SG11201706756VA - Compositions and methods for activating "stimulator of interferon gene" -dependent signalling - Google Patents
Compositions and methods for activating "stimulator of interferon gene" -dependent signallingInfo
- Publication number
- SG11201706756VA SG11201706756VA SG11201706756VA SG11201706756VA SG11201706756VA SG 11201706756V A SG11201706756V A SG 11201706756VA SG 11201706756V A SG11201706756V A SG 11201706756VA SG 11201706756V A SG11201706756V A SG 11201706756VA SG 11201706756V A SG11201706756V A SG 11201706756VA
- Authority
- SG
- Singapore
- Prior art keywords
- stimulator
- activating
- compositions
- methods
- interferon gene
- Prior art date
Links
- 108010050904 Interferons Proteins 0.000 title 1
- 230000003213 activating effect Effects 0.000 title 1
- 230000001419 dependent effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000011664 signaling Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562131235P | 2015-03-10 | 2015-03-10 | |
PCT/US2016/021597 WO2016145102A1 (en) | 2015-03-10 | 2016-03-09 | Compositions and methods for activating "stimulator of interferon gene" -dependent signalling |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201706756VA true SG11201706756VA (en) | 2017-09-28 |
Family
ID=56879700
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201706756VA SG11201706756VA (en) | 2015-03-10 | 2016-03-09 | Compositions and methods for activating "stimulator of interferon gene" -dependent signalling |
Country Status (30)
Country | Link |
---|---|
US (2) | US10449211B2 (es) |
EP (1) | EP3268035A4 (es) |
JP (1) | JP6692826B2 (es) |
KR (1) | KR20170129802A (es) |
CN (1) | CN107530415A (es) |
AR (1) | AR103894A1 (es) |
AU (1) | AU2016229146A1 (es) |
BR (1) | BR112017018908A2 (es) |
CA (1) | CA2979215A1 (es) |
CL (1) | CL2017002272A1 (es) |
CO (1) | CO2017009104A2 (es) |
CR (1) | CR20170410A (es) |
DO (1) | DOP2017000205A (es) |
EA (1) | EA035817B1 (es) |
EC (1) | ECSP17064523A (es) |
GT (1) | GT201700200A (es) |
HK (2) | HK1247089A1 (es) |
IL (1) | IL254047A0 (es) |
JO (1) | JO3746B1 (es) |
MA (1) | MA42146A (es) |
MX (1) | MX2017011597A (es) |
MY (1) | MY190404A (es) |
PE (1) | PE20171448A1 (es) |
PH (1) | PH12017501506A1 (es) |
SG (1) | SG11201706756VA (es) |
SV (1) | SV2017005529A (es) |
TN (1) | TN2017000375A1 (es) |
TW (1) | TWI706958B (es) |
UY (1) | UY36579A (es) |
WO (1) | WO2016145102A1 (es) |
Families Citing this family (116)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2886456A1 (en) * | 2012-12-13 | 2014-06-19 | Aduro Biotech, Inc. | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
WO2014110591A1 (en) | 2013-01-14 | 2014-07-17 | Fred Hutchinson Cancer Research Center | Compositions and methods for delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse |
JP6462006B2 (ja) | 2014-06-04 | 2019-01-30 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | Stingのモジュレーターとしての環式ジヌクレオチド |
GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
SG11201706756VA (en) | 2015-03-10 | 2017-09-28 | Aduro Biotech Inc | Compositions and methods for activating "stimulator of interferon gene" -dependent signalling |
EA034786B1 (ru) | 2015-08-13 | 2020-03-20 | Мерк Шарп И Доум Корп. | Циклические динуклеотидные соединения в качестве агонистов sting |
US11453697B1 (en) | 2015-08-13 | 2022-09-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
WO2017075477A1 (en) | 2015-10-28 | 2017-05-04 | Aduro Biotech, Inc. | Compositions and methods for activating "stimulator of interferon gene"-dependent signalling |
PE20181297A1 (es) | 2015-12-03 | 2018-08-07 | Glaxosmithkline Ip Dev Ltd | Dinucleotidos de purino ciclico como moduladores de sting |
WO2017106740A1 (en) * | 2015-12-16 | 2017-06-22 | Aduro Biotech, Inc. | Methods for identifying inhibitors of "stimulator of interferon gene"-dependent interferon production |
CA3011528A1 (en) | 2016-01-11 | 2017-07-20 | Innate Tumor Immunity, Inc. | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer |
EP3429596B1 (en) | 2016-03-18 | 2022-08-31 | Immune Sensor, LLC | Cyclic di-nucleotide compounds and methods of use |
US10188749B2 (en) | 2016-04-14 | 2019-01-29 | Fred Hutchinson Cancer Research Center | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers |
US10696985B1 (en) | 2016-06-06 | 2020-06-30 | Vanderbilt University | Reversibly crosslinked endosomolytic polymer vesicles for cytosolic drug delivery |
KR102722183B1 (ko) * | 2016-06-24 | 2024-10-24 | 바이오젠 엠에이 인코포레이티드 | 캡핑 단계 없이 티올화된 올리고뉴클레오타이드의 합성 |
EP3507367A4 (en) | 2016-07-05 | 2020-03-25 | Aduro BioTech, Inc. | CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF |
KR102569881B1 (ko) | 2016-07-06 | 2023-08-22 | 에프-스타 테라퓨틱스 인코포레이티드 | 질병 치료용 화합물, 조성물 및 방법 |
NL2017267B1 (en) | 2016-07-29 | 2018-02-01 | Aduro Biotech Holdings Europe B V | Anti-pd-1 antibodies |
US10537590B2 (en) | 2016-09-30 | 2020-01-21 | Boehringer Ingelheim International Gmbh | Cyclic dinucleotide compounds |
CA3038903C (en) | 2016-10-04 | 2021-07-27 | Merck Sharp & Dohme Corp. | Benzo[b]thiophene compounds as sting agonists |
EP3523314A1 (de) | 2016-10-07 | 2019-08-14 | Biolog Life Science Institute Forschungslabor Und Biochemica-Vertrieb GmbH | Benzimidazolhaltige cyclische dinukleotide, verfahren zu deren herstellung und ihre verwendung zur aktivierung von stimulator von interferongenen (sting)-abhängigen signalwegen |
JOP20170192A1 (ar) * | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | داي نوكليوتيد حلقي |
JP2018090562A (ja) * | 2016-12-01 | 2018-06-14 | 武田薬品工業株式会社 | 環状ジヌクレオチド |
US20190336532A1 (en) | 2016-12-21 | 2019-11-07 | Fred Hutchinson Cancer Research Center | Scaffolds to treat solid tumor cells and escape variants |
WO2018129270A1 (en) | 2017-01-05 | 2018-07-12 | Fred Hutchinson Cancer Research Center | Systems and methods to improve vaccine efficacy |
US20200055883A1 (en) | 2017-02-17 | 2020-02-20 | Eisai R&D Management Co., Ltd. | Cyclic di-nucleotides derivative for the treatment of cancer |
WO2018156625A1 (en) | 2017-02-21 | 2018-08-30 | Board Of Regents,The University Of Texas System | Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling |
JOP20190218A1 (ar) * | 2017-03-22 | 2019-09-22 | Boehringer Ingelheim Int | مركبات ثنائية النيوكليوتيدات حلقية معدلة |
WO2018190719A2 (en) | 2017-04-13 | 2018-10-18 | Aduro Biotech Holdings, Europe B.V. | Anti-sirp alpha antibodies |
UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
AR113224A1 (es) * | 2017-04-28 | 2020-02-19 | Novartis Ag | Conjugados de anticuerpo que comprenden un agonista de sting |
WO2018209125A1 (en) | 2017-05-10 | 2018-11-15 | Fred Hutchinson Cancer Research Center | Epstein barr virus antibodies, vaccines, and uses of the same |
WO2018208667A1 (en) | 2017-05-12 | 2018-11-15 | Merck Sharp & Dohme Corp. | Cyclic di-nucleotide compounds as sting agonists |
BR112019018759A2 (pt) | 2017-05-30 | 2020-05-05 | Bristol-Myers Squibb Company | composições compreendendo uma combinação de um anticorpo anti-lag-3, um inibidor da via pd-1, e um agente imunoterápico |
US11285131B2 (en) | 2017-08-04 | 2022-03-29 | Merck Sharp & Dohme Corp. | Benzo[b]thiophene STING agonists for cancer treatment |
EP3661499A4 (en) | 2017-08-04 | 2021-04-21 | Merck Sharp & Dohme Corp. | COMBINATIONS OF PD-1 ANTAGONISTS AND STING BENZO AGONISTS [B |
JP7311514B2 (ja) | 2017-08-30 | 2023-07-19 | ベイジン シュエンイー ファーマサイエンシズ カンパニー, リミテッド | インターフェロン遺伝子刺激因子調節薬としての環状ジヌクレオチド |
WO2019046511A1 (en) | 2017-08-31 | 2019-03-07 | Sperovie Biosciences, Inc. | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE |
ES2945140T3 (es) * | 2017-08-31 | 2023-06-28 | Bristol Myers Squibb Co | Dinucleótidos cíclicos como agentes anticancerosos |
ES2904317T3 (es) * | 2017-08-31 | 2022-04-04 | Bristol Myers Squibb Co | Dinucleótidos cíclicos como agentes anticancerosos |
WO2019051488A1 (en) | 2017-09-11 | 2019-03-14 | Sperovie Biosciences, Inc. | COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE |
US11707531B2 (en) | 2017-09-11 | 2023-07-25 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
SG11202004113VA (en) | 2017-11-10 | 2020-06-29 | Takeda Pharmaceuticals Co | Sting modulator compounds, and methods of making and using |
AU2018392213B2 (en) | 2017-12-20 | 2021-03-04 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein |
CN111511754B (zh) | 2017-12-20 | 2023-09-12 | 捷克共和国有机化学与生物化学研究所 | 活化sting转接蛋白的具有膦酸酯键的2’3’环状二核苷酸 |
US11685761B2 (en) | 2017-12-20 | 2023-06-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
EP3763724A4 (en) | 2018-03-09 | 2022-01-12 | Japan Science and Technology Agency | SS-MODIFIED PHOSPHORIC ACID COMPOUND PRECURSOR, SS-MODIFIED PHOSPHORIC ACID COMPOUND, RESPONSE INHIBITOR AND DRUG THEREOF, AND RESPONSE INHIBITION METHOD |
US20210015915A1 (en) | 2018-03-23 | 2021-01-21 | Takeda Pharmaceutical Company Limited | Sting modulator compounds with sulfamate linkages, and methods of making and using |
US20210322327A1 (en) | 2018-03-23 | 2021-10-21 | Codiak Biosciences, Inc. | Extracellular vesicles comprising sting-agonist |
US20210024567A1 (en) | 2018-03-27 | 2021-01-28 | Boehringer Ingelheim International Gmbh | Modified cyclic dinucleotide compounds |
JP2021519270A (ja) | 2018-03-27 | 2021-08-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 2−アザ−ヒポキサンチンまたは6h−ピラゾロ[1,5−d][1,2,4]トリアジン−7−オンをstingアゴニストとして含む環式ジヌクレオチド化合物 |
US11702430B2 (en) | 2018-04-03 | 2023-07-18 | Merck Sharp & Dohme Llc | Aza-benzothiophene compounds as STING agonists |
AU2019248545B2 (en) | 2018-04-03 | 2022-08-11 | Merck Sharp & Dohme Llc | Benzothiophenes and related compounds as sting agonists |
