OA13303A - Sustained-release tablet composition of pramipexole. - Google Patents

Sustained-release tablet composition of pramipexole. Download PDF

Info

Publication number: OA13303A
Authority: OA; OAPI
Prior art keywords: composition; tablet; pramipexole; coating; release
Prior art date: 2002-07-25

Application number

OA1200500016A

Other languages

English (en)

Inventor

Gregory E Amidon

Loksidh D Ganorkar

John M Heimlich

Ernest J Lee

Robert M Noack

Joseph P Reo

Connie J Skoug

Original Assignee

Pharmacia Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-25

Filing date

2003-07-25

Publication date

2007-04-13

2003-07-25 Application filed by Pharmacia Corp filed Critical Pharmacia Corp

2007-04-13 Publication of OA13303A publication Critical patent/OA13303A/en

Links

FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical group C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 title claims abstract description 42
229960003089 pramipexole Drugs 0.000 title claims abstract description 35
239000000203 mixture Substances 0.000 title claims description 61
239000007939 sustained release tablet Substances 0.000 title description 17
229920002472 Starch Polymers 0.000 claims abstract description 41
235000019698 starch Nutrition 0.000 claims abstract description 41
239000008107 starch Substances 0.000 claims abstract description 37
239000007787 solid Substances 0.000 claims abstract description 27
229920001477 hydrophilic polymer Polymers 0.000 claims abstract description 15
238000013268 sustained release Methods 0.000 claims abstract description 15
239000012730 sustained-release form Substances 0.000 claims abstract description 15
239000011159 matrix material Substances 0.000 claims abstract description 13
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 8
239000011248 coating agent Substances 0.000 claims description 52
238000000576 coating method Methods 0.000 claims description 52
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 39
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 39
229920000881 Modified starch Polymers 0.000 claims description 33
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 21
229960002652 pramipexole dihydrochloride Drugs 0.000 claims description 17
VQMNWIMYFHHFMC-UHFFFAOYSA-N tert-butyl 4-hydroxyindole-1-carboxylate Chemical group C1=CC=C2N(C(=O)OC(C)(C)C)C=CC2=C1O VQMNWIMYFHHFMC-UHFFFAOYSA-N 0.000 claims description 17
229950010601 pramipexole dihydrochloride monohydrate Drugs 0.000 claims description 13
239000001856 Ethyl cellulose Substances 0.000 claims description 12
229920001249 ethyl cellulose Polymers 0.000 claims description 12
235000019325 ethyl cellulose Nutrition 0.000 claims description 12
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
229940096895 Dopamine D2 receptor agonist Drugs 0.000 claims description 3
229920002125 Sokalan® Polymers 0.000 claims description 3
201000010099 disease Diseases 0.000 claims description 3
239000002288 dopamine 2 receptor stimulating agent Substances 0.000 claims description 3
229920000609 methyl cellulose Polymers 0.000 claims description 3
239000001923 methylcellulose Substances 0.000 claims description 3
235000010981 methylcellulose Nutrition 0.000 claims description 3
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
229960001631 carbomer Drugs 0.000 claims description 2
150000003839 salts Chemical class 0.000 abstract description 4
239000003826 tablet Substances 0.000 description 116
239000000463 material Substances 0.000 description 21
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 16
238000004090 dissolution Methods 0.000 description 16
238000012360 testing method Methods 0.000 description 14
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238000000338 in vitro Methods 0.000 description 13
238000001727 in vivo Methods 0.000 description 13
238000010998 test method Methods 0.000 description 12
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 11
238000000034 method Methods 0.000 description 11
238000011282 treatment Methods 0.000 description 11
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
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238000004458 analytical method Methods 0.000 description 7
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VOJRMYBBPKNLLI-ORHWHDKWSA-N sumanirole maleate Chemical compound OC(=O)\C=C/C(O)=O.C([C@H](C1)NC)C2=CC=CC3=C2N1C(=O)N3 VOJRMYBBPKNLLI-ORHWHDKWSA-N 0.000 description 4
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239000000843 powder Substances 0.000 description 3
229940124597 therapeutic agent Drugs 0.000 description 3
230000001225 therapeutic effect Effects 0.000 description 3
229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
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VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
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APVQOOKHDZVJEX-QTPLPEIMSA-N pramipexole hydrochloride Chemical compound O.Cl.Cl.C1[C@@H](NCCC)CCC2=C1SC(N)=N2 APVQOOKHDZVJEX-QTPLPEIMSA-N 0.000 description 2
238000001812 pycnometry Methods 0.000 description 2
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BIIBYWQGRFWQKM-JVVROLKMSA-N (2S)-N-[4-(cyclopropylamino)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-2-[[(E)-3-(2,4-dichlorophenyl)prop-2-enoyl]amino]-4,4-dimethylpentanamide Chemical compound CC(C)(C)C[C@@H](C(NC(C[C@H](CCN1)C1=O)C(C(NC1CC1)=O)=O)=O)NC(/C=C/C(C=CC(Cl)=C1)=C1Cl)=O BIIBYWQGRFWQKM-JVVROLKMSA-N 0.000 description 1
ZAMLGGRVTAXBHI-UHFFFAOYSA-N 3-(4-bromophenyl)-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Chemical compound CC(C)(C)OC(=O)NC(CC(O)=O)C1=CC=C(Br)C=C1 ZAMLGGRVTAXBHI-UHFFFAOYSA-N 0.000 description 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
229920000945 Amylopectin Polymers 0.000 description 1
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OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
206010013710 Drug interaction Diseases 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
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CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
229920003091 Methocel™ Polymers 0.000 description 1
FASDKYOPVNHBLU-UHFFFAOYSA-N N6-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine Chemical compound C1C(NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-UHFFFAOYSA-N 0.000 description 1
240000007594 Oryza sativa Species 0.000 description 1
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RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
244000061456 Solanum tuberosum Species 0.000 description 1
235000002595 Solanum tuberosum Nutrition 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
241000209140 Triticum Species 0.000 description 1
235000021307 Triticum Nutrition 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 1
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239000011575 calcium Substances 0.000 description 1
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235000019519 canola oil Nutrition 0.000 description 1
239000000828 canola oil Substances 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
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FETSQPAGYOVAQU-UHFFFAOYSA-N glyceryl palmitostearate Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O FETSQPAGYOVAQU-UHFFFAOYSA-N 0.000 description 1
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238000000589 high-performance liquid chromatography-mass spectrometry Methods 0.000 description 1
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QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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XULSCZPZVQIMFM-IPZQJPLYSA-N odevixibat Chemical compound C12=CC(SC)=C(OCC(=O)N[C@@H](C(=O)N[C@@H](CC)C(O)=O)C=3C=CC(O)=CC=3)C=C2S(=O)(=O)NC(CCCC)(CCCC)CN1C1=CC=CC=C1 XULSCZPZVQIMFM-IPZQJPLYSA-N 0.000 description 1
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WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
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125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
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- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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OA1200500016A 2002-07-25 2003-07-25 Sustained-release tablet composition of pramipexole. OA13303A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US39844702P	2002-07-25	2002-07-25
US39842702P	2002-07-25	2002-07-25
US47951303P	2003-06-18	2003-06-18

