[go: up one dir, main page]

ATE359812T1 - Intrinsische fluoreszierende, selbstmultimerisierende mhc-fusionsproteine und deren komplexe - Google Patents

Intrinsische fluoreszierende, selbstmultimerisierende mhc-fusionsproteine und deren komplexe

Info

Publication number
ATE359812T1
ATE359812T1 AT02713396T AT02713396T ATE359812T1 AT E359812 T1 ATE359812 T1 AT E359812T1 AT 02713396 T AT02713396 T AT 02713396T AT 02713396 T AT02713396 T AT 02713396T AT E359812 T1 ATE359812 T1 AT E359812T1
Authority
AT
Austria
Prior art keywords
complexes
multimerizing
fusion proteins
mhc fusion
lymphocytes
Prior art date
Application number
AT02713396T
Other languages
English (en)
Inventor
Kenneth A Davis
Bing-Yuan Wei
Original Assignee
Becton Dickinson Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson Co filed Critical Becton Dickinson Co
Application granted granted Critical
Publication of ATE359812T1 publication Critical patent/ATE359812T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT02713396T 2001-01-12 2002-01-11 Intrinsische fluoreszierende, selbstmultimerisierende mhc-fusionsproteine und deren komplexe ATE359812T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26144801P 2001-01-12 2001-01-12

Publications (1)

Publication Number Publication Date
ATE359812T1 true ATE359812T1 (de) 2007-05-15

Family

ID=22993349

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02713396T ATE359812T1 (de) 2001-01-12 2002-01-11 Intrinsische fluoreszierende, selbstmultimerisierende mhc-fusionsproteine und deren komplexe

Country Status (6)

Country Link
US (1) US7202349B2 (de)
EP (1) EP1349569B1 (de)
JP (1) JP2004524019A (de)
AT (1) ATE359812T1 (de)
DE (1) DE60219592T2 (de)
WO (1) WO2002055992A2 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020197651A1 (en) * 2001-06-01 2002-12-26 Ward William W. High throughput screening assays utilizing affinity binding of green fluorescent protein
GB2392158B (en) * 2002-08-21 2005-02-16 Proimmune Ltd Chimeric MHC protein and oligomer thereof
DE10247014A1 (de) * 2002-10-09 2004-04-22 Erfle, Volker, Prof. Priv.-Doz. Dr. MHC-Multimere
US7223560B2 (en) * 2003-02-07 2007-05-29 Academia Sinica Non-lytic baculovirus
US20070178532A1 (en) * 2003-03-24 2007-08-02 The Gov.Of The Us As Represented By The Secretary Identification, quantification, and characterization of t cells and t cell antigens
GB2408507B (en) * 2003-10-06 2005-12-14 Proimmune Ltd Chimeric MHC protein and oligomer thereof for specific targeting
GB2409456B (en) * 2003-10-30 2006-01-04 Proimmune Ltd Oligomeric receptor ligand pair member complexes
WO2005100553A2 (en) * 2004-04-16 2005-10-27 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method for assessment of cytotoxic lymphocyte activity
JP2008035701A (ja) * 2004-11-19 2008-02-21 Cellfree Sciences Co Ltd 無細胞タンパク質合成方法を用いた抗体検出方法及び特定タンパク質のスクリーニング方法
FR2890174B1 (fr) * 2005-08-30 2009-04-24 Cis Bio Internat Sa Procede pour la mise en evidence d'un processus biologique par mesure d'un fret
US20090061478A1 (en) * 2006-01-30 2009-03-05 Lene Have Poulsen High-Speed Quantification of Antigen Specific T-Cells in Whole Blood by Flow Cytometry
EP2361930A3 (de) 2007-03-26 2011-10-26 Dako Denmark A/S Multimere von peptide-mhc komplexen und deren verwendung in borrelia infektionskrankheiten
EP2641913B1 (de) 2007-06-01 2018-04-18 University of Maryland, Baltimore Fc-rezeptor-bindemittel für konstante Immunoglobulinregion
EP3620465B1 (de) * 2007-07-03 2025-02-19 Dako Denmark A/S Verbesserte verfahren zur herstellung, markierung und verwendung von mhc-multimeren
EP2197908A2 (de) 2007-09-27 2010-06-23 Dako Denmark A/S Mhc-multimere in tuberkulose-diagnostika, -impfstoff und therapeutika
US10968269B1 (en) 2008-02-28 2021-04-06 Agilent Technologies, Inc. MHC multimers in borrelia diagnostics and disease
US10722562B2 (en) 2008-07-23 2020-07-28 Immudex Aps Combinatorial analysis and repair
GB0817244D0 (en) * 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
US10369204B2 (en) 2008-10-02 2019-08-06 Dako Denmark A/S Molecular vaccines for infectious disease
MX347343B (es) 2010-07-28 2017-04-21 Gliknik Inc Proteinas de fusion de fragmentos de proteinas humanas naturales para crear composiciones de fc de inmunoglobulinas multimerizadas ordenadamente.
AU2013211824B2 (en) * 2012-01-27 2017-06-01 Gliknik Inc. Fusion proteins comprising IgG2 hinge domains
CN106940268B (zh) 2012-02-23 2021-09-21 朱诺治疗有限公司 细胞和其它复杂生物材料的色谱分离
JP2015527366A (ja) 2012-08-20 2015-09-17 グリックニック インコーポレイテッド 抗原結合および多価ｆｃガンマ受容体結合活性を有する分子
EP3995145B1 (de) 2013-06-24 2024-10-16 NexImmune, Inc. Zusammensetzungen und verfahren für die immuntherapie
US10761085B2 (en) 2014-06-10 2020-09-01 Medical & Biological Laboratories Co., Ltd. Method for determining a protein-protein interaction
IL256879B2 (en) 2015-07-24 2024-05-01 Gliknik Inc Fusion proteins of human protein fragments to create orderly multimerized immunoglobulin fc compositions with enhanced complement binding
RU2761555C2 (ru) 2015-10-22 2021-12-09 Джуно Терапьютикс Гмбх Способы, наборы, средства и устройства для трансдукции
MA45489A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés de culture de cellules, kits et appareil associés
EP3464347B1 (de) 2016-06-07 2023-05-31 Gliknik Inc. Cystein-optimierte stradomere
KR20190093186A (ko) 2016-12-09 2019-08-08 글리크닉 인코포레이티드 다가 Fc 화합물에 의해 염증성 장애를 치료하는 방법
MX2019006573A (es) 2016-12-09 2019-11-18 Gliknik Inc Optimizacion de fabricacion de gl-2045 un stradomer multimerizante.
JP7339160B2 (ja) 2017-04-27 2023-09-05 ジュノ セラピューティクス ゲーエムベーハー オリゴマー粒子試薬およびその使用方法
WO2020028627A1 (en) 2018-08-01 2020-02-06 Regents Of The University Of Minnesota Co-receptor affinity enhanced major histocompatibility class ii molecules
AU2019370705B2 (en) 2018-10-31 2026-01-22 Juno Therapeutics Gmbh Methods for selection and stimulation of cells and apparatus for same
US12258373B2 (en) 2018-12-17 2025-03-25 Immudex Aps Panel comprising Borrelia MHC multimers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902613A (en) * 1984-05-14 1990-02-20 Becton, Dickinson And Company Lysing agent for analysis of peripheral blood cells
US6015844A (en) * 1993-03-22 2000-01-18 Johnson & Johnson Medical, Inc. Composite surgical material
US5635363A (en) * 1995-02-28 1997-06-03 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for the detection, quantitation and purification of antigen-specific T cells
US5804387A (en) * 1996-02-01 1998-09-08 The Board Of Trustees Of The Leland Stanford Junior University FACS-optimized mutants of the green fluorescent protein (GFP)
US6140113A (en) * 1996-03-28 2000-10-31 The Johns Hopkins University Polynucleotides encoding molecular complexes which modify immune responses
CA2250166A1 (en) 1996-03-28 1997-10-02 The Johns Hopkins University Soluble divalent and multivalent heterodimeric analogs of proteins
US6090919A (en) * 1997-01-31 2000-07-18 The Board Of Trustees Of The Leland Stanford Junior University FACS-optimized mutants of the green fluorescent protein (GFP)
US6232445B1 (en) * 1997-10-29 2001-05-15 Sunol Molecular Corporation Soluble MHC complexes and methods of use thereof

