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SG11201810509PA - Anti-pd-l1 antibodies - Google Patents

Anti-pd-l1 antibodies

Info

Publication number
SG11201810509PA
SG11201810509PA SG11201810509PA SG11201810509PA SG11201810509PA SG 11201810509P A SG11201810509P A SG 11201810509PA SG 11201810509P A SG11201810509P A SG 11201810509PA SG 11201810509P A SG11201810509P A SG 11201810509PA SG 11201810509P A SG11201810509P A SG 11201810509PA
Authority
SG
Singapore
Prior art keywords
babraham
bennet
building
international
campus
Prior art date
Application number
SG11201810509PA
Inventor
Jamie Campbell
Nikole Sandy
Krinks Cassandra Van
Stephen John Arkinstall
Volker Germaschewski
Ian Kirby
Miha Kosmac
Thomas Gallagher
Cecilia Deantonio
Stephen Gillies
Original Assignee
Kymab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/211,504 external-priority patent/US9567399B1/en
Priority claimed from GBGB1615224.1A external-priority patent/GB201615224D0/en
Priority claimed from GBGB1615335.5A external-priority patent/GB201615335D0/en
Priority claimed from GBGB1620414.1A external-priority patent/GB201620414D0/en
Priority claimed from GBGB1621782.0A external-priority patent/GB201621782D0/en
Priority claimed from GBGB1702339.1A external-priority patent/GB201702339D0/en
Priority claimed from GBGB1702338.3A external-priority patent/GB201702338D0/en
Priority claimed from GBGB1703071.9A external-priority patent/GB201703071D0/en
Application filed by Kymab Ltd filed Critical Kymab Ltd
Publication of SG11201810509PA publication Critical patent/SG11201810509PA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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  • Transplantation (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) CORRECTED VERSION ---_. (19) World Intellectual Property 1111111101111 0 11101 HOE 010 1111 1 0 01 OH 0101101110111101101111011111101111 Organization International Bureau l i (10) International Publication Number (43) International Publication Date .......\"' WO 2017/220990 A9 28 December 2017 (28.12.2017) Wi PO I PCT (51) International Patent Classification: Babraham CB22 3AT (GB). GILLIES, Stephen, Douglas; A61K 38/20 (2006.01) A61K 39/395 (2006.01) 47 Swanson Lane, Carlisle, MA 01741-1044 (US). C07K 14/55 (2006.01) C07K 16/28 (2006.01) (74) Agent: LEONARD, Thomas; Kilburn & Strode LLP, 20 (21) International Application Number: Red Lion Street, London, WC1R 4PJ (GB). PCT/GB2017/051796 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: kind of national protection available): AE, AG, AL, AM, 20 June 2017 (20.06.2017) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (25) Filing Language: English CA, DZ, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (26) Publication Language: English HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (30) Priority Data: KR, 62/352,291 20 June 2016 (20.06.2016) US MG, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 15/211,504 15 July 2016 (15.07.2016) US OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 1613683.0 09 August 2016 (09.08.2016) GB SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 1615224.1 07 September 2016 (07.09.2016) GB TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 1615335.5 09 September 2016 (09.09.2016) GB (84) Designated States (unless otherwise indicated, for every — 15/354,971 17 November 2016 (17.11.2016) US kind of regional protection available): ARIPO (BW, GH, 1620414.1 01 December 2016 (01.12.2016) GB GM, 1621782.0 20 December 2016 (20.12.2016) GB UG, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = 1702338.3 13 February 2017 (13.02.2017) GB TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = 1702339.1 13 February 2017 (13.02.2017) GB EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, — 1703071.9 24 February 2017 (24.02.2017) GB MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 15/480,525 06 April 2017 (06.04.2017) US TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, — = KM, ML, MR, NE, SN, TD, TG). (71) Applicant: KYMAB LIMITED [GB/GB]; The Bennet = Building (B930), Babraham Research Campus, Cambridge Published: = CB22 3AT (GB). — with international search report (Art. 21(3)) (72) Inventors: CAMPBELL, Jamie; c/o The Bennet Build- (48) Date ing (B930), Babraham Research Campus, Babraham CB22 3AT (GB). SANDY, Nikole; c/o The Bennet Building of publication of this corrected version: 01 March 2018 (01.03.2018) = = (B930), Babraham Research Campus, Babraham CB22 (15) Information about Correction: = = = 3AT (GB). VAN KRINKS, Cassandra; c/o The Ben- see Notice of 01 March 2018 (01.03.2018) = net Building (B930), Babraham Research Campus, Babra- ham CB22 3AT (GB). ARKINSTALL, Stephen John; c/ o The Bennet Building (B930), Babraham Research Cam- pus, Babraham CB22 3AT (GB). GERMASCHEWSKI, Volker; c/o The Bennet Building (B930), Babraham Re- = = search Campus, Babraham CB22 3AT (GB). KIRBY, Ian; = c/o The Bennet Building (B930), Babraham Research Cam- - = pus, Babraham CB22 3AT (GB). KOSMAC, Miha; c/o The Bennet Building (B930), Babraham Research Campus, Babraham CB22 3AT (GB). GALLAGHER, Thomas; c/o _ The Bennet Building (B930), Babraham Research Campus, 0\ Babraham CB22 3AT (GB). DEANTONIO, Cecilia; c/o 0 The Bennet Building (B930), Babraham Research Campus, 0\ 0\ 0 ei el (54) Title: ANTI-PD-L1 ANTIBODIES IN (57) : The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity 1-1 c:::: , to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also N provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immuno- P1 cytokines.
SG11201810509PA 2016-06-20 2017-06-20 Anti-pd-l1 antibodies SG11201810509PA (en)

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US201662352291P 2016-06-20 2016-06-20
US15/211,504 US9567399B1 (en) 2016-06-20 2016-07-15 Antibodies and immunocytokines
GB201613683 2016-08-09
GBGB1615224.1A GB201615224D0 (en) 2016-09-07 2016-09-07 Antibodies
GBGB1615335.5A GB201615335D0 (en) 2016-09-09 2016-09-09 Antibodies and immunocytokines
US15/354,971 US9617338B1 (en) 2016-06-20 2016-11-17 Antibodies and immunocytokines
GBGB1620414.1A GB201620414D0 (en) 2016-12-01 2016-12-01 Antibodies
GBGB1621782.0A GB201621782D0 (en) 2016-12-20 2016-12-20 Antibodies and immunocytokines PD-L1 specific antibodies and PD-L1 specific immunocytokines
GBGB1702339.1A GB201702339D0 (en) 2017-02-13 2017-02-13 Antibodies and immunocytokines PD-L1 Specific antiboies and PD-L1 Specific immunocytokines
GBGB1702338.3A GB201702338D0 (en) 2017-02-13 2017-02-13 Antibodies and immunocytokines PD-L1 specific antibodies and specific immunocytokines
GBGB1703071.9A GB201703071D0 (en) 2017-02-24 2017-02-24 Antibodies
US15/480,525 US10604576B2 (en) 2016-06-20 2017-04-06 Antibodies and immunocytokines
PCT/GB2017/051796 WO2017220990A1 (en) 2016-06-20 2017-06-20 Anti-pd-l1 antibodies

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Families Citing this family (147)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12466897B2 (en) 2011-10-10 2025-11-11 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
US10738132B2 (en) 2013-01-14 2020-08-11 Xencor, Inc. Heterodimeric proteins
US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
KR20160030936A (en) 2013-07-16 2016-03-21 제넨테크, 인크. Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
US10618963B2 (en) 2014-03-12 2020-04-14 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
US10519237B2 (en) 2014-03-12 2019-12-31 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
BR112016020919A2 (en) 2014-03-12 2018-01-23 Yeda Res & Dev reduced levels or systemic activity of regulatory t cells for the treatment of snc disease and injury
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
IL252467B (en) 2014-11-26 2022-06-01 Xencor Inc Heterodimeric antibodies that bind cd3 and cd38
TN2017000223A1 (en) 2014-11-26 2018-10-19 Xencor Inc Heterodimeric antibodies that bind cd3 and tumor antigens
BR112017024899A2 (en) 2015-05-21 2018-11-13 Harpoon Therapeutics, Inc. trispecific binding proteins and methods of use.
JP7101621B2 (en) 2016-05-20 2022-07-15 ハープーン セラピューティクス，インク． Single domain serum albumin binding protein
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
US9567399B1 (en) 2016-06-20 2017-02-14 Kymab Limited Antibodies and immunocytokines
DK3472207T3 (en) 2016-06-20 2021-04-12 F Star Delta Ltd BINDING MOLECULES THAT BIND PD-L1 AND LAYER-3
SG11201810509PA (en) * 2016-06-20 2018-12-28 Kymab Ltd Anti-pd-l1 antibodies
CA3027302A1 (en) 2016-06-20 2017-12-28 F-Star Beta Limited Binding members(1)
CA3029328A1 (en) 2016-06-28 2018-01-04 Xencor, Inc. Heterodimeric antibodies that bind somatostatin receptor 2
GB201612520D0 (en) 2016-07-19 2016-08-31 F-Star Beta Ltd Binding molecules
RU2764548C2 (en) 2016-08-09 2022-01-18 Кимаб Лимитед Anti-icos antibodies
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods
CA3039316A1 (en) 2016-11-28 2018-05-31 Chugai Seiyaku Kabushiki Kaisha Ligand-binding molecule having adjustable ligand binding activity
US11168139B2 (en) 2016-11-28 2021-11-09 Chugai Seiyaku Kabushiki Kaisha Antigen-binding domain, and polypeptide including conveying section
WO2018115859A1 (en) * 2016-12-20 2018-06-28 Kymab Limited Multispecific antibody with combination therapy for immuno-oncology
EP4389226A3 (en) 2017-02-24 2024-12-18 MacroGenics, Inc. Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof
TWI788340B (en) 2017-04-07 2023-01-01 美商必治妥美雅史谷比公司 Anti-icos agonist antibodies and uses thereof
US11203611B2 (en) 2017-04-14 2021-12-21 Tollnine, Inc. Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use
US11168144B2 (en) 2017-06-01 2021-11-09 Cytomx Therapeutics, Inc. Activatable anti-PDL1 antibodies, and methods of use thereof
GB201709808D0 (en) 2017-06-20 2017-08-02 Kymab Ltd Antibodies
KR102425983B1 (en) 2017-10-13 2022-07-29 하푼 테라퓨틱스, 인크. Trispecific Proteins and Methods of Use
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B cell maturation antigen binding proteins
US11312770B2 (en) 2017-11-08 2022-04-26 Xencor, Inc. Bispecific and monospecific antibodies using novel anti-PD-1 sequences
PH12020550661A1 (en) 2017-11-21 2021-04-19 Univ Leland Stanford Junior Partial agonists of interleukin-2
TWI818934B (en) 2017-11-28 2023-10-21 日商中外製藥股份有限公司 Ligand-binding molecules with adjustable ligand-binding activity
WO2019107380A1 (en) 2017-11-28 2019-06-06 中外製薬株式会社 Polypeptide including antigen-binding domain and carrying section
WO2019121906A1 (en) 2017-12-19 2019-06-27 F-Star Beta Limited Specific pd-l1 binding sequences inserted in a ch3 domain
EP3728314A1 (en) 2017-12-19 2020-10-28 Kymab Limited Bispecific antibody for icos and pd-l1
GB201721338D0 (en) 2017-12-19 2018-01-31 Kymab Ltd Anti-icos Antibodies
CN110352202A (en) * 2018-01-25 2019-10-18 天境生物 anti-PD-L1 antibody and IL-7 fusion protein
CN112040971A (en) * 2018-02-08 2020-12-04 蜻蜓疗法股份有限公司 Combination cancer therapy involving multispecific binding proteins that activate natural killer cells
KR20200135313A (en) * 2018-02-26 2020-12-02 제넨테크, 인크. Dosing for treatment with anti-TIGIT and anti-PD-L1 antagonist antibodies
CA3115461A1 (en) 2018-03-09 2019-09-12 AskGene Pharma, Inc. Novel cytokine prodrugs
US11242393B2 (en) 2018-03-23 2022-02-08 Bristol-Myers Squibb Company Antibodies against MICA and/or MICB and uses thereof
US10982006B2 (en) 2018-04-04 2021-04-20 Xencor, Inc. Heterodimeric antibodies that bind fibroblast activation protein
WO2019241707A1 (en) * 2018-06-14 2019-12-19 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for preventing or reversing t-cell exhaustion through ectonucleotidase inhibition antibody-mediated target cytosis
JP2021529556A (en) * 2018-06-29 2021-11-04 ジェンサン バイオファーマ、 インコーポレイテッドＧｅｎｓｕｎ Ｂｉｏｐｈａｒｍａ， Ｉｎｃ． Antitumor antagonist
GB201811415D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd Anti-Mesothelin Anti bodies
GB201811408D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd CD137 Binding Molecules
IL280002B2 (en) 2018-07-12 2025-05-01 F Star Beta Ltd Antibody molecules that bind cd137 and ox40
GB201811450D0 (en) 2018-07-12 2018-08-29 F Star Delta Ltd Mesothelin and CD137 binding molecules
GB201811403D0 (en) * 2018-07-12 2018-08-29 F Star Beta Ltd Antibody molecules
GB201811404D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd Anti-CD137 Antibodies
GB201811410D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd OX40 Binding molecules
WO2020011964A1 (en) 2018-07-12 2020-01-16 F-Star Beta Limited Antibody molecules that bind pd-l1 and cd137
WO2020020307A1 (en) * 2018-07-25 2020-01-30 I-Mab Biopharma Co., Ltd. Anti-cd73 anti-pd-l1 bispecific antibodies
CN112534052B (en) 2018-07-25 2024-09-20 奥美药业有限公司 New IL-21 prodrug and method of use
CN110790839B (en) * 2018-08-03 2023-05-12 江苏恒瑞医药股份有限公司 anti-PD-1 antibody, antigen binding fragment thereof and medical application thereof
AU2019324170A1 (en) 2018-08-23 2021-02-18 Seagen, Inc. Anti-TIGIT antibodies
AU2019343850B2 (en) * 2018-09-17 2024-06-06 Gi Innovation, Inc. Fusion protein comprising IL-2 protein and CD80 protein, and use thereof
US12195544B2 (en) 2018-09-21 2025-01-14 Harpoon Therapeutics, Inc. EGFR binding proteins and methods of use
EP3856771A4 (en) 2018-09-25 2022-06-29 Harpoon Therapeutics, Inc. Dll3 binding proteins and methods of use
US12378295B2 (en) 2018-10-29 2025-08-05 1Globe Biomedical Co., Ltd. Rationally designed protein compositions
BR112021008795A2 (en) 2018-11-13 2021-08-31 Compass Therapeutics Llc MULTISPECIFIC BINDING CONSTRUCTS AGAINST CHECKPOINT MOLECULES AND THEIR USES
TW202020159A (en) * 2018-11-16 2020-06-01 大陸商南京金斯瑞生物科技有限公司 Humanized anti-human pd-l1 monoclonal antibody, preparation method and use thereof
AU2019390274A1 (en) * 2018-11-30 2021-07-22 Abl Bio Inc. Anti-PD-L1/anti-4-1BB bispecific antibodies and uses thereof
WO2020130300A1 (en) * 2018-12-21 2020-06-25 한미약품 주식회사 Novel immunosuppressive interleukin 2
BR112021012631A2 (en) 2018-12-26 2021-12-14 Xilio Dev Inc Anti-ctla4 antibodies and methods of using them
CN113811549A (en) 2019-02-21 2021-12-17 Xencor股份有限公司 Untargeted and targeted IL-10 FC fusion proteins
CN113874031A (en) * 2019-03-29 2021-12-31 苏黎士大学 Fc-modified biologics for local delivery to compartments, in particular CNS
CN109929037B (en) * 2019-04-01 2023-03-17 华博生物医药技术（上海）有限公司 Conjugates to programmed death ligands and uses thereof
GB201905552D0 (en) 2019-04-18 2019-06-05 Kymab Ltd Antagonists
EP3725370A1 (en) 2019-04-19 2020-10-21 ImmunoBrain Checkpoint, Inc. Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease
EP3976832A1 (en) 2019-05-30 2022-04-06 Bristol-Myers Squibb Company Methods of identifying a subject suitable for an immuno-oncology (i-o) therapy
KR20220016157A (en) 2019-05-30 2022-02-08 브리스톨-마이어스 스큅 컴퍼니 Cell localization signatures and combination therapies
CN110128550B (en) * 2019-05-30 2023-01-13 南京惟亚德生物医药有限公司 Novel replicative oncolytic adenovirus capable of simultaneously blocking immune check points PD-L1 and TIGIT and application
JP2022534967A (en) 2019-05-30 2022-08-04 ブリストル－マイヤーズ スクイブ カンパニー Multiple tumor gene signatures and their uses
US11845801B2 (en) 2019-06-12 2023-12-19 AskGene Pharma, Inc. IL-15 prodrugs and methods of use thereof
AU2020292421B2 (en) * 2019-06-14 2026-01-08 Cugene, Inc. Novel interleukin-2 variants and bifunctional fusion molecules thereof
CA3144617A1 (en) 2019-06-26 2020-12-30 Ap Biosciences, Inc. Antibodies for t-cell activation
WO2020264318A1 (en) * 2019-06-26 2020-12-30 The Johns Hopkins University Methods and materials for targeted expansion of regulatory t cells
KR20220054579A (en) * 2019-06-26 2022-05-03 더 존스 홉킨스 유니버시티 Methods and Materials for Targeted Expansion of Immune Effector Cells
CN116574183A (en) * 2019-08-22 2023-08-11 盛禾(中国)生物制药有限公司 Multifunctional antibodies, their preparation and use
AU2020339478A1 (en) 2019-08-29 2021-05-06 Remegen Co., Ltd. Anti PD-L1 antibody and use thereof
MX2022002524A (en) * 2019-08-30 2022-06-24 Dragonfly Therapeutics Inc PHARMACEUTICAL FORMULATIONS AND DOSING REGIMES FOR MULTI-SPECIFIC BINDING PROTEINS THAT BIND HER2, NKG2D AND CD16 FOR THE TREATMENT OF CANCER.
MX2022002315A (en) * 2019-08-30 2022-03-25 Agenus Inc ANTI-CD96 ANTIBODIES AND THEIR METHODS OF USE.
