PT2598533T - Proteínas de fusão de fragmentos de proteínas humanas naturais para criar composições fc de imunoglobulina multimerizada de forma ordenada - Google Patents
Proteínas de fusão de fragmentos de proteínas humanas naturais para criar composições fc de imunoglobulina multimerizada de forma ordenadaInfo
- Publication number
- PT2598533T PT2598533T PT11813204T PT11813204T PT2598533T PT 2598533 T PT2598533 T PT 2598533T PT 11813204 T PT11813204 T PT 11813204T PT 11813204 T PT11813204 T PT 11813204T PT 2598533 T PT2598533 T PT 2598533T
- Authority
- PT
- Portugal
- Prior art keywords
- compositions
- fusion proteins
- human protein
- protein fragments
- natural human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36846510P | 2010-07-28 | 2010-07-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2598533T true PT2598533T (pt) | 2019-05-08 |
Family
ID=45530725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT11813204T PT2598533T (pt) | 2010-07-28 | 2011-07-28 | Proteínas de fusão de fragmentos de proteínas humanas naturais para criar composições fc de imunoglobulina multimerizada de forma ordenada |
Country Status (21)
Country | Link |
---|---|
US (4) | US20130156765A1 (pt) |
EP (2) | EP2598533B1 (pt) |
JP (2) | JP5826270B2 (pt) |
KR (3) | KR20200111213A (pt) |
CN (2) | CN103154036B (pt) |
AR (1) | AR082404A1 (pt) |
AU (1) | AU2011282579B2 (pt) |
BR (1) | BR112013002074B1 (pt) |
CA (2) | CA2902942C (pt) |
DK (1) | DK2598533T3 (pt) |
ES (1) | ES2719623T3 (pt) |
HR (1) | HRP20190652T1 (pt) |
HU (1) | HUE044869T2 (pt) |
IL (3) | IL224427A (pt) |
MX (3) | MX347343B (pt) |
PL (1) | PL2598533T3 (pt) |
PT (1) | PT2598533T (pt) |
SI (1) | SI2598533T1 (pt) |
TR (1) | TR201906652T4 (pt) |
TW (2) | TWI588157B (pt) |
WO (1) | WO2012016073A2 (pt) |
Families Citing this family (30)
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CN107011445B (zh) | 2007-06-01 | 2021-06-29 | 马里兰大学巴尔的摩分校 | 免疫球蛋白恒定区Fc受体结合剂 |
WO2010065578A2 (en) * | 2008-12-04 | 2010-06-10 | Leukosight Inc. | POLYPEPTIDES COMPRISING Fc FRAGMENTS OF IMMUNOGLOBULIN G (IgG) AND METHODS OF USING THE SAME |
PT2598533T (pt) | 2010-07-28 | 2019-05-08 | Gliknik Inc | Proteínas de fusão de fragmentos de proteínas humanas naturais para criar composições fc de imunoglobulina multimerizada de forma ordenada |
US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
KR20150058236A (ko) * | 2012-08-20 | 2015-05-28 | 글리크닉 인코포레이티드 | 항원 결합 및 다가 fc 감마 수용체 결합 활성을 가진 분자 |
US20150218236A1 (en) * | 2012-10-17 | 2015-08-06 | Liverpool School Of Tropical Medicine | Immunomodulatory proteins |
WO2014168715A1 (en) * | 2013-04-08 | 2014-10-16 | R-Pharm Overseas, Inc. | B7 ligands/cd20 inhibitor composition and use thereof |
WO2015069745A2 (en) * | 2013-11-05 | 2015-05-14 | The Board Of Regents Of The University Of Texas System | Tumors expressing igg1 fc induce robust cd8 cell responses |
EP3071599A4 (en) * | 2013-11-18 | 2017-07-12 | University of Maryland, Baltimore | Hyper-glycosylated antibodies with selective fc receptor binding |
