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UY37456A - Inmunoglobulinas y sus usos - Google Patents

Inmunoglobulinas y sus usos

Info

Publication number
UY37456A
UY37456A UY0001037456A UY37456A UY37456A UY 37456 A UY37456 A UY 37456A UY 0001037456 A UY0001037456 A UY 0001037456A UY 37456 A UY37456 A UY 37456A UY 37456 A UY37456 A UY 37456A
Authority
UY
Uruguay
Prior art keywords
relates
immunoglobulinas
therapeutic
couple
life
Prior art date
Application number
UY0001037456A
Other languages
English (en)
Inventor
J Patch Raymond
Rui Zhang
Mark Macielag
A Case Martin
M Rangwala Shamina
N Leonard James
C Camacho Raul
j hunter Michael
E D’Aquino Katharine
Wilson Edwards
Ronald Swanson
Wenying Jian
Zhang Yue-Mei
Mark Wall
Ellen Chi
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62020814&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY37456(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of UY37456A publication Critical patent/UY37456A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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Abstract

La presente invención se refiere a una plataforma de anticuerpo monoclonal diseñada para acoplarse a péptidos terapéuticos para aumentar el período de semidesintegración del péptido terapéutico en un sujeto. La invención se refiere, además, a composiciones farmacéuticas y a métodos para su uso.
UY0001037456A 2016-10-27 2017-10-26 Inmunoglobulinas y sus usos UY37456A (es)

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UY0001037457A UY37457A (es) 2016-10-27 2017-10-26 Compuestos de anticuerpos acoplados de tirosina-tirosina cíclica como moduladores de receptores del neuropeptido y
UY0001037456A UY37456A (es) 2016-10-27 2017-10-26 Inmunoglobulinas y sus usos

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US10961293B2 (en) 2021-03-30
US20190367577A1 (en) 2019-12-05
KR20190073492A (ko) 2019-06-26

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