EP4034551A1 (en) 2019-09-28 2022-08-03 AskGene Pharma, Inc. Cytokine prodrugs and dual-prodrugs
EP4047021A4 (en) * 2019-10-17 2023-11-22 Jiangsu Alphamab Biopharmaceuticals Co., Ltd. Ox40/pd-l1 bispecific antibody
JP2022552841A (en) * 2019-10-18 2022-12-20 ザ ユニバーシティ オブ ユタ リサーチ ファウンデイション Polymer drug delivery conjugates and methods of making and using them
JP2022553108A (en) * 2019-10-23 2022-12-21 リビジェン バイオファーマ ホールディングス リミテッド Anti-CD40 binding molecules and bispecific antibodies including such
EP3816185A1 (en) * 2019-11-04 2021-05-05 Numab Therapeutics AG Multispecific antibody directed against pd-l1 and a tumor-associated antigen
TWI828951B (en) * 2019-11-14 2024-01-11 中央研究院 Use of anti-epcam antibodies in cancer therapy
KR102400884B1 (en) * 2019-11-15 2022-05-23 주식회사 제넥신 Fusion protein comprising modified interleukin-7 and interleukin-2 and use thereof
JP7543404B2 (en) 2019-11-20 2024-09-02 ジーアイ・セル・インコーポレイテッド Medium composition for culturing T cells and method for culturing T cells using the same
IL291909A (en) 2019-11-20 2022-06-01 Gi Cell Inc The composition of T regulatory cell culture and its use
IL292932A (en) 2019-11-20 2022-07-01 Gi Cell Inc Composition for culturing natural killer cells and method for preparing natural killer cells by using same
AU2020391280B2 (en) * 2019-11-27 2024-06-06 Gi Cell, Inc. Composition for anticancer treatment, comprising NK cells and fusion protein which comprises IL-2 protein and CD80 protein
MX2022006426A (en) 2019-11-27 2022-06-22 Gi Innovation Inc PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER, WHICH INCLUDES IMMUNE CHECKPOINT INHIBITOR AND FUSION PROTEIN WHICH INCLUDES IL-2 PROTEIN AND CD80 PROTEIN.
US12091440B2 (en) 2019-12-20 2024-09-17 Regeneron Pharmaceuticals, Inc. IL2 and peptide-MHC complex fusion proteins and methods of use thereof
BR112022013298A2 (en) 2020-01-10 2022-09-06 Shanghai Henlius Biotech Inc ANTI-TIGIT ANTIBODIES, MULTI-SPECIFIC ANTIBODIES THAT UNDERSTAND THEM AND METHODS OF USE THEREOF
CN115362168A (en) 2020-01-14 2022-11-18 辛德凯因股份有限公司 Methods and compositions for biasing IL2 muteins
EP4093875A4 (en) * 2020-01-20 2024-02-28 Chugai Seiyaku Kabushiki Kaisha LIGAND-BINDED FUSION PROTEINS
KR102559355B1 (en) * 2020-01-31 2023-07-25 주식회사 제넥신 Fusion protein comprising anti-tumor-associated antigen antibody, anti-pd-l1 antibody and il-2 and uses thereof
CA3170330A1 (en) * 2020-02-21 2021-08-26 Macrogenics, Inc. Cd137 binding molecules and uses thereof
EP4245373A3 (en) 2020-02-26 2023-12-20 VIR Biotechnology, Inc. Antibodies against sars-cov-2
KR20220162130A (en) 2020-02-28 2022-12-07 탈락 테라퓨틱스, 인크. transglutaminase-mediated conjugation
CN115989238A (en) * 2020-03-18 2023-04-18 Gi医诺微新 Fusion protein comprising IL-2 protein and CD80 protein fragment or variant thereof and use thereof
WO2021222150A2 (en) 2020-04-28 2021-11-04 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications
GB2621482B (en) * 2020-05-13 2024-09-04 Bonum Therapeutics Inc Compositions of protein complexes and methods of use thereof
GB202007099D0 (en) * 2020-05-14 2020-07-01 Kymab Ltd Tumour biomarkers for immunotherapy
US11919956B2 (en) 2020-05-14 2024-03-05 Xencor, Inc. Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3
JP2023531876A (en) * 2020-06-30 2023-07-26 ジーアイ イノベーション， インコーポレイテッド Fusion protein comprising anti-LAG-3 antibody and IL-2 and use thereof
CN118792252A (en) * 2020-07-07 2024-10-18 深圳市菲鹏生物治疗股份有限公司 T lymphocytes and their applications
MX2023000948A (en) 2020-07-20 2023-04-14 Deka Biosciences Inc Dual cytokine fusion proteins comprising il-10.
EP4192884A4 (en) * 2020-08-04 2025-04-09 Exelixis, Inc. PD-L1 BINDING AGENTS AND THEIR USES
KR20230166150A (en) 2020-08-19 2023-12-06 젠코어 인코포레이티드 Anti-cd28 compositions
CN111705038B (en) * 2020-08-24 2020-11-03 江苏集萃药康生物科技有限公司 Construction method and application of cell strain capable of stably expressing human PDL1/CD73 protein
US20230303700A1 (en) 2020-08-31 2023-09-28 Bristol-Myers Squibb Company Cell localization signature and immunotherapy
TWI894360B (en) * 2020-09-22 2025-08-21 大陸商南京聖和藥業股份有限公司 Anti-TIGIT antibodies and bispecific antibodies and their applications
US20220135684A1 (en) * 2020-10-14 2022-05-05 Xencor, Inc. Bispecific antibodies that bind pd-l1 and cd28
CN114437228B (en) * 2020-10-30 2024-02-06 中国科学院生物物理研究所 Double-function fusion protein composed of IL-2 and antibody subunit
CN114539418A (en) * 2020-11-26 2022-05-27 上海华奥泰生物药业股份有限公司 Bispecific antibodies and uses thereof
WO2022120179A1 (en) 2020-12-03 2022-06-09 Bristol-Myers Squibb Company Multi-tumor gene signatures and uses thereof
MX2023007650A (en) 2020-12-28 2023-09-11 Bristol Myers Squibb Co Subcutaneous administration of pd1/pd-l1 antibodies.
MX2023007734A (en) 2020-12-28 2023-08-21 Bristol Myers Squibb Co Antibody compositions and methods of use thereof.
US20240101675A1 (en) * 2021-01-21 2024-03-28 Biolojic Design Ltd. Dual binding antibodies, methods of producing dual binding antibodies, and uses thereof
AU2022217058A1 (en) 2021-02-04 2023-09-21 Genuv Inc. Anti-pd-1 antibody and use thereof
US11739144B2 (en) 2021-03-09 2023-08-29 Xencor, Inc. Heterodimeric antibodies that bind CD3 and CLDN6
KR20230154311A (en) 2021-03-10 2023-11-07 젠코어 인코포레이티드 Heterodimeric antibodies binding to CD3 and GPC3
JP2024514530A (en) 2021-04-02 2024-04-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Antibodies against truncated CDCP1 and uses thereof
GB202107994D0 (en) 2021-06-04 2021-07-21 Kymab Ltd Treatment of cancer
TW202317623A (en) 2021-06-14 2023-05-01 美商再生元醫藥公司 Il2-based therapeutics and methods of use thereof
US20240415884A1 (en) * 2022-02-01 2024-12-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Molecules that bind to cd276 polypeptides
CA3252619A1 (en) 2022-02-23 2023-08-31 Xencor, Inc. Anti-cd28 x anti-psma antibodies
WO2023178329A1 (en) 2022-03-18 2023-09-21 Bristol-Myers Squibb Company Methods of isolating polypeptides
US20250215089A1 (en) * 2022-04-02 2025-07-03 Harbour Biomed (Shanghai) Co., Ltd Antigen-binding protein targeting pd-l1 and cd40, preparation therefor, and use thereof
WO2023201237A1 (en) * 2022-04-11 2023-10-19 Flagship Pioneering Innovations Vii, Llc Compositions and methods
WO2023219147A1 (en) * 2022-05-13 2023-11-16 塩野義製薬株式会社 Novel anti-ccr8 antibodies for detecting ccr8
CA3258064A1 (en) 2022-06-02 2023-12-07 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof
JPWO2023238949A1 (en) 2022-06-10 2023-12-14
CN119731204A (en) 2022-06-16 2025-03-28 赛福伦有限责任公司 Anti-PD-1 antibody-attenuated IL-2 immunoconjugates and uses thereof
WO2024015733A1 (en) * 2022-07-13 2024-01-18 10X Genomics, Inc. Improved methods and systems for identification and characterization of antigen-binding molecules from single cells
WO2024054992A1 (en) 2022-09-09 2024-03-14 Bristol-Myers Squibb Company Methods of separating chelator
WO2024196952A1 (en) 2023-03-20 2024-09-26 Bristol-Myers Squibb Company Tumor subtype assessment for cancer therapy
WO2025006973A2 (en) * 2023-06-29 2025-01-02 Board Of Regents, The University Of Texas System Methods for treating immune related adverse events
WO2025038763A1 (en) 2023-08-15 2025-02-20 Bristol-Myers Squibb Company Ceramic hydroxyapatite chromatography flow through method
WO2025145207A1 (en) 2023-12-29 2025-07-03 Bristol-Myers Squibb Company Combination therapy of kras inhibitor and treg-depleting agent

Family Cites Families (818)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4741900A (en) 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4675187A (en) 1983-05-16 1987-06-23 Bristol-Myers Company BBM-1675, a new antibiotic complex
US4663281A (en) 1984-03-22 1987-05-05 Mass Institute Of Technology Enhanced production of proteinaceous materials in eucaryotic cells
US4789633A (en) 1984-04-19 1988-12-06 University Of Tennessee Research Corporation Fused liposome and acid induced method for liposome fusion
US4880078A (en) 1987-06-29 1989-11-14 Honda Giken Kogyo Kabushiki Kaisha Exhaust muffler
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
GB8720833D0 (en) 1987-09-04 1987-10-14 Celltech Ltd Recombinant dna product
DE768377T1 (en) 1988-09-02 1998-01-02 Dyax Corp Production and selection of recombinant proteins with different binding sites
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US6362325B1 (en) 1988-11-07 2002-03-26 Advanced Research And Technology Institute, Inc. Murine 4-1BB gene
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
ATE152174T1 (en) 1989-09-20 1997-05-15 Abbott Lab METHOD FOR PRODUCING FUSION PROTEINS
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
US5780225A (en) 1990-01-12 1998-07-14 Stratagene Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
AU7247191A (en) 1990-01-11 1991-08-05 Molecular Affinities Corporation Production of antibodies using gene libraries
DK0463151T3 (en) 1990-01-12 1996-07-01 Cell Genesys Inc Generation of xenogenic antibodies
US5314995A (en) 1990-01-22 1994-05-24 Oncogen Therapeutic interleukin-2-antibody based fusion proteins
EP0517754A1 (en) 1990-03-02 1992-12-16 Repligen Corporation Antibody constructs with enhanced binding affinity
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
CA2090126C (en) 1990-08-02 2002-10-22 John W. Schrader Methods for the production of proteins with a desired function
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
JP2938569B2 (en) 1990-08-29 1999-08-23 ジェンファーム インターナショナル，インコーポレイティド Method for producing xenogeneic immunoglobulin and transgenic mouse
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
WO1993012227A1 (en) 1991-12-17 1993-06-24 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5698426A (en) 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
GB9021679D0 (en) 1990-10-05 1990-11-21 Gorman Scott David Antibody preparation
EP0556328A4 (en) 1990-11-09 1994-06-08 Abbott Lab Bridging antibody fusion constructs
JPH09506761A (en) 1990-11-09 1997-07-08 ステファン ディー．ギリーズ Immune complex of cytokines
DE69129154T2 (en) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. METHOD FOR ENRICHING PROTEIN VARIANTS WITH CHANGED BINDING PROPERTIES
ATE269401T1 (en) 1991-04-10 2004-07-15 Scripps Research Inst LIBRARIES OF HETERODIMERIC RECEPTORS USING PHAGEMIDS
DE69232706T2 (en) 1991-05-01 2002-11-28 Henry M. Jackson Foundation For The Advancement Of Military Medicine, Rockville METHOD FOR TREATING INFECTIOUS RESPIRATORY DISEASES
GB9112536D0 (en) 1991-06-11 1991-07-31 Celltech Ltd Chemical compounds
DE69233782D1 (en) 1991-12-02 2010-05-20 Medical Res Council Preparation of Autoantibodies on Phage Surfaces Starting from Antibody Segment Libraries
US5869619A (en) 1991-12-13 1999-02-09 Xoma Corporation Modified antibody variable domains
CA2507749C (en) 1991-12-13 2010-08-24 Xoma Corporation Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
GB9206422D0 (en) 1992-03-24 1992-05-06 Bolt Sarah L Antibody preparation
US5229109A (en) 1992-04-14 1993-07-20 Board Of Regents, The University Of Texas System Low toxicity interleukin-2 analogues for use in immunotherapy
US5874082A (en) 1992-07-09 1999-02-23 Chiron Corporation Humanized anti-CD40 monoclonal antibodies and fragments capable of blocking B cell proliferation
US5934272A (en) 1993-01-29 1999-08-10 Aradigm Corporation Device and method of creating aerosolized mist of respiratory drug
JP3734262B2 (en) 1993-03-25 2006-01-11 メルク エンド カンパニー インコーポレーテッド Vascular endothelial growth factor inhibitor
CA2172376C (en) 1993-10-01 2008-11-18 William C. Fanslow, Iii Antibodies to cd40
AU696293B2 (en) 1993-12-08 1998-09-03 Genzyme Corporation Process for generating specific antibodies
DK0751781T3 (en) 1993-12-23 2004-08-09 Immunex Corp Use of monoclonal antibodies or soluble oligomeric ligands in the manufacture of a medicament for the prevention or treatment of neoplastic diseases
PT1231268E (en) 1994-01-31 2005-11-30 Univ Boston BANKS OF POLYCLONE ANTIBODIES
IL108501A (en) 1994-01-31 1998-10-30 Mor Research Applic Ltd Antibodies and pharmaceutical compositions containing them
US6242566B1 (en) 1994-02-10 2001-06-05 Board Of Trustees Of The Leland Stanford Junior University Ligand (ACT-4-L) to a receptor on the surface of activated CD4+ T-cells
BR9507618A (en) 1994-05-06 1997-08-19 Roussy Inst Gustave Soluble polypeptide fractions of the lag-3 protein production process therapeutic composition anti-idiotype antibodies
GB9410534D0 (en) 1994-05-26 1994-07-13 Lynxvale Ltd Improvements in or relating to growth factor inhibitors
US5516637A (en) 1994-06-10 1996-05-14 Dade International Inc. Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
US5541087A (en) 1994-09-14 1996-07-30 Fuji Immunopharmaceuticals Corporation Expression and export technology of proteins as immunofusins
AU5265296A (en) 1995-04-10 1996-10-30 Universite De Sherbrooke Atp-diphosphohydrolases, process of purification thereof and process of producing thereof by recombinant technology
US6019968A (en) 1995-04-14 2000-02-01 Inhale Therapeutic Systems, Inc. Dispersible antibody compositions and methods for their preparation and use
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US6576754B2 (en) 1995-11-09 2003-06-10 Dana-Farber Cancer Institute CD100 antigen and uses therefor
JP2978435B2 (en) 1996-01-24 1999-11-15 チッソ株式会社 Method for producing acryloxypropyl silane
US6750334B1 (en) 1996-02-02 2004-06-15 Repligen Corporation CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
AU2063197A (en) 1996-03-04 1997-09-22 Massachusetts Institute Of Technology Materials and methods for enhancing cellular internalization
US6100071A (en) 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
US5834597A (en) 1996-05-20 1998-11-10 Protein Design Labs, Inc. Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
US5985309A (en) 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5855913A (en) 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
CA2259122A1 (en) 1996-06-17 1997-12-24 Max Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. Novel ptp-20, pcp-2, bdp1, clk and sirp proteins and related products and methods
AU3505397A (en) 1996-06-25 1998-01-14 Trustees Of The University Of Pennsylvania, The Antibodies directed against cellular coreceptors for human immunodeficiency virus and methods of using the same
CA2258518C (en) 1996-06-27 2011-11-22 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Recognition molecules interacting specifically with the active site or cleft of a target molecule
US6028176A (en) 1996-07-19 2000-02-22 Bayer Corporation High-affinity interleukin-4 muteins
NL1003648C2 (en) 1996-07-19 1998-01-21 Carino Cornelis Sunderman Method and device for promoting the flue gas discharge of a fireplace.
CA2266419A1 (en) 1996-09-24 1998-04-02 Merck & Co., Inc. Gene therapy for inhibition of angiogenesis
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
CA2273194C (en) 1996-12-03 2011-02-01 Abgenix, Inc. Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom
GB9625640D0 (en) 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
CA2277801C (en) 1997-01-16 2002-10-15 Massachusetts Institute Of Technology Preparation of particles for inhalation
JP3521382B2 (en) 1997-02-27 2004-04-19 日本たばこ産業株式会社 Cell surface molecules that mediate cell-cell adhesion and signal transduction
US7112655B1 (en) 1997-02-27 2006-09-26 Japan Tobacco, Inc. JTT-1 protein and methods of inhibiting lymphocyte activation
US7411051B2 (en) 1997-03-07 2008-08-12 Human Genome Sciences, Inc. Antibodies to HDPPA04 polypeptide
US20060246483A1 (en) 1997-03-07 2006-11-02 Rosen Craig A 337 human secreted proteins
US20070015696A1 (en) 1997-03-07 2007-01-18 Rosen Craig A 621 human secreted proteins
US20060223088A1 (en) 1997-03-07 2006-10-05 Rosen Craig A Human secreted proteins
US7368531B2 (en) 1997-03-07 2008-05-06 Human Genome Sciences, Inc. Human secreted proteins
US7968689B2 (en) 1997-03-07 2011-06-28 Human Genome Sciences, Inc. Antibodies to HSDEK49 polypeptides
US20050197285A1 (en) 1997-03-07 2005-09-08 Rosen Craig A. Human secreted proteins
US20060223090A1 (en) 1997-03-07 2006-10-05 Rosen Craig A Polynucleotides encoding human secreted proteins
US20070224663A1 (en) 1997-03-07 2007-09-27 Human Genome Sciences, Inc. Human Secreted Proteins
US20080103090A1 (en) 1997-03-07 2008-05-01 Human Genome Sciences, Inc. Human Secreted Proteins
US20070055056A1 (en) 1997-03-07 2007-03-08 Rosen Craig A 251 human secreted proteins
NZ502052A (en) 1997-06-20 2001-01-26 Biogen Inc CD154 blockade therapy for pancreatic islet tissue transplantation
US6075007A (en) 1997-07-17 2000-06-13 Regeneron Pharmaceuticals, Inc. Modified noggin polypeptide and compositions
AR013184A1 (en) 1997-07-18 2000-12-13 Astrazeneca Ab SPYROZOBICYCLIC HETERO CYCLIC AMINES, PHARMACEUTICAL COMPOSITION, USE OF SUCH AMINES TO PREPARE MEDICINES AND METHOD OF TREATMENT OR PROPHYLAXIS
AU752433B2 (en) 1997-09-23 2002-09-19 Bundesrepublik Deutschland letzvertreten durch Den Direktor des Robert-Koch-Instituts Costimulating T-cell polypeptide, monoclonal antibodies, their preparation and use
DE19821060A1 (en) 1997-09-23 1999-04-15 Bundesrepublik Deutschland Let T cell co-stimulating polypeptide, monoclonal antibodies, and the production and use thereof
WO1999024565A1 (en) 1997-11-07 1999-05-20 Transplantation Technologies Inc. Methods and compositions for immunomodulation
DK1037927T3 (en) 1997-12-08 2004-09-06 Emd Lexigen Res Ct Corp Heterodimeric fusion proteins useful for targeted immunotherapy and general immune stimulation
US6051228A (en) 1998-02-19 2000-04-18 Bristol-Myers Squibb Co. Antibodies against human CD40
CZ20003099A3 (en) 1998-02-25 2002-04-17 Lexigen Pharmaceuticals Corporation Enhancing the circulating half-life of antibody-based fusion proteins
WO1999048927A1 (en) 1998-03-25 1999-09-30 Cornell Research Foundation, Inc. Methods for designing specific ion channel blockers
CA2323525C (en) 1998-03-30 2011-03-01 Gerald P. Murphy Therapeutic and diagnostic applications based on the role of the cxcr-4 gene in tumorigenesis
WO1999052562A2 (en) 1998-04-15 1999-10-21 Lexigen Pharmaceuticals Corp. Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with angiogenesis inhibitor
CA2328081A1 (en) 1998-04-17 1999-10-28 Lexigen Pharmaceuticals Corporation Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with prostaglandin inhibitor
GB9809839D0 (en) 1998-05-09 1998-07-08 Glaxo Group Ltd Antibody
DZ2788A1 (en) 1998-05-15 2003-12-01 Bayer Ag Selective IL-2 agonists and antagonists.
WO1999061057A2 (en) 1998-05-23 1999-12-02 Tanox, Inc. Molecules targeting cd40 and tumor cells
JP2002518432A (en) 1998-06-24 2002-06-25 アドバンスト インハレーション リサーチ，インコーポレイテッド Large porous particles released from an inhaler
EP1133563A2 (en) 1998-07-16 2001-09-19 Hyseq, Inc. Methods and molecules relating to cd39-like polypeptides
GB9815909D0 (en) 1998-07-21 1998-09-16 Btg Int Ltd Antibody preparation
US6696550B2 (en) 1998-07-23 2004-02-24 Millennium Pharmaceuticals, Inc. Humanized anti-CCR2 antibodies and methods of use therefor
CZ302303B6 (en) 1998-08-25 2011-02-16 Merck Patent Gmbh Homodimeric fusion protein exhibiting inhibition activity to angiogenesis, process for preparing thereof, DNA molecule and replicated expression vector
AU1224200A (en) 1998-10-23 2000-05-15 Agnes Vignery Methods for modulating cell fusion
CA2356215C (en) 1998-12-23 2015-11-24 Pfizer Inc. Human monoclonal antibodies to ctla-4
SK9432001A3 (en) 1999-01-07 2003-02-04 Lexigen Pharm Corp Expression and export of anti-obesity proteins as Fc fusion proteins
HK1038755A1 (en) 1999-01-15 2002-03-28 Biogen, Inc. Antagonists of tweak and of tweak receptor and their use to treat immunological disorders
US6488930B1 (en) 1999-01-15 2002-12-03 Millennium Pharmaceuticals, Inc. Anti-CCR4 antibodies and methods of use therefor
US6245332B1 (en) 1999-01-15 2001-06-12 The Board Of Trustees Of The Leland Stanford Junior University Modulation of systemic memory T cell trafficking
CA2360106C (en) 1999-02-12 2012-10-30 The Scripps Research Institute Methods for treatment of tumors and metastases using a combination of anti-angiogenic and immuno therapies
US6335013B1 (en) 1999-03-19 2002-01-01 Hyseq, Inc. Methods and materials relating to CD39-like polypeptides
GB9907965D0 (en) 1999-04-09 1999-06-02 Glaxo Group Ltd Medical use
EP1048299A1 (en) 1999-04-28 2000-11-02 Faculteit der Geneeskunde van de Vrije Universiteit Method for inhibiting cell functioning for use in anti-inflammatory and anti-tumour therapies
HK1045700B (en) 1999-04-28 2007-07-27 德克萨斯大学董事会 Compositions an methods for cancer treatment by selectively inhibiting vegf
US7306799B2 (en) 1999-06-08 2007-12-11 Regeneron Pharmaceuticals, Inc. Use of VEGF inhibitors for treatment of eye disorders
US6946129B1 (en) 1999-06-08 2005-09-20 Seattle Genetics, Inc. Recombinant anti-CD40 antibody and uses thereof
US7070959B1 (en) 1999-06-08 2006-07-04 Regeneron Pharmaceuticals, Inc. Modified chimeric polypeptides with improved pharmacokinetic properties
US7303746B2 (en) 1999-06-08 2007-12-04 Regeneron Pharmaceuticals, Inc. Methods of treating eye disorders with modified chimeric polypeptides
US6833268B1 (en) 1999-06-10 2004-12-21 Abgenix, Inc. Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
EP1514933A1 (en) 1999-07-08 2005-03-16 Research Association for Biotechnology Secretory protein or membrane protein
US7129338B1 (en) 1999-07-08 2006-10-31 Research Association For Biotechnology Secretory protein or membrane protein
SK782002A3 (en) 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
PL202058B1 (en) 1999-08-09 2009-05-29 Merck Patent Gmbh Multiple cytokine−antibody complexes
ATE354655T1 (en) 1999-08-24 2007-03-15 Medarex Inc HUMAN ANTIBODIES TO CTLA-4 AND THEIR USES
US6482411B1 (en) 1999-08-27 2002-11-19 Board Of Regents, The University Of Texas System Methods of reducing bone loss with CD40 ligand
JP3871503B2 (en) 1999-08-30 2007-01-24 日本たばこ産業株式会社 Immune disease treatment
US20030119038A1 (en) 1999-09-09 2003-06-26 Bingham Brendan William NARC1, novel subtilase-like homologs
US7029895B2 (en) 1999-09-27 2006-04-18 Millennium Pharmaceuticals, Inc. 27411, a novel human PGP synthase
US20100291099A1 (en) 1999-09-27 2010-11-18 Millennium Pharmaceuticals, Inc. Novel 27411, 23413, 22438, 23553, 25278, 26212, narc sc1, narc 10a, narc 1, narc 12, narc 13, narc17, narc 25, narc 3, narc 4, narc 7, narc 8, narc 11, narc 14a, narc 15, narc 16, narc 19, narc 20, narc 26, narc 27, narc 28, narc 30, narc 5, narc 6, narc 9, narc 10c, narc 8b, narc 9, narc2a, narc 16b, narc 1c, narc 1a, narc 25, 86604 and 32222 molecules and uses therefor
AU1099601A (en) 1999-10-22 2001-05-08 Millennium Pharmaceuticals, Inc. Nucleic acid molecules derived from rat brain and programmed cell death models
US20110230392A1 (en) 1999-10-22 2011-09-22 Millennium Pharmaceuticals, Inc. Novel narc sc1, narc 10a, narc 1, narc 12, narc 13, narc17, narc 25, narc 3, narc 4, narc 7, narc 8, narc 11, narc 14a, narc 15, narc 16, narc 19, narc 20, narc 26, narc 27, narc 28, narc 30, narc 5, narc 6, narc 9, narc 10c, narc 8b, narc 9, narc2a, narc 16b, narc 1c, narc 1a, and narc 25 molecules and uses therefor
US20020081679A1 (en) 1999-10-22 2002-06-27 Millennium Pharmaceuticals, Inc. NARC8 programmed cell-death-associated molecules and uses thereof
GB9927757D0 (en) 1999-11-25 2000-01-26 Kennedy Rheumatology Inst Treatment of autoimmune diseases
WO2001040307A1 (en) 1999-11-30 2001-06-07 Eberhard-Karls-Universität Tübingen Universitätsklinikum Antibodies against signal regulator proteins
WO2001042308A2 (en) 1999-12-08 2001-06-14 Novartis Ag Methods and compositions useful for inhibiting ccr5-dependent infection of cells by hiv-1
TWI263496B (en) 1999-12-10 2006-10-11 Novartis Ag Pharmaceutical combinations and their use in treating gastrointestinal disorders
DE10001372A1 (en) 2000-01-14 2001-08-02 Deutsches Krebsforsch Anti-CD3 single-chain antibodies with human Cmu3 and Cmu4 domains
US7034121B2 (en) 2000-01-27 2006-04-25 Genetics Institue, Llc Antibodies against CTLA4
EP1257572A2 (en) 2000-02-07 2002-11-20 Millennium Pharmaceuticals, Inc. Narc-1, subtilase-like homologs
DE60122286T2 (en) 2000-02-11 2007-08-02 Merck Patent Gmbh INCREASING THE CIRCULATORY HALF-TIME OF ANTIBODY-BASED FUSION PROTEINS
DE60134962D1 (en) 2000-03-03 2008-09-04 Kyowa Hakko Kogyo Kk ANTI-CCR4 ANTIBODIES AND FRAGMENTS THEREOF
WO2001078708A1 (en) 2000-04-14 2001-10-25 Millennium Pharmaceuticals, Inc. Treating graft rejection with cxcr3 inhibitors
US20030059427A1 (en) 2000-04-28 2003-03-27 Force Walker R. Isolation and characterization of highly active anti-CD40 antibody
AU2001259215A1 (en) 2000-04-28 2001-11-12 La Jolla Institute For Allergy And Immunology Human anti-cd40 antibodies and methods of making and using same
JP3597140B2 (en) 2000-05-18 2004-12-02 日本たばこ産業株式会社 Human monoclonal antibody against costimulatory molecule AILIM and pharmaceutical use thereof
US7094874B2 (en) 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
US6680315B2 (en) 2000-06-15 2004-01-20 Synta Pharmaceuticals Corp. Triazine compounds
AU2001269836A1 (en) 2000-06-16 2002-01-02 Incyte Genomics, Inc. Proteases
US6689353B1 (en) 2000-06-28 2004-02-10 Bayer Pharmaceuticals Corporation Stabilized interleukin 2
ES2288967T3 (en) 2000-06-29 2008-02-01 Merck Patent Gmbh REINFORCEMENT OF IMMUNE ANSWERS MEDIATED BY THE ANTIBODY-CYTOKIN FUSION PROTEIN THROUGH THE TREATMENT COMBINED BY AGENTS THAT IMPROVE THE INCORPORATION OF IMMUNOCITOQUINE.
CA2417874C (en) 2000-08-03 2012-10-02 Transplantation Technologies Inc. Use of ox-2 inhibitors for the treatment of cancer
EP1309614A2 (en) 2000-08-11 2003-05-14 Eli Lilly And Company Novel secreted proteins and their uses
AU2001288286B2 (en) 2000-08-18 2007-05-10 The Regents Of The University Of California Methods for treating demyelinating diseases
CN1284536C (en) 2000-09-18 2006-11-15 威克斯医药有限公司 Use of tetrodotoxin or saxitoxin and analogs thereof in the preparation of analgesics for systemic analgesia
CN1203857C (en) 2000-09-18 2005-06-01 威克斯医药有限公司 A New Approach to Local Anesthesia and Analgesia
US7052676B2 (en) 2000-09-26 2006-05-30 The Regents Of The University Of Michigan Methods for inhibition of HIV replication using a small molecule inhibitor
US20020064555A1 (en) 2000-09-29 2002-05-30 Dan Cullen Proton pump inhibitor formulation
CA2424296A1 (en) 2000-10-02 2002-04-11 Chiron Corporation Human anti-cd40 antibodies
DE60139944D1 (en) 2000-10-12 2009-10-29 Genentech Inc LOW VISCOSIS CONCENTRATED PROTEIN FORMULATIONS
AU2002246632B2 (en) 2000-12-08 2007-04-05 Alexion Pharmaceuticals, Inc. Chronic lymphocytic leukemia cell line and its use for producing an antibody
JP2005500005A (en) 2000-12-08 2005-01-06 インサイト・ゲノミックス・インコーポレイテッド Protein modifying and maintenance molecules
US20040198661A1 (en) 2000-12-08 2004-10-07 Bowdish Katherine S. Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof
US20060057651A1 (en) 2000-12-08 2006-03-16 Bowdish Katherine S Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof
HUP0401300A3 (en) 2001-01-18 2005-06-28 Merck Patent Gmbh Bifunctional fusion proteins with glucocerebrosidase activity
MXPA03007323A (en) 2001-02-19 2003-12-12 Merck Patent Gmbh Artificial proteins with reduced immunogenicity.