Also Published As

Publication number Publication date
DE60219592T2 (de) 2007-12-27
JP2004524019A (ja) 2004-08-12
EP1349569B1 (de) 2007-04-18
US7202349B2 (en) 2007-04-10
DE60219592D1 (de) 2007-05-31
EP1349569A2 (de) 2003-10-08
US20020115157A1 (en) 2002-08-22
WO2002055992A2 (en) 2002-07-18
EP1349569A4 (de) 2005-01-26
WO2002055992A3 (en) 2003-03-27

Similar Documents

Publication Publication Date Title
ATE359812T1 (de) Intrinsische fluoreszierende, selbstmultimerisierende mhc-fusionsproteine und deren komplexe
IL195338A (en) An antibody comprising an FC variant containing amino acid replaces d or e at position 239, a medicament containing it and its use
DE602004013372D1 (de) Il-7-fusionsproteine mit antikörperportionen, deren herstellung und deren verwendung
ATE342923T1 (de) Polyspezifische immunkonjugate und antikörper zusammensetzungen zur zielgerichteten erkennung des multidrug resistenz phenotyps
EP1554311A4 (de) Humanisierte antikörper, die beta amyloid-peptid erkennen
DK0921395T3 (da) Assays til måling af proteinfragmenter i biologiske medier
AU8316701A (en) Anti-dual integrin antibodies, compositions, methods and uses
GR910100453A (el) Ανάλυση και διάταξη συγκολλήσεως στήλης.
BRPI0411854A (pt) veìculos protéicos para vacinas
TR200001313T2 (tr) Protein etkileşimlerini ve fonksiyonel ilişkileri kaydeden tarama sistemleri
ATE468533T1 (de) Enzym-protein-komplex
ATE286073T1 (de) Antikörper gegen spaltprodukte von vimentin
ATE406449T1 (de) Antigene und vektoren für impfung
CY1108288T1 (el) Αντισωματα για το αντιγονο κυτταρων langerhans θηλαστικων και χρησεις τους
DE60222091D1 (de) Dendritische chemilumineszierende Substrate
DE60324003D1 (en) Hcv-test
WO2007014304A3 (en) Antibody profiles characteristic of tuberculosis state
DE60220642D1 (de) Perylenequinone zur anwendung mit immunotherapeutischen mitteln
WO2003017938A3 (en) Conjugates targeted to target receptors
BRPI0412372A (pt) reagentes, métodos e kits para detectar enzimas da alimentação
AU2003256016A1 (en) Differential labeling for quantitative analysis of complex protein mixtures by trifunctional synthetic peptide based reagents with iodoacetamido groups
WO2004087747A3 (en) Citrullinated synthetic peptides and uses thereof
DE69925736D1 (de) Lupus antikoagulant-antikörper gegen die f1 region von prothrombin
EA200600657A1 (ru) Новая комбинация антиатеротромботического средства и средства, предотвращающего агрегацию тромбоцитов
ATE447586T1 (de) Fprl1-liganden und deren verwendung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties