RU2014140147A - Контейнер под давлением, содержащий гемостатическую пасту - Google Patents
Контейнер под давлением, содержащий гемостатическую пасту Download PDFInfo
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- RU2014140147A RU2014140147A RU2014140147A RU2014140147A RU2014140147A RU 2014140147 A RU2014140147 A RU 2014140147A RU 2014140147 A RU2014140147 A RU 2014140147A RU 2014140147 A RU2014140147 A RU 2014140147A RU 2014140147 A RU2014140147 A RU 2014140147A
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- propellant
- compartment
- container
- valve
- hemostatic paste
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- 230000002439 hemostatic effect Effects 0.000 title claims abstract 20
- 239000003380 propellant Substances 0.000 claims abstract 20
- 239000003566 sealing material Substances 0.000 claims abstract 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000000463 material Substances 0.000 claims abstract 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims abstract 2
- 230000006835 compression Effects 0.000 claims abstract 2
- 238000007906 compression Methods 0.000 claims abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 4
- 102000008186 Collagen Human genes 0.000 claims 3
- 108010035532 Collagen Proteins 0.000 claims 3
- 108010010803 Gelatin Proteins 0.000 claims 3
- 229920001436 collagen Polymers 0.000 claims 3
- 239000008273 gelatin Substances 0.000 claims 3
- 229920000159 gelatin Polymers 0.000 claims 3
- 235000019322 gelatine Nutrition 0.000 claims 3
- 235000011852 gelatine desserts Nutrition 0.000 claims 3
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims 2
- 239000004952 Polyamide Substances 0.000 claims 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 claims 2
- 230000002421 anti-septic effect Effects 0.000 claims 2
- 229940064004 antiseptic throat preparations Drugs 0.000 claims 2
- 230000000740 bleeding effect Effects 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 239000004033 plastic Substances 0.000 claims 2
- 229920003023 plastic Polymers 0.000 claims 2
- 229920002647 polyamide Polymers 0.000 claims 2
- -1 polyethylene Polymers 0.000 claims 2
- 230000001954 sterilising effect Effects 0.000 claims 2
- 238000004659 sterilization and disinfection Methods 0.000 claims 2
- 239000004698 Polyethylene Substances 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 claims 1
- 239000003570 air Substances 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000001273 butane Substances 0.000 claims 1
- KYKAJFCTULSVSH-UHFFFAOYSA-N chloro(fluoro)methane Chemical compound F[C]Cl KYKAJFCTULSVSH-UHFFFAOYSA-N 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims 1
- 229920001903 high density polyethylene Polymers 0.000 claims 1
- 239000004700 high-density polyethylene Substances 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 claims 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
- 239000001294 propane Substances 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 238000007789 sealing Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00491—Surgical glue applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
- A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
- A61M5/14526—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons the piston being actuated by fluid pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/155—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by gas introduced into the reservoir
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
- B65B55/02—Sterilising, e.g. of complete packages
- B65B55/04—Sterilising wrappers or receptacles prior to, or during, packaging
- B65B55/08—Sterilising wrappers or receptacles prior to, or during, packaging by irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00535—Surgical instruments, devices or methods pneumatically or hydraulically operated
- A61B2017/00544—Surgical instruments, devices or methods pneumatically or hydraulically operated pneumatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M2005/14513—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Reproductive Health (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Toxicology (AREA)
- Mechanical Engineering (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Materials For Medical Uses (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Surgical Instruments (AREA)
Abstract
1. Устройство для выдачи гемостатической пасты под давлением, содержащее:a. контейнер, имеющий внутреннее пространство, включающее в себя отделение для продукта и отделение для пропеллента, отделенные друг от друга, причем упомянутый контейнер имеет первый конец с выпускным отверстием для гемостатической пасты, продолжающийся от отделения для продукта, причем упомянутое выпускное отверстие выполнено с возможностью открытия и закрытия;b. клапан, сообщающийся с первым концом отделения для продукта;с. гемостатическую пасту, содержащуюся в отделении для продукта;d. пропеллент, обеспеченный в отделении для пропеллента;e. подвижный поршень, отделяющий отделение для продукта от отделения для пропеллента.2. Устройство по п. 1, в котором упомянутый поршень содержит основной поршень, имеющий основную зацепляющую стенку юбку, вспомогательный поршень, имеющий вспомогательную зацепляющую стенку юбку, при этом между основным и вспомогательным поршнем вставлен деформируемый уплотняющий материал.3. Устройство по п. 2, в котором под давлением упомянутый деформируемый материал сжат между поршнями и прижат к стенке контейнера с образованием уплотнения.4. Устройство по п. 2, в котором основной поршень находитсяв сцеплении силами трения со стенкой, при этом вспомогательный поршень находится в свободной посадке, что способствует сжатию вставленного деформируемого уплотняющего материала.5. Устройство по п. 2, в котором деформируемый уплотняющий материал является гелем.6. Устройство по п. 2, в котором деформируемый уплотняющий материал является водным гелем.7. Устройство по п. 1, в котором пропеллент выбран из группы, состоящей из: азота, кислорода, сжатого воздуха,
Claims (27)
1. Устройство для выдачи гемостатической пасты под давлением, содержащее:
a. контейнер, имеющий внутреннее пространство, включающее в себя отделение для продукта и отделение для пропеллента, отделенные друг от друга, причем упомянутый контейнер имеет первый конец с выпускным отверстием для гемостатической пасты, продолжающийся от отделения для продукта, причем упомянутое выпускное отверстие выполнено с возможностью открытия и закрытия;
b. клапан, сообщающийся с первым концом отделения для продукта;
с. гемостатическую пасту, содержащуюся в отделении для продукта;
d. пропеллент, обеспеченный в отделении для пропеллента;
e. подвижный поршень, отделяющий отделение для продукта от отделения для пропеллента.
