[go: up one dir, main page]

AR248024A1 - Preparacion del isomero dextrogiro de la (cloro-5 piridil-2)-6 (metil-4 piperazinil-1) carboniloxi-5 oxo-7 hihidro-6, 7 5h-pirrolo ¡3, 4-b¿pirazina, y sus sales farmaceuticamente aceptables. - Google Patents

Preparacion del isomero dextrogiro de la (cloro-5 piridil-2)-6 (metil-4 piperazinil-1) carboniloxi-5 oxo-7 hihidro-6, 7 5h-pirrolo ¡3, 4-b¿pirazina, y sus sales farmaceuticamente aceptables.

Info

Publication number
AR248024A1
AR248024A1 AR92321649A AR32164992A AR248024A1 AR 248024 A1 AR248024 A1 AR 248024A1 AR 92321649 A AR92321649 A AR 92321649A AR 32164992 A AR32164992 A AR 32164992A AR 248024 A1 AR248024 A1 AR 248024A1
Authority
AR
Argentina
Prior art keywords
salt
preparation
dextrogiro
pyrrolo
pyrazine
Prior art date
Application number
AR92321649A
Other languages
English (en)
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9408772&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR248024(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of AR248024A1 publication Critical patent/AR248024A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PREPARACION DEL ISOMERO DEXTROGIRO DE LA (CLORO-5 PIRIDIL-2)-6 (METIL-4 PIPERAZINIL-1) CARBONILOXI-5 OXO-7 DIHIDRO-6, 7 5H-PIRROLO ¡3, 4- B¿PIRAZINA, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, QUE COMPRENDE DESDOBLAR LA (CLORO-5 PIRIDIL-2)-6 (METIL-4 PIPERAZINIL-1)CARBONILOXI-5 OXO 7 DIHIDRO-6, 7 5H-PIRROLO ¡3, 4-B¿PIRAZINA RACEMICA MEDIANTE ACIDO D(+)-0, 0'-DIBENZOILTARTARICO OPERANDOSE EN UNSOLVENTE ORGANICO; AISLAR LA SAL BRUTA; RECRISTALIZARLA DESDE UN SOLVENTE ORGANICO PARA OBTENER LA SAL DEL ISOM-RO DEXTROGIRO; DESDOBLAR LA SAL EN MEDIO ALCALINO Y SEPARAR LA FASE ORGANICA; LAVAR Y SECAR LA FASE ORGANICA; Y PURIFICAR LA FASE ORGANICA POR RECRISTALIZACION EN UN SOLVENTE ORGANICO PARA OBTENER EL ISOMERO DEXTROGIRO PURO, EL CUAL EVENTUALMENTE SE TRANSFORMA EN UNA SAL FARMACEUTICAMENTE ACEPTABLE.
AR92321649A 1991-01-17 1992-01-16 Preparacion del isomero dextrogiro de la (cloro-5 piridil-2)-6 (metil-4 piperazinil-1) carboniloxi-5 oxo-7 hihidro-6, 7 5h-pirrolo ¡3, 4-b¿pirazina, y sus sales farmaceuticamente aceptables. AR248024A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9100490A FR2671800B1 (fr) 1991-01-17 1991-01-17 Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.

Publications (1)

Publication Number Publication Date
AR248024A1 true AR248024A1 (es) 1995-05-31

Family

ID=9408772

Family Applications (1)

Application Number Title Priority Date Filing Date
AR92321649A AR248024A1 (es) 1991-01-17 1992-01-16 Preparacion del isomero dextrogiro de la (cloro-5 piridil-2)-6 (metil-4 piperazinil-1) carboniloxi-5 oxo-7 hihidro-6, 7 5h-pirrolo ¡3, 4-b¿pirazina, y sus sales farmaceuticamente aceptables.

Country Status (29)