JP4212278B2 (en) 2001-03-01 2009-01-21 日本たばこ産業株式会社 Graft rejection inhibitor
BR0207854A (en) 2001-03-07 2004-08-24 Merck Patent Gmbh Expression technology for proteins containing a hybrid isotype antibody moiety
WO2003038063A2 (en) 2001-03-21 2003-05-08 Human Genome Sciences, Inc. Human secreted proteins
WO2002079415A2 (en) 2001-03-30 2002-10-10 Lexigen Pharmaceuticals Corp. Reducing the immunogenicity of fusion proteins
US7794710B2 (en) 2001-04-20 2010-09-14 Mayo Foundation For Medical Education And Research Methods of enhancing T cell responsiveness
HUP0400284A3 (en) 2001-05-03 2012-09-28 Merck Patent Gmbh Recombinant tumor specific antibody and use thereof
WO2002092784A2 (en) 2001-05-15 2002-11-21 Emory University POLYNUCLEOTIDES AND POLYPEPTIDES RELATING TO THE MODULATION OF SIRP α-CD47
DK1397153T3 (en) 2001-05-23 2008-05-26 Bristol Myers Squibb Co Method for protecting allogeneic islet cell graft using soluble CTLA4 mutant molecules
US20040023243A1 (en) 2001-06-13 2004-02-05 Yue Henry Proteases
AU2002329540A1 (en) 2001-06-20 2003-01-02 Morphosys Ag Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
US20030124149A1 (en) 2001-07-06 2003-07-03 Shalaby Shalaby W. Bioactive absorbable microparticles as therapeutic vaccines
EP1411966A4 (en) 2001-07-12 2005-06-01 Univ California METHOD FOR TREATING SECONDARY TISSUE DEGENERATION WITH INJURY OF THE CENTRAL NERVOUS SYSTEM
WO2003006058A1 (en) 2001-07-12 2003-01-23 Wyeth Cd25+ differential markers and uses thereof
US20040038242A1 (en) 2001-07-30 2004-02-26 Edmonds Brian Taylor Novel secreted proteins and their uses
CA2456470A1 (en) 2001-08-13 2003-02-27 University Of Southern California Interleukin-2 mutants with reduced toxicity
WO2003018635A1 (en) 2001-08-31 2003-03-06 Kyowa Hakko Kogyo Co., Ltd. Human cdr-grafted antibodies and antibody fragments thereof
WO2003029296A1 (en) 2001-10-02 2003-04-10 Chiron Corporation Human anti-cd40 antibodies
AR039067A1 (en) 2001-11-09 2005-02-09 Pfizer Prod Inc ANTIBODIES FOR CD40
EP1441758A2 (en) 2001-11-09 2004-08-04 MediGene Aktiengesellschaft Allogenic vaccine that contains a costimulatory polypeptide-expressing tumor cell
PL206975B1 (en) 2001-12-04 2010-10-29 Merck Patent Gmbh Immunocytokines with modulated selectivity
GB0129105D0 (en) 2001-12-05 2002-01-23 Celltech R&D Ltd Expression control using variable intergenic sequences
WO2003050531A2 (en) 2001-12-11 2003-06-19 Algonomics N.V. Method for displaying loops from immunoglobulin domains in different contexts
WO2003059245A2 (en) 2001-12-18 2003-07-24 J & J Research Pty Ltd Method of treating asthma
AU2003303082B2 (en) 2002-01-30 2009-07-02 Dana-Farber Cancer Institute, Inc. Compositions and methods related to TIM-3, a Th1-specific cell surface molecule
WO2003066830A2 (en) 2002-02-08 2003-08-14 Genetastix Corporation Human monoclonal antibodies against membrane proteins
US20060093771A1 (en) 2002-02-15 2006-05-04 Frantisek Rypacek Polymer coating for medical devices
US7659082B2 (en) 2002-02-19 2010-02-09 Xenon Pharmaceuticals Inc. Methods for identifying analgesic agents
AU2003217912A1 (en) 2002-03-01 2003-09-16 Xencor Antibody optimization
EP2206517B1 (en) 2002-07-03 2023-08-02 Ono Pharmaceutical Co., Ltd. Immunopotentiating compositions comprising anti-PD-L1 antibodies
WO2004010947A2 (en) 2002-07-30 2004-02-05 Bristol-Myers Squibb Company Humanized antibodies against human 4-1bb
US6875433B2 (en) 2002-08-23 2005-04-05 The United States Of America As Represented By The Secretary Of The Army Monoclonal antibodies and complementarity-determining regions binding to Ebola glycoprotein
ES2559763T3 (en) 2002-09-10 2016-02-15 Affimed Gmbh CD3 specific human antibody with immunosuppressive properties
US7291331B1 (en) 2002-09-11 2007-11-06 La Jolla Institute For Allergy And Immunology Methods of treating OX40 medicated recall immune responses
EP1549678A4 (en) 2002-09-30 2006-01-18 Pfizer Prod Inc Hybridomas producing high levels of human sequence antibody
AR047392A1 (en) 2002-10-22 2006-01-18 Wyeth Corp NEUTRALIZATION OF ANTIBODIES AGAINST GDF 8 AND ITS USE FOR SUCH PURPOSES
US7964194B2 (en) 2002-11-15 2011-06-21 Morehouse School Of Medicine Anti-chemokine and associated receptor antibodies and uses for inhibition of inflammation
AU2003291549A1 (en) 2002-11-15 2004-06-15 Morehouse School Of Medicine Anti-chemokine and associated receptors antibodies for inhibition of growth of neoplasms
WO2004051268A1 (en) 2002-12-03 2004-06-17 Celltech R & D Limited Assay for identifying antibody producing cells
JP2006511620A (en) 2002-12-05 2006-04-06 プロテイン デザイン ラブス インコーポレイティド Method for treating ulcerative colitis with anti-CD3 antibody
EP1575672A2 (en) 2002-12-16 2005-09-21 Herbert Schwarz Use of cd137 antagonists for the treatment of tumors
RU2366664C2 (en) 2002-12-17 2009-09-10 Мерк Патент Гмбх Humanised antibody (h14,18) based on mouse antibody 14,18, contacting gd2, and its fusion with il-2
US20050002939A1 (en) 2002-12-23 2005-01-06 Albert Zlotnik Tumor killing/tumor regression using CXCR4 antagonists
JP4511943B2 (en) 2002-12-23 2010-07-28 ワイス エルエルシー Antibody against PD-1 and use thereof
EP1585545A4 (en) 2002-12-27 2006-04-12 Schering Corp TECHNIQUES FOR INDUCING AND MAINTAINING IMMUNE TOLERANCE
AU2003299971A1 (en) 2002-12-30 2004-07-29 Amgen Inc. Combination therapy with co-stimulatory factors
US7608260B2 (en) 2003-01-06 2009-10-27 Medimmune, Llc Stabilized immunoglobulins
EP2659893A3 (en) 2003-02-28 2014-02-12 The Johns Hopkins University T cell regulation
AU2003257041A1 (en) 2003-03-17 2004-10-11 The Board Of Regents Of The University Of Oklahoma Methods for treating ocular inflammation by neutralizing cxcl10 activity
EP1462114A1 (en) 2003-03-28 2004-09-29 Universiteit Utrecht Holding B.V. Methods and means to suppress symptons of an allergic disease by inhibiting the glucocorticoid-induced tumor necrosis factor receptor (GRIT or TNFRSF18)
AU2004232928A1 (en) 2003-04-22 2004-11-04 Ibc Pharmaceuticals Polyvalent protein complex
EP1471152A1 (en) 2003-04-25 2004-10-27 Institut National De La Sante Et De La Recherche Medicale (Inserm) Mutations in the human PCSK9 gene associated to hypercholesterolemia
WO2004101511A2 (en) 2003-05-09 2004-11-25 Protein Design Labs, Inc Anti-ip-10 antibodies and methods of using thereof for the treatment of inflamatory bowel diseases
EP1633785B1 (en) 2003-05-21 2012-11-28 Medarex, Inc. Human monoclonal antibodies against bacillusanthracis protective antigen
GB0312481D0 (en) 2003-05-30 2003-07-09 Celltech R&D Ltd Antibodies
CA2527878A1 (en) 2003-05-30 2005-01-27 Alexion Pharmaceuticals, Inc. Antibodies and fusion proteins that include engineered constant regions
US20070292416A1 (en) 2003-06-02 2007-12-20 Alexion Pharmaceuticals, Inc. De-Immunized Anti-Cd3 Antibody
JP3936673B2 (en) 2003-06-02 2007-06-27 国立大学法人群馬大学 CD47 partial peptide and anti-SHPS-1 monoclonal antibody
WO2004110490A2 (en) 2003-06-06 2004-12-23 Regeneron Pharmaceuticals, Inc. Use of vegf inhibitors for tumor regression
JP2007536898A (en) 2003-07-01 2007-12-20 セルテック アール アンド ディ リミテッド Modified antibody Fab fragment
GB0315450D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0315457D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
US7569215B2 (en) 2003-07-18 2009-08-04 Massachusetts Institute Of Technology Mutant interleukin-2 (IL-2) polypeptides
PL207804B1 (en) 2003-07-29 2011-02-28 Htl Strefa Społka Z Ograniczoną Odpowiedzialnością Piercing apparatus
US20050025744A1 (en) 2003-08-01 2005-02-03 Lane Thomas E. Combination therapies for multiple sclerosis
US8147832B2 (en) 2003-08-14 2012-04-03 Merck Patent Gmbh CD20-binding polypeptide compositions and methods
US20050069521A1 (en) 2003-08-28 2005-03-31 Emd Lexigen Research Center Corp. Enhancing the circulating half-life of interleukin-2 proteins
WO2005023201A2 (en) 2003-09-09 2005-03-17 Medarex, Inc. Methods for treating rheumatoid arthritis
US20050118625A1 (en) 2003-10-02 2005-06-02 Mounts William M. Nucleic acid arrays for detecting gene expression associated with human osteoarthritis and human proteases
JPWO2005035582A1 (en) 2003-10-08 2007-11-22 協和醗酵工業株式会社 Antibody composition that specifically binds to CCR4
US7288638B2 (en) 2003-10-10 2007-10-30 Bristol-Myers Squibb Company Fully human antibodies against human 4-1BB
JP2005130764A (en) 2003-10-30 2005-05-26 Pharmaceuticals & Medical Devices Agency Method for examining diseases caused by abnormal lipid metabolism using polymorphism on NARC-1 gene, and use for drug discovery
PL1684805T3 (en) 2003-11-04 2010-12-31 Novartis Vaccines & Diagnostics Inc Use of antagonist anti-cd40 monoclonal antibodies for treatment of multiple myeloma
US20070098718A1 (en) 2003-11-04 2007-05-03 Chiron Methods of therapy for b cell-related cancers
EP1694360B1 (en) 2003-11-04 2010-08-04 Novartis Vaccines and Diagnostics, Inc. Use of antagonist anti-cd40 antibodies for treatment of autoimmune and inflammatory diseases and organ transplant rejection
WO2005044305A2 (en) 2003-11-04 2005-05-19 Chiron Corporation Methods of therapy for solid tumors expressing the cd40 cell-surface antigen
JP4765037B2 (en) 2003-11-04 2011-09-07 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Use of antagonist anti-CD40 monoclonal antibodies for the treatment of chronic lymphocytic leukemia
AU2004294842B2 (en) 2003-12-04 2010-05-13 Kyowa Kirin Co., Ltd. Medicine containing genetically modified antibody against chemokine receptor CCR4
EP1708961B1 (en) 2003-12-04 2011-03-09 Abbott Biotherapeutics Corp. Anti-ip-10 antibodies
PT1691837E (en) 2003-12-10 2012-08-27 Medarex Inc Ip-10 antibodies and their uses
US20050136055A1 (en) 2003-12-22 2005-06-23 Pfizer Inc CD40 antibody formulation and methods
PL1707627T3 (en) 2003-12-25 2013-04-30 Kyowa Hakko Kirin Co Ltd Antagonistic anti-CD40 antibody mutant
BRPI0418286A (en) 2003-12-30 2007-05-02 Merck Patent Gmbh il-7 fusion proteins
CA2551916C (en) 2003-12-31 2014-04-29 Merck Patent Gesellschaft Mit Beschraenkter Haftung Fc-erythropoietin fusion protein with improved pharmacokinetics
EP1702069A2 (en) 2004-01-05 2006-09-20 EMD Lexigen Research Center Corp. Interleukin-12 targeted to oncofoetal fibronectin
JP2007527242A (en) 2004-03-05 2007-09-27 カイロン コーポレーション In vitro test system for predicting patient tolerance of therapeutic agents
AU2005219322B2 (en) 2004-03-09 2008-09-18 Kyoto University Pharmaceutical Composition Comprising CXCR3 Inhibitor
EP1740208A2 (en) 2004-03-23 2007-01-10 Amgen, Inc Monoclonal antibodies specific for human ox40l (cd134l)
US7998481B2 (en) 2004-04-05 2011-08-16 The Regents Of The University Of California Modulation of NKG2D for treating or preventing solid organ allograft rejection
CA2562764A1 (en) 2004-04-23 2005-11-03 Richard Kroczek Method for the treatment of t cell mediated conditions by depletion of icos-positive cells in vivo
KR20070026522A (en) 2004-04-27 2007-03-08 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 Antagonist anti-CD40 monoclonal antibodies and methods of using them
GB0411186D0 (en) 2004-05-19 2004-06-23 Celltech R&D Ltd Biological products
GB0412181D0 (en) 2004-06-01 2004-06-30 Celltech R&D Ltd Biological products
EA010350B1 (en) 2004-06-03 2008-08-29 Новиммун С.А. Anti-cd3 antibodies and methods of use thereof
GB0412986D0 (en) 2004-06-10 2004-07-14 Xention Discovery Ltd Compounds
AU2005265071A1 (en) 2004-06-18 2006-01-26 Memorial Sloan-Kettering Cancer Center VEGF inhibitors for the treatment of malignant pleural effusion
AU2005259958A1 (en) 2004-06-29 2006-01-12 The Johns Hopkins University Amelioration of drug-induced toxicity
US20090252741A1 (en) 2004-09-08 2009-10-08 Ohio State University Research Foundation Human monoclonal anti-ctla4 antibodies in cancer treatment
CN101023102B (en) 2004-09-17 2013-05-29 霍夫曼-拉罗奇有限公司 anti-OX40L antibody
US7563443B2 (en) 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
TWI380996B (en) 2004-09-17 2013-01-01 Hoffmann La Roche Anti-ox40l antibodies
NZ553500A (en) 2004-09-23 2009-11-27 Genentech Inc Genentech Inc Cysteine engineered antibodies and conjugates withCysteine engineered antibodies and conjugates with a free cysteine amino acid in the heavy chain a free cysteine amino acid in the heavy chain
MX2007004176A (en) 2004-10-06 2007-06-15 Mayo Foundation B7-h1 and methods of diagnosis, prognosis, and treatment of cancer.
WO2006039819A1 (en) 2004-10-15 2006-04-20 St. Michael's Hospital Markers of lung injury
WO2006050172A2 (en) 2004-10-29 2006-05-11 University Of Southern California Combination cancer immunotherapy with co-stimulatory molecules
CA2586844A1 (en) 2004-11-04 2006-05-11 Pfizer Products Inc. Ctla-4 antibody and aromatase inhibitor or combination treatment for breast cancer
GB0521621D0 (en) 2005-10-24 2005-11-30 Domantis Ltd Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases
RU2437893C2 (en) 2004-12-09 2011-12-27 Мерк Патент Гмбх Il-7 versions with low immunising capacity
CN105085678B (en) 2004-12-21 2019-05-07 阿斯利康公司 Angiopoietin-2 antibody and its application
DE102004063494A1 (en) 2004-12-23 2006-07-13 Tegenero Ag antibody
US20060147945A1 (en) 2005-01-06 2006-07-06 Edmonds Brian T Novel secreted proteins and their uses
PE20061391A1 (en) 2005-02-14 2007-01-09 Wyeth Corp ANTIBODIES TO INTERLEUKIN-17F AND OTHER ANTAGONISTS OF IL-17F SIGNALING
US8329178B2 (en) 2005-02-18 2012-12-11 Dana-Farber Cancer Institute, Inc. Antibodies against CXCR4 and methods of use thereof
CA2601936C (en) 2005-02-24 2014-06-17 Amgen Inc. Epidermal growth factor receptor mutations
JP2006249083A (en) 2005-03-08 2006-09-21 Pharmacia & Upjohn Co Llc Anti-m-csf antibody composition
EP1855708A1 (en) 2005-03-11 2007-11-21 Regeneron Pharmaceuticals, Inc. Treating anemia by inhibition of vegf
WO2006101692A1 (en) 2005-03-23 2006-09-28 Pfizer Products Inc. Anti-ctla4 antibody and indolinone combination therapy for treatment of cancer
RU2007134867A (en) 2005-03-23 2009-04-27 Пфайзер Продактс Инк. (Us) Prostate Cancer Therapy with CTLA4 Antibodies and Hormone Therapy
CA2602777C (en) 2005-03-25 2018-12-11 Tolerrx, Inc. Gitr binding molecules and uses therefor
EP1891972A1 (en) 2005-04-26 2008-02-27 Stelic Institute of Regenerative Medicine Agent for promoting hepatic cell replication and agent for improving insulin resistance
PL2161336T5 (en) 2005-05-09 2017-10-31 Ono Pharmaceutical Co Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
EP1885399B1 (en) 2005-05-26 2010-10-20 Seattle Genetics, Inc. Humanized anti-cd40 antibodies and their methods of use
DK1907000T4 (en) 2005-06-08 2020-03-30 The President And Fellows Of Harvard College Methods and compositions for treating persistent HIV infections by inhibiting the pathway of programmed cell death 1 (PD-1).
EP1910828A4 (en) 2005-07-01 2012-03-14 Univ St Louis ANTIBODIES FROM PHOSPHOSPECIFIC CHEMOKINE RECEPTORS
CN104356236B (en) 2005-07-01 2020-07-03 E.R.施贵宝&圣斯有限责任公司 Human monoclonal antibody against programmed death ligand 1 (PD-L1)
WO2007008463A2 (en) 2005-07-07 2007-01-18 Coley Pharmaceutical Group, Inc. Anti-ctla-4 antibody and cpg-motif-containing synthetic oligodeoxynucleotide combination therapy for cancer treatment
EP1917024A2 (en) 2005-08-12 2008-05-07 Regeneron Pharmaceuticals, Inc. Methods of treating diseases with a vegf antagonist
GB0517487D0 (en) 2005-08-26 2005-10-05 Isis Innovation Antibodies
US7972813B2 (en) 2005-09-30 2011-07-05 Vertex Pharmaceuticals Incorporated Tetrodotoxin-resistant sodium channel alpha subunit
US8926979B2 (en) 2005-11-01 2015-01-06 Novartis Ag Treatment of cancer or pre-malignant conditions using anti-CD40 antibodies
AU2006308860B2 (en) 2005-11-01 2012-01-12 Novartis Ag Uses of anti-CD40 antibodies
TWI461436B (en) 2005-11-25 2014-11-21 Kyowa Hakko Kirin Co Ltd Human CD134 (OX40) human monoclonal antibody and method of making and using same
TW200732349A (en) 2005-12-16 2007-09-01 Genentech Inc Anti-OX40L antibodies and methods using same
ES2439641T3 (en) 2005-12-20 2014-01-24 Bristol-Myers Squibb Company Compositions and production procedures of a composition
ES2709672T3 (en) 2006-01-12 2019-04-17 Alexion Pharma Inc Antibodies for OX-2 / CD200 and uses thereof
WO2007133822A1 (en) 2006-01-19 2007-11-22 Genzyme Corporation Gitr antibodies for the treatment of cancer
WO2007109324A2 (en) 2006-03-21 2007-09-27 Xenon Pharmaceuticals, Inc. Potent and selective nav 1.7 sodium channel blockers
EP2001509A1 (en) 2006-04-03 2008-12-17 Medizinische Hochschule Hannover Pharmaceuticals for influencing the reaction of the human immune system
EP2007423A2 (en) 2006-04-05 2008-12-31 Pfizer Products Incorporated Ctla4 antibody combination therapy
NZ571757A (en) 2006-04-21 2012-01-12 Novartis Ag Antagonist anti-CD40 antibody pharmaceutical compositions comprising arginine-HCl and a citrate or citric acid buffer
WO2007130493A2 (en) 2006-05-03 2007-11-15 Regents Of The University Of Colorado Cd40 agonist antibody/type1 interferon synergistic adjuvant combination, conjugates containing and use thereof as a therapeutic to enhance cellular immunity
CA2652247C (en) 2006-05-08 2015-11-17 Adaerata, Limited Partnership Chimeric pcsk9 proteins, cells comprising same, and assays using same
EP1854810A1 (en) 2006-05-09 2007-11-14 PanGenetics B.V. Deimmunized antagonistic anti-human CD40 monoclonal antibody from the ch5D12 antibody
EP2194128B1 (en) 2006-05-11 2012-08-01 Alnylam Pharmaceuticals Inc. Compositions and methods for inhibiting expression of the PCSK9 gene
US7572618B2 (en) 2006-06-30 2009-08-11 Bristol-Myers Squibb Company Polynucleotides encoding novel PCSK9 variants
AT503889B1 (en) 2006-07-05 2011-12-15 Star Biotechnologische Forschungs Und Entwicklungsges M B H F MULTIVALENT IMMUNE LOBULINE
AU2007271398B2 (en) 2006-07-06 2013-06-20 Merck Patent Gmbh Compositions and methods for enhancing the efficacy of IL-2 mediated immune responses
EP2064243A2 (en) 2006-08-28 2009-06-03 Kyowa Hakko Kirin Co., Ltd. Antagonistic human light-specific human monoclonal antibodies
GB0619291D0 (en) 2006-09-29 2006-11-08 Ucb Sa Altered antibodies
SI2486941T1 (en) 2006-10-02 2017-08-31 E. R. Squibb & Sons, L.L.C. Human antibodies that bind CXCR4 and uses thereof
WO2008044824A1 (en) 2006-10-13 2008-04-17 Seoul National University Industry Foundation Antibodies to ip-10 for treating bone diseases with bone destruction
JP2010013355A (en) 2006-10-19 2010-01-21 Stelic Institute Of Regenerative Medicine Myocardial injury-controlling agent
GB0620894D0 (en) 2006-10-20 2006-11-29 Univ Southampton Human immune therapies using a CD27 agonist alone or in combination with other immune modulators
WO2008050962A1 (en) 2006-10-24 2008-05-02 College Of Medicine Pochon Cha University Industry-Academic Cooperation Foundation Composition for in vivo transplantation for treatment of human cervical cancer comprising mononuclear cells derived from umbilical cord blood
WO2008057457A2 (en) 2006-11-07 2008-05-15 Merck & Co., Inc. Antagonists of pcsk9
US20100040610A1 (en) 2006-11-07 2010-02-18 Ayesha Sitlani Antagonists of pcsk9
JP5588175B2 (en) 2006-11-07 2014-09-10 メルク・シャープ・アンド・ドーム・コーポレーション PCSK9 antagonist
WO2008057458A2 (en) 2006-11-07 2008-05-15 Merck & Co., Inc. Antagonists of pcsk9
AU2007334264A1 (en) 2006-11-15 2008-06-26 Medarex, Inc. Human monoclonal antibodies to BTLA and methods of use
EP2097535B1 (en) 2006-12-07 2016-09-21 The Board of Trustees of the Leland Stanford Junior University Identification and isolation of acute myeloid leukemia stem cells
US8440185B2 (en) 2006-12-26 2013-05-14 The Johns Hopkins University Compositions and methods for the treatment of immunologic disorders
AU2007339897B2 (en) 2006-12-27 2013-02-14 Dana-Farber Cancer Institute, Inc. Compositions and methods for the treatment of infections and tumors
AR064826A1 (en) 2007-01-09 2009-04-29 Wyeth Corp FORMULATIONS OF ANTI-IL-13 ANTIBODIES AND USES OF THE SAME. DEVICES, PATCH AND SYRINGE
EP2125893A2 (en) 2007-01-23 2009-12-02 Xencor, Inc. Optimized cd40 antibodies and methods of using the same
WO2008090958A1 (en) 2007-01-24 2008-07-31 Kyowa Hakko Kirin Co., Ltd. Domain-exchanged recombinant antibody composition
JP2010518873A (en) 2007-02-27 2010-06-03 ジェネンテック， インコーポレイテッド Antagonist anti-OX40 antibodies and their use in the treatment of inflammatory and autoimmune diseases
AU2008219570B2 (en) 2007-02-28 2013-08-22 Novimmune Sa Human anti-IP-10 antibodies and uses thereof
WO2008109871A2 (en) 2007-03-08 2008-09-12 Irm Llc Crystal structure of proprotein convertase 9 (pcsk9) and uses thereof
MX2009010957A (en) 2007-04-13 2009-10-29 Novartis Ag Molecules and methods for modulating proprotein convertase subtilisin/kexin type 9 (pcsk9).