WO2019195658A1 (en) | 2018-04-05 | 2019-10-10 | Dana-Farber Cancer Institute, Inc. | Sting levels as a biomarker for cancer immunotherapy |
TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | 2,2,─環二核苷酸 |
US20190359645A1 (en) | 2018-05-03 | 2019-11-28 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotides comprising carbocyclic nucleotide |
AU2019277679B2 (en) | 2018-06-01 | 2024-11-28 | Eisai R&D Management Co., Ltd. | Methods for the treatment of bladder cancer |
US12291548B2 (en) | 2018-07-10 | 2025-05-06 | Sperovie Biosciences, Inc. | Compounds, compositions, and methods for the treatment of disease |
KR102783784B1 (ko) | 2018-08-16 | 2025-03-21 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 화합물의 염 및 이의 결정 |
WO2020041720A1 (en) | 2018-08-24 | 2020-02-27 | Codiak Biosciences, Inc. | Extracellular vesicles targeting dendritic cells and uses thereof |
WO2020047263A2 (en) | 2018-08-29 | 2020-03-05 | Fred Hutchinson Cancer Research Center | Sequential immunization strategies to guide the maturation of antibodies against human immmunodeficiency virus |
EP3848054B1 (en) | 2018-09-06 | 2025-01-29 | Daiichi Sankyo Company, Limited | Antibody-drug conjugates of cyclic dinucleotide derivatives |
CN110938104B (zh) | 2018-09-21 | 2024-07-12 | 上海迪诺医药科技有限公司 | 环状二核苷酸类似物、其药物组合物及应用 |
US12011485B2 (en) | 2018-09-27 | 2024-06-18 | Pierre Fabre Medicament | Sulfomaleimide-based linkers and corresponding conjugates |
US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
TWI855000B (zh) | 2018-10-11 | 2024-09-11 | 日商小野藥品工業股份有限公司 | Sting促效化合物 |
US11110106B2 (en) | 2018-10-29 | 2021-09-07 | Venenum Biodesign, LLC | Sting agonists for treating bladder cancer and solid tumors |
WO2020092127A1 (en) | 2018-10-29 | 2020-05-07 | Venenum Biodesign, LLC | Novel sting agonists |
US20220008346A1 (en) | 2018-10-30 | 2022-01-13 | Vanderbilt University | Graft copolymers, methods of forming graft copolymers, and methods of use thereof |
JP2022509929A (ja) | 2018-10-31 | 2022-01-25 | ノバルティス アーゲー | Stingアゴニストを含むdc-sign抗体コンジュゲート |
KR102707808B1 (ko) | 2019-03-07 | 2024-09-19 | 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. | 2'3'-사이클릭 다이뉴클레오티드 및 이의 프로드럭 |
WO2020178768A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
CN113574063B (zh) | 2019-03-07 | 2025-03-18 | 捷克共和国有机化学与生物化学研究所 | 3’3’-环二核苷酸及其前药 |
AU2020241903A1 (en) | 2019-03-21 | 2021-10-14 | Lonza Sales Ag | Extracellular vesicle conjugates and uses thereof |
KR20220004035A (ko) | 2019-03-21 | 2022-01-11 | 코디악 바이오사이언시즈, 인크. | 백신 전달을 위한 세포외 소포 |
WO2020227159A2 (en) | 2019-05-03 | 2020-11-12 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity |
AU2020267486A1 (en) * | 2019-05-09 | 2021-11-11 | Aligos Therapeutics, Inc. | Modified cyclic dinucleoside compounds as STING modulators |
PE20220764A1 (es) | 2019-05-10 | 2022-05-16 | Takeda Pharmaceuticals Co | Conjugados de anticuerpo y farmaco |
US20220251200A1 (en) | 2019-07-03 | 2022-08-11 | Codiak Biosciences, Inc. | Extracellular vesicles targeting t cells and uses thereof |
CN114340680A (zh) | 2019-07-05 | 2022-04-12 | 坦博公司 | 反式环辛烯生物正交剂及在癌症和免疫疗法中的用途 |
WO2021013234A1 (en) * | 2019-07-25 | 2021-01-28 | Beigene, Ltd. | Cyclic dinucleotides as sting agonists |
JP2022544549A (ja) | 2019-08-12 | 2022-10-19 | ピュリノミア バイオテック, インコーポレイテッド | Cd39発現細胞のadcc標的化を介してt細胞媒介性免疫応答を促進及び増強するための方法及び組成物 |
WO2021041532A1 (en) | 2019-08-26 | 2021-03-04 | Dana-Farber Cancer Institute, Inc. | Use of heparin to promote type 1 interferon signaling |
CN110508327B (zh) * | 2019-09-19 | 2021-01-19 | 南京林业大学 | 基于松香的苯并咪唑并吡啶杂环衍生物构建的不对称Henry反应的催化剂体系及其应用 |
US20230241089A1 (en) | 2019-09-25 | 2023-08-03 | Codiak Biosciences, Inc. | Sting agonist comprising exosomes for treating neuroimmunological disorders |
US20230103726A1 (en) | 2019-09-25 | 2023-04-06 | Codiak Biosciences, Inc. | Methods of producing extracellular vesicles |
WO2021062060A1 (en) | 2019-09-25 | 2021-04-01 | Codiak Biosciences, Inc. | Sting agonist comprising exosomes combined with il-12 displaying exosomes for treating a tumour |
WO2021062317A1 (en) | 2019-09-25 | 2021-04-01 | Codiak Biosciences, Inc. | Extracellular vesicle compositions |
WO2021074695A1 (en) | 2019-10-16 | 2021-04-22 | Avacta Life Sciences Limited | PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES. |
PH12022551961A1 (en) | 2020-03-06 | 2023-10-09 | Daiichi Sankyo Co Ltd | Antibody-drug conjugate including novel cyclic dinucleotide derivative |
EP4117717A1 (en) | 2020-03-13 | 2023-01-18 | Codiak BioSciences, Inc. | Extracellular vesicles for treating neurological disorders |
JP2023518414A (ja) | 2020-03-20 | 2023-05-01 | コディアック バイオサイエンシーズ, インコーポレイテッド | 治療のための細胞外小胞 |
WO2021206158A1 (ja) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | がん治療方法 |
