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PE20191354A1 - Optimizacion de fabricacion de gl-2045, un stradomer multimerizante - Google Patents

Optimizacion de fabricacion de gl-2045, un stradomer multimerizante

Info

Publication number
PE20191354A1
PE20191354A1 PE2019001190A PE2019001190A PE20191354A1 PE 20191354 A1 PE20191354 A1 PE 20191354A1 PE 2019001190 A PE2019001190 A PE 2019001190A PE 2019001190 A PE2019001190 A PE 2019001190A PE 20191354 A1 PE20191354 A1 PE 20191354A1
Authority
PE
Peru
Prior art keywords
diseases
manufacturing optimization
multimerizing stradomer
methods
stradomers
Prior art date
Application number
PE2019001190A
Other languages
English (en)
Inventor
David S Block
Emmanuel Y Merigeon
Henrik Olsen
Original Assignee
Gliknik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gliknik Inc filed Critical Gliknik Inc
Publication of PE20191354A1 publication Critical patent/PE20191354A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)

Abstract

La presente descripcion implica metodos optimizados para la produccion de proteinas biologicamente activas denominadas stradomers elaborados de forma optima. La presente descripcion proporciona ademas composiciones y metodos utiles en el tratamiento de enfermedades y afecciones que incluyen enfermedades autoinmunes, enfermedades inflamatorias o enfermedades infecciosas
PE2019001190A 2016-12-09 2017-12-08 Optimizacion de fabricacion de gl-2045, un stradomer multimerizante PE20191354A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662432402P 2016-12-09 2016-12-09
PCT/US2017/065397 WO2018107079A1 (en) 2016-12-09 2017-12-08 Manufacturing optimization of gl-2045, a multimerizing stradomer

Publications (1)

Publication Number Publication Date
PE20191354A1 true PE20191354A1 (es) 2019-10-01

Family

ID=62491412

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2019001190A PE20191354A1 (es) 2016-12-09 2017-12-08 Optimizacion de fabricacion de gl-2045, un stradomer multimerizante

Country Status (17)

Country Link
US (3) US11155574B2 (es)
EP (1) EP3551647A4 (es)
JP (2) JP2020503855A (es)
KR (2) KR20240162607A (es)
CN (1) CN110177802A (es)
AU (2) AU2017371179B2 (es)
BR (1) BR112019009484A2 (es)
CA (1) CA3043261A1 (es)
CO (1) CO2019005851A2 (es)
IL (2) IL317014A (es)
MX (1) MX2019006573A (es)
MY (1) MY205702A (es)
PE (1) PE20191354A1 (es)
PH (1) PH12019501133A1 (es)
TW (1) TW201835098A (es)
WO (1) WO2018107079A1 (es)
ZA (1) ZA201903157B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20191354A1 (es) 2016-12-09 2019-10-01 Gliknik Inc Optimizacion de fabricacion de gl-2045, un stradomer multimerizante
AU2017371182B2 (en) 2016-12-09 2024-03-28 Gliknik Inc. Methods of treating inflammatory disorders with multivalent Fc compounds