KR102452173B1 (ko) * | 2013-12-24 | 2022-10-17 | 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | Fcrn 길항제 및 사용방법 |
CA2935960C (en) | 2014-01-08 | 2023-01-10 | Bart Lipkens | Acoustophoresis device with dual acoustophoretic chamber |
CN106068274A (zh) | 2014-03-05 | 2016-11-02 | Ucb生物制药私人有限公司 | 多聚体Fc蛋白 |
EP3137506B1 (en) | 2014-05-02 | 2023-08-30 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered fc constructs |
EP3265131A1 (en) * | 2015-03-05 | 2018-01-10 | UCB Biopharma SPRL | Polymeric fc proteins and methods of screening to alter their functional characteristics |
US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
JP6937737B2 (ja) | 2015-07-24 | 2021-09-22 | グリックニック インコーポレイテッド | 改良された補体結合を有する高次多量体化免疫グロブリンfc組成物を作製するためのヒトタンパク質断片の融合タンパク質 |
CN109312000A (zh) | 2016-03-30 | 2019-02-05 | Ab生物科学有限公司 | 重组静脉内免疫球蛋白(rIVIG)组合物及其生产和使用方法 |
US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
US11623964B2 (en) | 2016-05-23 | 2023-04-11 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered Fc constructs |
CA3026420A1 (en) | 2016-06-07 | 2017-12-14 | Gliknik Inc. | Cysteine-optimized stradomers |
EP3487534A4 (en) * | 2016-07-22 | 2020-03-25 | Gliknik Inc. | FUSION PROTEINS FROM HUMAN PROTEIN FRAGMENTS FOR THE PRODUCTION OF MULTIMERIZED IMMUNOGLOBULIN FC COMPOSITIONS WITH INCREASED FC RECEPTOR BINDING |
AU2017371182B2 (en) * | 2016-12-09 | 2024-03-28 | Gliknik Inc. | Methods of treating inflammatory disorders with multivalent Fc compounds |
PE20191354A1 (es) * | 2016-12-09 | 2019-10-01 | Gliknik Inc | Optimizacion de fabricacion de gl-2045, un stradomer multimerizante |
CN110650748B (zh) | 2017-01-06 | 2024-01-02 | 动量制药公司 | 与经工程改造的Fc构建体相关的组合物和方法 |
CN112004550A (zh) | 2017-12-14 | 2020-11-27 | 康诺贝林伦瑙有限公司 | 用于治疗视神经脊髓炎的重组IgG Fc多聚体 |
WO2019118921A1 (en) | 2017-12-14 | 2019-06-20 | Flodesign Sonics, Inc. | Acoustic transducer drive and controller |
CN114401985A (zh) | 2019-09-13 | 2022-04-26 | 康诺贝林伦瑙有限公司 | 用于治疗免疫复合物介导的肾病症的重组IgG Fc多聚体 |
AU2021297998A1 (en) * | 2020-06-25 | 2022-12-15 | Gliknik Inc. | ACE2-Fc fusion proteins and methods of use |
KR20230061710A (ko) * | 2021-10-29 | 2023-05-09 | 주식회사 이뮤노로지컬디자이닝랩 | Cadm1을 인식하는 재조합 단백질 및 이를 유효성분으로 포함하는 암의 치료용 약학적 조성물 |
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CN103068399A (zh) | 2010-06-30 | 2013-04-24 | 卡姆普根有限公司 | 用于治疗多发性硬化、类风湿性关节炎以及其他自身免疫病症的c1orf32 |
AU2015200330B2 (en) | 2010-07-28 | 2016-10-27 | Gliknik Inc. | Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin Fc compositions |
PT2598533T (pt) | 2010-07-28 | 2019-05-08 | Gliknik Inc | Proteínas de fusão de fragmentos de proteínas humanas naturais para criar composições fc de imunoglobulina multimerizada de forma ordenada |
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AU2017371182B2 (en) | 2016-12-09 | 2024-03-28 | Gliknik Inc. | Methods of treating inflammatory disorders with multivalent Fc compounds |
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