Country Link
US (5) US6319926B1 (es)
EP (2) EP0609210B1 (es)
JP (1) JPH06504548A (es)
AR (1) AR248024A1 (es)
AT (1) ATE121089T1 (es)
AU (2) AU671797B2 (es)
CA (1) CA2099782C (es)
CZ (1) CZ281011B6 (es)
DE (1) DE69202060T2 (es)
DK (1) DK0609210T3 (es)
ES (1) ES2071486T3 (es)
FI (1) FI100331B (es)
FR (1) FR2671800B1 (es)
HU (1) HU218928B (es)
IE (1) IE66110B1 (es)
IL (1) IL100677A (es)
MA (1) MA22392A1 (es)
MX (1) MX9200180A (es)
NO (1) NO179911C (es)
NZ (1) NZ241313A (es)
OA (1) OA09807A (es)
PH (1) PH30982A (es)
PL (1) PL166976B1 (es)
RU (1) RU2110519C1 (es)
SK (1) SK279060B6 (es)
TN (1) TNSN92004A1 (es)
WO (1) WO1992012980A1 (es)
YU (1) YU48878B (es)
ZA (1) ZA92302B (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2671800B1 (fr) 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
US5786357A (en) 1991-12-02 1998-07-28 Sepracor Inc. Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone
ES2101653B1 (es) * 1995-07-10 1998-04-01 Asturpharma S A (+)-6-(5-cloropirid-2-il)-7-oxo-viniloxicarboniloxi-5,6-dihidropirrolo(3,4b)pirazina y su uso para un procedimiento de preparacion de (+)-6-(5-cloropirid-2-il)-5-(4-metilpiperazin-1-il)-carboniloxi-7-oxo-5,6-dihidropirrolo(3,4b)pirazina.
US6339086B1 (en) * 1999-05-14 2002-01-15 Swpracor, Inc. Methods of making and using N-desmethylzopiclone
TW200734460A (en) 1999-10-04 2007-09-16 Ajinomoto Kk Genes for heat resistant enzymes of amino acid biosynthetic pathway derived from thermophilic coryneform bacteria
DK1691811T3 (da) * 2003-12-11 2014-10-20 Sunovion Pharmaceuticals Inc Kombination af et sedativ og en neurotransmittermodulator og fremgangsmåder til forbedring af søvnkvaliteten og behandling af depression
WO2005063248A1 (en) * 2003-12-22 2005-07-14 Sepracor Inc. Modafinil combination therapy for improving sleep quality
CA2551637A1 (en) * 2003-12-24 2005-07-14 Sepracor Inc. Melatonin combination therapy for improving sleep quality
DK1742624T3 (da) * 2004-02-18 2010-03-08 Sepracor Inc Dopamin-agonist-kombinationsterapi med sedativer til forbedring af søvnkvalitet
EP1732559B1 (en) * 2004-04-05 2017-03-22 Sunovion Pharmaceuticals Inc. Methods of treatment using eszopiclone
CA2612763A1 (en) * 2005-06-21 2006-12-28 Generics (Uk) Limited Process for enantiomeric separation of zopiclone
CN101257898A (zh) * 2005-07-06 2008-09-03 塞普拉科公司 艾司佐匹克隆与o-去甲基文拉法辛的组合以及治疗绝经期和心境障碍、焦虑症和认知障碍的方法
WO2007006003A2 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
US7476737B2 (en) * 2005-09-05 2009-01-13 Dr. Reddy's Laboratories Limited Eszopiclone process
US20070098788A1 (en) * 2005-10-28 2007-05-03 Gore Subhash P Non-benzodiazepine hypnotic compositions
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
EP1984368A2 (en) * 2006-01-17 2008-10-29 Glenmark Pharmaceuticals Limited Improved process for the preparation of an optically active 5h-pyrrolo [3,4-b]pyrazine derivative
AR059296A1 (es) * 2006-02-03 2008-03-26 Synthon Bv Compuesto de l-tartrato de s-zopiclona y proceso para resolver los enantiomeros de zopiclona.
WO2007109799A2 (en) * 2006-03-23 2007-09-27 Teva Pharmaceutical Industries Ltd. Polymorphs of eszopiclone malate
WO2007124025A2 (en) * 2006-04-20 2007-11-01 Teva Pharmaceutical Industries Ltd. Methods for preparing eszopiclone crystalline form a, substantially pure eszopiclone and optically enriched eszopiclone
WO2008002629A1 (en) * 2006-06-26 2008-01-03 Teva Pharmaceutical Industries Ltd. Process for the preparation of zopiclone
US7786304B2 (en) * 2006-11-06 2010-08-31 Centaur Pharmaceutical Pvt. Ltd. Process for the preparation of eszopiclone
TW200846340A (en) * 2007-01-31 2008-12-01 Teva Pharma Methods for preparing eszopiclone
ATE515259T1 (de) * 2007-05-29 2011-07-15 Lek Pharmaceuticals Pharmazeutische zusammensetzung mit eszopiclon
