NO179911C - Optisk aktivt 5H-pyrrolo[3,4-bÅpyrazinderivat samt farmasöytiske preparater inneholdende derivatet - Google Patents

Optisk aktivt 5H-pyrrolo[3,4-bÅpyrazinderivat samt farmasöytiske preparater inneholdende derivatet

Info

Publication number: NO179911C
Authority: NO; Norway
Prior art keywords: derivative; bpyrazine; pyrrolo; well; optically active
Prior art date: 1991-01-17

Application number

NO931919A

Other languages

English (en)

Norwegian (no)

Other versions

NO179911B (no

NO931919L (no

NO931919D0 (no

Inventor

Claude Cotrel

Gerard Roussel

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-17

Filing date

1993-05-26

Publication date

1997-01-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9408772&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO179911(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-05-26 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1993-05-26 Publication of NO931919L publication Critical patent/NO931919L/no

1993-05-26 Publication of NO931919D0 publication Critical patent/NO931919D0/no

1996-09-30 Publication of NO179911B publication Critical patent/NO179911B/no

1997-01-08 Publication of NO179911C publication Critical patent/NO179911C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

NO931919A 1991-01-17 1993-05-26 Optisk aktivt 5H-pyrrolo[3,4-bÅpyrazinderivat samt farmasöytiske preparater inneholdende derivatet NO179911C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9100490A FR2671800B1 (fr)	1991-01-17	1991-01-17	Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
PCT/FR1992/000031 WO1992012980A1 (fr)	1991-01-17	1992-01-16	DERIVE DE LA 5H-PYRROLO[3,4-b]PYRAZINE OPTIQUEMENT ACTIF, SA PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LE CONTIENNENT

Publications (4)

Publication Number	Publication Date
NO931919L NO931919L (no)	1993-05-26
NO931919D0 NO931919D0 (no)	1993-05-26
NO179911B NO179911B (no)	1996-09-30
NO179911C true NO179911C (no)	1997-01-08

Family

ID=9408772

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO931919A NO179911C (no)	1991-01-17	1993-05-26	Optisk aktivt 5H-pyrrolo[3,4-bÅpyrazinderivat samt farmasöytiske preparater inneholdende derivatet

Country Status (29)

Country	Link
US (5)	US6319926B1 (hu)
EP (2)	EP0495717A1 (hu)
JP (1)	JPH06504548A (hu)
AR (1)	AR248024A1 (hu)
AT (1)	ATE121089T1 (hu)
AU (2)	AU671797B2 (hu)
CA (1)	CA2099782C (hu)
CZ (1)	CZ281011B6 (hu)
DE (1)	DE69202060T2 (hu)
DK (1)	DK0609210T3 (hu)
ES (1)	ES2071486T3 (hu)
FI (1)	FI100331B (hu)
FR (1)	FR2671800B1 (hu)
HU (1)	HU218928B (hu)
IE (1)	IE66110B1 (hu)
IL (1)	IL100677A (hu)
MA (1)	MA22392A1 (hu)
MX (1)	MX9200180A (hu)
NO (1)	NO179911C (hu)
NZ (1)	NZ241313A (hu)
OA (1)	OA09807A (hu)
PH (1)	PH30982A (hu)
PL (1)	PL166976B1 (hu)
RU (1)	RU2110519C1 (hu)
SK (1)	SK279060B6 (hu)
TN (1)	TNSN92004A1 (hu)
WO (1)	WO1992012980A1 (hu)
YU (1)	YU48878B (hu)
ZA (1)	ZA92302B (hu)

Families Citing this family (50)