Publications (1)

Publication Number	Publication Date
OA13303A true OA13303A (en)	2007-04-13

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ID=31192087

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Application Number	Title	Priority Date	Filing Date
OA1200500016A OA13303A (en)	2002-07-25	2003-07-25	Sustained-release tablet composition of pramipexole.

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US (2)	US20050226926A1 (pt)
EP (2)	EP1987832A1 (pt)
JP (1)	JP4700963B2 (pt)
KR (1)	KR100712832B1 (pt)
CN (1)	CN1313092C (pt)
AP (1)	AP2201A (pt)
AR (1)	AR040681A1 (pt)
AT (1)	ATE406162T1 (pt)
AU (1)	AU2003261241B2 (pt)
BR (1)	BR0312960A (pt)
CA (1)	CA2492854C (pt)
CR (1)	CR7661A (pt)
CU (1)	CU23440B7 (pt)
CY (1)	CY1110408T1 (pt)
DE (1)	DE60323235D1 (pt)
DK (1)	DK1531814T3 (pt)
EA (2)	EA200702187A1 (pt)
EC (1)	ECSP055568A (pt)
ES (1)	ES2310673T3 (pt)
GE (1)	GEP20074048B (pt)
HK (1)	HK10777456A1 (pt)
HR (1)	HRP20041235B1 (pt)
IL (1)	IL166078A0 (pt)
IS (1)	IS7623A (pt)
MA (1)	MA27328A1 (pt)
ME (1)	MEP52308A (pt)
MX (1)	MXPA05001054A (pt)
MY (1)	MY138846A (pt)
NO (1)	NO334298B1 (pt)
NZ (1)	NZ537790A (pt)
OA (1)	OA13303A (pt)
PA (1)	PA8578301A1 (pt)
PE (1)	PE20040130A1 (pt)
PL (1)	PL215587B1 (pt)
PT (1)	PT1531814E (pt)
RS (1)	RS51719B (pt)
SI (1)	SI1531814T1 (pt)
TW (1)	TWI347849B (pt)
UY (1)	UY27912A1 (pt)
WO (1)	WO2004010997A1 (pt)
ZA (1)	ZA200500439B (pt)

