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NO20092116L - Alfa-substituerte omega-3 lipider som er aktivatorer eller modulatorer for den peroksisom-proliferatoraktiverte reseptoren (PRAR) - Google Patents

Alfa-substituerte omega-3 lipider som er aktivatorer eller modulatorer for den peroksisom-proliferatoraktiverte reseptoren (PRAR)

Info

Publication number
NO20092116L
NO20092116L NO20092116A NO20092116A NO20092116L NO 20092116 L NO20092116 L NO 20092116L NO 20092116 A NO20092116 A NO 20092116A NO 20092116 A NO20092116 A NO 20092116A NO 20092116 L NO20092116 L NO 20092116L
Authority
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Norway
Prior art keywords
group
compounds
prar
activators
modulators
Prior art date
Application number
NO20092116A
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English (en)
Inventor
Morten Bryhn
Anne Kristin Holmeide
Jenny Rosman
Original Assignee
Pronova Biopharma Norge As
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Application filed by Pronova Biopharma Norge As filed Critical Pronova Biopharma Norge As
Publication of NO20092116L publication Critical patent/NO20092116L/no

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/54—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
    • A—HUMAN NECESSITIES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
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    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
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Abstract

Omega-3 lipidforbindelser med den generelle formel (I): (I) der R1 og R2 er like eller forskjellige og kan være valgt fra en gruppe av substituenter bestående av et hydrogenatom, en hydroksygruppe, en alkylgruppe, et halogenatom, en alkoksygruppe, en acyloksygruppe, en acylgruppe, en alkenylgruppe, en alkynylgruppe, en arylgruppe, en alkyltiogruppe, en alkoksykarbonylgruppe, en karboksygruppe, en alkylsulfinylgruppe, en alkylsulfonylgruppe, en aminogruppe og en alkylaminogruppe; X representerer en karboksylsyre eller et derivat derav, et karboksylat, et karboksylsyreanhydrid eller et karboksamid; og Y er et C16 til C22 alken med to eller flere dobbeltbindinger, med E- og/eller Z-konfigurasjon, er beskrevet. Farmasøytiske preparater og lipidpreparater som omfatter slike forbindelser, slike forbindelser for anvendelse som medikamenter, i særdeleshet for behandling av kardiovaskulære og metaboliske sykdommer, er også beskrevet.
NO20092116A 2006-11-01 2009-05-29 Alfa-substituerte omega-3 lipider som er aktivatorer eller modulatorer for den peroksisom-proliferatoraktiverte reseptoren (PRAR) NO20092116L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85573306P 2006-11-01 2006-11-01
SE0602310 2006-11-01
PCT/IB2007/003305 WO2008053331A1 (en) 2006-11-01 2007-11-01 Alpha-substituted omega-3 lipids that are activators or modulators of the peroxisome proliferators-activated receptor (ppar).

Publications (1)

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NO20092116L true NO20092116L (no) 2009-05-29

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Country Status (9)

Country Link
US (1) US8399516B2 (no)
EP (1) EP2094640A4 (no)
JP (1) JP5552313B2 (no)
KR (1) KR101438177B1 (no)
CN (1) CN101535238A (no)
CA (1) CA2667211A1 (no)
MX (1) MX2009004336A (no)
NO (1) NO20092116L (no)
WO (1) WO2008053331A1 (no)

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