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FR2671800B1 (fr)	1991-01-17	1993-03-12	Rhone Poulenc Rorer Sa	Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
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US6339086B1 (en) *	1999-05-14	2002-01-15	Swpracor, Inc.	Methods of making and using N-desmethylzopiclone
TW200734460A (en)	1999-10-04	2007-09-16	Ajinomoto Kk	Genes for heat resistant enzymes of amino acid biosynthetic pathway derived from thermophilic coryneform bacteria
ES2515092T3 (es)	2003-12-11	2014-10-29	Sunovion Pharmaceuticals Inc.	Combinación de un sedante y un modulador neurotransmisor y métodos de mejorar la calidad del sueño y de tratar la depresión
US20050215521A1 (en) *	2003-12-22	2005-09-29	Karim Lalji	Modafinil combination therapy for improving sleep quality
CA2551637A1 (en) *	2003-12-24	2005-07-14	Sepracor Inc.	Melatonin combination therapy for improving sleep quality
EP1742624B1 (en) *	2004-02-18	2010-01-06	Sepracor, Inc.	Dopamine-agonist combination therapy with sedatives for improving sleep quality
WO2005097132A2 (en) *	2004-04-05	2005-10-20	Sepracor Inc.	Methods of treatment using eszopiclone
CA2612763A1 (en) *	2005-06-21	2006-12-28	Generics (Uk) Limited	Process for enantiomeric separation of zopiclone
AU2006264317B2 (en)	2005-07-06	2012-02-23	Sunovion Pharmaceuticals Inc.	Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
EP1904046A4 (en) *	2005-07-06	2008-10-01	Sepracor Inc	COMBINATIONS OF ESZOPICLON AND O-DESMETHYLVENLAFAXINE AND METHOD FOR THE TREATMENT OF MENOPAUSE AND HUMOR FLUCTUATIONS; ANXIETY AND COGNITIVE INTERFERENCE
US7476737B2 (en) *	2005-09-05	2009-01-13	Dr. Reddy's Laboratories Limited	Eszopiclone process
US20070098788A1 (en) *	2005-10-28	2007-05-03	Gore Subhash P	Non-benzodiazepine hypnotic compositions
EP1942879A1 (en)	2005-10-31	2008-07-16	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
WO2007083188A2 (en) *	2006-01-17	2007-07-26	Glenmark Pharmaceuticals Limited	Improved process for the preparation of an optically active 5h-pyrrolo [3,4-b] pyrazine derivative
WO2007088073A1 (en) *	2006-02-03	2007-08-09	Synthon B.V.	Zopiclone resolution using l-tartaric acid
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US20070270590A1 (en) *	2006-04-20	2007-11-22	Marioara Mendelovici	Methods for preparing eszopiclone crystalline form a, substantially pure eszopiclone and optically enriched eszopiclone
US20080015197A1 (en) *	2006-06-26	2008-01-17	Alex Mainfeld	Process for the preparatrion of zopiclone
US7786304B2 (en) *	2006-11-06	2010-08-31	Centaur Pharmaceutical Pvt. Ltd.	Process for the preparation of eszopiclone
EP2032557A2 (en) *	2007-01-31	2009-03-11	Teva Pharmaceutical Industries Ltd.	Methods for preparing eszopiclone
ATE515259T1 (de) *	2007-05-29	2011-07-15	Lek Pharmaceuticals	Pharmazeutische zusammensetzung mit eszopiclon
US20080305171A1 (en) *	2007-06-07	2008-12-11	Kristin Anne Arnold	Pyrrolopyrazine, formulations, methods of manufacture, and methods of use there
WO2009002552A1 (en) *	2007-06-25	2008-12-31	Teva Pharmaceutical Industries Ltd.	Racemization process of r-zopiclone