2. Устройство по п. 1, в котором упомянутый поршень содержит основной поршень, имеющий основную зацепляющую стенку юбку, вспомогательный поршень, имеющий вспомогательную зацепляющую стенку юбку, при этом между основным и вспомогательным поршнем вставлен деформируемый уплотняющий материал.
3. Устройство по п. 2, в котором под давлением упомянутый деформируемый материал сжат между поршнями и прижат к стенке контейнера с образованием уплотнения.
4. Устройство по п. 2, в котором основной поршень находится
в сцеплении силами трения со стенкой, при этом вспомогательный поршень находится в свободной посадке, что способствует сжатию вставленного деформируемого уплотняющего материала.
5. Устройство по п. 2, в котором деформируемый уплотняющий материал является гелем.
6. Устройство по п. 2, в котором деформируемый уплотняющий материал является водным гелем.
7. Устройство по п. 1, в котором пропеллент выбран из группы, состоящей из: азота, кислорода, сжатого воздуха, бутана, пропана, хлорофторуглерода, фторуглерода и диметилового эфира.
8. Устройство по п. 1, в котором упомянутая камера для пропеллента также содержит впускное отверстие для пропеллента, причем упомянутое впускное отверстие выполнено с возможностью открытия и закрытия.
9. Устройство по п. 1, в котором давление в отделении для пропеллента составляет 100-500 кПа при комнатной температуре.
10. Устройство по п. 1, в котором гемостатическая паста является желатиновой пастой или коллагеновой пастой.
11. Устройство по п. 10, в котором гемостатическая паста является желатиновой пастой, содержащей 10-25% в объемном отношении желатина, подходящую жидкость и при необходимости один или более антисептиков.
12. Устройство по п. 10, в котором гемостатическая паста является коллагеновой пастой, содержащей 10-25% в объемном отношении коллагена, подходящую жидкость и возможно один или более антисептиков.
13. Устройство по п. 1, в котором гемостатическая паста имеет вязкость в диапазоне 500-6000 Па·с при комнатной температуре.
14. Устройство по п. 1, в котором клапан содержит подвижный клапанный элемент, выполненный с возможностью перемещения из закрытого положения в открытое положение для обеспечения протекания гемостатической пасты через выпускное отверстие для гемостатической пасты устройства.
15. Устройство по п. 14, в котором клапан выполнен из пластичного материала, выбранного из группы, состоящей из: полиэтилена (ПНД), полистирола, акрилнитрил-бутадиен-стирола (АБС), полиамида (ПА), полипропилена и поливинилхлорида (ПВХ).
16. Устройство по п. 1, дополнительно содержащее выполненный с возможностью перемещения привод, соединенный с клапанным элементом, при этом приводящее в действие перемещение привода переводило клапанный элемент в открытое положение.
17. Устройство по п. 1, в котором клапан дополнительно включает в себя отклоняющий элемент, отклоняющий клапанный элемент в направлении закрытого положения.
18. Устройство по п. 1, в котором клапан дополнительно содержит уплотнение, взаимодействующее с клапанным элементом для предотвращения потока гемостатической пасты из клапана, когда клапанный элемент находится в закрытом положении.
19. Устройство по п. 1, в котором контейнер выполнен из металла или пластика.
20. Устройство по п. 19, в котором контейнер выполнен из алюминия.
21. Устройство по п. 1, в котором контейнер покрыт одобренным агентством FDA покрытием, выбранным из группы, состоящей из:
PPG2497-303/A, PPG2956-401/A и J3121.
22. Устройство по п. 1, в котором отделение для продукта контейнера имеет объем в диапазоне 5-250 мл.
23. Устройство по п. 1, в котором отделение для пропеллента контейнера имеет объем в диапазоне 5-250 мл.
24. Способ нанесения гемостатической пасты к месту кровотечения, содержащий стадии, на которых:
a. обеспечивают устройство по любому из предшествующих пунктов,
b. прикрепляют сгибаемый или несгибаемый и/или отрезной наконечник к устройству,
с. приводят в действие клапан для выдачи гемостатической пасты из устройства,
и d. направляют выданную гемостатическую пасту к месту кровотечения.
