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RU95112506A - METHODS OF TREATMENT, ANTIBODIES AND HYBRIDOMAS - Google Patents

METHODS OF TREATMENT, ANTIBODIES AND HYBRIDOMAS

Info

Publication number
RU95112506A
RU95112506A RU95112506/14A RU95112506A RU95112506A RU 95112506 A RU95112506 A RU 95112506A RU 95112506/14 A RU95112506/14 A RU 95112506/14A RU 95112506 A RU95112506 A RU 95112506A RU 95112506 A RU95112506 A RU 95112506A
Authority
RU
Russia
Prior art keywords
antibody
administration
period
person
therapeutically effective
Prior art date
Application number
RU95112506/14A
Other languages
Russian (ru)
Other versions
RU2139731C1 (en
Inventor
Р.Андерсон Даррел
Х.Растеттер Вильям
Ханна Нэбил
Е.Леонард Джон
А.Ньюмэн Роланд
Е.Рефф Митчелл
Original Assignee
Айдек Фармасьютикалс Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/149,099 external-priority patent/US5736137A/en
Application filed by Айдек Фармасьютикалс Корпорейшн filed Critical Айдек Фармасьютикалс Корпорейшн
Priority claimed from PCT/US1993/010953 external-priority patent/WO1994011026A2/en
Publication of RU95112506A publication Critical patent/RU95112506A/en
Application granted granted Critical
Publication of RU2139731C1 publication Critical patent/RU2139731C1/en

Links

Claims (20)

