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RS61711B1 - Anti-her3 antitelo-lek konjugat - Google Patents

Anti-her3 antitelo-lek konjugat

Info

Publication number
RS61711B1
RS61711B1 RS20210435A RSP20210435A RS61711B1 RS 61711 B1 RS61711 B1 RS 61711B1 RS 20210435 A RS20210435 A RS 20210435A RS P20210435 A RSP20210435 A RS P20210435A RS 61711 B1 RS61711 B1 RS 61711B1
Authority
RS
Serbia
Prior art keywords
drug conjugate
her3 antibody
her3
antibody
conjugate
Prior art date
Application number
RS20210435A
Other languages
English (en)
Inventor
Thore Hettmann
Reimar Abraham
Sabine Blum
Suguru Ueno
Original Assignee
Daiichi Sankyo Co Ltd
Daiichi Sankyo Europe Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53008825&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS61711(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daiichi Sankyo Co Ltd, Daiichi Sankyo Europe Gmbh filed Critical Daiichi Sankyo Co Ltd
Publication of RS61711B1 publication Critical patent/RS61711B1/sr

Links

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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/53751,4-Oxazines, e.g. morpholine
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Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111228510B (zh) * 2013-12-25 2024-06-18 第一三共株式会社 抗trop2抗体-药物偶联物
EP4464707A2 (en) 2014-01-31 2024-11-20 Daiichi Sankyo Company, Limited Anti-her2 antibody-drug conjugate
RS61711B1 (sr) 2014-04-10 2021-05-31 Daiichi Sankyo Co Ltd Anti-her3 antitelo-lek konjugat
CA2990572C (en) 2015-06-29 2022-07-26 Daiichi Sankyo Company, Limited Method for selectively manufacturing antibody-drug conjugate
AU2017359043B2 (en) 2016-11-08 2022-06-16 Regeneron Pharmaceuticals, Inc. Steroids and protein-conjugates thereof
TWI862473B (zh) 2016-12-12 2024-11-21 日商第一三共股份有限公司 抗體-藥物結合物與免疫檢查點抑制劑之組合、以及醫藥組成物之用途
IL268102B2 (en) * 2017-01-17 2024-12-01 Daiichi Sankyo Co Ltd Anti-GPR 20 antibody and anti-GPR 20 antibody-drug conjugate
JP7181181B2 (ja) 2017-02-28 2022-11-30 第一三共株式会社 抗her3抗体-薬物コンジュゲート投与によるegfr-tki抵抗性の非小細胞肺癌の治療方法
TWI855528B (zh) 2017-05-15 2024-09-11 日商第一三共股份有限公司 抗體-藥物結合物之製造方法
WO2018213077A1 (en) 2017-05-18 2018-11-22 Regeneron Pharmaceuticals, Inc. Cyclodextrin protein drug conjugates
KR20200044044A (ko) * 2017-08-23 2020-04-28 다이이찌 산쿄 가부시키가이샤 항체-약물 콘주게이트의 제제 및 그 동결 건조 방법
CA3073924C (en) * 2017-08-31 2023-10-17 Daiichi Sankyo Company, Limited Improved method for producing antibody-drug conjugate
KR102422860B1 (ko) 2017-08-31 2022-07-19 다이이찌 산쿄 가부시키가이샤 항체-약물 콘주게이트의 신규 제조 방법
SG11202004151YA (en) 2017-11-07 2020-06-29 Regeneron Pharma Hydrophilic linkers for antibody drug conjugates
CN109771658B (zh) * 2017-11-14 2021-12-10 博瑞生物医药(苏州)股份有限公司 靶向多臂偶联物
JP7044523B2 (ja) 2017-11-20 2022-03-30 三菱重工サーマルシステムズ株式会社 モータ制御装置及びこれを備えた電動圧縮機、移動体用の空気調和機、モータ制御方法及びモータ制御プログラム
CA3083675A1 (en) 2017-11-30 2019-06-06 Bayer Aktiengesellschaft Ildr2 antagonists and combinations thereof
AU2019205542A1 (en) 2018-01-08 2020-07-16 Regeneron Pharmaceuticals, Inc. Steroids and antibody-conjugates thereof
MX2020010740A (es) * 2018-04-11 2021-01-20 Salubris Biotherapeutics Inc Composiciones de proteina de fusion recombinante neuregulina-1 (nrg-1) humana y metodos para su uso.
