NO328902B1 - Anvendelse av glykosaminoglykaner med en midlere molekylvekt lik 2400D for fremstilling av en farmasoytisk sammensetning for behandling av senil demens - Google Patents

Anvendelse av glykosaminoglykaner med en midlere molekylvekt lik 2400D for fremstilling av en farmasoytisk sammensetning for behandling av senil demens Download PDF

Info

Publication number: NO328902B1
Authority: NO; Norway
Prior art keywords: molecular weight; treatment; glycosaminoglycans; senile dementia; use according
Prior art date: 1999-05-14

Application number

NO20015544A

Other languages

English (en)

Norwegian (no)

Other versions

NO20015544D0 (no

NO20015544L (no

Inventor

Luigi De Ambrosi

Israel Hanin

Jawed Fareed

John Lee

Stanley Lorens

Ronald F Mervis

Original Assignee

Cornelli Umberto

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-14

Filing date

2001-11-13

Publication date

2010-06-14

2001-11-13 Application filed by Cornelli Umberto filed Critical Cornelli Umberto

2001-11-13 Publication of NO20015544D0 publication Critical patent/NO20015544D0/no

2002-01-14 Publication of NO20015544L publication Critical patent/NO20015544L/no

2010-06-14 Publication of NO328902B1 publication Critical patent/NO328902B1/no

Links

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products

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Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
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General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
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Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Polymers & Plastics (AREA)
Neurosurgery (AREA)
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Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
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Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Treatments Of Macromolecular Shaped Articles (AREA)
Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
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NO20015544A 1999-05-14 2001-11-13 Anvendelse av glykosaminoglykaner med en midlere molekylvekt lik 2400D for fremstilling av en farmasoytisk sammensetning for behandling av senil demens NO328902B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1999MI001066A IT1312107B1 (it)	1999-05-14	1999-05-14	Glicosaminoglicani aventi peso molecolare medio di 2400 d atti altrattamento della demenza senile
PCT/EP2000/004311 WO2000069444A1 (en)	1999-05-14	2000-05-12	Glycosaminoglycans having an average molecular weight equal to 2400 d suitable for the treatment of senile dementia

Publications (3)

Publication Number	Publication Date
NO20015544D0 NO20015544D0 (no)	2001-11-13
NO20015544L NO20015544L (no)	2002-01-14
NO328902B1 true NO328902B1 (no)	2010-06-14

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Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20015544A NO328902B1 (no)	1999-05-14	2001-11-13	Anvendelse av glykosaminoglykaner med en midlere molekylvekt lik 2400D for fremstilling av en farmasoytisk sammensetning for behandling av senil demens

Country Status (22)

Country	Link
US (1)	US6979680B1 (zh)
EP (1)	EP1181024B1 (zh)
JP (1)	JP2002544233A (zh)
KR (1)	KR100711142B1 (zh)
CN (1)	CN1178667C (zh)
AT (1)	ATE288761T1 (zh)
AU (1)	AU764743C (zh)
CA (1)	CA2373975A1 (zh)
CZ (1)	CZ20014092A3 (zh)
DE (1)	DE60018061T2 (zh)
DK (1)	DK1181024T3 (zh)
ES (1)	ES2237425T3 (zh)
HK (1)	HK1039903B (zh)
HU (1)	HUP0201100A3 (zh)
IL (1)	IL146458A0 (zh)
IT (1)	IT1312107B1 (zh)
NO (1)	NO328902B1 (zh)
PL (1)	PL198016B1 (zh)
PT (1)	PT1181024E (zh)
RU (1)	RU2248800C2 (zh)
WO (1)	WO2000069444A1 (zh)
ZA (1)	ZA200109331B (zh)

