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JOP20190095A1 - مركبات ببتيد تيروسين-تيروسين الحلقية كمعدلات لمستقبلات الببتيد العصبي y - Google Patents

مركبات ببتيد تيروسين-تيروسين الحلقية كمعدلات لمستقبلات الببتيد العصبي y

Info

Publication number
JOP20190095A1
JOP20190095A1 JOP/2019/0095A JOP20190095A JOP20190095A1 JO P20190095 A1 JOP20190095 A1 JO P20190095A1 JO P20190095 A JOP20190095 A JO P20190095A JO P20190095 A1 JOP20190095 A1 JO P20190095A1
Authority
JO
Jordan
Prior art keywords
tyrosine
compounds
neuropeptide
modulators
receptors
Prior art date
Application number
JOP/2019/0095A
Other languages
English (en)
Inventor
Yue-Mei Zhang
Martin A Case
Mark Macielag
Mark Wall
Rui Zhang
Raymond J Patch
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62020814&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JOP20190095(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of JOP20190095A1 publication Critical patent/JOP20190095A1/ar

Links

Classifications

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57545—Neuropeptide Y
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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Abstract

يتضمن الاختراع مركبات بالصيغة I. الصيغة I حيث: يتم تعريف Z4 وZ7 وZ9 وZ11 وZ22 وZ23 وZ26 وZ30 وZ34 وZ35 وp وm وn وq وBRIDGE في المواصفات. يتعلق هذا الاختراع أيضًا بالتركيبات الصيدلانية وطرق استخدامها. والمركبات المبتكرة مفيدة لمنع أو علاج أو تخفيف أمراض واضطرابات، مثل السمنة وداء السكري من النوع 2 ومتلازمة الأيض ومقاومة الأنسولين وعسر شحميات الدم وغير ذلك.
JOP/2019/0095A 2016-10-27 2017-06-16 مركبات ببتيد تيروسين-تيروسين الحلقية كمعدلات لمستقبلات الببتيد العصبي y JOP20190095A1 (ar)

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JOP/2019/0096A JOP20190096B1 (ar) 2016-10-27 2017-10-26 مركبات ببتيد تيروسين-تيروسين الحلقية المقترنة بجسم مضاد كمعدلات لمستقبلات الببتيد العصبي y

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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015095604A2 (en) 2013-12-18 2015-06-25 President And Fellows Of Harvard College Methods and assays relating to circulating tumor cells
JOP20190097A1 (ar) * 2016-10-27 2019-04-28 Janssen Pharmaceutica Nv الجلوبولينات المناعية واستخداماتها
US10875902B2 (en) 2018-04-25 2020-12-29 Janssen Pharmaceutica Nv Glucagon like peptide 1 (GLP-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof
TWI847981B (zh) * 2018-04-25 2024-07-11 比利時商健生藥品公司 類升糖素肽1 (glp-1)融合肽偶合環狀酪酪肽接合物及其用途
CN113748125A (zh) * 2019-03-19 2021-12-03 恩泽生物科学有限公司 胰高血糖素样肽-1(glp-1)受体激动剂及其类似物的制备方法
WO2020262590A1 (ja) * 2019-06-28 2020-12-30 味の素株式会社 環状ペプチドの製造方法
CA3156452A1 (en) 2019-11-11 2021-05-20 Boehringer Ingelheim International Gmbh Npy2 receptor agonists
CN111494606B (zh) * 2020-04-24 2021-12-14 广州医科大学 神经肽y的新应用
CN116171282A (zh) 2020-08-07 2023-05-26 勃林格殷格翰国际有限公司 可溶npy2受体激动剂
CN115073556A (zh) * 2021-03-12 2022-09-20 上海天慈生命科学发展有限公司 一类阿片/神经肽ff受体多靶点环肽分子及其制备和应用
US20230015478A1 (en) * 2021-06-14 2023-01-19 Resolute Bio, Inc. Glp-1 receptor agonists having improved pharmacological and drug delivery properties
WO2023097363A1 (en) * 2021-11-30 2023-06-08 Garvan Institute Of Medical Research Improved binding proteins and uses thereof
CN115028551B (zh) * 2022-07-15 2024-01-05 成都普康生物科技有限公司 一种叠氮-九甘醇-丙酸的制备方法
CN116098987A (zh) * 2023-02-09 2023-05-12 华东医院 甘丙肽在制备治疗非酒精性脂肪性肝病药物中的用途

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2434149A1 (fr) 1978-06-22 1980-03-21 Parcor Nouveaux derives de la l-cysteine
US5393669A (en) 1993-02-05 1995-02-28 Martek Biosciences Corp. Compositions and methods for protein structural determinations
US7166575B2 (en) 2002-12-17 2007-01-23 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity
WO2005077094A2 (en) 2004-02-11 2005-08-25 Amylin Pharmaceuticals, Inc. Pancreatic polypeptide family motifs and polypeptides comprising the same
US20070244041A1 (en) * 2004-02-23 2007-10-18 Reoscience A/S Peptide Yy Analogues
MXPA06010347A (es) * 2004-03-17 2007-06-19 7Tm Pharma As Agonistas de receptor selectivo de y2 para intervenciones terapeuticas.
JP2008511337A (ja) 2004-09-02 2008-04-17 ジェネンテック・インコーポレーテッド ヘテロ多量体分子
ES2592271T3 (es) 2005-03-31 2016-11-29 Chugai Seiyaku Kabushiki Kaisha Métodos de producción de polipéptidos mediante la regulación de la asociación de los polipéptidos
DE102005028778A1 (de) 2005-06-22 2006-12-28 SUNJÜT Deutschland GmbH Mehrlagige Folie mit einer Barriere- und einer antistatischen Lage
EP2471810A1 (en) 2006-02-22 2012-07-04 Merck Sharp & Dohme Corporation Oxyntomodulin derivatives
CA2646598C (en) * 2006-03-21 2014-08-19 Amylin Pharmaceuticals, Inc. Peptide-peptidase inhibitor conjugates and methods of using same
EP2035456A1 (en) 2006-06-22 2009-03-18 Novo Nordisk A/S Production of bispecific antibodies
CA2665808A1 (en) 2006-10-05 2008-05-22 Centocor Ortho Biotech Inc. Ccr2 antagonists for treatment of fibrosis
JP2008169195A (ja) * 2007-01-05 2008-07-24 Hanmi Pharmaceutical Co Ltd キャリア物質を用いたインスリン分泌ペプチド薬物結合体
WO2009033743A1 (en) 2007-09-13 2009-03-19 University Of Zurich Prorektorat Forschung Monoclonal amyloid beta (abeta)-specific antibody and uses thereof
WO2009085462A1 (en) 2007-12-19 2009-07-09 Centocor, Inc. Design and generation of human de novo pix phage display libraries via fusion to pix or pvii, vectors, antibodies and methods
CN102272151B (zh) 2008-11-04 2014-08-20 詹森药业有限公司 Crhr2肽激动剂及其用途
JP2012507487A (ja) * 2008-11-05 2012-03-29 エフ．ホフマン−ラ ロシュ アーゲー 神経ペプチド２受容体（ｙ−２ｒ）アゴニスト及びその使用
AU2010245011B2 (en) 2009-04-27 2015-09-03 Oncomed Pharmaceuticals, Inc. Method for making heteromultimeric molecules
US9156901B2 (en) 2009-07-13 2015-10-13 Ditte Riber Acylated glucagon analogues
JP2013505221A (ja) 2009-09-18 2013-02-14 ノヴォ ノルディスク アー／エス 長時間作用性ｙ２受容体アゴニスト
JP2013506628A (ja) 2009-09-30 2013-02-28 グラクソ グループ リミテッド 延長された半減期を有する薬物融合物及びコンジュゲート
NZ701825A (en) 2010-04-20 2016-06-24 Genmab As Heterodimeric antibody fc-containing proteins and methods for production thereof
ES2757857T3 (es) 2010-09-27 2020-04-30 Janssen Biotech Inc Anticuerpos de unión a colágeno II humano
US8906649B2 (en) * 2010-09-27 2014-12-09 Janssen Biotech, Inc. Antibodies binding human collagen II
JP6167040B2 (ja) 2010-11-05 2017-07-19 ザイムワークス，インコーポレイテッド Ｆｃドメイン中に突然変異を有する、安定したヘテロ二量体抗体の設計
BR112013018877A2 (pt) * 2011-01-28 2016-10-04 Sanofi Sa composições farmacêuticas que compreendem anticorpos humanos para pcsk9
CA3080189C (en) 2011-06-17 2023-01-17 Hanmi Science Co., Ltd. A conjugate comprising oxyntomodulin and an immunoglobulin fragment, and use thereof
WO2013063702A1 (en) 2011-11-04 2013-05-10 Zymeworks Inc. Stable heterodimeric antibody design with mutations in the fc domain
JP6148729B2 (ja) * 2012-07-04 2017-06-14 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 共有結合している抗原−抗体結合体
TWI816739B (zh) 2012-11-06 2023-10-01 南韓商韓美藥品股份有限公司 包含調酸素及免疫球蛋白片段之蛋白質接合物的液態製劑
WO2014102299A2 (en) 2012-12-27 2014-07-03 Sanofi Anti-lamp1 antibodies and antibody drug conjugates, and uses thereof
EP2943512A4 (en) * 2013-01-11 2016-06-01 California Inst Biomedical Res BOVINE FUSION ANTIBODY
HK1214829A1 (zh) 2013-05-02 2016-08-05 Glaxosmithkline Intellectual Property Development Limited 治疗肽
TR201903526T4 (tr) 2014-04-11 2019-03-21 Medimmune Llc Sistein-mühendislik uygulanmış antikorlar içeren konjuge edilmiş bileşikler.
AR100978A1 (es) 2014-06-26 2016-11-16 Hoffmann La Roche LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS
EA035581B1 (ru) 2014-07-30 2020-07-10 НДжМ БИОФАРМАСЬЮТИКАЛЗ, ИНК. Композиции и способы применения для лечения метаболических расстройств
EA201891084A1 (ru) 2015-11-02 2019-10-31 Антитела к il1rap, биспецифические антигенсвязывающие молекулы, которые связываются с il1rap и cd3, и их применение
JOP20190097A1 (ar) * 2016-10-27 2019-04-28 Janssen Pharmaceutica Nv الجلوبولينات المناعية واستخداماتها
TWI847981B (zh) * 2018-04-25 2024-07-11 比利時商健生藥品公司 類升糖素肽1 (glp-1)融合肽偶合環狀酪酪肽接合物及其用途