EP2020403A1 (en)	2007-08-02	2009-02-04	Esteve Quimica, S.A.	Process for the resolution of zopiclone and intermediate compounds
US20090198058A1 (en) *	2007-08-06	2009-08-06	Dhananjay Govind Sathe	Process for Preparation of Dextrorotatory Isomer of 6-(5- chloro-pyrid-2-yl)-5-[(4-methyl -1-piperazinyl) carbonyloxy] -7-oxo-6,7-dihydro-5H-pyrrolo [3,4-b] pyrazine (Eszopiclone)
US8198277B2 (en) *	2007-12-19	2012-06-12	Sunovion Pharmaceuticals Inc.	L-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8198278B2 (en) *	2007-12-19	2012-06-12	Sunovion Pharmaceuticals Inc.	Besylate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
CA2812705C (en) *	2007-12-19	2015-08-18	Sunovion Pharmaceuticals Inc.	Maleate, besylate and l-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine
US8212036B2 (en)	2007-12-19	2012-07-03	Sunovion Pharmaceuticals Inc.	Maleate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8269005B2 (en) *	2007-12-19	2012-09-18	Sunovion Pharmaceuticals Inc.	L-malate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-Oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8268832B2 (en) *	2007-12-19	2012-09-18	Sunovion Pharmaceuticals Inc.	Maleate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
CA2747008C (en) *	2007-12-19	2017-12-12	Richard Hsia	Salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine
WO2009101634A2 (en) *	2008-02-13	2009-08-20	Lupin Limited	A novel process for the preparation of eszopiclone
EP2300015A4 (en)	2008-03-12	2011-06-29	Univ Emory	USE OF GABAA RECEPTOR ANTAGONISTS FOR THE TREATMENT OF EXCESSIVE SLIP AND DISEASES RELATED TO EXCESSIVE SLIP
US20090269409A1 (en) *	2008-04-24	2009-10-29	Mukesh Kumar Garg	Pharmaceutical compositions comprising eszopiclone
CN101607961B (zh) *	2008-06-18	2011-08-10	天津天士力集团有限公司	一种右佐匹克隆结晶及其组合物
WO2010052475A1 (en)	2008-11-07	2010-05-14	Cipla Limited	Process for resolving zopiclone
WO2010065547A1 (en) *	2008-12-01	2010-06-10	Map Pharmaceuticals, Inc.	Inhalation delivery methods and devices
WO2010074753A1 (en)	2008-12-23	2010-07-01	Map Pharmaceuticals, Inc.	Inhalation devices and related methods for administration of sedative hypnotic compounds
JP2012516348A (ja)	2009-01-30	2012-07-19	サノビオンファーマシューティカルズインク	６−（５−クロロ−２−ピリジル）−５−［（４−メチル−１−ピペラジニル）カルボニルオキシ］−７−オキソ−６，７−ジヒドロ−５Ｈ−ピロロ［３，４−ｂ］ピラジンの被覆錠剤及びコーティングの効果を測定する方法
WO2010116385A2 (en)	2009-04-08	2010-10-14	Rubicon Research Private Limited	Pharmaceutical compositions for alleviating unpleasant taste
EP2345654A1 (en)	2010-01-05	2011-07-20	LEK Pharmaceuticals d.d.	Eszopiclone particles and a process for their preparation
EP2345655A1 (en)	2010-01-05	2011-07-20	LEK Pharmaceuticals d.d.	A process for racemisation of 6-(5-chloropyridin-2-yl)-7-(4-methyl-1-piperazinyl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
CN103193779B (zh) *	2012-01-05	2016-04-20	成都弘达药业有限公司	一种右佐匹克隆的制备方法
RU2015128794A (ru) *	2012-12-20	2017-01-25	КАШИВ ФАРМА, ЭлЭлСи	Композиция перорально распадающейся таблетки, обеспечивающая повышенную биодоступность
US9636340B2 (en)	2013-11-12	2017-05-02	Ayyappan K. Rajasekaran	Kinase inhibitors
JP2020007252A (ja) *	2018-07-05	2020-01-16	アクティブファーマ株式会社	エスゾピクロンジベンゾイル−ｄ−酒石酸塩の製造方法、エスゾピクロンの製造方法、及びエスゾピクロンジベンゾイル−ｄ−酒石酸塩の結晶