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EP1344781A1 (en)	2002-03-12	2003-09-17	Laboratori Derivati Organici S.P.A.	Process for the depolymerization of glycosaminoglycanes and products obtained therefrom
ITMI20031023A1 (it) *	2003-05-21	2004-11-22	Umberto Cornelli	Glicosaminoglicani aventi peso molecolare medio 2400 d atti al trattamento delle disfunzioni emozionali.
EP1524276A1 (en) *	2003-10-16	2005-04-20	Laboratori Derivati Organici S.P.A.	Multistep process for the physical depolymerization of heparin and products obtained therefrom
US7939512B2 (en)	2004-10-13	2011-05-10	Laboratori Derivati Organici Spa	Multistep process for the physical depolymerization of heparin and products obtained therefrom
CA2634871A1 (en)	2005-12-22	2007-11-08	Neurochem (International) Limited	Treatment of renal disorders, diabetic nephopathy and dyslipidemias
WO2009007224A1 (en) *	2007-07-10	2009-01-15	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Low molecular weight heparin derivatives having neuroprotective activity
EP2283713B1 (en)	2008-05-22	2018-03-28	Vladimir Yegorovich Balakin	Multi-axis charged particle cancer therapy apparatus
US8896239B2 (en)	2008-05-22	2014-11-25	Vladimir Yegorovich Balakin	Charged particle beam injection method and apparatus used in conjunction with a charged particle cancer therapy system
CN102119586B (zh)	2008-05-22	2015-09-02	弗拉迪米尔·叶戈罗维奇·巴拉金	多场带电粒子癌症治疗方法和装置
JP2011523169A (ja)	2008-05-22	2011-08-04	エゴロヴィチバラキン、ウラジミール	荷電粒子癌治療システムと併用する荷電粒子ビーム抽出方法及び装置
WO2009142547A2 (en)	2008-05-22	2009-11-26	Vladimir Yegorovich Balakin	Charged particle beam acceleration method and apparatus as part of a charged particle cancer therapy system
JP2012519532A (ja)	2009-03-04	2012-08-30	ザクリトエアクツィアニェールナエオーブシチェストヴォプロトム	多方向荷電粒子線癌治療方法及び装置
US8609097B2 (en) *	2009-06-10	2013-12-17	Hoffmann-La Roche Inc.	Use of an anti-Tau pS422 antibody for the treatment of brain diseases
EP2766495B1 (en)	2011-10-14	2018-04-04	Centre National De La Recherche Scientifique	Method of diagnosis, prognostic or treatment of neurodegenerative diseases
CN112426434A (zh) *	2020-11-04	2021-03-02	山东大学	硫酸乙酰肝素在防治阿尔兹海默症中的应用
CN114478816A (zh) *	2022-02-11	2022-05-13	上海兴糖生物技术有限公司	一种白玉蜗牛多糖及其制备方法和用途

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US4847338A (en) *	1985-03-28	1989-07-11	University Of Iowa Research Foundation	Low molecular weight heparin fragments as inhibitors of complement activation
DE3789159T2 (de) *	1986-05-01	1994-07-28	Toppan Printing Co Ltd	Vorrichtung zur Simulation der Einstellung eines Abtasters.
IT1213384B (it) *	1986-11-24	1989-12-20	Lab Derivati Organici Mediolan	Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare.
IT1205042B (it) *	1987-05-28	1989-03-10	Crinos Industria Farmaco	Composizione farmaceutica ad attivita' terapeutica per il trattamento della demenza senile di tipo alzheimer
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1999
- 1999-05-14 IT IT1999MI001066A patent/IT1312107B1/it active
2000
- 2000-05-12 JP JP2000617903A patent/JP2002544233A/ja active Pending
- 2000-05-12 PT PT00925281T patent/PT1181024E/pt unknown
- 2000-05-12 CN CNB00807562XA patent/CN1178667C/zh not_active Expired - Fee Related
- 2000-05-12 WO PCT/EP2000/004311 patent/WO2000069444A1/en active IP Right Grant
- 2000-05-12 EP EP00925281A patent/EP1181024B1/en not_active Expired - Lifetime
- 2000-05-12 DE DE60018061T patent/DE60018061T2/de not_active Expired - Fee Related
- 2000-05-12 AT AT00925281T patent/ATE288761T1/de not_active IP Right Cessation
- 2000-05-12 CA CA002373975A patent/CA2373975A1/en not_active Abandoned
- 2000-05-12 DK DK00925281T patent/DK1181024T3/da active
- 2000-05-12 PL PL352070A patent/PL198016B1/pl not_active IP Right Cessation
- 2000-05-12 CZ CZ20014092A patent/CZ20014092A3/cs unknown
- 2000-05-12 US US10/048,542 patent/US6979680B1/en not_active Expired - Fee Related
- 2000-05-12 IL IL14645800A patent/IL146458A0/xx not_active IP Right Cessation
- 2000-05-12 HU HU0201100A patent/HUP0201100A3/hu unknown
- 2000-05-12 RU RU2001130882/14A patent/RU2248800C2/ru not_active IP Right Cessation
- 2000-05-12 AU AU44052/00A patent/AU764743C/en not_active Ceased
- 2000-05-12 KR KR1020017014505A patent/KR100711142B1/ko not_active IP Right Cessation
- 2000-05-12 ES ES00925281T patent/ES2237425T3/es not_active Expired - Lifetime
2001
- 2001-11-13 ZA ZA200109331A patent/ZA200109331B/xx unknown
- 2001-11-13 NO NO20015544A patent/NO328902B1/no not_active IP Right Cessation
2002
- 2002-02-28 HK HK02101550.8A patent/HK1039903B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
RU2248800C2 (ru)	2005-03-27
AU764743C (en)	2004-03-18
CA2373975A1 (en)	2000-11-23
ZA200109331B (en)	2002-08-28
IT1312107B1 (it)	2002-04-04
PT1181024E (pt)	2005-06-30
HUP0201100A2 (hu)	2002-07-29
ATE288761T1 (de)	2005-02-15
KR20020005033A (ko)	2002-01-16
IL146458A0 (en)	2002-07-25
CN1350459A (zh)	2002-05-22
PL198016B1 (pl)	2008-05-30
KR100711142B1 (ko)	2007-04-24
CZ20014092A3 (cs)	2002-04-17
NO20015544D0 (no)	2001-11-13
ES2237425T3 (es)	2005-08-01
HK1039903A1 (en)	2002-05-17
HUP0201100A3 (en)	2003-03-28
CN1178667C (zh)	2004-12-08
NO20015544L (no)	2002-01-14
US6979680B1 (en)	2005-12-27
AU764743B2 (en)	2003-08-28
JP2002544233A (ja)	2002-12-24
DK1181024T3 (da)	2005-06-13
PL352070A1 (en)	2003-07-28
HK1039903B (zh)	2005-08-26
EP1181024B1 (en)	2005-02-09
ITMI991066A1 (it)	2000-11-14
DE60018061T2 (de)	2006-04-13
EP1181024A1 (en)	2002-02-27
DE60018061D1 (de)	2005-03-17
AU4405200A (en)	2000-12-05
WO2000069444A1 (en)	2000-11-23