1. Способ лечения В-клеточной лимфомы, отличающийся тем, что включает стадию введения терапевтически эффективного количества по меньшей мере одного иммунологически активного анти-CD20 антитела человеку.1. A method of treating B-cell lymphoma, characterized in that it comprises the step of administering a therapeutically effective amount of at least one immunologically active anti-CD20 antibody to a human. 2. Способ по п.1, отличающийся тем, что количество вводимого человеку антитела составляет приблизительно 0,001 - 30 мг на 1 кг веса тела этого человека. 2. The method according to claim 1, characterized in that the amount of antibody administered to a person is approximately 0.001-30 mg per kg of body weight of that person. 3. Способ по п.1, отличающийся тем, что антитело получено из трансфектомы, содержащей анти-CD20 в ТАСЕ 8, депонированной в American Type Culture Collection как часть АТСС депозитного номера 69119. 3. The method according to claim 1, characterized in that the antibody is obtained from transfectoma containing anti-CD20 in TACE 8, deposited in the American Type Culture Collection as part of ATCC deposit number 69119. 4. Способ по п.1, отличающийся тем, что он включает дополнительно стадию введения второго терапевтически активного количества по меньшей мере одного иммунологически активного химерного анти-CD20 антитела. 4. The method according to claim 1, characterized in that it further comprises the step of administering a second therapeutically active amount of at least one immunologically active chimeric anti-CD20 antibody. 5. Способ по п.4, отличающийся тем, что дополнительное введение упомянутого антитела человеку производят в пределах приблизительно семи дней от первого введения этого антитела человеку. 5. The method according to claim 4, characterized in that the additional introduction of the said antibodies to humans is carried out within approximately seven days from the first administration of this antibody to humans. 6. Способ лечения В-клеточной лимфомы, отличающийся тем, что осуществляют введение в первом периоде введения первого терапевтически эффективного количества иммунологически активного химерного анти-CD20 антитела человеку, введение во втором последующем периоде введения второго терапевтически эффективного количества этого антитела, введение в третьем последующем периоде введения третьего терапевтически эффективного количества этого антитела. 6. A method of treating B-cell lymphoma, characterized in that the first therapeutically effective amount of an immunologically active chimeric anti-CD20 antibody is administered to a person in the first period, the second therapeutically effective amount of the antibody is administered in the second subsequent period, and the third subsequent period is administered the introduction of a third therapeutically effective amount of this antibody. 7. Способ по п.6, отличающийся тем, что первое, второе и третье терапевтически эффективные количества антитела составляют приблизительно 0,001 - 30 мг/кг. 7. The method according to claim 6, characterized in that the first, second and third therapeutically effective amounts of antibodies are approximately 0.001 to 30 mg / kg 8. Способ по п.6, отличающийся тем, что второй период введения лежит в пределах приблизительно семи дней от первого периода введения. 8. The method according to claim 6, characterized in that the second administration period lies within approximately seven days from the first administration period. 9. Способ по п.6, отличающийся тем, что третий период введения лежит в пределах приблизительно 14 дней от первого периода введения. 9. The method according to claim 6, characterized in that the third administration period lies within about 14 days from the first administration period. 10. Способ по п.6, отличающийся тем, что упомянутое антитело получено из трансфектомы, содержащей анти-CD20 в ТСАЕ 8 (в АТСС депозитном номере 69119). 10. The method according to claim 6, characterized in that said antibody is obtained from a transfectoma containing anti-CD20 in TCAE 8 (in ATCC deposit number 69119). 11. Иммунологически активное химерное анти-CD20 антитело, полученное из трансфекторы, содержащей анти-CD20 в ТСАЕ 8 ( в АТСС депозитном номере 69119). 11. Immunologically active chimeric anti-CD20 antibody obtained from transfections containing anti-CD20 in TCAE 8 (ATCC deposit number 69119). 12. Гибридома, секретирующая анти-CD20 антитело, идентифицируемая АТСС депозитным номером НВ 11388. 12. A hybridoma secreting an anti-CD20 antibody identified by ATCC with deposit number HB 11388. 13. Моноклональное антитело, секретируемое гибридомой по п.12. 13. The monoclonal antibody secreted by the hybridoma of claim 12. 14. Радиоактивно меченое антитело по п.12. 14. The radiolabeled antibody of claim 12. 15. Антитело по п.14, отличающееся тем, что радиоактивная метка выбрана из группы, состоящей из иттрия [90], индия [111] и иода [131]. 15. The antibody according to 14, characterized in that the radioactive label is selected from the group consisting of yttrium [90], indium [111] and iodine [131]. 16. Способ лечения В-клеточной лимфомы, отличающийся тем, что включает стадии введения человеку терапевтически эффективного количества антитела по п.14. 16. A method of treating B-cell lymphoma, characterized in that it comprises the steps of administering to the person a therapeutically effective amount of an antibody of claim 14. 17. Способ по п.16, отличающийся тем, что радиоактивной меткой антитела является иттрий [90]. 17. The method according to clause 16, wherein the radioactive label of the antibody is yttrium [90]. 18. Способ лечения В-клеточной лимфомы, отличающийся тем, что осуществляют введение в первом периоде введения иммунологически активного химерного анти-CD20 антитела человеку и введение во втором периоде введения радиоактивно меченого анти-CD20 антитела человеку. 18. A method of treating B-cell lymphoma, characterized in that the introduction of the immunologically active chimeric anti-CD20 antibody to the person in the first period of administration and the administration of the radioactively labeled anti-CD20 antibody to the person in the second period of administration. 19. Способ по п.18, отличающийся тем, что химерное анти-CD20 антитело получено из трансфектомы, содержащей анти-CD20 в ТСАЕ 8, депонированной в АТСС как часть АТСС депозитного номера 69119. 19. The method according to p. 18, characterized in that the chimeric anti-CD20 antibody is obtained from transfectoma containing anti-CD20 in TCAE 8, deposited in ATCC as part of ATCC deposit number 69119. 20. Способ по п.8, отличающийся тем, что радиоактивно меченое антитело представляет собой моноклонально антитело, секретируемое гибридомой, идентифицируемой по АТСС депозитному номеру НВ 11388. 20. The method according to claim 8, characterized in that the radiolabeled antibody is a monoclonal antibody secreted by a hybridoma identified by ATCC deposit number HB 11388.
RU95112506A 1992-11-13 1993-11-12 Methods of treatment, antibodies, hybridoma RU2139731C1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97889192A 1992-11-13 1992-11-13
US07/978,891 1992-11-13
US08/149,099 US5736137A (en) 1992-11-13 1993-11-03 Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US08/149,099 1993-11-03
PCT/US1993/010953 WO1994011026A2 (en) 1992-11-13 1993-11-12 Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma

Publications (2)

Publication Number Publication Date
RU95112506A true RU95112506A (en) 1998-05-10
RU2139731C1 RU2139731C1 (en) 1999-10-20

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EP (3) EP0752248B1 (en)
JP (3) JP3095175B2 (en)
AT (2) ATE139900T1 (en)
AU (1) AU688743B2 (en)
BG (1) BG62386B1 (en)
CA (1) CA2149329C (en)
DE (3) DE69303494T2 (en)
DK (2) DK0669836T3 (en)
ES (2) ES2091684T3 (en)
FI (1) FI112033B (en)
GR (2) GR3020731T3 (en)
LU (1) LU91089I2 (en)
LV (1) LV11732B (en)
MD (1) MD1367C2 (en)
NL (1) NL300156I2 (en)
NO (4) NO321137B1 (en)
NZ (1) NZ258392A (en)
PL (2) PL174721B1 (en)
PT (1) PT752248E (en)
RO (1) RO118524B1 (en)
RU (1) RU2139731C1 (en)
WO (1) WO1994011026A2 (en)

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