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EP3532486B8 (en) 2022-01-12
US11767354B2 (en) 2023-09-26
US20180117170A1 (en) 2018-05-03
SA519401647B1 (ar) 2022-01-26
JP2022137031A (ja) 2022-09-21
US20190345214A1 (en) 2019-11-14
CO2019004203A2 (es) 2019-05-10
CL2019001129A1 (es) 2019-07-05
JP7231539B2 (ja) 2023-03-01
EP3534928A1 (en) 2019-09-11
US11401315B2 (en) 2022-08-02
PH12019500906A1 (en) 2020-01-20
TW201829455A (zh) 2018-08-16
US20210094998A1 (en) 2021-04-01
CL2019001110A1 (es) 2019-07-05
EP3988123B1 (en) 2025-02-26
JP7090077B2 (ja) 2022-06-23
MD3532486T2 (ro) 2022-01-31
IL266204A (en) 2019-06-30
EP3534928A4 (en) 2020-08-12
CA3041672A1 (en) 2018-05-03
KR20230129194A (ko) 2023-09-06
MX2019004952A (es) 2019-06-24
MA46665A (fr) 2019-09-04
AU2021269420B2 (en) 2023-11-23
US20190298849A1 (en) 2019-10-03
EP4574166A2 (en) 2025-06-25
IL266206A (en) 2019-06-30
AU2022200089B2 (en) 2023-11-16
TWI781118B (zh) 2022-10-21
MA46665B1 (fr) 2021-09-30
AU2021269420A1 (en) 2021-12-16
US10968265B2 (en) 2021-04-06
MA46672A (fr) 2019-09-04
IL266202B2 (en) 2023-09-01
ZA202200648B (en) 2024-02-28
ES3025907T3 (en) 2025-06-10
JOP20190096A1 (ar) 2019-04-28
CY1124732T1 (el) 2022-07-22

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