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IL242984A0 - Thrombin microcapsules, preparation and uses thereof - Google Patents

Thrombin microcapsules, preparation and uses thereof

Info

Publication number
IL242984A0
IL242984A0 IL242984A IL24298415A IL242984A0 IL 242984 A0 IL242984 A0 IL 242984A0 IL 242984 A IL242984 A IL 242984A IL 24298415 A IL24298415 A IL 24298415A IL 242984 A0 IL242984 A0 IL 242984A0
Authority
IL
Israel
Prior art keywords
preparation
thrombin
microcapsules
thrombin microcapsules
Prior art date
Application number
IL242984A
Other languages
Hebrew (he)
Original Assignee
Omrix Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omrix Biopharmaceuticals Ltd filed Critical Omrix Biopharmaceuticals Ltd
Priority to IL242984A priority Critical patent/IL242984A0/en
Publication of IL242984A0 publication Critical patent/IL242984A0/en
Priority to KR1020187018990A priority patent/KR20180091035A/en
Priority to JP2018529535A priority patent/JP6918799B2/en
Priority to AU2016367536A priority patent/AU2016367536B2/en
Priority to BR112018011504A priority patent/BR112018011504A2/en
Priority to PCT/IL2016/000024 priority patent/WO2017098493A1/en
Priority to CA3007900A priority patent/CA3007900A1/en
Priority to CN201680072297.XA priority patent/CN108366967B/en
Priority to EP16822750.2A priority patent/EP3386487A1/en
Priority to IL259185A priority patent/IL259185B/en
Priority to US16/184,321 priority patent/US10869912B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
IL242984A 2015-10-29 2015-12-08 Thrombin microcapsules, preparation and uses thereof IL242984A0 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IL242984A IL242984A0 (en) 2015-12-08 2015-12-08 Thrombin microcapsules, preparation and uses thereof
EP16822750.2A EP3386487A1 (en) 2015-12-08 2016-12-01 Thrombin microcapsules
BR112018011504A BR112018011504A2 (en) 2015-12-08 2016-12-01 thrombin microcapsules
JP2018529535A JP6918799B2 (en) 2015-12-08 2016-12-01 Thrombin microcapsules
AU2016367536A AU2016367536B2 (en) 2015-12-08 2016-12-01 Thrombin microcapsules
KR1020187018990A KR20180091035A (en) 2015-12-08 2016-12-01 Thrombin microcapsule
PCT/IL2016/000024 WO2017098493A1 (en) 2015-12-08 2016-12-01 Thrombin microcapsules
CA3007900A CA3007900A1 (en) 2015-12-08 2016-12-01 Thrombin microcapsules
CN201680072297.XA CN108366967B (en) 2015-12-08 2016-12-01 Thrombin Microcapsules
IL259185A IL259185B (en) 2015-12-08 2018-05-07 Thrombin microcapsules
US16/184,321 US10869912B2 (en) 2015-10-29 2018-11-08 Thrombin microcapsules, preparation and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL242984A IL242984A0 (en) 2015-12-08 2015-12-08 Thrombin microcapsules, preparation and uses thereof

Publications (1)

Publication Number Publication Date
IL242984A0 true IL242984A0 (en) 2016-02-29

Family

ID=59012760

Family Applications (2)

Application Number Title Priority Date Filing Date
IL242984A IL242984A0 (en) 2015-10-29 2015-12-08 Thrombin microcapsules, preparation and uses thereof
IL259185A IL259185B (en) 2015-12-08 2018-05-07 Thrombin microcapsules

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL259185A IL259185B (en) 2015-12-08 2018-05-07 Thrombin microcapsules

Country Status (9)

Country Link
EP (1) EP3386487A1 (en)
JP (1) JP6918799B2 (en)
KR (1) KR20180091035A (en)
CN (1) CN108366967B (en)
AU (1) AU2016367536B2 (en)
BR (1) BR112018011504A2 (en)
CA (1) CA3007900A1 (en)
IL (2) IL242984A0 (en)
WO (1) WO2017098493A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104159527B (en) 2012-03-06 2017-04-12 弗罗桑医疗设备公司 Pressure vessel containing hemostatic paste
WO2013185776A1 (en) 2012-06-12 2013-12-19 Ferrosan Medical Devices A/S Dry haemostatic composition
JP6390873B2 (en) 2013-06-21 2018-09-19 フェッローサン メディカル ディバイス エー／エス Dry composition expanded under reduced pressure and syringe for holding the same
WO2015086028A1 (en) 2013-12-11 2015-06-18 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
CA2960309A1 (en) 2014-10-13 2016-04-21 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
US10653837B2 (en) 2014-12-24 2020-05-19 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
BR112017027695A2 (en) 2015-07-03 2018-09-04 Ferrosan Medical Devices As first and second substance retention and mixing syringe
SG11202005231RA (en) 2017-12-29 2020-07-29 Baxter Int Spray-dried thrombin and methods of using and making spray-dried thrombin
ES2968412T3 (en) 2018-05-09 2024-05-09 Ferrosan Medical Devices As Method for preparing a hemostatic composition
IL263679A (en) * 2018-12-12 2019-03-31 Omrix Biopharmaceuticals Ltd Kits, methods, and ingredients for preventing tissue adhesion
CN116392394B (en) * 2023-05-18 2025-09-26 合肥芯能相变新材料科技有限公司 A probiotic microcapsule preparation device and preparation method thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9107628D0 (en) 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
DE69418334T2 (en) 1993-08-06 2000-01-27 Opperbas Holding B.V., Amsterdam METHOD FOR HIGH LOADING OF VESICLES WITH BIOPOLYMER SUBSTANCES
AU702955B2 (en) * 1996-05-17 1999-03-11 Quadrant Healthcare (Uk) Limited Microparticles and their use in wound therapy
US6121232A (en) 1997-01-31 2000-09-19 Omrix Biopharmaceuticals Sa Stabilized mixture comprising fibrinogen
EP0856317A1 (en) 1997-01-31 1998-08-05 Omrix Biopharmaceuticals S.A. A stabilized mixture comprising fibrinogen
GB9727102D0 (en) 1997-12-22 1998-02-25 Andaris Ltd Microparticles and their therapeutic use
US6703047B2 (en) 2001-02-02 2004-03-09 Incept Llc Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
ES2274044T3 (en) 2001-05-21 2007-05-16 Omrix Biopharmaceuticals S.A. DISPOSAL OF PLASMINE (PLASMINOGEN) OF PROTEIN SOLUTIONS.
JP5037603B2 (en) 2006-04-10 2012-10-03 エシコン・インコーポレイテッド Enhanced absorbent multi-layer hemostatic wound dressing and method of manufacture
GB0623607D0 (en) 2006-11-27 2007-01-03 Haemostatix Ltd Tissue adhesive
EP2269594B1 (en) * 2008-04-16 2016-03-02 The Chemo-Sero-Therapeutic Research Institute Method of producing thrombin-immobilized bioabsorbable sheet preparation
US9827205B2 (en) * 2008-12-12 2017-11-28 Mallinckrodt Pharma Ip Trading D.A.C. Dry powder fibrin sealant
WO2011083154A1 (en) 2010-01-08 2011-07-14 Profibrix Bv Dry powder fibrin sealant
AU2011260258B2 (en) 2010-06-01 2015-07-09 Baxter Healthcare S.A. Process for making dry and stable hemostatic compositions
US8940335B2 (en) * 2010-06-01 2015-01-27 Baxter International Inc. Process for making dry and stable hemostatic compositions
US9212357B2 (en) * 2012-12-03 2015-12-15 Omrix Biopharmaceuticals Ltd. Thrombin solution and methods of use thereof
EA201591657A1 (en) 2013-03-07 2015-12-30 Профибрикс Бв POWDER COMPOSITION
IL229645A0 (en) * 2013-11-26 2014-03-31 Omrix Biopharmaceuticals Ltd Dry pad comprising thrombin and pectin

Also Published As

Publication number Publication date
JP6918799B2 (en) 2021-08-11
EP3386487A1 (en) 2018-10-17
JP2019501893A (en) 2019-01-24
BR112018011504A2 (en) 2018-12-04
KR20180091035A (en) 2018-08-14
AU2016367536B2 (en) 2021-12-02
WO2017098493A1 (en) 2017-06-15
IL259185A (en) 2018-07-31
CN108366967A (en) 2018-08-03
CA3007900A1 (en) 2017-06-15
CN108366967B (en) 2021-03-12
IL259185B (en) 2021-07-29
AU2016367536A1 (en) 2018-05-17

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