JP7590871B2 (ja) 2018-05-09 2024-11-27 レゲネロン ファーマシューティカルス,インコーポレーテッド 抗msr1抗体及びその使用方法
PL3794042T3 (pl) 2018-05-18 2024-06-10 Daiichi Sankyo Co., Ltd. Koniugat przeciwciało-lek przeciwciało skierowane przeciwko muc1 - eksatekan
TWI851577B (zh) 2018-06-07 2024-08-11 美商思進公司 喜樹鹼結合物
EP3828206A4 (en) 2018-07-25 2022-04-20 Daiichi Sankyo Company, Limited METHOD OF PREPARING AN ANTIBODY DRUG CONJUGATE
KR20210040059A (ko) 2018-07-27 2021-04-12 다이이찌 산쿄 가부시키가이샤 항체-약물 콘주게이트의 약물 부위를 인식하는 단백질
TW202415410A (zh) * 2018-07-31 2024-04-16 日商第一三共股份有限公司 抗體-藥物結合物之用途
JP7458981B2 (ja) * 2018-08-06 2024-04-01 第一三共株式会社 抗体-薬物コンジュゲートとチューブリン阻害剤の組み合わせ
CN112739826A (zh) 2018-08-23 2021-04-30 第一三共株式会社 抗体-药物缀合物的敏感性标志物
EP3854418A4 (en) * 2018-09-20 2022-07-27 Daiichi Sankyo Company, Limited Treatment of her3 mutant cancer by administration of anti-her3 antibody-drug conjugate
EP4428142A3 (en) 2018-11-20 2024-11-20 Regeneron Pharmaceuticals, Inc. Bis-octahydrophenanthrene carboxamide derivatives and protein conjugates thereof
CN113271942A (zh) * 2018-12-11 2021-08-17 第一三共株式会社 抗体-药物缀合物与parp抑制剂的组合
SG11202106635WA (en) * 2018-12-21 2021-07-29 Daiichi Sankyo Co Ltd Combination of antibody-drug conjugate and kinase inhibitor
KR20210114008A (ko) * 2019-01-08 2021-09-17 리제너론 파마슈티칼스 인코포레이티드 흔적이 없는 링커 및 이의 단백질-접합체
CN117679532A (zh) * 2019-02-15 2024-03-12 上海药明合联生物技术有限公司 用于制备具有改善的同质性的抗体-药物缀合物的方法
US12109273B2 (en) 2019-02-15 2024-10-08 Wuxi Xdc Singapore Private Limited Process for preparing antibody-drug conjugates with improved homogeneity
DK3946464T3 (da) 2019-03-29 2022-10-31 Medimmune Ltd Forbindelser og konjugater deraf
CN114341162A (zh) * 2019-07-10 2022-04-12 赛博克萨2公司 作为治疗剂的细胞毒素的肽缀合物
PH12022550037A1 (en) 2019-07-10 2023-04-12 Cybrexa 3 Inc Peptide conjugates of microtubule-targeting agents as therapeutics
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
US12029736B2 (en) 2020-02-25 2024-07-09 Mediboston Limited Camptothecin derivatives and conjugates thereof
WO2021260582A1 (en) 2020-06-24 2021-12-30 Astrazeneca Uk Limited Combination of antibody-drug conjugate and aurora b inhibitor
EP4171654A1 (en) 2020-06-24 2023-05-03 AstraZeneca UK Limited Combination of antibody-drug conjugate and cdk9 inhibitor
WO2021260583A1 (en) 2020-06-24 2021-12-30 Astrazeneca Uk Limited Combination of antibody-drug conjugate and dna-pk inhibitor
WO2021260579A1 (en) 2020-06-24 2021-12-30 Astrazeneca Uk Limited Combination of antibody-drug conjugate and atr inhibitor
WO2021260580A1 (en) 2020-06-24 2021-12-30 Astrazeneca Uk Limited Combination of antibody-drug conjugate and atm inhibitor
EP4178559A4 (en) * 2020-07-10 2025-03-05 Velosbio Inc NEW ROR1 ANTIBODY IMMUNOCONJUGATES
CN116390771A (zh) * 2020-07-13 2023-07-04 瑞泽恩制药公司 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途
CN116348115A (zh) 2020-10-09 2023-06-27 阿斯利康(英国)有限公司 抗体-药物缀合物和parp1选择性抑制剂的组合
AU2021360625A1 (en) 2020-10-14 2023-06-01 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Anti-her3 antibody and anti-her3 antibody-drug conjugate and medical use thereof
CN116406379A (zh) 2020-10-22 2023-07-07 瑞泽恩制药公司 抗fgfr2抗体和其使用方法
AU2021378152A1 (en) 2020-11-11 2023-06-22 Daiichi Sankyo Company, Limited COMBINATION OF AN ANTIBODY-DRUG CONJUGATE WITH ANTI-SIRPα ANTIBODY
KR20230107239A (ko) 2020-11-12 2023-07-14 다이이찌 산쿄 가부시키가이샤 항 b7-h3 항체-약물 콘주게이트 투여에 의한 중피종의 치료
KR20230117589A (ko) * 2020-12-04 2023-08-08 상하이 후단-장지앙 바이오-파마슈티컬 컴퍼니 리미티드 항체 약물 접합체, 이의 중간체, 제조 방법 및 용도
CN115279417B (zh) * 2021-02-09 2025-01-03 苏州宜联生物医药有限公司 生物活性物偶联物及其制备方法和用途
US11806405B1 (en) 2021-07-19 2023-11-07 Zeno Management, Inc. Immunoconjugates and methods
CA3238578A1 (en) * 2021-11-17 2023-05-25 Bing Yao Antibody-drug conjugate and use thereof
EP4433172A1 (en) 2021-11-18 2024-09-25 AstraZeneca UK Limited Combination of antibody-drug conjugate and parp1 selective inhibitor
WO2023109965A1 (zh) 2021-12-16 2023-06-22 迈威(上海)生物科技股份有限公司 一种喜树碱类化合物及其偶联物
CA3240724A1 (en) 2021-12-28 2023-07-06 Astrazeneca Uk Limited Combination of antibody-drug conjugate and atr inhibitor
TW202333800A (zh) 2021-12-28 2023-09-01 英商阿斯特捷利康英國股份有限公司 抗體-藥物結合物及rasg12c抑制劑之組合
EP4460330A1 (en) * 2022-01-06 2024-11-13 Virtuoso Binco, Inc. Conjugates, compositions and methods of use
CN118829449A (zh) * 2022-01-12 2024-10-22 瑞泽恩制药公司 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途
CN118829450A (zh) 2022-01-18 2024-10-22 甘李药业股份有限公司 一种依喜替康衍生物-抗体偶联物及其医药用途
KR20240137076A (ko) * 2022-01-25 2024-09-19 메디링크 테라퓨틱스 (쑤저우) 컴퍼니, 리미티드 Her3에 대한 항체, 접합체 및 이의 용도
MX2024009159A (es) * 2022-01-28 2024-08-06 Duality Biologics Suzhou Co Ltd Conjugado anticuerpo-farmaco her3 y uso del mismo.
WO2023165475A1 (zh) * 2022-03-03 2023-09-07 四川科伦博泰生物医药股份有限公司 Her3结合蛋白及其用途
EP4493933A1 (en) 2022-03-16 2025-01-22 AstraZeneca UK Limited A scoring method for an anti-trop2 antibody-drug conjugate therapy
EP4514391A1 (en) 2022-04-27 2025-03-05 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate with ezh1 and/or ezh2 inhibitor
CN119403829A (zh) 2022-05-11 2025-02-07 第一三共株式会社 对于肿瘤抗原特异性的抗体和cd47抑制剂的组合
KR20250020660A (ko) * 2022-06-09 2025-02-11 베이진 엘티디 항체 약물 접합체
CN118955614A (zh) * 2022-07-05 2024-11-15 上海药明合联生物技术有限公司 偶联连接子
WO2024012523A1 (zh) * 2022-07-14 2024-01-18 苏州宜联生物医药有限公司 抗体药物偶联物及其制备方法和用途
AU2023313120A1 (en) 2022-07-28 2025-02-06 Astrazeneca Uk Limited Combination of antibody-drug conjugate and bispecific checkpoint inhibitor
WO2024067811A1 (en) * 2022-09-30 2024-04-04 Beigene, Ltd. Ligand-drug conjugate of exatecan analogue, and medical use thereof
WO2024083166A1 (zh) * 2022-10-19 2024-04-25 普众发现医药科技(上海)有限公司 抗体-药物偶联物及其制备方法和在抗肿瘤中的用途
WO2024088388A1 (en) * 2022-10-28 2024-05-02 Hansoh Bio Llc Ligand-cytotoxicity drug conjugates and pharmaceutical uses thereof
WO2024138000A1 (en) * 2022-12-21 2024-06-27 Regeneron Pharmaceuticals, Inc. Prodrugs of topoisomerase i inhibitor for adc conjugations and methods of use thereof
WO2024215515A1 (en) * 2023-04-14 2024-10-17 Ambrx, Inc. Drug linkers and antibody conjugates thereof
CN119183387A (zh) * 2023-04-23 2024-12-24 石药集团巨石生物制药有限公司 一种抗体偶联药物的用途
WO2024248123A1 (ja) * 2023-06-02 2024-12-05 第一三共株式会社 抗her3抗体-薬物コンジュゲートとrasg12c阻害剤の組み合わせ
CN119490559A (zh) * 2023-08-16 2025-02-21 中山康方生物医药有限公司 化合物以及含有该化合物的抗体偶联药物

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5183884A (en) 1989-12-01 1993-02-02 United States Of America Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
EP0585287B1 (en) 1990-07-10 1999-10-13 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5658920A (en) 1991-01-16 1997-08-19 Daiichi Pharmaceutical Co., Ltd. Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound
JP3008226B2 (ja) 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
CA2119930C (en) 1991-09-23 2002-10-01 Hendricus R. J. M. Hoogenboom Production of chimeric antibodies - a combinatorial approach
DE69233782D1 (de) 1991-12-02 2010-05-20 Medical Res Council Herstellung von Autoantikörpern auf Phagenoberflächen ausgehend von Antikörpersegmentbibliotheken
EP0656941B1 (en) 1992-03-24 2005-06-01 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
JP3359955B2 (ja) 1992-07-16 2002-12-24 第一製薬株式会社 抗腫瘍剤
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
AU690171B2 (en) 1993-12-03 1998-04-23 Medical Research Council Recombinant binding proteins and peptides
JPH08337584A (ja) 1995-04-10 1996-12-24 Dai Ichi Seiyaku Co Ltd 縮合六環式アミノ化合物、これを含有する医薬及びその製法
US6504029B1 (en) 1995-04-10 2003-01-07 Daiichi Pharmaceutical Co., Ltd. Condensed-hexacyclic compounds and a process therefor
SG50747A1 (en) 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
JPH1095802A (ja) 1995-12-28 1998-04-14 Tanabe Seiyaku Co Ltd カンプトテシン誘導体
CA2192725C (en) 1995-12-28 2004-04-20 Kenji Tsujihara Camptothecin derivatives
US5968511A (en) 1996-03-27 1999-10-19 Genentech, Inc. ErbB3 antibodies
TW527183B (en) 1996-06-06 2003-04-11 Daiichi Seiyaku Co Drug complex
TW409058B (en) 1996-06-06 2000-10-21 Daiichi Seiyaku Co Method for preparation of a drug complex
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
JPH1171280A (ja) 1997-06-26 1999-03-16 Tanabe Seiyaku Co Ltd 医薬組成物
JPH1192405A (ja) 1997-09-19 1999-04-06 Dai Ichi Seiyaku Co Ltd 薬物複合体
EP2180007B2 (en) 1998-04-20 2017-08-30 Roche Glycart AG Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
CA2333321A1 (en) 1998-05-22 1999-12-02 Daiichi Pharmaceutical Co., Ltd. Drug complex
CN1661044A (zh) 1998-10-30 2005-08-31 第一制药株式会社 Dds化合物及其测定方法
CA2369292C (en) 1999-04-09 2010-09-21 Kyowa Hakko Kogyo Co. Ltd. Method of modulating the activity of functional immune molecules
US20030086924A1 (en) * 1999-06-25 2003-05-08 Genentech, Inc. Treatment with anti-ErbB2 antibodies
KR20010005238A (ko) 1999-06-30 2001-01-15 윤종용 데이터 리코딩 방법
JP2002060351A (ja) 2000-03-22 2002-02-26 Dai Ichi Seiyaku Co Ltd 水酸基を有する薬物を含むdds化合物
CA2412582A1 (en) 2000-06-29 2002-01-03 Daiichi Pharmaceutical Co., Ltd. Dds compound and process for the preparation thereof
CN1556712A (zh) 2000-07-13 2004-12-22 ��һ��������ҩ��ʽ���� 含dds化合物的药用组合物
MXPA03002974A (es) 2000-10-06 2004-05-05 Kyowa Hakko Kogyo Kk Celulas que producen composiciones de anticuerpo.
EP1283053A1 (en) 2001-08-09 2003-02-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibitors of HER3 activity
CN100506277C (zh) 2001-11-01 2009-07-01 Uab研究基金会 肿瘤坏死因子相关细胞凋亡诱导配体受体的选择性抗体和其它治疗剂的联合体系
AU2002363939A1 (en) 2001-11-20 2003-06-10 Seattle Genetics, Inc. Treatment of immunological disorders using anti-cd30 antibodies
US8877901B2 (en) 2002-12-13 2014-11-04 Immunomedics, Inc. Camptothecin-binding moiety conjugates
US9745380B2 (en) 2002-03-01 2017-08-29 Immunomedics, Inc. RS7 antibodies
JP4959136B2 (ja) 2002-12-13 2012-06-20 イミューノメディクス、インコーポレイテッド 細胞内で開裂可能な結合を有する免疫接合体
US20040202666A1 (en) 2003-01-24 2004-10-14 Immunomedics, Inc. Anti-cancer anthracycline drug-antibody conjugates
JP4942643B2 (ja) 2004-03-02 2012-05-30 シアトル ジェネティックス, インコーポレイテッド 部分的に付加された抗体およびそれらの結合体化方法
JP4806680B2 (ja) 2004-05-19 2011-11-02 メダレックス インコーポレイテッド 自己犠牲リンカー及び薬剤複合体
CA2567520A1 (en) 2004-06-01 2005-12-15 Genentech, Inc. Maytansinoid-antibody conjugates
CA2587589A1 (en) 2004-11-29 2006-06-22 Seattle Genetics, Inc. Engineered antibodies and immunoconjugates
DE102005009099A1 (de) 2005-02-28 2006-08-31 Ktb Tumorforschungsgesellschaft Mbh Proteinbindende Camptothecin-Peptid-Derivate und diese enthaltende Arzneimittel
DE102005009084A1 (de) 2005-02-28 2006-08-31 Ktb Tumorforschungsgesellschaft Mbh Proteinbindende Anthrazyklin-Peptid-Derivate und diese enthaltende Arzneimittel
US7833979B2 (en) 2005-04-22 2010-11-16 Amgen Inc. Toxin peptide therapeutic agents
EP1942944A2 (en) 2005-10-31 2008-07-16 Genentech, Inc. Macrocyclic depsipeptide antibody-drug conjugates and methods
AR056857A1 (es) 2005-12-30 2007-10-24 U3 Pharma Ag Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
PT2032606E (pt) 2006-05-30 2014-02-05 Genentech Inc Anticorpos e imunoconjugados e respetivas utilizações
ZA200809776B (en) 2006-05-30 2010-03-31 Genentech Inc Antibodies and immunoconjugates and uses therefor
SG178789A1 (en) 2007-02-16 2012-03-29 Merrimack Pharmaceuticals Inc Antibodies against erbb3 and uses thereof
NO2281006T3 (sr) 2008-04-30 2017-12-30
EP3470087A1 (en) 2009-02-13 2019-04-17 Immunomedics, Inc. Lyophilised compositions of immunoconjugates with an intracellularly-cleavable linkage
JP2013500253A (ja) 2009-07-22 2013-01-07 エンゾン ファーマシューティカルズ,インコーポレーテッド 7−エチル−10−ヒドロキシカンプトテシンのマルチアーム型ポリマー性複合体と組み合わせたher2受容体拮抗薬を用いるher2陽性がんの治療方法
EP2480230A4 (en) 2009-09-24 2015-06-10 Seattle Genetics Inc DR5 Ligand-HEILMITTELKONJUGATE
MX358013B (es) * 2009-11-13 2018-08-01 Amgen Inc Materiales y metodos para el tratamiento o prevencion de enfermedades asociadas al her-3.
ES2978177T3 (es) 2009-12-02 2024-09-06 Immunomedics Inc Combinación de radio inmunoterapia y conjugados anticuerpo-fármaco para mejorar la terapia contra el cáncer
MX2012013001A (es) 2010-05-13 2013-02-26 Univ Indiana Res & Tech Corp Peptidos de la superfamilia de glucagon que presentan actividad del receptor nuclear de hormonas.
CA2927832C (en) 2010-05-18 2021-03-23 Cerulean Pharma Inc. Cyclodextrin-containing polymer-therapeutic agent conjugates and their use
KR20130050966A (ko) 2010-07-12 2013-05-16 씨오브이엑스 테크놀로지스 아일랜드 리미티드 다기능적 항체 접합체
WO2012019024A2 (en) * 2010-08-04 2012-02-09 Immunogen, Inc. Her3-binding molecules and immunoconjugates thereof
EP2601220A2 (en) 2010-08-06 2013-06-12 U3 Pharma GmbH Use of her3 binding agents in prostate treatment
JP6014596B2 (ja) * 2010-11-09 2016-10-25 メディミューン,エルエルシー 均一コンジュゲーションのための抗体足場
CA2816426A1 (en) 2010-11-17 2012-06-07 Genentech, Inc. Alaninyl maytansinol antibody conjugates
JP5750989B2 (ja) * 2011-04-22 2015-07-22 大同特殊鋼株式会社 丸棒材の超音波探傷方法
MX2014007121A (es) 2011-12-14 2014-09-04 Seattle Genetics Inc Nuevos conjugados de principio activo-ligante (adc) y su uso.
US20130280282A1 (en) * 2012-04-24 2013-10-24 Daiichi Sankyo Co., Ltd. Dr5 ligand drug conjugates
SG11201408347UA (en) 2012-06-14 2015-01-29 Ambrx Inc Anti-psma antibodies conjugated to nuclear receptor ligand polypeptides
SMT202000138T1 (it) * 2012-10-11 2020-05-08 Daiichi Sankyo Co Ltd Raccordi per coniugati anticorpo-farmaco
US9872924B2 (en) 2012-10-19 2018-01-23 Daiichi Sankyo Company, Limited Antibody-drug conjugate produced by binding through linker having hydrophilic structure
US9814784B2 (en) 2013-01-03 2017-11-14 Celltrion, Inc. Antibody-linker-drug conjugate, preparation method therefor, and anticancer drug composition containing same
RS61711B1 (sr) 2014-04-10 2021-05-31 Daiichi Sankyo Co Ltd Anti-her3 antitelo-lek konjugat

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