 2010-10-25 JP JP2010238833A patent/JP2011051999A/ja active Pending

Also Published As

Publication number	Publication date
EP1517899B1 (de)	2007-08-29
DE60315984T2 (de)	2008-05-29
TW200404538A (en)	2004-04-01
WO2003097616A1 (en)	2003-11-27
HK1076099A1 (en)	2006-01-06
NO330184B1 (no)	2011-02-28
CA2485903A1 (en)	2003-11-27
MY135226A (en)	2008-02-29
KR20050013549A (ko)	2005-02-04
SI1517899T1 (sl)	2008-02-29
US7462636B2 (en)	2008-12-09
IL165043A0 (en)	2005-12-18
ATE371652T1 (de)	2007-09-15
EA200401524A1 (ru)	2005-06-30
CN100582097C (zh)	2010-01-20
ES2292976T3 (es)	2008-03-16
CN1668605A (zh)	2005-09-14
EP1517899A1 (de)	2005-03-30
JP2011051999A (ja)	2011-03-17
AP2004003190A0 (en)	2004-12-31
AU2003238074B2 (en)	2009-04-30
JP2005527607A (ja)	2005-09-15
US20050171173A1 (en)	2005-08-04
CA2485903C (en)	2011-08-16
PT1517899E (pt)	2007-11-16
MXPA04011466A (es)	2005-02-14
KR101019648B1 (ko)	2011-03-07
EA010908B1 (ru)	2008-12-30
DK1517899T3 (da)	2007-12-03
JP4674084B2 (ja)	2011-04-20
AU2003238074A1 (en)	2003-12-02
TWI356700B (en)	2012-01-21
ZA200410156B (en)	2005-11-30
KR20100130234A (ko)	2010-12-10
BR0310089A (pt)	2005-02-15
AR039887A1 (es)	2005-03-09
NO20045444L (no)	2005-02-16
PL373425A1 (en)	2005-08-22
NZ536496A (en)	2006-06-30
HRP20050607A2 (en)	2006-02-28
HRP20050607B1 (hr)	2014-07-04
CY1107040T1 (el)	2012-09-26

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ATE318817T1 (de)	2006-03-15	Aza-arylpiperazine
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ATA1572002A (de)	2003-06-15	Managementspleisskassette
DE60315984D1 (de)	2007-10-11	Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung
DE602004027792D1 (de)	2010-08-05	Indazolamide mit analgetischer wirkung
ATE444953T1 (de)	2009-10-15	Substituierte spirobenzazepine
DE602004017199D1 (de)	2008-11-27	Silikonverbindungen mit mikrobizider wirkung
DE502004009935D1 (de)	2009-10-01	Substituierte dihydrochinazoline ii
DE50311770D1 (de)	2009-09-17	Oberfräse
DE60330246D1 (de)	2010-01-07	Geschenkverpackung
ATA19152002A (de)	2004-11-15	Hubkupplung
SE0202927D0 (sv)	2002-10-03	Spridare
IS2316B (is)	2007-11-15	Stöðugt rotvarnarefni
ATE350379T1 (de)	2007-01-15	Substituierte benzdioxepine
AT5889U3 (de)	2003-04-25	Brennholzspleisser

Legal Events

Date	Code	Title	Description
2008-09-18	8364	No opposition during term of opposition