UA99608C2 (en) 2007-04-17 2012-09-10 Имклоун Ллк PDGFRb-SPECIFIC INHIBITORS
FR2915102B1 (en) 2007-04-23 2014-05-16 Pf Medicament USE OF ANTI-CXCR4 ANTIBODY FOR THE TREATMENT OF CANCER
EP1987839A1 (en) 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
US20080279851A1 (en) 2007-05-07 2008-11-13 Medlmmune, Llc Anti-icos antibodies and their use in treatment of oncology, transplantation and autoimmune disease
CA2691357C (en) 2007-06-18 2014-09-23 N.V. Organon Antibodies to human programmed death receptor pd-1
WO2009009547A2 (en) 2007-07-09 2009-01-15 Qualcomm Incorporated Methods for sending small packets in a peer-to-peer (p2p) network
EP2014680A1 (en) 2007-07-10 2009-01-14 Friedrich-Alexander-Universität Erlangen-Nürnberg Recombinant, single-chain, trivalent tri-specific or bi-specific antibody derivatives
ES2591281T3 (en) 2007-07-12 2016-11-25 Gitr, Inc. Combination therapies that employ GITR binding molecules
BRPI0814644A2 (en) 2007-07-25 2015-01-27 Alexion Pharma Inc CD200 ANTIBODIES AND USES OF THESE INHIBITING IMMUNE ANSWERS.
US20090324609A1 (en) 2007-08-09 2009-12-31 Genzyme Corporation Method of treating autoimmune disease with mesenchymal stem cells
EP3330292A1 (en) 2007-08-21 2018-06-06 Amgen, Inc Human c-fms antigen binding proteins
US20130072665A1 (en) 2007-08-23 2013-03-21 Simon Mark Jackson Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
JOP20080381B1 (en) 2007-08-23 2023-03-28 Amgen Inc Antigen Binding Proteins to Proprotein Convertase subtillisin Kexin type 9 (pcsk9)
US8183221B2 (en) 2007-09-05 2012-05-22 Medtronic, Inc. Suppression of SCN9A gene expression and/or function for the treatment of pain
EP2573112A1 (en) 2007-10-11 2013-03-27 The Hospital For Sick Children Modulation of sirpa - cd47 interaction for increasing human hematopoietic stem cell engraftment and compounds therefor
MX2010004454A (en) 2007-10-26 2010-07-28 Schering Corp Anti-pcsk9 and methods for treating lipid and cholesterol disorders.
WO2009061853A2 (en) 2007-11-05 2009-05-14 Massachusetts Institute Of Technology Mutant interleukin-2 (il-2) polypeptides
CA2704499C (en) 2007-11-07 2020-03-10 Genentech, Inc. Methods and compositions for assessing responsiveness of b-cell lymphoma to treatment with anti-cd40 antibodies
CA2705263A1 (en) 2007-11-09 2009-05-14 Novartis Ag Combination therapy with an antagonist anti-cd 40 antibody and cyclophosphamide, doxorubicin, vincristine and prednisone (chop) for treatment of b-cell malignancies
US9308257B2 (en) 2007-11-28 2016-04-12 Medimmune, Llc Protein formulation
US8962806B2 (en) 2007-12-28 2015-02-24 Dana-Farber Cancer Institute, Inc. Humanized monoclonal antibodies and methods of use
AU2009206506B2 (en) 2008-01-23 2013-01-10 Xencor, Inc. Optimized CD40 antibodies and methods of using the same
JP6018361B2 (en) 2008-01-31 2016-11-02 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Antibodies against human CD39 and their use for inhibiting regulatory T cell activity
US8263073B2 (en) 2008-02-04 2012-09-11 Medarex, Inc. Anti-CTLA-4 antibodies with reduced blocking of binding of CTLA-4 to B7 and uses thereof
AR070316A1 (en) * 2008-02-07 2010-03-31 Merck & Co Inc PCSK9 ANTAGONISTS (SUBTILISINE-KEXINA TYPE 9 PROPROTEIN)
AR070315A1 (en) 2008-02-07 2010-03-31 Merck & Co Inc ANTIBODIES 1B20 ANTAGONISTS OF PCSK9
EP2262836B1 (en) 2008-03-14 2016-03-09 Transgene SA Antibody against the csf-1 r
US8470977B2 (en) 2008-03-14 2013-06-25 Transgene S.A. Antibody against the CSF-1R
US20110262386A1 (en) 2008-03-20 2011-10-27 Carolus Therpeutics, Inc. Methods of treating inflammation
US9176122B2 (en) 2008-03-24 2015-11-03 University Of South Florida Biomarkers for predicting response to immunosuppressive therapy
CA2716628A1 (en) 2008-03-24 2009-10-01 Carolus Therapeutics, Inc. Methods and compositions for treating atherosclerosis and related conditions
HUE036780T2 (en) 2008-04-09 2018-07-30 Genentech Inc New compositions and methods for treating immunologically related diseases
CA2720681C (en) 2008-04-23 2016-08-02 Amgen Inc. Neutralizing proprotein convertase subtilisin kexin type 9 (pcsk9) variants and uses thereof
US20100260668A1 (en) * 2008-04-29 2010-10-14 Abbott Laboratories Dual Variable Domain Immunoglobulins and Uses Thereof
EP2300040A4 (en) 2008-05-01 2012-06-27 Beth Israel Hospital METHODS AND COMPOSITIONS FOR IMMUNOTHERAPY OF PROSTATE CANCER
WO2009140124A1 (en) 2008-05-14 2009-11-19 Eli Lilly And Company Anti-cxcr4 antibodies
BRPI0911984A2 (en) 2008-05-16 2016-09-20 Ablynx Nv amino acid sequences directed against cxcr4 and other gpcrs compounds comprising the same
WO2009141239A1 (en) 2008-05-20 2009-11-26 F. Hoffmann-La Roche Ag A pharmaceutical formulation comprising an antibody against ox40l, uses thereof
KR20110039220A (en) 2008-06-30 2011-04-15 교와 핫꼬 기린 가부시키가이샤 Anti-CD27 antibody
AR072999A1 (en) 2008-08-11 2010-10-06 Medarex Inc HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE
CA2735421A1 (en) 2008-08-29 2010-03-04 Academisch Ziekenhuis Leiden H.O.D.N. Lumc Delivery of a cd40 agonist to a tumor draining lymph node of a subject
EP2342228B1 (en) 2008-09-12 2017-09-06 Oxford University Innovation Limited Pd-1 specific antibodies and uses thereof
CA2736829C (en) 2008-09-12 2018-02-27 Isis Innovation Limited Pd-1 specific antibodies and uses thereof
TWI445716B (en) 2008-09-12 2014-07-21 Rinat Neuroscience Corp Pcsk9 antagonists
JP5524967B2 (en) 2008-09-19 2014-06-18 エフ．ホフマン−ラ ロシュ アーゲー New antibody formulation
HUE033438T2 (en) 2008-09-26 2017-11-28 Ucb Biopharma Sprl Biological products
CA2998281C (en) 2008-09-26 2022-08-16 Dana-Farber Cancer Institute, Inc. Human anti-pd-1 antobodies and uses therefor
EP2172485A1 (en) 2008-10-01 2010-04-07 Pierre Fabre Medicament Novel anti CXCR4 antibodies and their use for the treatment of cancer
JP2012508017A (en) 2008-11-07 2012-04-05 ファブラス エルエルシー Anti-DLL4 antibody and use thereof
CN102438652B (en) 2008-11-12 2014-08-13 米迪缪尼有限公司 Antibody formulation
EP4331604B9 (en) 2008-12-09 2025-07-23 F. Hoffmann-La Roche AG Anti-pd-l1 antibodies and their use to enhance t-cell function
US20130064834A1 (en) 2008-12-15 2013-03-14 Regeneron Pharmaceuticals, Inc. Methods for treating hypercholesterolemia using antibodies to pcsk9
US8357371B2 (en) 2008-12-15 2013-01-22 Regeneron Pharmaceuticals, Inc. Methods for treating hypercholesterolemia using antibodies to PCSK9
JO3672B1 (en) 2008-12-15 2020-08-27 Regeneron Pharma High Affinity Human Antibodies to PCSK9
WO2010073180A1 (en) 2008-12-23 2010-07-01 Koninklijke Philips Electronics N.V. Combining body-coupled communication and radio frequency communication
ES2629337T3 (en) 2009-02-09 2017-08-08 Inserm - Institut National De La Santé Et De La Recherche Médicale Antibodies against PD-1 and antibodies against PD-L1 and uses thereof
MX2011008697A (en) 2009-02-17 2011-11-18 Ucb Pharma Sa Antibody molecules having specificity for human ox40.
GB0903325D0 (en) 2009-02-26 2009-04-08 Univ Aberdeen Antibody molecules
ES2622228T3 (en) 2009-03-10 2017-07-06 Baylor Research Institute Antiviral vaccines targeting antigen presenting cells
CA2754862C (en) 2009-03-10 2019-04-02 Baylor Research Institute Anti-cd40 antibodies and uses thereof
EP2408818A1 (en) 2009-03-17 2012-01-25 Université de la Méditerranée Btla antibodies and uses thereof
CN102428103B (en) 2009-03-24 2015-04-08 泰华生物制药美国公司 Humanized antibodies against light and uses thereof
WO2010117448A2 (en) 2009-04-05 2010-10-14 Provenance Biopharmaceuticals Corp. Chimeric immunocytokines and methods of use thereof
CN102459639A (en) 2009-04-18 2012-05-16 健泰科生物技术公司 Methods for assessing responsiveness of b-cell lymphoma to treatment with anti-cd40 antibodies
HUE028537T2 (en) 2009-04-20 2016-12-28 Kyowa Hakko Kirin Co Ltd Antibody containing igg2 having amino acid mutation introduced therein
EP2246364A1 (en) 2009-04-29 2010-11-03 Pierre Fabre Médicament Anti CXCR4 antibodies for the treatment of HIV
GB0909906D0 (en) 2009-06-09 2009-07-22 Affitech As Antibodies
SG177560A1 (en) 2009-07-06 2012-03-29 Hoffmann La Roche Bi-specific digoxigenin binding antibodies
DK2564695T3 (en) 2009-07-08 2015-05-26 Kymab Ltd Animal models and therapeutic molecules
CA2769473A1 (en) 2009-07-31 2011-02-03 N.V. Organon Fully human antibodies to btla
JP5883384B2 (en) 2009-08-13 2016-03-15 ザ ジョンズ ホプキンス ユニバーシティー How to regulate immune function
JP5764127B2 (en) 2009-08-17 2015-08-12 ロシュ グリクアート アーゲー Targeted immunoconjugate
IN2012DN01331A (en) 2009-08-31 2015-06-05 Ibc Pharmaceuticals Inc
CA2772613C (en) 2009-09-03 2020-03-10 Schering Corporation Anti-gitr antibodies
US20120283116A1 (en) 2009-09-11 2012-11-08 Leppert Mark F Mutant Sodium Channel Nav1.7 and Methods Related Thereto
WO2011037791A1 (en) 2009-09-25 2011-03-31 Merck Sharp & Dohme Corp. Antagonists of pcsk9
CN102740887B (en) 2009-09-30 2015-04-15 斯隆凯特林防癌纪念中心 Combination immunotherapy for the treatment of cancer
WO2011042398A1 (en) 2009-10-09 2011-04-14 Ablynx Nv Immunoglobulin single variable domain directed against human cxcr4 and other cell associated proteins and methods to generate them
EP2493926B1 (en) 2009-10-27 2020-03-11 UCB Biopharma SRL Function modifying nav 1.7 antibodies
GB0922435D0 (en) 2009-12-22 2010-02-03 Ucb Pharma Sa Method
GB0919054D0 (en) 2009-10-30 2009-12-16 Isis Innovation Treatment of obesity
WO2011053743A1 (en) 2009-10-30 2011-05-05 Merck Sharp & Dohme Corp. Pcsk9 immunoassay
IN2012DN03824A (en) 2009-10-30 2015-08-28 Merck Sharp & Dohme
CN102596249A (en) 2009-10-30 2012-07-18 默沙东公司 AX1 and AX189 PCSK9 antagonists and variants
EP2494354A1 (en) 2009-10-30 2012-09-05 Merck Sharp & Dohme Corp. Pcsk9 immunoassay
JP6007420B2 (en) 2009-11-04 2016-10-12 ファブラス エルエルシー Antibody optimization method based on affinity maturation
CA2778714C (en) 2009-11-24 2018-02-27 Medimmune Limited Targeted binding agents against b7-h1
SG181533A1 (en) 2009-12-07 2012-07-30 Univ Leland Stanford Junior Methods for enhancing anti-tumor antibody therapy
HUE044179T2 (en) 2009-12-10 2019-10-28 Hoffmann La Roche Antibodies binding preferentially human csf1r extracellular domain 4 and their use
AR079336A1 (en) 2009-12-11 2012-01-18 Irm Llc ANTAGONISTS OF THE PRO-PROTEIN CONVERTASE-SUBTILISINE / TYPE 9 QUEXINE (PCSK9)
US8962807B2 (en) 2009-12-14 2015-02-24 Ablynx N.V. Single variable domain antibodies against OX40L, constructs and therapeutic use
CN102939303A (en) 2009-12-22 2013-02-20 诺瓦提斯公司 Tetravalent cd47-antibody constant region fusion protein for use in therapy
CA2785964C (en) 2009-12-29 2021-03-30 Kyowa Hakko Kirin Co., Ltd. Anti-cd27 antibody
WO2011083141A2 (en) 2010-01-08 2011-07-14 Ablynx Nv Method for generation of immunoglobulin sequences by using lipoprotein particles
ES2724451T3 (en) 2010-02-04 2019-09-11 Univ Pennsylvania ICOS fundamentally regulates the expansion and function of inflammatory human Th17 lymphocytes
GB201002238D0 (en) 2010-02-10 2010-03-31 Affitech As Antibodies
KR20130036192A (en) 2010-02-11 2013-04-11 알렉시온 파마슈티칼스, 인코포레이티드 Therapeutic methods using anti-cd200 antibodies
US9169323B2 (en) 2010-03-05 2015-10-27 Hoffmann-La Roche Inc. Antibodies against human CSF-1R
EP2542588A1 (en) 2010-03-05 2013-01-09 F. Hoffmann-La Roche AG Antibodies against human csf-1r and uses thereof
US8993731B2 (en) 2010-03-11 2015-03-31 Ucb Biopharma Sprl PD-1 antibody
KR20150002894A (en) 2010-03-11 2015-01-07 리나트 뉴로사이언스 코프. ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING
TW201134488A (en) 2010-03-11 2011-10-16 Ucb Pharma Sa PD-1 antibodies
EP2371863A1 (en) 2010-03-30 2011-10-05 Pierre Fabre Médicament Humanized anti CXCR4 antibodies for the treatment of cancer
EP2552965A2 (en) 2010-03-31 2013-02-06 Boehringer Ingelheim International GmbH Anti-cd40 antibodies
EP2371857A1 (en) 2010-04-01 2011-10-05 CSL Behring GmbH Factor XII inhibitors for treating interstitial lung disease
AR080698A1 (en) 2010-04-01 2012-05-02 Imclone Llc ANTIBODY OR FRAGMENT OF THE SAME THAT SPECIFICALLY LINKS THE VARIOUS OF HUMAN CSF -1R, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, ITS USE FOR THE MANUFACTURE OF A USEFUL MEDICINAL PRODUCT FOR THE TREATMENT OF CANCER AND METHOD TO DETERMINE IF A BASED SUBJECT MATTER AND
MX392483B (en) 2010-04-13 2025-03-24 Bristol Myers Squibb Co FIBRONECTIN-BASED SFIELD DOMAIN PROTEINS THAT BIND THE PROTEIN CONVERTASE SUBTILISIN KEXIN TYPE Q (PCSK9).
NZ602892A (en) 2010-04-13 2014-08-29 Celldex Therapeutics Inc Antibodies that bind human cd27 and uses thereof
EA201291065A1 (en) 2010-04-16 2013-03-29 Байоджен Айдек Ма Инк. ANTIBODIES AGAINST VLA-4
NZ603193A (en) 2010-05-04 2014-07-25 Five Prime Therapeutics Inc Antibodies that bind csf1r
US8486647B2 (en) 2010-06-09 2013-07-16 Regeneron Pharmaceuticals, Inc. Neuropeptide release assay for sodium channels
US8871996B2 (en) 2010-06-09 2014-10-28 Regeneron Pharmaceuticals, Inc. Mice expressing human voltage-gated sodium channels
JP6158511B2 (en) 2010-06-11 2017-07-05 協和発酵キリン株式会社 Anti-TIM-3 antibody
EP3366125A1 (en) 2010-06-17 2018-08-29 Kymab Limited Animal models and therapeutic molecules
WO2011161266A1 (en) 2010-06-25 2011-12-29 Ablynx Nv Improved immunoglobulin single variable domains and constructs thereof directed against cxcr4
AU2011275749C1 (en) 2010-07-09 2015-09-17 Aduro Biotech Holdings, Europe B.V. Agonistic antibody to CD27
SG187592A1 (en) * 2010-07-23 2013-03-28 Univ Boston Anti-despr inhibitors as therapeutics for inhibition of pathological angiogenesis and tumor cell invasiveness and for molecular imaging and targeted delivery
NZ716369A (en) 2010-08-23 2017-05-26 Univ Texas Anti-ox40 antibodies and methods of using the same
CN103080132B (en) 2010-08-25 2016-06-08 弗·哈夫曼-拉罗切有限公司 Antibodies against IL-18R1 and uses thereof
MY177065A (en) 2010-09-09 2020-09-03 Pfizer 4-1bb binding molecules
EP2618656B1 (en) 2010-09-20 2018-06-20 Yale University, Inc. HUMAN SIRPalpha TRANSGENIC ANIMALS AND THEIR METHODS OF USE
AU2011310887A1 (en) 2010-09-29 2013-05-02 Universite De Liege Combination of an agonistic anti-CD40 monoclonal antibody or a CD40 ligand and inactivated or attenuated bacteria for use in the treatment and/or prevention of mastitis
WO2012054438A1 (en) 2010-10-22 2012-04-26 Schering Corporation Anti-pcsk9
EP2632953A1 (en) 2010-10-27 2013-09-04 Pierre Fabre Medicament Antibodies for the treatment of hiv
CU24111B1 (en) 2010-11-08 2015-08-27 Novartis Ag POLYPEPTIDES THAT LINK TO CXCR2
CU23923B1 (en) 2010-11-12 2013-07-31 Ct De Inmunología Molecular POLYPEPTIDES DERIVED FROM IL-2 WITH AGONIST ACTIVITY
AR083847A1 (en) 2010-11-15 2013-03-27 Novartis Ag FC VARIANTS (CONSTANT FRAGMENT) SILENCERS OF ANTI-CD40 ANTIBODIES
WO2012075111A1 (en) 2010-11-30 2012-06-07 Novartis Ag Uses of anti-cd40 antibodies in combination therapy for b cell-related cancers
GB201020738D0 (en) 2010-12-07 2011-01-19 Affitech Res As Antibodies
CA2860170C (en) 2010-12-22 2022-06-14 The Board Of Trustees Of The Leland Stanford Junior University Superagonists and antagonists of interleukin-2
SG191219A1 (en) 2010-12-22 2013-07-31 Genentech Inc Anti-pcsk9 antibodies and methods of use
EP2654789B1 (en) 2010-12-22 2018-05-30 Orega Biotech Antibodies against human cd39 and use thereof
JP2014507136A (en) 2011-01-18 2014-03-27 アムジエン・インコーポレーテツド NaV1.7 knockout mice and their use
EP2650016A1 (en) 2011-01-28 2013-10-16 Sanofi Human antibodies to PSCK9 for use in methods of treatment based on particular dosage regimens (11565)
EP2481758A1 (en) 2011-01-28 2012-08-01 Sanofi Human antibodies to PSCK9 for use in methods of treating particular groups of subjects (11566)
PL2668212T3 (en) 2011-01-28 2018-08-31 Sanofi Biotechnology Human antibodies to pcsk9 for use in methods of treating particular groups of subjects
CN103476433A (en) 2011-02-10 2013-12-25 罗切格利卡特公司 Improved immunotherapy
TWI666027B (en) 2011-02-10 2019-07-21 羅齊克雷雅公司 Mutant interleukin-2 polypeptides
CA2827091A1 (en) 2011-02-11 2012-08-16 Irm Llc Pcsk9 antagonists
WO2012111762A1 (en) 2011-02-17 2012-08-23 協和発酵キリン株式会社 Highly concentrated anti-cd40 antibody pharmaceutical preparation
WO2012132067A1 (en) 2011-03-30 2012-10-04 中外製薬株式会社 Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity
WO2012119093A1 (en) 2011-03-03 2012-09-07 Board Of Trustees Of The Leland Stanford Junior University Superagonists and antagonists of interleukin-2
GB201103955D0 (en) 2011-03-09 2011-04-20 Antitope Ltd Antibodies
FI3556774T3 (en) 2011-03-11 2024-03-15 Beth Israel Deaconess Medical Ct Inc ANTI-CD40 ANTIBODIES AND THEIR USES
ES2612914T3 (en) 2011-03-31 2017-05-19 Inserm - Institut National De La Santé Et De La Recherche Médicale Antibodies directed against Icos and their uses
MX341076B (en) 2011-03-31 2016-08-04 Merck Sharp & Dohme Stable formulations of antibodies to human programmed death receptor pd-1 and related treatments.
ES2724801T3 (en) 2011-04-19 2019-09-16 Pfizer Combinations of anti-4-1BB antibodies and ADCC inducing antibodies for cancer treatment
PT2699264T (en) 2011-04-20 2018-05-23 Medimmune Llc ANTIBODIES AND OTHER MOLECULES CONNECTING B7-H1 AND PD-1
ES2664619T3 (en) 2011-04-21 2018-04-20 Bristol-Myers Squibb Company Antibody polypeptides that antagonize CD40
US8778345B2 (en) 2011-04-29 2014-07-15 Apexigen, Inc. Anti-CD40 antibodies
EA201892619A1 (en) 2011-04-29 2019-04-30 Роше Гликарт Аг IMMUNOCONJUGATES CONTAINING INTERLEUKIN-2 MUTANT POLYPETIPS
EP2702076A1 (en) 2011-04-29 2014-03-05 Bristol-Myers Squibb Company Ip-10 antibody dosage escalation regimens
JOP20200043A1 (en) 2011-05-10 2017-06-16 Amgen Inc Ways to treat or prevent cholesterol disorders
US9732196B2 (en) 2011-05-10 2017-08-15 Sabic Global Technologies B.V. Adhesive for bonding polyimide resins
ES2732213T3 (en) 2011-05-21 2019-11-21 Macrogenics Inc Molecules that bind to CD3 capable of binding to human and non-human CD3
WO2012162583A1 (en) 2011-05-26 2012-11-29 Ibc Pharmaceuticals, Inc. Design and construction of novel multivalent antibodies
US9574002B2 (en) 2011-06-06 2017-02-21 Amgen Inc. Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor
WO2012170607A2 (en) 2011-06-10 2012-12-13 Novartis Ag Use of pcsk9 antagonists
WO2012168491A1 (en) 2011-06-10 2012-12-13 Novartis Ag Pharmaceutical formulations of pcsk9 antagonists
WO2012173819A2 (en) 2011-06-14 2012-12-20 Mayo Foundation For Medical Education And Research Anti-cd3 therapies
CA2841416A1 (en) 2011-06-15 2012-12-20 Glaxosmithkline Intellectual Property (No.2) Limited Method of selecting therapeutic indications
MX2013014789A (en) 2011-06-16 2014-01-20 Novartis Ag Soluble proteins for use as therapeutics.
US20140120555A1 (en) 2011-06-20 2014-05-01 Pierre Fabre Medicament Anti-cxcr4 antibody with effector functions and its use for the treatment of cancer
US20140234320A1 (en) 2011-06-20 2014-08-21 La Jolla Institute For Allergy And Immunology Modulators of 4-1bb and immune responses
BR112013032667A2 (en) 2011-06-20 2017-12-12 Genentech Inc pcsk9 binding polypeptide, isolated nucleic acid, vector, host cell, method for producing the polypeptide, pharmaceutical composition, method of lowering ldl cholesterol level in a subject, method of treating cholesterol related dysfunction in a subject, method of treatment of hypercholesterolemia in one subject, pcsk9 to ldlr binding inhibition method and pcsk9 protein detection method in one sample
US11492383B2 (en) 2011-06-24 2022-11-08 Stephen D. Gillies Light chain immunoglobulin fusion proteins and methods of use thereof
WO2013006490A2 (en) 2011-07-01 2013-01-10 Cellerant Therapeutics, Inc. Antibodies that specifically bind to tim3
EA036047B1 (en) 2011-07-11 2020-09-18 Икнос Сайенсиз Са Antibodies that bind to ox40 and their uses
HK1202804A1 (en) 2011-07-14 2015-10-09 辉瑞公司 Treatment with anti-pcsk9 antibodies
US20140314784A1 (en) 2011-07-20 2014-10-23 Medlmmune Limited Anti-cxcr4 antibodies and methods of use
AR087305A1 (en) 2011-07-28 2014-03-12 Regeneron Pharma STABILIZED FORMULATIONS CONTAINING ANTI-PCSK9 ANTIBODIES, PREPARATION METHOD AND KIT
AR087363A1 (en) 2011-07-29 2014-03-19 Pf Medicament USE OF ANTIBODY I-3859 FOR THE DETECTION AND DIAGNOSIS OF CANCERES
AR087364A1 (en) 2011-07-29 2014-03-19 Pf Medicament ANTI-CXCR4 ANTIBODY AND ITS USE FOR CANCERES DETECTION AND DIANOSTIC
CA2845810C (en) 2011-08-23 2017-03-28 Board Of Regents, The University Of Texas System Anti-ox40 antibodies and methods of using the same
GB201115280D0 (en) 2011-09-05 2011-10-19 Alligator Bioscience Ab Antibodies, uses and methods
US20130108641A1 (en) 2011-09-14 2013-05-02 Sanofi Anti-gitr antibodies
GB201116092D0 (en) 2011-09-16 2011-11-02 Bioceros B V Antibodies and uses thereof
PL4252857T3 (en) 2011-09-16 2025-03-03 Regeneron Pharmaceuticals, Inc. Methods for reducing lipoprotein(a) levels by administering an inhibitor of proprotein convertase subtilisin kexin-9 (pcsk9)
AR087715A1 (en) 2011-09-16 2014-04-09 Lilly Co Eli ANTI PCSK9 ANTIBODIES AND USES OF THE SAME
AU2012311286B2 (en) 2011-09-19 2018-07-26 Kymab Limited Antibodies, variable domains and chains tailored for human use
SMT202000091T1 (en) 2011-10-13 2020-05-08 Bristol Myers Squibb Co Antibody polypeptides that antagonize cd40l
WO2013056352A1 (en) 2011-10-19 2013-04-25 University Health Network Antibodies and antibody fragments targeting sirp-alpha and their use in treating hematologic cancers
HK1200032A1 (en) 2011-10-21 2015-07-31 Transgene Sa Modulation of macrophage activation
CN104136047B (en) 2011-10-26 2018-02-06 安姆根有限公司 Reduce or eliminate protein modification and the method for degraded as caused by exposed to UV light
GB2496375A (en) 2011-10-28 2013-05-15 Kymab Ltd A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof
MX357100B (en) 2011-11-09 2018-06-26 Bristol Myers Squibb Co Treatment of hematologic malignancies with an anti-cxcr4 antibody.
US20130115171A1 (en) 2011-11-09 2013-05-09 Stefan I. McDonough Nav1.7-related assays
UA112203C2 (en) 2011-11-11 2016-08-10 Юсб Фарма С.А. Fusion protein of a biospecific antibody that binds to human OX40 and serum human albumin
ES2808152T3 (en) 2011-11-28 2021-02-25 Merck Patent Gmbh Anti-PD-L1 antibodies and their uses
US9253965B2 (en) 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
BR112014012624A2 (en) 2011-12-15 2018-10-09 F Hoffmann-La Roche Ag antibodies, pharmaceutical composition, nucleic acid, expression vectors, host cell, method for producing a recombinant antibody and use of the antibody
WO2013119202A1 (en) 2012-02-06 2013-08-15 Providence Health & Services - Oregon Cancer treatment and monitoring methods using ox40 agonists
GB201203442D0 (en) * 2012-02-28 2012-04-11 Univ Birmingham Immunotherapeutic molecules and uses
AR090263A1 (en) 2012-03-08 2014-10-29 Hoffmann La Roche COMBINED ANTIBODY THERAPY AGAINST HUMAN CSF-1R AND USES OF THE SAME
HK1206251A1 (en) 2012-03-15 2016-01-08 Janssen Biotech, Inc. Human anti-cd27 antibodies, methods and uses
US20130315913A1 (en) 2012-03-26 2013-11-28 Sanofi Anti-light antibody therapy for inflammatory bowel disease
WO2013148284A1 (en) 2012-03-29 2013-10-03 Genentech, Inc. Antibodies that bind to a pcsk9 cleavage site and methods of use
HK1207398A1 (en) 2012-04-20 2016-01-29 Emergent Product Development Seattle, Llc Cd3 binding polypeptides
US20140004131A1 (en) 2012-05-04 2014-01-02 Novartis Ag Antibody formulation
HK1207655A1 (en) 2012-05-04 2016-02-05 Dana-Farber Cancer Institute, Inc. Affinity matured anti-ccr4 humanized monoclonal antibodies and methods of use
US9328174B2 (en) 2012-05-09 2016-05-03 Novartis Ag Chemokine receptor binding polypeptides
HK1208233A1 (en) 2012-05-11 2016-02-26 戊瑞治疗有限公司 Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
SG10201700698WA (en) 2012-05-15 2017-02-27 Bristol Myers Squibb Co Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
CN103417967B (en) 2012-05-15 2017-05-10 中国医学科学院基础医学研究所 Application of inhibitor of CXCL-10 in preparation of drug for treatment and/or prevention of lung injury
WO2013172933A1 (en) 2012-05-15 2013-11-21 University Of Southern California Ethnic gene profile of genes involved in angiogenesis may predict regional bevacizumab efficacy difference in gastric cancer
EP2849788B1 (en) 2012-05-17 2018-01-03 Cyon Therapeutics Inc. Proprotein convertase subtilisin kexin 9 (pcsk9) inhibitors for use in treating sepsis and septic shock
US9102751B2 (en) 2012-05-18 2015-08-11 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
DK2857419T3 (en) 2012-05-30 2021-03-29 Chugai Pharmaceutical Co Ltd Antigen-binding molecule for the elimination of aggregated antigens
JP2015519375A (en) 2012-05-31 2015-07-09 ソレント・セラピューティクス・インコーポレイテッドＳｏｒｒｅｎｔｏ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Antigen binding protein that binds to PD-L1
ES2672974T3 (en) 2012-06-01 2018-06-19 Ibc Pharmaceuticals, Inc. Multimeric complexes with improved in vivo stability, improved pharmacokinetics and efficacy
EP2858673A4 (en) 2012-06-06 2016-06-22 Oncomed Pharm Inc BINDING AGENTS MODULATING THE HIPPO SIGNALING PATH AND USES THEREOF
US10000567B2 (en) 2012-06-14 2018-06-19 Therapix Biosciences Ltd. Humanized antibodies to cluster of differentiation 3 (CD3)
EP2895203A4 (en) 2012-06-15 2016-09-28 Imaginab Inc ANTIGEN BINDING CONSTRUCTIONS FOR CD3
CN104870013A (en) 2012-06-27 2015-08-26 吉安特科技公司 Anti-CXCL9, Anti-CXCL10, Anti-CXCL11, Anti-CXCL13, Anti-CXCR3, and Anti-CXCR5 Reagents for Inhibition of Inflammation
US20140005352A1 (en) 2012-06-29 2014-01-02 Invista North America S.A R.L. Gas scrubber and related processes
UY34887A (en) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware OPTIMIZATION OF ANTIBODIES THAT FIX THE LYMPHOCYTE ACTIVATION GEN 3 (LAG-3) AND ITS USES
DE102012013637A1 (en) 2012-07-09 2014-01-09 Iwis Motorsysteme Gmbh & Co. Kg Lantern planetary gear
EP2879709B1 (en) 2012-07-31 2020-01-08 The Brigham and Women's Hospital, Inc. Modulation of the immune response
PL3434695T3 (en) 2012-08-07 2021-05-17 Roche Glycart Ag Improved immunotherapy
US20140044675A1 (en) 2012-08-10 2014-02-13 Roche Glycart Ag Interleukin-2 fusion proteins and uses thereof
HK1212214A1 (en) 2012-08-31 2016-06-10 戊瑞治疗有限公司 Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
ES2684552T3 (en) 2012-09-03 2018-10-03 Inserm - Institut National De La Santé Et De La Recherche Médicale Antibodies directed against ICOS to treat graft versus host disease
BR112015005772A2 (en) 2012-09-17 2017-08-08 Galectin Therapeutics Inc Method for Intensifying Specific Immunotherapies in Cancer Treatment
JOP20200236A1 (en) 2012-09-21 2017-06-16 Regeneron Pharma Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof
CN114507282B (en) 2012-10-04 2025-05-16 达纳－法伯癌症研究所公司 Human monoclonal anti-PD-L1 antibodies and methods of use
WO2014065402A1 (en) 2012-10-26 2014-05-01 株式会社ペルセウスプロテオミクス Anti-human cd40 monoclonal antibody, and use thereof
JP2016011258A (en) 2012-10-26 2016-01-21 株式会社ペルセウスプロテオミクス Anti-human CD40 monoclonal antibody and use thereof
WO2014070934A1 (en) 2012-10-30 2014-05-08 Apexigen, Inc. Anti-cd40 antibodies and methods of use
SG11201502827RA (en) 2012-11-09 2015-05-28 Transgene Sa Modulation of monocytes, or precursors thereof, differentiation
CN104968364A (en) 2012-12-03 2015-10-07 百时美施贵宝公司 Enhanced anticancer activity of immunomodulatory Fc fusion proteins
JP2016502554A (en) 2012-12-04 2016-01-28 オンコメッド ファーマシューティカルズ インコーポレイテッド Immunotherapy using binding substances
AU2013363962B2 (en) * 2012-12-21 2016-11-24 Amplimmune, Inc. Anti-H7CR antibodies
AR093984A1 (en) 2012-12-21 2015-07-01 Merck Sharp & Dohme ANTIBODIES THAT JOIN LEGEND 1 OF SCHEDULED DEATH (PD-L1) HUMAN
JO3405B1 (en) 2013-01-09 2019-10-20 Regeneron Pharma ANTI-PDGFR-beta ANTIBODIES AND USES THEREOF
WO2014110258A1 (en) 2013-01-09 2014-07-17 Podack Eckhard R Compositions and methods for the regulation of t regulatory cells using tl1a-ig fusion protein
EP2948475A2 (en) 2013-01-23 2015-12-02 AbbVie Inc. Methods and compositions for modulating an immune response
WO2014165082A2 (en) 2013-03-13 2014-10-09 Medimmune, Llc Antibodies and methods of detection
ES2774549T3 (en) 2013-03-13 2020-07-21 Bioasis Technologies Inc Fragments of P97 and uses thereof
US20160067337A1 (en) 2013-03-14 2016-03-10 Bristol-Myers Squibb Company Combination of dr5 agonist and anti-pd-1 antagonist and methods of use
WO2014159595A2 (en) 2013-03-14 2014-10-02 Regeneron Pharmaceuticals, Inc. Human antibodies to nav1.7
WO2014140374A2 (en) 2013-03-15 2014-09-18 Novo Nordisk A/S Monovalent cd27 antibodies
US9097712B2 (en) 2013-03-15 2015-08-04 Allied Innovative Systems Llc Flow-through cell counting assay
ES2808654T3 (en) 2013-03-15 2021-03-01 Glaxosmithkline Ip Dev Ltd Anti-LAG-3 binding proteins
EP2976361B1 (en) 2013-03-18 2018-07-18 BiocerOX Products B.V. Humanized anti-cd134 (ox40) antibodies and uses thereof
CA2918196A1 (en) 2013-04-11 2014-10-16 The Brigham And Women's Hospital, Inc. Methods and compositions of treating autoimmune diseases
EP2986642A1 (en) 2013-04-17 2016-02-24 MorphoSys AG Antibodies targeting specifically human cxcr2
AR095882A1 (en) 2013-04-22 2015-11-18 Hoffmann La Roche ANTIBODY COMBINATION THERAPY AGAINST HUMAN CSF-1R WITH A TLR9 AGONIST
HUE053069T2 (en) 2013-05-02 2021-06-28 Anaptysbio Inc Antibodies to programmed death-1 (PD-1)
JP2016520595A (en) 2013-05-22 2016-07-14 メタボリック エンジニアリング ラボラトリーズ カンパニー リミテッド Anti-TNF-α / CXCL10 double target antibody and use thereof
AU2014268298B2 (en) 2013-05-24 2019-01-17 Medlmmune, Llc Anti-B7-H5 antibodies and their uses
TWI682780B (en) 2013-05-30 2020-01-21 美商再生元醫藥公司 Use of a pharmaceutical composition for the manufacture of a medicament for treating autosomal dominant hypercholesterolemia associated with pcsk9 gain-of-function mutations
CA2913977C (en) 2013-05-31 2022-11-29 Sorrento Therapeutics, Inc. Antigen binding proteins that bind pd-1
CN104250302B (en) 2013-06-26 2017-11-14 上海君实生物医药科技股份有限公司 The anti-antibody of PD 1 and its application
DK3016681T5 (en) 2013-07-05 2020-05-04 Genmab As Humanized or chimeric CD3 antibodies
EP3786187A1 (en) 2013-08-01 2021-03-03 Université catholique de Louvain Antibody binding a complex of human glycoprotein a repetitions predominant (garp) and latent tgf-beta-1
BR112016002008B1 (en) 2013-08-02 2021-06-22 Pfizer Inc. ANTI-CXCR4 ANTIBODIES, THEIR USE, ANTIBODY-DRUG CONJUGATE AND PHARMACEUTICAL COMPOSITION
RU2016107426A (en) 2013-08-02 2017-09-07 Адуро Байотек Холдингс, Юроуп Б.В. COMBINING CD27 AGONISTS AND INHIBITING IMMUNE CONTROL POINTS TO STIMULATE IMMUNITY
AR097306A1 (en) 2013-08-20 2016-03-02 Merck Sharp & Dohme MODULATION OF TUMOR IMMUNITY
BR112016003532A8 (en) 2013-08-22 2018-01-30 Council Queensland Inst Medical Res immunoreceptor modulation to treat cancer and viral infections
BR112016003528A8 (en) 2013-08-22 2018-01-30 Council Queensland Inst Medical Res immune receptor modulation for cancer and viral infection treatment
TW201605896A (en) 2013-08-30 2016-02-16 安美基股份有限公司 GITR antigen binding proteins
GB201315486D0 (en) 2013-08-30 2013-10-16 Ucb Pharma Sa Antibodies
GB201315487D0 (en) 2013-08-30 2013-10-16 Ucb Pharma Sa Antibodies
US10077305B2 (en) 2013-09-10 2018-09-18 Medimmune Limited Antibodies against PD-1 and uses thereof
IL292193B2 (en) 2013-09-11 2024-11-01 Medimmune Ltd Anti-B7-H1 antibodies for the treatment of tumors
AR097584A1 (en) 2013-09-12 2016-03-23 Hoffmann La Roche ANTIBODY COMBINATION THERAPY AGAINST HUMAN CSF-1R AND ANTIBODIES AGAINST HUMAN PD-L1
PT3702373T (en) 2013-09-13 2022-09-27 Beigene Switzerland Gmbh Anti-pd1 antibodies and their use as therapeutics and diagnostics
GB201316644D0 (en) 2013-09-19 2013-11-06 Kymab Ltd Expression vector production & High-Throughput cell screening
PT3508502T (en) 2013-09-20 2023-06-22 Bristol Myers Squibb Co Combination of anti-lag-3 antibodies and anti-pd-1 antibodies to treat tumors
WO2015048312A1 (en) 2013-09-26 2015-04-02 Costim Pharmaceuticals Inc. Methods for treating hematologic cancers
GB201317622D0 (en) 2013-10-04 2013-11-20 Star Biotechnology Ltd F Cancer biomarkers and uses thereof
CN104558177B (en) 2013-10-25 2020-02-18 苏州思坦维生物技术股份有限公司 Monoclonal antibody for antagonizing and inhibiting programmed death receptor PD-1and ligand combination thereof, and coding sequence and application thereof
US10202454B2 (en) 2013-10-25 2019-02-12 Dana-Farber Cancer Institute, Inc. Anti-PD-L1 monoclonal antibodies and fragments thereof
GB2519786A (en) 2013-10-30 2015-05-06 Sergej Michailovic Kiprijanov Multivalent antigen-binding protein molecules
US10233248B2 (en) 2013-11-06 2019-03-19 Bristol-Myers Squibb Company Treatment of C1013G/CXCR4-associated waldenstroöm's macroglobulinemia with an anti-CXCR4 antibody
SG10201804945WA (en) 2013-12-12 2018-07-30 Shanghai hengrui pharmaceutical co ltd Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof
PT3091991T (en) 2013-12-13 2020-02-04 Swedish Stromabio Ab Immunomodulatory compositions
EP3192812B1 (en) 2013-12-17 2020-05-27 Genentech, Inc. Anti-cd3 antibodies and methods of use
GB201322583D0 (en) 2013-12-19 2014-02-05 Alligator Bioscience Ab Antibodies
EP3083694B1 (en) 2013-12-20 2023-11-22 Intervet International B.V. Caninized murine anti-canine pd-1 antibodies
SI3712174T1 (en) 2013-12-24 2022-06-30 Janssen Pharmaceutica Nv VISTA antibodies and particles
AU2014374055B2 (en) 2013-12-30 2018-11-08 Epimab Biotherapeutics Inc. Fabs-in-tandem immunoglobulin and uses thereof
US10407502B2 (en) 2014-01-15 2019-09-10 Kadmon Corporation, Llc Immunomodulatory agents
TWI680138B (en) * 2014-01-23 2019-12-21 美商再生元醫藥公司 Human antibodies to pd-l1
TWI681969B (en) 2014-01-23 2020-01-11 美商再生元醫藥公司 Human antibodies to pd-1
JOP20200094A1 (en) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc Antibody molecules to pd-1 and uses thereof
KR20160106762A (en) 2014-01-28 2016-09-12 브리스톨-마이어스 스큅 컴퍼니 Anti-lag-3 antibodies to treat hematological malignancies
JOP20200096A1 (en) 2014-01-31 2017-06-16 Children’S Medical Center Corp TIM-3 Antibody Molecules and Their Uses
EP3508496A1 (en) 2014-02-06 2019-07-10 F. Hoffmann-La Roche AG Interleukin-2 fusion proteins and uses thereof
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
WO2015134988A1 (en) 2014-03-07 2015-09-11 Bristol-Myers Squibb Company Method of using antibody polypeptides that antagonize cd40 to treat ibd
EP3116544A4 (en) 2014-03-11 2017-08-23 The Board of Trustees of the Leland Stanford Junior University Anti sirp-alpha antibodies and bi-specific macrophage enhancing antibodies
US9394365B1 (en) 2014-03-12 2016-07-19 Yeda Research And Development Co., Ltd Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease
BR112016020919A2 (en) * 2014-03-12 2018-01-23 Yeda Res & Dev reduced levels or systemic activity of regulatory t cells for the treatment of snc disease and injury
LT3116909T (en) 2014-03-14 2020-02-10 Novartis Ag ANTI-BODY MOLECULES AGAINST LAG-3 AND THEIR USE
KR20160146747A (en) 2014-03-31 2016-12-21 제넨테크, 인크. Combination therapy comprising anti-angiogenesis agents and ox40 binding agonists
EP3126394B1 (en) 2014-03-31 2019-10-30 F.Hoffmann-La Roche Ag Anti-ox40 antibodies and methods of use
US20150307620A1 (en) 2014-04-16 2015-10-29 University Of Connecticut Linked immunotherapeutic agonists that costimulate multiple pathways
EP3134102B1 (en) 2014-04-24 2019-07-03 The Board of Trustees of The Leland Stanford Junior University Superagonists, partial agonists and antagonists of interleukin-2
WO2015169811A2 (en) 2014-05-06 2015-11-12 Medimmune Limited Anti-cxc chemokine receptor-2 binding molecules and uses thereof
WO2015173267A1 (en) 2014-05-13 2015-11-19 Medimmune Limited Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small cell lung cancer
BR112016026993A2 (en) 2014-05-21 2017-10-31 Kyowa Hakko Kirin Co Ltd combination of an anti-ccr4 antibody and a 4-1bb agonist to treat cancer
US10302653B2 (en) 2014-05-22 2019-05-28 Mayo Foundation For Medical Education And Research Distinguishing antagonistic and agonistic anti B7-H1 antibodies
SMT202100116T1 (en) 2014-05-28 2021-05-07 Agenus Inc Anti-gitr antibodies and methods of use thereof
EP3149042B1 (en) 2014-05-29 2019-08-28 Spring Bioscience Corporation Pd-l1 antibodies and uses thereof
PT3151921T (en) 2014-06-06 2019-11-21 Bristol Myers Squibb Co ANTIBODIES AGAINST GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEIVER AND USES OF THE SAME
WO2015195163A1 (en) 2014-06-20 2015-12-23 R-Pharm Overseas, Inc. Pd-l1 antagonist fully human antibody
WO2015198312A1 (en) 2014-06-24 2015-12-30 Ccam Therapeutics Ltd. Compositions comprising antibodies to ceacam-1 and lag-3 for cancer therapy
CN110156892B (en) 2014-07-03 2023-05-16 百济神州有限公司 anti-PD-L1 antibodies and their use as therapeutic and diagnostic agents
RU2715038C2 (en) 2014-07-11 2020-02-21 Дженентек, Инк. Anti-pd-l1 antibodies and methods for their diagnostic use
SG10201900571YA (en) 2014-07-22 2019-02-27 Cb Therapeutics Inc Anti-pd-1 antibodies
US10669337B2 (en) 2014-07-25 2020-06-02 Cytomx Therapeutics, Inc. Bispecific anti-CD3 antibodies, bispecific activatable anti-CD3 antibodies, and methods of using the same
CN105330740B (en) 2014-07-30 2018-08-17 珠海市丽珠单抗生物技术有限公司 Anti- PD-1 antibody and its application
CN105296433B (en) 2014-08-01 2018-02-09 中山康方生物医药有限公司 A kind of CTLA4 antibody, its medical composition and its use
AU2015301338C1 (en) 2014-08-04 2021-07-22 Baylor Research Institute Antagonistic anti-OX40L antibodies and methods of their use
SG10201901057UA (en) 2014-08-05 2019-03-28 Cb Therapeutics Inc Anti-pd-l1 antibodies
EP3180087B1 (en) 2014-08-12 2019-03-13 Alligator Bioscience AB Combination therapies with anti cd40 antibodies
AU2015303239A1 (en) 2014-08-14 2016-12-15 F. Hoffmann-La Roche Ag Combination therapy of antibodies activating human CD40 and antibodies against human PD-L1
WO2016028810A1 (en) 2014-08-18 2016-02-25 Biogen Ma Inc. Anti-cd40 antibodies and uses thereof
SG11201701161QA (en) 2014-08-19 2017-03-30 Merck Sharp & Dohme Anti-tigit antibodies
JO3663B1 (en) 2014-08-19 2020-08-27 Merck Sharp & Dohme Anti-lag3 antibodies and antigen-binding fragments
AU2015308527C1 (en) * 2014-08-29 2021-07-15 F. Hoffmann-La Roche Ag Combination therapy of tumor-targeted IL-2 variant immunocytokines and antibodies against human PD-L1
JP6797111B2 (en) 2014-09-30 2020-12-09 インターベット インターナショナル ベー． フェー． PD-L1 antibody that binds to canine PD-L1
MX2017004311A (en) 2014-10-03 2017-12-07 Dana Farber Cancer Inst Inc Glucocorticoid-induced tumor necrosis factor receptor (gitr) antibodies and methods of use thereof.
US10675349B2 (en) 2014-10-06 2020-06-09 Dana-Farber Cancer Institute, Inc. Humanized CC chemokine receptor 4 (CCR4) antibodies and methods of use thereof
WO2016131950A1 (en) 2015-02-20 2016-08-25 Innate Pharma Cd73 blockade
TW201619200A (en) 2014-10-10 2016-06-01 麥迪紐有限責任公司 Humanized anti-OX40 antibodies and uses thereof
DK3204417T3 (en) 2014-10-10 2020-10-12 Innate Pharma CD73 BLOCKING
JP6877339B2 (en) 2014-10-14 2021-05-26 ノバルティス アーゲー Antibody molecule against PD-L1 and its use
US20160145344A1 (en) 2014-10-20 2016-05-26 University Of Southern California Murine and human innate lymphoid cells and lung inflammation
EP3012271A1 (en) 2014-10-24 2016-04-27 Effimune Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and infectious diseases
GB201419084D0 (en) 2014-10-27 2014-12-10 Agency Science Tech & Res Anti-PD-1 antibodies
GB201419094D0 (en) 2014-10-27 2014-12-10 Agency Science Tech & Res Anti-TIM-3-antibodies
SG11201703403TA (en) 2014-10-27 2017-05-30 Agency Science Tech & Res Anti-tim-3 antibodies
CA2964830C (en) 2014-11-06 2024-01-02 F. Hoffmann-La Roche Ag Anti-tim3 antibodies and methods of use
US10556959B2 (en) 2014-11-07 2020-02-11 Xencor, Inc. Anti-CD39 antibodies and uses thereof
LT3218406T (en) 2014-11-10 2021-06-25 Medimmune Limited BINDING MOLECULARS, SPECIFIC CD73 AND THEIR USES
EP3218409A2 (en) 2014-11-11 2017-09-20 Sutro Biopharma, Inc. Anti-pd-1 antibodies, compositions comprising anti-pd-1 antibodies and methods of using anti-pd-1 antibodies
WO2016075176A1 (en) 2014-11-11 2016-05-19 Medimmune Limited Therapeutic combinations comprising anti-cd73 antibodies and a2a receptor inhibitor and uses thereof
LT3789402T (en) 2014-11-20 2022-09-26 F. Hoffmann-La Roche Ag Combination therapy of t cell activating bispecific antigen binding molecules and pd-1 axis binding antagonists
DK3221363T3 (en) 2014-11-21 2020-08-10 Bristol Myers Squibb Co ANTIBODIES TO CD73 AND USES THEREOF
TWI595006B (en) 2014-12-09 2017-08-11 禮納特神經系統科學公司 Anti-PD-1 antibodies and methods of using same
EP3237447B1 (en) 2014-12-22 2020-12-02 Five Prime Therapeutics, Inc. Anti-csf1r antibodies for treating pvns
CA2971734C (en) 2014-12-22 2025-11-18 Enumeral Biomedical Holdings Inc ANTI-PD-1 ANTIBODIES
MA40662B1 (en) 2014-12-23 2020-12-31 Bristol Myers Squibb Co Antibodies against tigit
WO2016111947A2 (en) 2015-01-05 2016-07-14 Jounce Therapeutics, Inc. Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof
SG11201705583XA (en) 2015-01-09 2017-08-30 Adalta Pty Ltd Cxcr4 binding molecules
GB201500319D0 (en) 2015-01-09 2015-02-25 Agency Science Tech & Res Anti-PD-L1 antibodies
CN114230667A (en) 2015-01-23 2022-03-25 赛诺菲 anti-CD 3 antibodies, anti-CD 123 antibodies, and bispecific antibodies that specifically bind to CD3 and/or CD123
MA41414A (en) 2015-01-28 2017-12-05 Centre Nat Rech Scient ICOS AGONIST BINDING PROTEINS
MA41463A (en) 2015-02-03 2017-12-12 Anaptysbio Inc ANTIBODIES DIRECTED AGAINST LYMPHOCYTE ACTIVATION GEN 3 (LAG-3)
WO2016127179A2 (en) 2015-02-06 2016-08-11 Kadmon Corporation, Llc Immunomodulatory agents
CA2976446A1 (en) 2015-02-13 2016-08-18 Sorrento Therapeutics, Inc. Antibody therapeutics that bind ctla4
EP3258959A4 (en) 2015-02-22 2018-10-17 Sorrento Therapeutics, Inc. Antibody therapeutics that bind cd137
US9512229B2 (en) 2015-03-03 2016-12-06 Kymab Limited Synergistic combinations of OX40L antibodies for the treatment of GVHD
US9139653B1 (en) 2015-04-30 2015-09-22 Kymab Limited Anti-human OX40L antibodies and methods of treatment
DE112016001013T5 (en) 2015-03-03 2017-12-21 Kymab Limited ANTIBODIES, USES AND METHODS
US9434785B1 (en) 2015-04-30 2016-09-06 Kymab Limited Anti-human OX40L antibodies and methods of treating graft versus host disease with the same
WO2016145085A2 (en) 2015-03-09 2016-09-15 Celldex Therapeutics, Inc. Cd27 agonists
SG11201707383PA (en) 2015-03-13 2017-10-30 Cytomx Therapeutics Inc Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof
EP3735986A1 (en) 2015-03-23 2020-11-11 Jounce Therapeutics, Inc. Antibodies to icos
WO2016160792A1 (en) 2015-03-30 2016-10-06 Stcube & Co., Inc. Antibodies specific to glycosylated pd-l1 and methods of use thereof
SMT202400420T1 (en) 2015-04-01 2024-11-15 Anaptysbio Inc Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3)
CN107646039B (en) 2015-04-02 2022-04-15 埃博灵克斯股份有限公司 Bispecific CXCR4-CD4 polypeptides having potent anti-HIV activity
PT3283527T (en) 2015-04-13 2021-03-03 Five Prime Therapeutics Inc COMBINATION THERAPEUTIC FOR CANCER
US20180298095A1 (en) 2015-04-24 2018-10-18 The Brigham And Women's Hospital, Inc. Interactions between ceacam and tim family members
WO2016176583A1 (en) 2015-04-29 2016-11-03 Sanford-Burnham Medical Research Institute Modulation of immune response using btla agonist antibodies
HK1252158A1 (en) 2015-05-01 2019-05-17 Genentech, Inc. Masked anti-cd3 antibodies and methods of use
CN107849134B (en) 2015-05-01 2022-05-03 达纳－法伯癌症研究所公司 Methods of mediating cytokine expression with anti-CCR 4 antibodies
WO2016179194A1 (en) 2015-05-04 2016-11-10 Jounce Therapeutics, Inc. Lilra3 and method of using the same
CN115109158A (en) 2015-05-07 2022-09-27 阿吉纳斯公司 anti-OX 40 antibodies and methods of use thereof
EP3091032A1 (en) 2015-05-08 2016-11-09 Miltenyi Biotec GmbH Humanized antibody or fragment thereof specific for cd3
TWI715587B (en) 2015-05-28 2021-01-11 美商安可美德藥物股份有限公司 Tigit-binding agents and uses thereof
PE20180193A1 (en) 2015-05-29 2018-01-26 Abbvie Inc ANTI-CD40 ANTIBODIES AND THEIR USES
DK3303396T5 (en) 2015-05-29 2024-10-07 Bristol Myers Squibb Co ANTIBODIES AGAINST OX40 AND USES THEREOF
DK3303394T3 (en) 2015-05-29 2020-07-06 Agenus Inc ANTI-CTLA-4 ANTIBODIES AND PROCEDURES FOR USE THEREOF
AU2016271018A1 (en) 2015-05-29 2017-11-30 Dynavax Technologies Corporation Combination of a PD-1 antagonist and CPG-C type oligonucleotide for treating cancer
BR112017025297A2 (en) 2015-06-03 2018-08-14 Bristol-Myers Squibb Company anti-gitr antibodies for cancer diagnosis
TWI773646B (en) 2015-06-08 2022-08-11 美商宏觀基因股份有限公司 Lag-3-binding molecules and methods of use thereof
CA2985483A1 (en) 2015-06-08 2016-12-15 Genentech, Inc. Methods of treating cancer using anti-ox40 antibodies
US20170000885A1 (en) 2015-06-08 2017-01-05 Genentech, Inc. Methods of treating cancer using anti-ox40 antibodies and pd-1 axis binding antagonists
CN105061597B (en) 2015-06-09 2016-04-27 北京东方百泰生物科技有限公司 The monoclonal antibody of a kind of anti-PD-1 and preparation method thereof
US10696745B2 (en) 2015-06-11 2020-06-30 Wuxi Biologics (Shanghai) Co. Ltd. Anti-PD-L1 antibodies
TWI870335B (en) 2015-06-12 2025-01-21 美商宏觀基因股份有限公司 Variant chimeric 4d5 antibodies and uses thereof in combination with anti-pd-1 antibodies for the treatment of cancer
EP3310811B1 (en) 2015-06-16 2021-06-16 Genentech, Inc. Anti-cd3 antibodies and methods of use
WO2016205042A1 (en) 2015-06-16 2016-12-22 The Board Of Trustees Of The Leland Stanford Junior University SIRPα AGONIST ANTIBODY
WO2016207717A1 (en) 2015-06-24 2016-12-29 Janssen Pharmaceutica Nv Anti-vista antibodies and fragments
RU2018102575A (en) 2015-06-24 2019-07-25 Ф. Хоффманн-Ля Рош Аг ANTIBODIES AGAINST HUMAN CSF-1R, INTENDED FOR USE FOR THE INDUCTION OF LYMPHOCYTOSIS IN LYMPHOMAS OR LEUKOSIS
KR20180021833A (en) 2015-06-29 2018-03-05 더 락커펠러 유니버시티 Antibodies to CD40 with enhanced agonist activity
HK1252666A1 (en) 2015-06-29 2019-05-31 Bristol-Myers Squibb Company Antibodies to cd40
CN106331470A (en) 2015-07-03 2017-01-11 中兴通讯股份有限公司 Photographing terminal and photographing method
EA201890028A1 (en) 2015-07-10 2018-08-31 Мерус Н.В. HUMAN CD3 ANTIBODY
CN114989302B (en) 2015-07-15 2025-08-05 根马布股份公司 Humanized or chimeric CD3 antibodies
AR105444A1 (en) 2015-07-22 2017-10-04 Sorrento Therapeutics Inc THERAPEUTIC ANTIBODIES THAT JOIN THE PROTEIN CODIFIED BY THE GENOPHYPE ACTIVATION GEN 3 (LAG3)
CN106699888B (en) 2015-07-28 2020-11-06 上海昀怡健康科技发展有限公司 PD-1 antibody and preparation method and application thereof
EP3878465A1 (en) 2015-07-29 2021-09-15 Novartis AG Combination therapies comprising antibody molecules to tim-3
WO2017019896A1 (en) 2015-07-29 2017-02-02 Novartis Ag Combination therapies comprising antibody molecules to pd-1
EP3964528A1 (en) 2015-07-29 2022-03-09 Novartis AG Combination therapies comprising antibody molecules to lag-3
SG10201906059VA (en) 2015-07-30 2019-08-27 Macrogenics Inc Pd-1-binding molecules and methods of use thereof
CN106397592A (en) 2015-07-31 2017-02-15 苏州康宁杰瑞生物科技有限公司 Single-domain antibody directed at programmed death ligand (PD-L1) and derived protein thereof
BR112018002436A2 (en) 2015-08-04 2018-09-18 Glaxosmithkline Ip Dev Ltd combination treatment of methods uses of these
WO2017020291A1 (en) 2015-08-06 2017-02-09 Wuxi Biologics (Shanghai) Co. Ltd. Novel anti-pd-l1 antibodies
WO2017021912A1 (en) 2015-08-06 2017-02-09 Glaxosmithkline Intellectual Property Development Limited Combined tlrs modulators with anti ox40 antibodies
WO2017024465A1 (en) 2015-08-10 2017-02-16 Innovent Biologics (Suzhou) Co., Ltd. Pd-1 antibodies
DK3334763T3 (en) 2015-08-11 2024-10-07 Wuxi Biologics Ireland Ltd Novel anti-PD-1 antibodies
WO2017024515A1 (en) 2015-08-11 2017-02-16 Wuxi Biologics (Cayman) Inc. Novel anti-pd-1 antibodies
CN115925931A (en) 2015-08-14 2023-04-07 默沙东公司 anti-TIGIT antibody
US11014983B2 (en) 2015-08-20 2021-05-25 Sutro Biopharma, Inc. Anti-Tim-3 antibodies, compositions comprising anti-Tim-3 antibodies and methods of making and using anti-Tim-3 antibodies
AR105654A1 (en) 2015-08-24 2017-10-25 Lilly Co Eli ANTIBODIES PD-L1 (LINKING 1 OF PROGRAMMED CELL DEATH)
JP2018529661A (en) 2015-09-01 2018-10-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Use of anti-CD40 antibodies for the treatment of lupus nephritis
WO2017040790A1 (en) 2015-09-01 2017-03-09 Agenus Inc. Anti-pd-1 antibodies and methods of use thereof
CN108137691B (en) 2015-09-02 2021-10-19 耶路撒冷希伯来大学伊萨姆研究发展有限公司 Antibodies specific for human T-cell immunoglobulin and ITIM domain (TIGIT)
MX2018002610A (en) 2015-09-02 2018-09-27 Immutep Sas ANTI-LAG-3 ANTIBODIES.
HUE056769T2 (en) 2015-09-04 2022-03-28 Primatope Therapeutics Inc Humanized anti-cd40 antibodies and uses thereof
EP3349794A4 (en) 2015-09-16 2019-07-31 Ablexis, LLC ANTI-CD115 ANTIBODIES
EP3353206A1 (en) 2015-09-22 2018-08-01 Spring Bioscience Corporation Anti-ox40 antibodies and diagnostic uses thereof
TWI836305B (en) 2015-09-24 2024-03-21 日商第一三共股份有限公司 Anti-garp antibody and producing method and use thereof
NZ739750A (en) 2015-09-25 2019-11-29 Genentech Inc Anti-tigit antibodies and methods of use
WO2017058859A1 (en) * 2015-09-29 2017-04-06 Celgene Corporation Pd-1 binding proteins and methods of use thereof
CA3000638C (en) 2015-09-29 2024-02-27 Asia Biotech Pte. Ltd. Pd-1 antibodies and uses thereof
BR112018006360A2 (en) 2015-09-30 2018-10-09 Janssen Biotech Inc agonistic antibodies that specifically bind to human cd40 and methods of use
PT3356413T (en) 2015-10-01 2022-04-04 Potenza Therapeutics Inc Anti-tigit antigen-binding proteins and methods of use thereof
CA3000564A1 (en) 2015-10-02 2017-04-06 Symphogen A/S Anti-pd-1 antibodies and compositions
MY192202A (en) 2015-10-02 2022-08-06 Hoffmann La Roche Bispecific antibodies specific for pd1 and tim3
TWI756187B (en) 2015-10-09 2022-03-01 美商再生元醫藥公司 Anti-lag3 antibodies and uses thereof
US11130817B2 (en) 2015-10-12 2021-09-28 Innate Pharma CD73 blocking agents
JP6771551B2 (en) 2015-10-15 2020-10-21 ディンフー バイオターゲット カンパニー リミテッド Anti-OX40 antibody and its applications
KR20180066236A (en) 2015-10-22 2018-06-18 조운스 테라퓨틱스, 인크. Gene traits for measuring ICOS expression
CN106632674B (en) 2015-10-30 2018-11-16 泽达生物医药有限公司 A kind of anti-PD-1 monoclonal antibody, its medical composition and its use
LT3370768T (en) 2015-11-03 2022-05-25 Janssen Biotech, Inc. ANTIBODIES SPECIFICLY BINDING PD-1 AND THEIR USE
GB201519481D0 (en) 2015-11-04 2015-12-16 Cancer Rec Tech Ltd Immunomodulatory antibodies
WO2017087547A1 (en) 2015-11-17 2017-05-26 Oncomed Pharmaceuticals, Inc. Pd-l1-binding agents and uses thereof
CN106699889A (en) 2015-11-18 2017-05-24 礼进生物医药科技（上海）有限公司 PD-1 resisting antibody and treatment application thereof
EA038179B1 (en) 2015-11-18 2021-07-20 Мерк Шарп И Доум Корп. Ctla4 binders
UA121914C2 (en) 2015-11-18 2020-08-10 Мерк Шарп І Доум Корп. Pd1 and/or lag3 binders
RU2755724C2 (en) 2015-11-18 2021-09-20 Мерк Шарп И Доум Корп. Pd1/ctla4-binding substances
US20190330336A1 (en) 2015-11-19 2019-10-31 Sutro Biopharma, Inc. Anti-lag3 antibodies, compositions comprising anti-lag3 antibodies and methods of making and using anti-lag3 antibodies
CN108738324B (en) 2015-11-19 2022-06-21 百时美施贵宝公司 Anti-glucocorticoid-induced tumor necrosis factor receptor (GITR) antibodies and uses thereof
CN107406504B (en) 2015-11-19 2021-04-30 蔡则玲 CTLA-4 antibodies and uses thereof
EP3380519A1 (en) 2015-11-23 2018-10-03 Innate Pharma Cd39 vascular isoform targeting agents
JP2018531278A (en) 2015-11-24 2018-10-25 イーライ リリー アンド カンパニー Combination therapy for cancer
CN106939047B (en) 2016-01-04 2021-08-31 江苏怀瑜药业有限公司 PD-L1 antibody and preparation method thereof
CN109715821B (en) 2016-01-29 2022-09-06 索伦托药业有限公司 Antigen binding proteins that bind to PD-L1
ES2801873T3 (en) 2016-03-04 2021-01-14 Sichuan Kelun Biotech Biopharmaceutical Co Ltd PDL-1 antibody, its pharmaceutical composition and its uses
CA3021669A1 (en) 2016-05-09 2017-11-16 Igm Biosciences, Inc. Anti-pd-l1 antibodies
CN105968200B (en) 2016-05-20 2019-03-15 瑞阳(苏州)生物科技有限公司 Anti-human PD-L1 humanized monoclonal antibody and its application
US11534496B2 (en) 2016-06-07 2022-12-27 The Brigham And Women's Hospital, Inc. Compositions and methods relating to T peripheral helper cells in autoantibody-associated conditions
CN109414500B (en) 2016-06-13 2022-02-25 奥美药业有限公司 PD-L1-specific monoclonal antibodies for therapy and diagnosis
MX2018015584A (en) 2016-06-13 2019-09-18 I Mab Anti-pd-l1 antibodies and uses thereof.
DK3472207T3 (en) 2016-06-20 2021-04-12 F Star Delta Ltd BINDING MOLECULES THAT BIND PD-L1 AND LAYER-3
US9567399B1 (en) * 2016-06-20 2017-02-14 Kymab Limited Antibodies and immunocytokines
SG11201810509PA (en) 2016-06-20 2018-12-28 Kymab Ltd Anti-pd-l1 antibodies
AU2017290709B2 (en) 2016-06-29 2024-08-01 Checkpoint Therapeutics, Inc. PD-L1-specific antibodies and methods of using the same
ES3000676T3 (en) 2016-07-07 2025-03-03 Iovance Biotherapeutics Inc Programmed death 1 ligand 1 (pd-l1) binding proteins and methods of use thereof
EP3369745B1 (en) 2016-08-04 2021-09-29 Innovent Biologics (Suzhou) Co., Ltd. Anti-pd-l1 nanobody and use thereof
WO2018025221A1 (en) 2016-08-04 2018-02-08 Glaxosmithkline Intellectual Property Development Limited Anti-icos and anti-pd-1 antibody combination therapy
CN110072889B (en) 2016-08-05 2023-06-13 Y生物股份有限公司 Antibodies against programmed cell death ligand 1 (PD-L1) and uses thereof
WO2018045110A1 (en) 2016-08-30 2018-03-08 Xencor, Inc. Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
AU2017322656B2 (en) 2016-09-10 2024-02-29 Yeda Research And Development Co. Ltd. Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
IL265485B2 (en) 2016-09-20 2024-07-01 Pfizer Diagnostic anti-pd-l1 antibody and use thereof
CN117088979A (en) 2016-10-30 2023-11-21 上海复宏汉霖生物技术股份有限公司 Anti-PD-L1 antibodies and variants
HUE057559T2 (en) 2016-11-02 2022-06-28 Jounce Therapeutics Inc Antibodies against PD-1 and their applications
WO2018115859A1 (en) 2016-12-20 2018-06-28 Kymab Limited Multispecific antibody with combination therapy for immuno-oncology
JP7128529B2 (en) 2016-12-23 2022-08-31 アールイーエムディー バイオセラピューティクス，インコーポレイテッド Immunization using an antibody that binds programmed death ligand-1 (PD-L1)
WO2018136553A1 (en) 2017-01-18 2018-07-26 Genentech, Inc. Idiotypic antibodies against anti-pd-l1 antibodies and uses thereof
IL322509A (en) 2017-03-09 2025-10-01 Genmab As Antibodies against pd-l1
WO2018187191A1 (en) 2017-04-03 2018-10-11 Jounce Therapeutics, Inc Compositions and methods for the treatment of cancer
TWI788340B (en) 2017-04-07 2023-01-01 美商必治妥美雅史谷比公司 Anti-icos agonist antibodies and uses thereof
MX2019012461A (en) 2017-04-18 2019-12-11 R Pharm Overseas Inc Anti-pd-l1 antibody and use thereof.
US11168144B2 (en) 2017-06-01 2021-11-09 Cytomx Therapeutics, Inc. Activatable anti-PDL1 antibodies, and methods of use thereof
WO2019028367A1 (en) 2017-08-04 2019-02-07 Regeneron Pharmaceuticals, Inc. Methods for treating active eosinophilic esophagitis
AU2019343850B2 (en) * 2018-09-17 2024-06-06 Gi Innovation, Inc. Fusion protein comprising IL-2 protein and CD80 protein, and use thereof
US10442866B1 (en) 2019-01-23 2019-10-15 Beijing Mabworks Biotech Co. Ltd Antibodies binding OX40 and uses thereof

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