Publication	Publication Date	Title
NO328902B1 (no)	2010-06-14	Anvendelse av glykosaminoglykaner med en midlere molekylvekt lik 2400D for fremstilling av en farmasoytisk sammensetning for behandling av senil demens
Plant et al.	2001	Inhibitory proteoglycan immunoreactivity is higher at the caudal than the rostral Schwann cell graft-transected spinal cord interface
Landman et al.	1998	Avian amyloidosis
AU634199B2 (en)	1993-02-18	Heparin fragments as inhibitors of smooth muscle cell proliferation
EP0577716A1 (en)	1994-01-12	New non-anticoagulant heparin derivatives
WO2009007224A1 (en)	2009-01-15	Low molecular weight heparin derivatives having neuroprotective activity
US5605891A (en)	1997-02-25	Use of polysaccharides in acute peripheral neuropathies
US6573251B2 (en)	2003-06-03	Drug and pharmaceutical composition for the treatment of lesions of the nervous system and fractions enriched in heparan sulfate
Walzer et al.	2002	Low molecular weight glycosaminoglycan blockade of β-amyloid induced neuropathology
JP2010518251A (ja)	2010-05-27	ビオチンまたはビオチン誘導体との少なくとも１つの共有結合を含むヘパリン、これらの調製方法およびこれらの使用
EP1345612B1 (de)	2005-03-16	Verwendung von niedermolekularen heparin zur behandlung von osteoarthrose
JP4463510B2 (ja)	2010-05-19	グリア瘢痕形成抑制剤
Papakonstantinou et al.	1999	Glycosaminoglycan analysis in brain stems from animals infected with the bovine spongiform encephalopathy agent
JP2010534232A (ja)	2010-11-04	組成物および治療
Cornelli et al.	2002	Historical overview of glycosaminoglycans (GAGs) and their potential value in the treatment of Alzheimer’s disease
Krzywkowski	2007	Céline Morissette, Diane Lacombe, Xianqi Kong, Ahmed Aman, Pascale Krzywkowski, Lioudmila Rodionova, Mounia Azzi, Daniel Delorme, and Barry D. Greenberg
Dudas et al.	2004	Glycosaminoglycans and neuroprotection: effect on cholinergic neurodegeneration
EP0351809A2 (en)	1990-01-24	Blood anticoagulant

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