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
OA04285A (fr) *	1972-01-07	1979-12-31	Rhone Poulenc Sa	Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation.
AR208414A1 (es) *	1974-11-07	1976-12-27	Rhone Poulenc Ind	Procedimiento para obtener nuevos derivados de la((acil-4piperazinil-1)carboniloxi-5 pirrolinona-2)
US4962124A (en)	1987-11-17	1990-10-09	Analgesic Associates	Onset-hastened/enhanced antipyretic response
US4868214A (en)	1987-11-17	1989-09-19	Analgesic Associates	Onset-hastened/enhanced analgesia
US5102890A (en)	1989-09-05	1992-04-07	Rhone-Poulenc Sante	Pyrrole derivatives, their preparation and pharmaceutical compositions which contain them
FR2671800B1 (fr)	1991-01-17	1993-03-12	Rhone Poulenc Rorer Sa	Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
US5786357A (en)	1991-12-02	1998-07-28	Sepracor Inc.	Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone
AU3275993A (en)	1991-12-02	1993-06-28	Sepracor, Inc.	Methods and compositions for treating sleep disorders, convulsive seizures, and other disorders using optically pure (-) zopiclone
US5331000A (en)	1992-03-09	1994-07-19	Sepracor Inc.	Antipyretic and analgesic methods and compositions containing optically pure R(-) ketoprofen
US6436926B1 (en) *	1999-05-10	2002-08-20	Medpointe, Inc.	Compositions and methods for treating superficial fungal infections
US7476737B2 (en) *	2005-09-05	2009-01-13	Dr. Reddy's Laboratories Limited	Eszopiclone process
WO2007088073A1 (en) *	2006-02-03	2007-08-09	Synthon B.V.	Zopiclone resolution using l-tartaric acid