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- 2003-07-25 KR KR1020057001392A patent/KR100712832B1/ko not_active Expired - Fee Related
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- 2003-07-25 ME MEP-523/08A patent/MEP52308A/xx unknown
- 2003-07-25 DK DK03771807T patent/DK1531814T3/da active
- 2003-07-25 EP EP03771807A patent/EP1531814B1/en not_active Expired - Lifetime
- 2003-07-31 UY UY27912A patent/UY27912A1/es not_active Application Discontinuation
2004
- 2004-12-29 IS IS7623A patent/IS7623A/is unknown
- 2004-12-30 HR HRP20041235AA patent/HRP20041235B1/hr not_active IP Right Cessation
- 2004-12-30 IL IL16607804A patent/IL166078A0/xx unknown
2005
- 2005-01-06 NO NO20050093A patent/NO334298B1/no not_active IP Right Cessation
- 2005-01-17 ZA ZA200500439A patent/ZA200500439B/xx unknown
- 2005-01-24 CR CR7661A patent/CR7661A/es unknown
- 2005-01-24 EC EC2005005568A patent/ECSP055568A/es unknown
- 2005-01-25 CU CU20050018A patent/CU23440B7/es not_active IP Right Cessation
- 2005-01-25 MA MA28066A patent/MA27328A1/fr unknown
- 2005-11-08 HK HK05109947A patent/HK10777456A1/xx unknown
2008
- 2008-10-13 CY CY20081101125T patent/CY1110408T1/el unknown
2010
- 2010-03-03 US US12/716,755 patent/US8399016B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2492854C (en)	2009-10-20
EA200702187A1 (ru)	2008-06-30
IL166078A0 (en)	2006-01-15
AP2201A (en)	2011-01-24
IS7623A (is)	2004-12-29
PT1531814E (pt)	2008-10-29
CY1110408T1 (el)	2015-04-29
WO2004010997A8 (en)	2005-02-24
CN1671382A (zh)	2005-09-21
US20050226926A1 (en)	2005-10-13
EA009663B1 (ru)	2008-02-28
PA8578301A1 (es)	2004-07-20
AU2003261241B2 (en)	2009-06-18
PL375696A1 (en)	2005-12-12
MA27328A1 (fr)	2005-05-02
DE60323235D1 (de)	2008-10-09
BR0312960A (pt)	2005-06-14
DK1531814T3 (da)	2008-10-13
US20100316710A1 (en)	2010-12-16
NO334298B1 (no)	2014-01-27
SI1531814T1 (sl)	2008-12-31
PE20040130A1 (es)	2004-03-06
WO2004010997A1 (en)	2004-02-05
RS20050059A (en)	2007-08-03
AU2003261241A1 (en)	2004-02-16
CR7661A (es)	2005-06-08
CA2492854A1 (en)	2004-02-05
TW200418523A (en)	2004-10-01
EP1531814A1 (en)	2005-05-25
JP4700963B2 (ja)	2011-06-15
PL215587B1 (pl)	2013-12-31
GEP20074048B (en)	2007-02-26
NO20050093L (no)	2005-02-24
MY138846A (en)	2009-07-31
MXPA05001054A (es)	2005-04-08
RS51719B (sr)	2011-10-31
NZ537790A (en)	2005-10-28
EP1531814B1 (en)	2008-08-27
TWI347849B (en)	2011-09-01
US8399016B2 (en)	2013-03-19
ZA200500439B (en)	2006-08-30
ATE406162T1 (de)	2008-09-15
KR100712832B1 (ko)	2007-04-30
MEP52308A (en)	2011-02-10
HK10777456A1 (en)	2007-11-30
CU23440B7 (es)	2009-10-16
AP2005003205A0 (en)	2005-03-31
ES2310673T3 (es)	2009-01-16
HRP20041235B1 (hr)	2013-07-31
HRP20041235A2 (en)	2005-06-30
EP1987832A1 (en)	2008-11-05
JP2005538106A (ja)	2005-12-15
CN1313092C (zh)	2007-05-02
UY27912A1 (es)	2004-02-27
AR040681A1 (es)	2005-04-13
EA200500079A1 (ru)	2005-06-30
ECSP055568A (es)	2005-04-18
KR20050062516A (ko)	2005-06-23