US11857618B2 (en) | 2020-04-17 | 2024-01-02 | Emory University | Boosting immunogenicity of vaccines using saponins and agonists of the intracellular stimulator of interferon genes pathway |
US20230149560A1 (en) | 2020-04-20 | 2023-05-18 | Massachusetts Institute Of Technology | Lipid compositions for delivery of sting agonist compounds and uses thereof |
CN111592570B (zh) * | 2020-05-15 | 2022-04-29 | 清华大学 | 新型sting激动剂及其制备方法和应用 |
WO2021237100A1 (en) | 2020-05-21 | 2021-11-25 | Codiak Biosciences, Inc. | Methods of targeting extracellular vesicles to lung |
US11938152B2 (en) | 2020-08-06 | 2024-03-26 | Kedar N Prasad | High-dose antioxidants in cancer treatment |
CN111920946B (zh) * | 2020-08-07 | 2021-05-28 | 合肥诺为尔基因科技服务有限公司 | 环二核苷酸修饰铝纳米粒疫苗佐剂-传递系统及基于其的SARS-CoV-2亚单位疫苗 |
JP2023537066A (ja) | 2020-08-07 | 2023-08-30 | タンボ・インコーポレイテッド | トランス-シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用 |
AU2021338014A1 (en) | 2020-09-02 | 2023-03-09 | Daiichi Sankyo Company, Limited | Novel endo-β-N-acetylglucosaminidase |
WO2022066883A1 (en) | 2020-09-23 | 2022-03-31 | Codiak Biosciences, Inc. | Extracellular vesicles comprising kras antigens and uses thereof |
US20240082389A1 (en) | 2020-09-23 | 2024-03-14 | Lonza Sales Ag | Methods of producing extracellular vesicles |
KR20230107586A (ko) | 2020-10-20 | 2023-07-17 | 타이리간드 바이오사이언스 (상하이) 리미티드 | 다기능성 사이클릭 디뉴클레오티드 및 이의 용도 |
US20220168330A1 (en) | 2020-11-09 | 2022-06-02 | Takeda Pharmaceutical Company Limited | Antibody drug conjugates |
TW202241516A (zh) | 2020-12-17 | 2022-11-01 | 美商杜夫特學院信託管理公司 | 經fap活化之放射性治療診斷(radiotheranostics),與其相關用途 |
TW202241454A (zh) | 2021-02-01 | 2022-11-01 | 日商第一三共股份有限公司 | 抗體-免疫賦活化劑共軛物之新穎製造方法 |
WO2022234003A1 (en) | 2021-05-07 | 2022-11-10 | Avacta Life Sciences Limited | Cd33 binding polypeptides with stefin a protein |
WO2023056468A1 (en) | 2021-09-30 | 2023-04-06 | Codiak Biosciences, Inc. | Extracellular vesicle comprising cholesterol tagged sting-agonist |
WO2023057567A1 (en) | 2021-10-07 | 2023-04-13 | Avacta Life Sciences Limited | Pd-l1 binding affimers |
IL315341A (en) | 2022-03-02 | 2024-10-01 | Daiichi Sankyo Co Ltd | METHOD FOR PRODUCING Fc-CONTAINING MOLECULE |
AU2023230110A1 (en) | 2022-03-08 | 2024-10-24 | Alentis Therapeutics Ag | Use of anti-claudin-1 antibodies to increase t cell availability |
WO2023218243A1 (en) | 2022-05-12 | 2023-11-16 | Avacta Life Sciences Limited | Lag-3/pd-l1 binding fusion proteins |
IL319250A (en) | 2022-08-29 | 2025-04-01 | Daiichi Sankyo Co Ltd | Antibody-drug conjugate including a mutant FC region |
Family Cites Families (142)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4978672A (en) | 1986-03-07 | 1990-12-18 | Ciba-Geigy Corporation | Alpha-heterocyclc substituted tolunitriles |
DE3884470T2 (de) | 1987-06-17 | 1994-03-10 | Sandoz Ag | Cyclosporine und deren Benutzung als Arzneimittel. |
GB9110808D0 (en) | 1991-05-17 | 1991-07-10 | Retroscreen Ltd | Aids vaccine and method for its production |
GB2257704B (en) | 1991-07-18 | 1995-03-01 | Erba Carlo Spa | Cyclic oligonucleotides phosphorothioates |
US5904920A (en) | 1991-10-04 | 1999-05-18 | Whitehead Institute For Biomedical Research | Regulation of systemic immune responses utilizing cytokines and antigens |
US5637483A (en) | 1991-10-04 | 1997-06-10 | Whitehead Institute For Biomedical Research | Irradiated tumor cell vaccine engineered to express GM-CSF |
US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
US6033674A (en) | 1995-12-28 | 2000-03-07 | Johns Hopkins University School Of Medicine | Method of treating cancer with a tumor cell line having modified cytokine expression |
MY129541A (en) | 1996-06-25 | 2007-04-30 | Novartis Ag | Substituded 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators |
US6277368B1 (en) | 1996-07-25 | 2001-08-21 | The Regents Of The University Of California | Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokine |
US6111090A (en) | 1996-08-16 | 2000-08-29 | Schering Corporation | Mammalian cell surface antigens; related reagents |
ATE397660T1 (de) | 1996-08-16 | 2008-06-15 | Schering Corp | Zelloberflächen-antigen aus säugetieren und verwandte reagenzien |
CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
GB9721961D0 (en) | 1997-10-16 | 1997-12-17 | Glaxo Group Ltd | Novel molecules |
US6689607B2 (en) | 1997-10-21 | 2004-02-10 | Human Genome Sciences, Inc. | Human tumor, necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2 |
JP2001520039A (ja) | 1997-10-21 | 2001-10-30 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | ヒト腫瘍壊死因子レセプター様タンパク質、tr11,tr11sv1およびtr11sv2 |
ATE264911T1 (de) | 1998-02-02 | 2004-05-15 | Univ Johns Hopkins Med | Eine universelle immunmodulatorische cytokin- expressierende zelllinie in wartestelling. entsprechende zusammensetzungen und methoden ihrer herstellung und verwendungen |
EP1053321A1 (en) | 1998-02-09 | 2000-11-22 | Genentech, Inc. | Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same |
AU6085700A (en) | 1999-07-12 | 2001-01-30 | Genentech Inc. | Promotion or inhibition of angiogenesis and cardiovascularization by tumor necrosis factor ligand/receptor homologs |
GB0018891D0 (en) | 2000-08-01 | 2000-09-20 | Novartis Ag | Organic compounds |
PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
KR100926194B1 (ko) | 2001-10-30 | 2009-11-09 | 노파르티스 아게 | Flt3 수용체 티로신 키나아제 활성의 억제제로서의스타우로스포린 유도체 |
CN101633644B (zh) | 2002-03-13 | 2012-05-09 | 阵列生物制药公司 | 作为mek抑制剂的n3烷基化苯并咪唑衍生物 |
GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
CN1787837A (zh) | 2002-11-15 | 2006-06-14 | 希龙公司 | 防止和治疗癌转移以及与癌转移相关的骨质损失的方法 |
JP4511943B2 (ja) | 2002-12-23 | 2010-07-28 | ワイス エルエルシー | Pd−1に対する抗体およびその使用 |
CA2511538C (en) | 2002-12-30 | 2013-11-26 | 3M Innovative Properties Company | Immunostimulatory combinations |
ES2393483T3 (es) | 2003-02-11 | 2012-12-21 | Vernalis (R&D) Limited | Compuestos de isoxazol como inhibidores de las proteínas de choque térmico |
MXPA05012475A (es) | 2003-05-23 | 2006-05-25 | Wyeth Corp | Anticuerpos y moleculas relacionadas con el ligando para el receptor tnf inducido por glucorticoides (gitr) y el ligando (gitr) y usos de los mismos. |
WO2005007190A1 (en) | 2003-07-11 | 2005-01-27 | Schering Corporation | Agonists or antagonists of the clucocorticoid-induced tumour necrosis factor receptor (gitr) or its ligand for the treatment of immune disorders, infections and cancer |
US8367716B2 (en) | 2003-07-28 | 2013-02-05 | Karaolis David K R | Method for attentuating virulence of microbial pathogens and for inhibiting microbial biofilm formation |
EP1682103A1 (en) | 2003-10-27 | 2006-07-26 | Novartis AG | Indolyl-pyrroledione derivatives for the treatment of neurological and vascular disorders related to beta-amyloid generation and/or aggregation |
JP2007518399A (ja) | 2003-12-02 | 2007-07-12 | ジェンザイム コーポレイション | 肺癌を診断および治療する組成物並びに方法 |
AU2005207946A1 (en) | 2004-01-23 | 2005-08-11 | Amgen Inc. | Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer |
US7709458B2 (en) | 2004-03-15 | 2010-05-04 | David K. R. Karaolis | Method for inhibiting cancer cell proliferation or increasing cancer cell apoptosis |
US7592326B2 (en) | 2004-03-15 | 2009-09-22 | Karaolis David K R | Method for stimulating the immune, inflammatory or neuroprotective response |
GB0409799D0 (en) | 2004-04-30 | 2004-06-09 | Isis Innovation | Method of generating improved immune response |
WO2006083289A2 (en) | 2004-06-04 | 2006-08-10 | Duke University | Methods and compositions for enhancement of immunity by in vivo depletion of immunosuppressive cell activity |
GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
DK2343320T3 (da) | 2005-03-25 | 2018-01-29 | Gitr Inc | Anti-gitr-antistoffer og anvendelser deraf |
CA2607147C (en) | 2005-05-09 | 2018-07-17 | Ono Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
UA99701C2 (ru) | 2005-07-01 | 2012-09-25 | Медарекс, Инк. | Человеческое моноклональное антитело, которое специфически связывается с лигандом-1 запрограммированной гибели клеток (pd-l1) |
GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
PE20070335A1 (es) | 2005-08-30 | 2007-04-21 | Novartis Ag | Benzimidazoles sustituidos y metodos para su preparacion |
EP1782826A1 (en) * | 2005-11-08 | 2007-05-09 | GBF Gesellschaft für Biotechnologische Forschung mbH | PQS and c-diGMP and its conjugates as adjuvants and their uses in pharmaceutical compositions |
ES2373688T3 (es) | 2005-12-13 | 2012-02-07 | Incyte Corporation | Pirrolo[2,3-b]piridinas y pirrolo[2,3-b]pirimidinas sustituidas con heteroarilo como inhibidores de quinasas janus. |
US20110212086A1 (en) | 2006-01-19 | 2011-09-01 | Genzyme Corporation | GITR Antibodies For The Treatment of Cancer |
JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
UA93548C2 (uk) | 2006-05-05 | 2011-02-25 | Айерем Елелсі | Сполуки та композиції як модулятори хеджхогівського сигнального шляху |
PE20110224A1 (es) | 2006-08-02 | 2011-04-05 | Novartis Ag | PROCEDIMIENTO PARA LA SINTESIS DE UN PEPTIDOMIMETICO DE Smac INHIBIDOR DE IAP, Y COMPUESTOS INTERMEDIARIOS PARA LA SINTESIS DEL MISMO |
EP2423231A3 (en) | 2006-08-18 | 2012-05-30 | Novartis AG | PRLR-specific antibody and uses thereof |
RS57741B1 (sr) | 2006-11-22 | 2018-12-31 | Incyte Holdings Corp | Imidazotriazini i imidazopirimidini kao inhibitori kinaze |
PL2091918T3 (pl) | 2006-12-08 | 2015-02-27 | Novartis Ag | Związki i kompozycje jako inhibitory kinazy białkowej |
NZ577197A (en) | 2006-12-08 | 2011-02-25 | Irm Llc | Pyrimidine compounds especially 4-phenylamino-2-arylamino-pyrimidine derivatives and compositions as protein kinase inhibitors |
BRPI0808523A2 (pt) | 2007-03-01 | 2014-08-19 | Novartis Vaccines & Diagnostic | Inibidores de pim cinase e métodos de seu uso |
US8354509B2 (en) | 2007-06-18 | 2013-01-15 | Msd Oss B.V. | Antibodies to human programmed death receptor PD-1 |
AU2008275589B2 (en) | 2007-07-12 | 2013-11-21 | Gitr, Inc. | Combination therapies employing GITR binding molecules |
EP2242512B1 (en) | 2008-01-15 | 2016-04-27 | The Board of Trustees of the Leland Stanford Junior University | Methods for manipulating phagocytosis mediated by cd47 |
BRPI0907718A2 (pt) | 2008-02-11 | 2017-06-13 | Curetech Ltd | método para tratar um tumor, método para melhorar a tolerabilidade a pelo menos um agente quimiterápico, método para aumentar a sobrevida de um indivíduo que tem um tumor, método para reduzir ou prevenir recidiva tumoral, uso de um anticorpo monoclonal humanizado ou seu fragmento e anticorpo monoclonal humanizado ou seu fragmento |
WO2009114335A2 (en) | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
AR070924A1 (es) | 2008-03-19 | 2010-05-12 | Novartis Ag | Formas cristalinas y dos formas solvatadas de sales del acido lactico de 4- amino -5- fluoro-3-(5-(4-metilpiperazin-1-il ) -1h- bencimidazol-2-il) quinolin -2-(1h) - ona |
EP2111869A1 (en) | 2008-04-23 | 2009-10-28 | Stichting Sanquin Bloedvoorziening | Compositions and methods to enhance the immune system |
CN103936743B (zh) | 2008-05-21 | 2018-04-24 | 因西特控股公司 | 2-氟-N-甲基-4-[7-(喹啉-6-基甲基)咪唑并[1,2-b][1,2,4]三嗪-2-基]苯甲酰胺的盐及与其相关的制备方法 |
MY155535A (en) | 2008-05-23 | 2015-10-30 | Novartis Ag | Derivatives of quinolines and quinoxalines as protien tyrosine kinase inhibitors |
PE20100087A1 (es) | 2008-06-25 | 2010-02-08 | Irm Llc | Compuestos y composiciones como inhibidores de cinasa |
EA201170031A1 (ru) | 2008-07-02 | 2011-08-30 | Эмерджент Продакт Дивелопмент Сиэтл, Ллс | СВЯЗЫВАЮЩИЕ НЕСКОЛЬКО МИШЕНЕЙ БЕЛКИ, ОБЛАДАЮЩИЕ АНТАГОНИСТИЧЕСКИМ ДЕЙСТВИЕМ ПО ОТНОШЕНИЮ К TGF-β |
US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
KR20130140222A (ko) | 2008-08-22 | 2013-12-23 | 노파르티스 아게 | Cdk 억제제로서 피롤로피리미딘 화합물 |
CN104740610A (zh) | 2008-08-25 | 2015-07-01 | 安普利穆尼股份有限公司 | Pd-1拮抗剂及其使用方法 |
NZ591130A (en) | 2008-08-25 | 2012-09-28 | Amplimmune Inc | Compositions comprising a PD-1 antagonists and cyclophosphamide and methods of use thereof |
US8840881B2 (en) | 2008-08-28 | 2014-09-23 | Aduro Gvax Inc. | Methods and compositions for treating prostate cancer or inducing a humoral immune response against prostate cancer |
EA020136B1 (ru) | 2008-09-02 | 2014-08-29 | Новартис Аг | Производные пиколинамида в качестве ингибиторов киназы |
UA104147C2 (uk) | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
CN102149820B (zh) | 2008-09-12 | 2014-07-23 | 国立大学法人三重大学 | 能够表达外源gitr配体的细胞 |
ES2621141T3 (es) | 2008-11-28 | 2017-07-03 | Novartis Ag | Combinación farmacéutica que comprende un inhibidor de Hsp 90 y un inhibidor de mTOR |
RU2636023C2 (ru) | 2008-12-09 | 2017-11-17 | Дженентек, Инк. | Антитела к pd-l1 и их применение для усиления функции т-клеток |
EP2393835B1 (en) | 2009-02-09 | 2017-04-05 | Université d'Aix-Marseille | Pd-1 antibodies and pd-l1 antibodies and uses thereof |
UA103918C2 (en) | 2009-03-02 | 2013-12-10 | Айерем Элелси | N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators |
CA2919467C (en) | 2009-03-02 | 2018-04-17 | Jan Paul Medema | Antibodies against a proliferating inducing ligand (april) |
ES2593862T3 (es) | 2009-03-09 | 2016-12-13 | Molecular Express, Inc. | Métodos y composiciones de formulación liposomal de antígenos y usos de los mismos |
US8414630B2 (en) | 2009-03-10 | 2013-04-09 | Marc Evan Richelsoph | Active bone screw |
TWI549688B (zh) | 2009-06-05 | 2016-09-21 | 美國疾病傳染研究機構 | 合成的葡萄吡喃糖基脂質佐劑 |
AR078228A1 (es) | 2009-06-26 | 2011-10-26 | Novartis Ag | Inhibidores de cyp17 |
WO2011003025A1 (en) | 2009-07-01 | 2011-01-06 | Rutgers, The State University Of New Jersey | Synthesis of cyclic diguanosine monophosphate and thiophosphate analogs thereof |
JO3002B1 (ar) | 2009-08-28 | 2016-09-05 | Irm Llc | مركبات و تركيبات كمثبطات كيناز بروتين |
BR112012004823B1 (pt) | 2009-09-03 | 2021-11-30 | Merck Sharp & Dohme Corp | Anticorpo ou fragmento de ligação de antígeno do mesmo, uso de um anticorpo ou um fragmento de ligação de antígeno do mesmo, e composição farmacêutica |
GB0919054D0 (en) | 2009-10-30 | 2009-12-16 | Isis Innovation | Treatment of obesity |
US20130017199A1 (en) | 2009-11-24 | 2013-01-17 | AMPLIMMUNE ,Inc. a corporation | Simultaneous inhibition of pd-l1/pd-l2 |
US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
BR112012016135A2 (pt) | 2009-12-29 | 2017-03-07 | Emergent Product Dev Seattle | proteínas de ligação de heterodímero e seus usos |
UY33227A (es) | 2010-02-19 | 2011-09-30 | Novartis Ag | Compuestos de pirrolopirimidina como inhibidores de la cdk4/6 |
CN102199183B (zh) | 2010-03-26 | 2013-12-18 | 北京大学 | 环二鸟苷酸及其类似物和制备方法 |
HUE040213T2 (hu) | 2010-06-11 | 2019-02-28 | Kyowa Hakko Kirin Co Ltd | Anti-TIM antitest |
JP6023706B2 (ja) | 2010-07-09 | 2016-11-09 | アデュロ・バイオテック・ホールディングス・ヨーロッパ・ベスローテン・フエンノートシャップAduro Biotech Holdings, Europe B.V. | Cd27に対するアゴニスト抗体 |
WO2012022814A1 (en) | 2010-08-20 | 2012-02-23 | Novartis Ag | Antibodies for epidermal growth factor receptor 3 (her3) |
HUE039747T2 (hu) | 2010-11-17 | 2019-02-28 | Aduro Biotech Inc | Eljárások és kompozíciók EGFRVIII-ra való immunválasz indukálására |
US20130108641A1 (en) | 2011-09-14 | 2013-05-02 | Sanofi | Anti-gitr antibodies |
HUE051954T2 (hu) | 2011-11-28 | 2021-03-29 | Merck Patent Gmbh | ANTI-PD-L1 ellenanyagok és alkalmazásaik |
UY34591A (es) | 2012-01-26 | 2013-09-02 | Novartis Ag | Compuestos de imidazopirrolidinona |
UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
AU2013256468A1 (en) | 2012-04-30 | 2014-12-04 | Glen N. Barber | Modulating immune responses |
DK2861579T5 (da) | 2012-05-15 | 2022-10-24 | Novartis Ag | Benzamidderivater til at hæmme aktiviteten af ABL1, ABL2 og BCR-ABL1 |
WO2013171641A1 (en) | 2012-05-15 | 2013-11-21 | Novartis Ag | Compounds and compositions for inhibiting the activity of abl1, abl2 and bcr-abl1 |
EP2858988B1 (en) | 2012-05-15 | 2018-02-28 | Novartis AG | Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1 |
WO2013171642A1 (en) | 2012-05-15 | 2013-11-21 | Novartis Ag | Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1 |
JO3300B1 (ar) | 2012-06-06 | 2018-09-16 | Novartis Ag | مركبات وتركيبات لتعديل نشاط egfr |
KR101566538B1 (ko) | 2012-06-08 | 2015-11-05 | 국립암센터 | 신규한 Th17 세포 전환용 에피토프 및 이의 용도 |
AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
CN103566377A (zh) | 2012-07-18 | 2014-02-12 | 上海博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
CN104508149A (zh) | 2012-07-27 | 2015-04-08 | 诺华股份有限公司 | 对jak/stat抑制剂治疗响应的预测 |
CA2890663A1 (en) | 2012-11-08 | 2014-05-15 | Novartis Ag | Pharmaceutical combination comprising a b-raf inhibitor and a histone deacetylase inhibitor and their use in the treatment of proliferative diseases |
HK1211475A1 (en) | 2012-11-28 | 2016-05-27 | Novartis Ag | Combination therapy |
US9090646B2 (en) | 2012-12-05 | 2015-07-28 | Rutgers, The State University Of New Jersey | Biotinylated compounds |
CA2886456A1 (en) | 2012-12-13 | 2014-06-19 | Aduro Biotech, Inc. | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
US9498532B2 (en) | 2013-03-13 | 2016-11-22 | Novartis Ag | Antibody drug conjugates |
AU2014229313B2 (en) | 2013-03-14 | 2016-07-28 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH |
US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
PE20160167A1 (es) | 2013-04-29 | 2016-04-21 | Sloan Kettering Inst Cancer | Composiciones y metodos para alterar la senalizacion del segundo mensajero |
EP2992000B1 (en) | 2013-05-03 | 2020-07-08 | The Regents of The University of California | Cyclic di-nucleotide induction of type i interferon |
AU2014268836B2 (en) | 2013-05-18 | 2018-08-02 | Aduro Biotech, Inc. | Compositions and methods for activating "stimulator of interferon gene"-dependent signalling |
US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling |
CN105188373B (zh) | 2013-05-18 | 2017-09-22 | 艾杜罗生物科技公司 | 抑制“干扰素基因刺激蛋白”依赖性信号传导的组合物和方法 |
EP3027227A4 (en) | 2013-07-31 | 2018-05-23 | Memorial Sloan Kettering Cancer Center | Sting crystals and modulators |
AR097306A1 (es) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | Modulación de la inmunidad tumoral |
BR112016008133B1 (pt) | 2013-11-01 | 2020-11-24 | Novartis Ag | amino-heteroaril benzamidas como inibidores de quinase, seus usos, e composição farmacêutica |
EP3071209A4 (en) | 2013-11-19 | 2017-08-16 | The University of Chicago | Use of sting agonist as cancer treatment |
CA2931146C (en) | 2013-11-22 | 2022-06-28 | Brock University | Use of fluorinated cyclic dinucleotides as oral vaccine adjuvants |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
PE20170071A1 (es) | 2014-03-14 | 2017-03-17 | Novartis Ag | Moleculas de anticuerpo que se unen a lag-3 y usos de las mismas |
JP6462006B2 (ja) | 2014-06-04 | 2019-01-30 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | Stingのモジュレーターとしての環式ジヌクレオチド |
EP3233191A1 (en) | 2014-12-16 | 2017-10-25 | Invivogen | Combined use of a chemotherapeutic agent and a cyclic dinucleotide for cancer treatment |
EP3546473A1 (en) * | 2014-12-16 | 2019-10-02 | Kayla Therapeutics | Cyclic [(2',5')p(3',5')p]-dinucleotides for cytokine induction |
GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
SG11201706756VA (en) | 2015-03-10 | 2017-09-28 | Aduro Biotech Inc | Compositions and methods for activating "stimulator of interferon gene" -dependent signalling |
EA034786B1 (ru) | 2015-08-13 | 2020-03-20 | Мерк Шарп И Доум Корп. | Циклические динуклеотидные соединения в качестве агонистов sting |
PE20181297A1 (es) | 2015-12-03 | 2018-08-07 | Glaxosmithkline Ip Dev Ltd | Dinucleotidos de purino ciclico como moduladores de sting |
CA3011528A1 (en) | 2016-01-11 | 2017-07-20 | Innate Tumor Immunity, Inc. | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer |
WO2017123657A1 (en) | 2016-01-11 | 2017-07-20 | Gary Glick | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer |
-
2016
- 2016-03-09 SG SG11201706756VA patent/SG11201706756VA/en unknown
- 2016-03-09 HK HK18106549.3A patent/HK1247089A1/zh unknown
- 2016-03-09 MX MX2017011597A patent/MX2017011597A/es unknown
- 2016-03-09 AR ARP160100626A patent/AR103894A1/es unknown
- 2016-03-09 BR BR112017018908-9A patent/BR112017018908A2/pt not_active IP Right Cessation
- 2016-03-09 JP JP2017547400A patent/JP6692826B2/ja not_active Expired - Fee Related
- 2016-03-09 MA MA042146A patent/MA42146A/fr unknown
- 2016-03-09 KR KR1020177028534A patent/KR20170129802A/ko not_active Withdrawn
- 2016-03-09 TN TNP/2017/000375A patent/TN2017000375A1/en unknown
- 2016-03-09 CR CR20170410A patent/CR20170410A/es unknown
- 2016-03-09 TW TW105107250A patent/TWI706958B/zh not_active IP Right Cessation
- 2016-03-09 EA EA201791999A patent/EA035817B1/ru unknown
- 2016-03-09 EP EP16762447.7A patent/EP3268035A4/en not_active Withdrawn
- 2016-03-09 CN CN201680022466.9A patent/CN107530415A/zh active Pending
- 2016-03-09 PE PE2017001512A patent/PE20171448A1/es unknown
- 2016-03-09 WO PCT/US2016/021597 patent/WO2016145102A1/en active Application Filing
- 2016-03-09 US US15/556,982 patent/US10449211B2/en not_active Expired - Fee Related
- 2016-03-09 JO JOP/2016/0039A patent/JO3746B1/ar active
- 2016-03-09 HK HK18108617.6A patent/HK1248603A1/zh unknown
- 2016-03-09 CA CA2979215A patent/CA2979215A1/en not_active Abandoned
- 2016-03-09 MY MYPI2017703039A patent/MY190404A/en unknown
- 2016-03-09 AU AU2016229146A patent/AU2016229146A1/en not_active Abandoned
- 2016-03-10 UY UY0001036579A patent/UY36579A/es not_active Application Discontinuation
-
2017
- 2017-08-17 IL IL254047A patent/IL254047A0/en unknown
- 2017-08-18 PH PH12017501506A patent/PH12017501506A1/en unknown
- 2017-09-06 DO DO2017000205A patent/DOP2017000205A/es unknown
- 2017-09-07 CL CL2017002272A patent/CL2017002272A1/es unknown
- 2017-09-08 SV SV2017005529A patent/SV2017005529A/es unknown
- 2017-09-08 GT GT201700200A patent/GT201700200A/es unknown
- 2017-09-08 CO CONC2017/0009104A patent/CO2017009104A2/es unknown
- 2017-10-02 EC ECIEPI201764523A patent/ECSP17064523A/es unknown
-
2019
- 2019-10-21 US US16/659,093 patent/US11040053B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL254047A0 (en) | Preparations and methods for signal-dependent activation of sting protein | |
IL242359B (en) | Preparations and methods for the activation of a "stimulator of the interferon gene" dependent signal | |
EP2996472A4 (en) | COMPOSITIONS AND METHODS FOR INHIBITING DEPENDENT SIGNALING OF "INTERFERON GENE STIMULATOR" | |
IL271903A (en) | Combination of unnatural nucleotides and methods therefor | |
IL273959A (en) | Methods and preparations for the treatment of rare diseases | |
LT3386484T (lt) | Gydomųjų medžiagų sudėtis ir pristatymo metodai | |
SG11201706755SA (en) | Methods and compositions for treating genetic eye diseases | |
IL274702A (en) | Compounds and Methods for Neurological Diseases | |
IL281089A (en) | LINGO–1 antagonists and uses for the treatment of demyelinating disorders | |
HK1259372A1 (zh) | 治療化合物、其組合物及使用方法 | |
IL275182A (en) | Preparations and methods for the treatment of metabolic conditions | |
IL259894A (en) | Improved compositions and improved methods for viral delivery of neoepitopes and their use | |
SG11201702554QA (en) | Compositions and methods for the treatment of multiple sclerosis | |
IL258487B1 (en) | Preparations and methods for the treatment of excessive homocysteine in the urine | |
SG11201803284YA (en) | Novel method of use and compositions | |
IL259710A (en) | Preparations and methods for the treatment of Davidson's disease (microvillus inclusion disease) and related diseases | |
GB201511799D0 (en) | Composition and methods of treatment | |
PT3503885T (pt) | Composição farmacêutica e métodos de utilização | |
GB201621737D0 (en) | Compositions and methods of treatment | |
GB201605127D0 (en) | Composition and methods of treatment | |
ZA201801945B (en) | Compositions and methods for the treatment of parkinson's disease | |
GB201710491D0 (en) | Composition and methods of treatment | |
ZA202004110B (en) | Compositions and methods for the treatment of metabolic conditions | |
SG11201704282UA (en) | Compositions and methods for the treatment of multiple sclerosis | |
GB201521083D0 (en) | Compositions for treatment and methods thereof |