1991
- 1991-01-17 FR FR9100490A patent/FR2671800B1/fr not_active Expired - Fee Related
1992
- 1992-01-15 MA MA22677A patent/MA22392A1/fr unknown
- 1992-01-15 ZA ZA92302A patent/ZA92302B/xx unknown
- 1992-01-15 NZ NZ241313A patent/NZ241313A/xx not_active IP Right Cessation
- 1992-01-16 CA CA002099782A patent/CA2099782C/fr not_active Expired - Fee Related
- 1992-01-16 EP EP92400111A patent/EP0495717A1/fr active Pending
- 1992-01-16 IE IE920126A patent/IE66110B1/en not_active IP Right Cessation
- 1992-01-16 CZ CS931380A patent/CZ281011B6/cs not_active IP Right Cessation
- 1992-01-16 IL IL10067792A patent/IL100677A/en not_active IP Right Cessation
- 1992-01-16 MX MX9200180A patent/MX9200180A/es unknown
- 1992-01-16 HU HU9302063A patent/HU218928B/hu unknown
- 1992-01-16 AU AU12264/92A patent/AU671797B2/en not_active Expired
- 1992-01-16 DK DK92903994.9T patent/DK0609210T3/da active
- 1992-01-16 AR AR92321649A patent/AR248024A1/es active
- 1992-01-16 RU RU93051787A patent/RU2110519C1/ru active
- 1992-01-16 JP JP4504006A patent/JPH06504548A/ja active Pending
- 1992-01-16 ES ES92903994T patent/ES2071486T3/es not_active Expired - Lifetime
- 1992-01-16 EP EP92903994A patent/EP0609210B1/fr not_active Expired - Lifetime
- 1992-01-16 PH PH43784A patent/PH30982A/en unknown
- 1992-01-16 AT AT92903994T patent/ATE121089T1/de not_active IP Right Cessation
- 1992-01-16 SK SK719-93A patent/SK279060B6/sk not_active IP Right Cessation
- 1992-01-16 PL PL92299834A patent/PL166976B1/pl unknown
- 1992-01-16 WO PCT/FR1992/000031 patent/WO1992012980A1/fr active IP Right Grant
- 1992-01-16 DE DE69202060T patent/DE69202060T2/de not_active Expired - Lifetime
- 1992-01-17 TN TNTNSN92004A patent/TNSN92004A1/fr unknown
- 1992-01-17 YU YU5592A patent/YU48878B/sh unknown
1993
- 1993-05-26 NO NO931919A patent/NO179911C/no not_active IP Right Cessation
- 1993-06-17 OA OA60387A patent/OA09807A/fr unknown
- 1993-07-16 FI FI933248A patent/FI100331B/fi active
1995
- 1995-08-30 AU AU30321/95A patent/AU3032195A/en not_active Abandoned
1998
- 1998-07-29 US US09/124,651 patent/US6319926B1/en not_active Expired - Fee Related
2000
- 2000-11-28 US US09/722,438 patent/US6444673B1/en not_active Expired - Lifetime
2002
- 2002-07-23 US US10/200,510 patent/US6864257B2/en not_active Expired - Fee Related
2004
- 2004-09-28 US US10/951,844 patent/US7125874B2/en not_active Expired - Fee Related
2006
- 2006-05-03 US US11/416,570 patent/US7381724B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK0609210T3 (da)	1995-07-03
ATE121089T1 (de)	1995-04-15
IE920126A1 (en)	1992-07-29
EP0609210B1 (fr)	1995-04-12
IL100677A (en)	1995-11-27
IL100677A0 (en)	1992-09-06
AU671797B2 (en)	1996-09-12
FR2671800A1 (fr)	1992-07-24
EP0609210A1 (fr)	1994-08-10
NZ241313A (en)	1993-03-26
US20060194806A1 (en)	2006-08-31
EP0609210A4 (fr)	1993-09-17
DE69202060T2 (de)	1995-10-26
CA2099782A1 (fr)	1992-07-18
AU1226492A (en)	1992-08-27
YU5592A (sh)	1994-11-15
YU48878B (sh)	2002-09-19
HU218928B (hu)	2000-12-28
US7381724B2 (en)	2008-06-03
FI100331B (fi)	1997-11-14
US20020193378A1 (en)	2002-12-19
AR248024A1 (es)	1995-05-31
WO1992012980A1 (fr)	1992-08-06
CA2099782C (fr)	2002-12-03
ES2071486T3 (es)	1995-06-16
HUT68915A (en)	1995-08-28
US20050043311A1 (en)	2005-02-24
US7125874B2 (en)	2006-10-24
HU9302063D0 (en)	1993-10-28
JPH06504548A (ja)	1994-05-26
NO179911B (no)	1996-09-30
AU3032195A (en)	1995-11-09
PH30982A (en)	1997-12-23
US6864257B2 (en)	2005-03-08
FI933248A (fi)	1993-07-16
SK279060B6 (sk)	1998-06-03
SK71993A3 (en)	1993-12-08
OA09807A (fr)	1994-04-15
EP0495717A1 (fr)	1992-07-22
ZA92302B (en)	1992-10-28
RU2110519C1 (ru)	1998-05-10
CZ138093A3 (en)	1994-02-16
US6319926B1 (en)	2001-11-20
CZ281011B6 (cs)	1996-05-15
FR2671800B1 (fr)	1993-03-12
PL166976B1 (pl)	1995-07-31
TNSN92004A1 (fr)	1993-06-08
DE69202060D1 (de)	1995-05-18
US6444673B1 (en)	2002-09-03
FI933248A0 (fi)	1993-07-16
IE66110B1 (en)	1995-12-13
MX9200180A (es)	1992-07-01
NO931919L (no)	1993-05-26
MA22392A1 (fr)	1992-10-01
NO931919D0 (no)	1993-05-26

Publication	Publication Date	Title
NO179911C (no)	1997-01-08	Optisk aktivt 5H-pyrrolo[3,4-bÅpyrazinderivat samt farmasöytiske preparater inneholdende derivatet
NO965377D0 (no)	1996-12-13	Indolinonforbindelser samt farmasöytiske preparater inneholdende forbindelsene
DE68911473D1 (de)	1994-01-27	Arzneimittelformulierungen.
MX9102473A (es)	1992-06-01	Agentes farmaceuticos.
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