25. Способ выполнения устройства по любому из пп. 1-23, содержащий стадии, на которых:
a. обеспечивают устройство по любому из пп. 1-23,
b. обеспечивают гемостатическую пасту,
с. заполняют гемостатической пастой отделение для продукта через верхнюю часть открытого контейнера,
d. прикрепляют клапан к открытому концу контейнера,
e. надежно герметизируют клапаном контейнер путем обжатия корпусом клапана горлышка верхней части контейнера,
f. заполняют отделение для пропеллента под давлением подходящим пропеллентом через отверстие в отделении для пропеллента,
g. герметизируют отделение для пропеллента путем установки пробки в отверстие отделения для пропеллента.
26. Способ по п. 25, в котором устройство стерилизуется облучением, при этом устройство заполняют гемостатической пастой и пропеллентом предпочтительно перед стерилизацией.
27. Способ по п. 26, в котором стерилизация производится гамма- или бета-излучением.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201270099 | 2012-03-06 | ||
| DKPA201270099 | 2012-03-06 | ||
| PCT/DK2013/050054 WO2013131520A2 (en) | 2012-03-06 | 2013-03-05 | Pressurized container containing haemostatic paste |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2014140147A true RU2014140147A (ru) | 2016-04-27 |
| RU2657955C2 RU2657955C2 (ru) | 2018-06-18 |
Family
ID=48013685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014140147A RU2657955C2 (ru) | 2012-03-06 | 2013-03-05 | Контейнер под давлением, содержащий гемостатическую пасту |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11109849B2 (ru) |
| EP (1) | EP2822474B1 (ru) |
| JP (1) | JP6241624B2 (ru) |
| CN (1) | CN104159527B (ru) |
| CA (1) | CA2865349C (ru) |
| HK (1) | HK1204904A1 (ru) |
| IN (1) | IN2014DN08122A (ru) |
| RU (1) | RU2657955C2 (ru) |
| WO (1) | WO2013131520A2 (ru) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2259803B2 (en) | 2008-02-29 | 2019-03-13 | Ferrosan Medical Devices A/S | Device for promotion of hemostasis and/or wound healing |
| EP2977066A3 (en) | 2012-06-12 | 2016-07-27 | Ferrosan Medical Devices A/S | Dry haemostatic composition |
| JP6390873B2 (ja) | 2013-06-21 | 2018-09-19 | フェッローサン メディカル ディバイス エー／エス | 減圧膨張させた乾燥組成物およびそれを保持するためのシリンジ |
| CA2928963C (en) | 2013-12-11 | 2020-10-27 | Ferrosan Medical Devices A/S | Dry composition comprising an extrusion enhancer |
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| JP6390873B2 (ja) | 2013-06-21 | 2018-09-19 | フェッローサン メディカル ディバイス エー／エス | 減圧膨張させた乾燥組成物およびそれを保持するためのシリンジ |
| CA2928963C (en) | 2013-12-11 | 2020-10-27 | Ferrosan Medical Devices A/S | Dry composition comprising an extrusion enhancer |
| CA2960309A1 (en) | 2014-10-13 | 2016-04-21 | Ferrosan Medical Devices A/S | Dry composition for use in haemostasis and wound healing |
| RU2705905C2 (ru) | 2014-12-24 | 2019-11-12 | Ферросан Медикал Дивайсиз А/С | Шприц для удерживания и смешивания первого и второго веществ |
| CA2986981A1 (en) | 2015-07-03 | 2017-01-12 | Ferrosan Medical Devices A/S | Syringe for mixing two components and for retaining a vacuum in a storage condition |
| IL242984A0 (en) | 2015-12-08 | 2016-02-29 | Omrix Biopharmaceuticals Ltd | Thrombin microcapsules, their preparation and how to use them |
-
2013
- 2013-03-05 CN CN201380012440.2A patent/CN104159527B/zh active Active
- 2013-03-05 EP EP13712675.1A patent/EP2822474B1/en active Active
- 2013-03-05 US US14/383,461 patent/US11109849B2/en active Active
- 2013-03-05 RU RU2014140147A patent/RU2657955C2/ru active
- 2013-03-05 CA CA2865349A patent/CA2865349C/en active Active
- 2013-03-05 JP JP2014560250A patent/JP6241624B2/ja active Active
- 2013-03-05 IN IN8122DEN2014 patent/IN2014DN08122A/en unknown
- 2013-03-05 WO PCT/DK2013/050054 patent/WO2013131520A2/en active Application Filing
-
2015
- 2015-06-19 HK HK15105847.7A patent/HK1204904A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2865349A1 (en) | 2013-09-12 |
| EP2822474B1 (en) | 2018-05-02 |
| HK1204904A1 (en) | 2015-12-11 |
| EP2822474A2 (en) | 2015-01-14 |
| RU2657955C2 (ru) | 2018-06-18 |
| US11109849B2 (en) | 2021-09-07 |
| CN104159527B (zh) | 2017-04-12 |
| WO2013131520A3 (en) | 2013-10-24 |
| CA2865349C (en) | 2021-07-06 |
| JP6241624B2 (ja) | 2017-12-06 |
| WO2013131520A2 (en) | 2013-09-12 |
| US20150045830A1 (en) | 2015-02-12 |
| CN104159527A (zh) | 2014-11-19 |
| JP2015509408A (ja) | 2015-03-30 |
| IN2014DN08122A (ru) | 2015-05-01 |
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