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004781A (en) 1988-01-22 1999-12-21 The General Hospital Corporation Nucleic acid encoding Ig-CD4 fusion proteins
GB8824869D0 (en) 1988-10-24 1988-11-30 Stevenson G T Synthetic antibody
US5681566A (en) 1988-10-24 1997-10-28 3I Research Exploitation Limited Antibody conjugates with two or more covalently linked FC regions
ES2109362T3 (es) 1991-06-21 1998-01-16 Univ Cincinnati Unas proteinas administrables oralmente y metodo para hacerlas.
IL102915A (en) 1992-01-19 2005-12-18 Yeda Res & Dev Soluble ldl receptor and its preparation
JPH08503125A (ja) 1992-08-07 1996-04-09 プロジェニクス・ファーマスーティカルス・インコーポレーテッド 非ペプチジル成分と複合化されたＣＤ４−ガンマ２およびＣＤ４−ＩｇＧ２免疫複合体、並びにその使用
WO1994015640A1 (en) 1993-01-12 1994-07-21 Anthony George Gristina Methods and compositions for the direct concentrated delivery of passive immunity
US5877396A (en) 1993-04-23 1999-03-02 Sloan Kettering Institute For Cancer Research Mice mutant for functional Fc receptors and method of treating autoimmune diseases
US6750334B1 (en) 1996-02-02 2004-06-15 Repligen Corporation CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
US20020147326A1 (en) 1996-06-14 2002-10-10 Smithkline Beecham Corporation Hexameric fusion proteins and uses therefor
EP1082137A4 (en) 1998-05-06 2004-05-19 Univ Temple REVERSE OF PERCENTAL RESPONSE BY INTERRUPTING THE MACROPHAGE RECEPTOR FcSg (g) RI
US7250494B2 (en) 1998-06-15 2007-07-31 Biosynexus Incorporated Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of Gram positive bacteria
EP1105427A2 (en) 1998-08-17 2001-06-13 Abgenix, Inc. Generation of modified molecules with increased serum half-lives
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
ES2391760T3 (es) 2000-01-03 2012-11-29 The Trustees Of The University Of Pennsylvania Proteínas quiméricas novedosas y métodos para usar las mismas
ATE359812T1 (de) 2001-01-12 2007-05-15 Becton Dickinson Co Intrinsische fluoreszierende, selbstmultimerisierende mhc-fusionsproteine und deren komplexe
EP2316951A1 (en) 2001-01-17 2011-05-04 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
PL206701B1 (pl) 2001-03-07 2010-09-30 Merck Patent Gmbh Immunoglobulinowe białko fuzyjne, kodujący je kwas nukleinowy, replikujący wektor ekspresji zawierający taki kwas nukleinowy, eukariotyczna komórka gospodarza zawierająca taki wektor ekspresji oraz sposób zwiększania ekspresji takiego białka fuzyjnego
US7511121B2 (en) 2001-03-09 2009-03-31 Arnason Barry G W Polymeric immunoglobulin fusion proteins that target low-affinity Fcγreceptors
US7282556B2 (en) 2001-05-15 2007-10-16 Emory University Polynucleotides and polypeptides relating to the modulation of SIRPα-CD47
KR100453877B1 (ko) 2001-07-26 2004-10-20 메덱스젠 주식회사 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 ＴＮＦＲ/Ｆｃ 융합 단백질, 상기 단백질을 코딩하는 ＤＮＡ, 상기 ＤＮＡ를 포함하는벡터, 및 상기 벡터에 의한 형질전환체
ATE335770T1 (de) 2001-12-18 2006-09-15 Dow Corning Toray Silicone Photohärtbare organische polymerzusammensetzung
AU2003217912A1 (en) 2002-03-01 2003-09-16 Xencor Antibody optimization
JP2008522583A (ja) 2002-06-14 2008-07-03 セントカー・インコーポレーテツド 修飾“ｓ”抗体
EP2292259A3 (en) 2002-11-15 2011-03-23 MUSC Foundation For Research Development Complement receptor 2 targeted complement modulators
CA2512974A1 (en) 2003-01-13 2004-07-29 Macrogenics, Inc. Soluble fc.gamma.r fusion proteins and methods of use thereof
ATE438662T1 (de) 2003-03-26 2009-08-15 Apogenix Gmbh Verbesserte fc-fusionsproteine
US7348004B2 (en) 2003-05-06 2008-03-25 Syntonix Pharmaceuticals, Inc. Immunoglobulin chimeric monomer-dimer hybrids
EP1635872A4 (en) 2003-05-30 2008-01-02 Alexion Pharma Inc ANTIBODIES AND FUSION PROTEINS COMPRISING MODIFIED CONSTANT REGIONS
WO2005005604A2 (en) 2003-06-30 2005-01-20 Centocor, Inc. Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses
AU2004321500A1 (en) 2003-09-29 2006-05-11 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Immunoglobulins with potent and broad antiviral activity
DK2239273T3 (da) 2003-11-13 2013-12-09 Hanmi Science Co Ltd Farmaceutisk sammensætning, der omfatter en immunoglobulin Fc-region som en bærer
EP1697520A2 (en) 2003-12-22 2006-09-06 Xencor, Inc. Fc polypeptides with novel fc ligand binding sites
WO2005089503A2 (en) 2004-03-19 2005-09-29 Progenics Pharmaceuticals, Inc. Cd4-igg2 formulations
WO2006008739A2 (en) 2004-07-19 2006-01-26 Elutex Ltd. Modified conductive surfaces having active substances attached thereto
WO2006031994A2 (en) 2004-09-14 2006-03-23 Xencor, Inc. Monomeric immunoglobulin fc domains
EP1824979A2 (en) 2004-12-10 2007-08-29 Trigen GmbH Methods, products and uses involving platelets and/or the vasculature
WO2006113889A2 (en) 2005-04-19 2006-10-26 University Of Maryland Compositions and methods for modulating interleukin-10
AU2006244885B2 (en) 2005-05-09 2011-03-31 E. R. Squibb & Sons, L.L.C. Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US7968316B2 (en) 2005-08-16 2011-06-28 Hanmi Holdings Co., Ltd. Method for the mass production of immunoglobulin Fc region deleted initial methionine residues
US7666622B2 (en) 2005-10-19 2010-02-23 Regeneron Pharmaceuticals, Inc. Monomeric self-associating fusion polypeptides and therapeutic uses thereof
EP1991578A2 (en) 2006-02-17 2008-11-19 Rappaport Family Institute For Research in the Medical Sciences Molecules and methods of using same for treating ccr5/ccr5 ligands associated diseases
ES2602439T3 (es) 2006-03-03 2017-02-21 The Chemo-Sero-Therapeutic Research Institute Anticuerpo modificado con bioactividad mejorada
EP3805269A1 (en) 2006-06-12 2021-04-14 Aptevo Research and Development LLC Single-chain multivalent binding proteins with effector function
AT503889B1 (de) 2006-07-05 2011-12-15 Star Biotechnologische Forschungs Und Entwicklungsges M B H F Multivalente immunglobuline
GB0614780D0 (en) 2006-07-25 2006-09-06 Ucb Sa Biological products
US20080260738A1 (en) 2007-04-18 2008-10-23 Moore Margaret D Single chain fc, methods of making and methods of treatment
RS53302B (en) 2007-05-11 2014-08-29 Alexion Pharma Holding BONE-Focused Alkaline Phosphatase, Supplies, and Methods of Use
CN101802197A (zh) 2007-05-14 2010-08-11 比奥根艾迪克Ma公司 单链FC（ScFc）区、包含其的结合多肽及与其相关的方法
AU2008260498B2 (en) 2007-05-30 2012-11-29 Xencor, Inc. Methods and compositions for inhibiting CD32b expressing cells
CN107011445B (zh) 2007-06-01 2021-06-29 马里兰大学巴尔的摩分校 免疫球蛋白恒定区Fc受体结合剂
JP5706688B2 (ja) 2007-06-14 2015-04-22 ギャラクティカ ファーマシューティカルズ， インク． Ｒａｇｅ融合タンパク質
AU2008302111B2 (en) 2007-09-21 2014-04-24 The Regents Of The University Of California Targeted interferon demonstrates potent apoptotic and anti-tumor activities
US20090104210A1 (en) 2007-10-17 2009-04-23 Tota Michael R Peptide compounds for treating obesity and insulin resistance
PL2222697T3 (pl) 2007-11-01 2013-05-31 Astellas Pharma Inc Immunosupresyjne polipeptydy i kwasy nukleinowe
TW201024318A (en) * 2008-10-20 2010-07-01 Abbott Lab Isolation and purification of antibodies using protein A affinity chromatography
WO2010065578A2 (en) 2008-12-04 2010-06-10 Leukosight Inc. POLYPEPTIDES COMPRISING Fc FRAGMENTS OF IMMUNOGLOBULIN G (IgG) AND METHODS OF USING THE SAME
CN105061593B (zh) * 2009-02-19 2018-08-03 葛兰素集团有限公司 改良的抗血清清蛋白结合变体
US20100311116A1 (en) 2009-06-04 2010-12-09 Excellgene Sa Fast generation of high expression stable cell lines expressing recombinant proteins under minimal and short-term selective pressure
KR101808751B1 (ko) 2009-11-13 2017-12-13 그리폴스 테라퓨틱스 인코포레이티드 폰 빌레브란트 인자(ｖＷＦ)-함유 제제, 및 그와 관련된 방법, 키트 및 용도
GB0922209D0 (en) 2009-12-18 2010-02-03 Univ Nottingham Proteins, nucleic acid molecules and compositions
CN103068399A (zh) 2010-06-30 2013-04-24 卡姆普根有限公司 用于治疗多发性硬化、类风湿性关节炎以及其他自身免疫病症的c1orf32
AU2015200330B2 (en) * 2010-07-28 2016-10-27 Gliknik Inc. Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin Fc compositions
PT2598533T (pt) 2010-07-28 2019-05-08 Gliknik Inc Proteínas de fusão de fragmentos de proteínas humanas naturais para criar composições fc de imunoglobulina multimerizada de forma ordenada
JP2015506372A (ja) 2012-01-27 2015-03-02 グリックニック インコーポレイテッド ＩｇＧ２ヒンジドメインを含む融合タンパク質
US9249182B2 (en) * 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
DK2692865T3 (en) * 2012-07-30 2015-02-16 Nbe Therapeutics Llc Transponeringsmedieret identification of specific binding proteins, or functional
KR20150058236A (ko) 2012-08-20 2015-05-28 글리크닉 인코포레이티드 항원 결합 및 다가 fc 감마 수용체 결합 활성을 가진 분자
US20150218236A1 (en) 2012-10-17 2015-08-06 Liverpool School Of Tropical Medicine Immunomodulatory proteins
US20150038682A1 (en) 2013-08-02 2015-02-05 Jn Biosciences Llc Antibodies or fusion proteins multimerized via homomultimerizing peptide
CN106068274A (zh) 2014-03-05 2016-11-02 Ucb生物制药私人有限公司 多聚体Fc蛋白
EP3137506B1 (en) 2014-05-02 2023-08-30 Momenta Pharmaceuticals, Inc. Compositions and methods related to engineered fc constructs
US20180282424A1 (en) * 2014-11-06 2018-10-04 Gliknik Inc. Molecules with bimodal activity depleting target at low dose and increasing immunosuppression at higher dose
WO2016179472A2 (en) 2015-05-07 2016-11-10 University Of Maryland, Baltimore Modulation of natural killer cell tolerance
JP6937737B2 (ja) * 2015-07-24 2021-09-22 グリックニック インコーポレイテッド 改良された補体結合を有する高次多量体化免疫グロブリンｆｃ組成物を作製するためのヒトタンパク質断片の融合タンパク質
PE20190209A1 (es) 2016-04-04 2019-02-07 Bioverativ Usa Inc Anticuerpos anti-factor bb del complemento y uso de estos
CA3026420A1 (en) * 2016-06-07 2017-12-14 Gliknik Inc. Cysteine-optimized stradomers
EP3487534A4 (en) 2016-07-22 2020-03-25 Gliknik Inc. FUSION PROTEINS FROM HUMAN PROTEIN FRAGMENTS FOR THE PRODUCTION OF MULTIMERIZED IMMUNOGLOBULIN FC COMPOSITIONS WITH INCREASED FC RECEPTOR BINDING
AU2017371182B2 (en) 2016-12-09 2024-03-28 Gliknik Inc. Methods of treating inflammatory disorders with multivalent Fc compounds
PE20191354A1 (es) 2016-12-09 2019-10-01 Gliknik Inc Optimizacion de fabricacion de gl-2045, un stradomer multimerizante

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Publication number Publication date
AU2022252699B2 (en) 2024-02-22
JP2020503855A (ja) 2020-02-06
CA3043261A1 (en) 2018-06-14
CO2019005851A2 (es) 2019-06-19
ZA201903157B (en) 2022-12-21
IL266936A (en) 2019-08-29
RU2019120393A (ru) 2021-01-12
EP3551647A4 (en) 2021-01-13
IL317014A (en) 2025-01-01
KR20240162607A (ko) 2024-11-15
BR112019009484A2 (pt) 2019-07-30
AU2017371179B2 (en) 2022-07-14
AU2022252699A1 (en) 2022-11-03
US11155574B2 (en) 2021-10-26
KR20190095929A (ko) 2019-08-16
JP2023052137A (ja) 2023-04-11
TW201835098A (zh) 2018-10-01
EP3551647A1 (en) 2019-10-16
US20200239518A1 (en) 2020-07-30
CN110177802A (zh) 2019-08-27
US20240279273A1 (en) 2024-08-22
US20220204552A1 (en) 2022-06-30
MY205702A (en) 2024-11-07
RU2019120393A3 (es) 2021-05-31
US11795193B2 (en) 2023-10-24
IL266936B1 (en) 2024-12-01
KR102729723B1 (ko) 2024-11-15
WO2018107079A1 (en) 2018-06-14
PH12019501133A1 (en) 2019-08-19
US12195499B2 (en) 2025-01-14
MX2019006573A (es) 2019-11-18
AU2017371179A1 (en) 2019-05-23

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