US20080305171A1 (en) * 2007-06-07 2008-12-11 Kristin Anne Arnold Pyrrolopyrazine, formulations, methods of manufacture, and methods of use there
US20090018336A1 (en) * 2007-06-25 2009-01-15 Nina Finkelstein Racemization process of R-zopiclone
EP2020403A1 (en) 2007-08-02 2009-02-04 Esteve Quimica, S.A. Process for the resolution of zopiclone and intermediate compounds
WO2009063486A2 (en) * 2007-08-06 2009-05-22 Usv Limited Process for preparation of dextrorotatory isomer of 6-(5-chloro-pyrid-2-yi)-5-[(4-methyl -1-piperazinyl) carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo [3,4-b] pyrazine (eszopiclone)
CA2747008C (en) * 2007-12-19 2017-12-12 Richard Hsia Salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine
CA2812705C (en) * 2007-12-19 2015-08-18 Sunovion Pharmaceuticals Inc. Maleate, besylate and l-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine
US8212036B2 (en) 2007-12-19 2012-07-03 Sunovion Pharmaceuticals Inc. Maleate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8268832B2 (en) * 2007-12-19 2012-09-18 Sunovion Pharmaceuticals Inc. Maleate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8269005B2 (en) * 2007-12-19 2012-09-18 Sunovion Pharmaceuticals Inc. L-malate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-Oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8198278B2 (en) * 2007-12-19 2012-06-12 Sunovion Pharmaceuticals Inc. Besylate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8198277B2 (en) 2007-12-19 2012-06-12 Sunovion Pharmaceuticals Inc. L-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
WO2009101634A2 (en) * 2008-02-13 2009-08-20 Lupin Limited A novel process for the preparation of eszopiclone
AU2009223153A1 (en) 2008-03-12 2009-09-17 Emory University Use of GABAa receptor antagonists for the treatment of excessive sleepiness and disorders associated with excessive sleepiness
US20090269409A1 (en) * 2008-04-24 2009-10-29 Mukesh Kumar Garg Pharmaceutical compositions comprising eszopiclone
CN101607961B (zh) * 2008-06-18 2011-08-10 天津天士力集团有限公司 一种右佐匹克隆结晶及其组合物
US8461334B2 (en) 2008-11-07 2013-06-11 Cipla Limited Process for resolving zopiclone
WO2010065547A1 (en) * 2008-12-01 2010-06-10 Map Pharmaceuticals, Inc. Inhalation delivery methods and devices
US8555875B2 (en) * 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
EP3632417A1 (en) 2009-01-30 2020-04-08 Sunovion Pharmaceuticals Inc. Coated tablets of 6-(5-chloro-2-pyridyl) -5-[ (4-methyl-1-piperazinyl) carbonyloxy]-7-oxo-6, 7-dihydro-5h-pyrrolo [3,4-b] pyrazine
WO2010116385A2 (en) 2009-04-08 2010-10-14 Rubicon Research Private Limited Pharmaceutical compositions for alleviating unpleasant taste
EP2345655A1 (en) 2010-01-05 2011-07-20 LEK Pharmaceuticals d.d. A process for racemisation of 6-(5-chloropyridin-2-yl)-7-(4-methyl-1-piperazinyl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
EP2345654A1 (en) 2010-01-05 2011-07-20 LEK Pharmaceuticals d.d. Eszopiclone particles and a process for their preparation
CN103193779B (zh) * 2012-01-05 2016-04-20 成都弘达药业有限公司 一种右佐匹克隆的制备方法
EP2934486A2 (en) * 2012-12-20 2015-10-28 Kashiv Pharma, LLC Orally disintegrating tablet formulation for enhanced bioavailability
US9636340B2 (en) 2013-11-12 2017-05-02 Ayyappan K. Rajasekaran Kinase inhibitors
JP2020007252A (ja) * 2018-07-05 2020-01-16 アクティブファーマ株式会社 エスゾピクロンジベンゾイル−ｄ−酒石酸塩の製造方法、エスゾピクロンの製造方法、及びエスゾピクロンジベンゾイル−ｄ−酒石酸塩の結晶

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2166314A1 (en) * 1972-01-07 1973-08-17 Rhone Poulenc Sa 6-substd 5-(4-methyl 1-piperazinyl)carbonyloxy 7-oxo - 5,6-dihydro-pyrrolo (3,4-b)pyrazines - tranquillizers and anticonvuls
OA04285A (fr) * 1972-01-07 1979-12-31 Rhone Poulenc Sa Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation.
AR208414A1 (es) * 1974-11-07 1976-12-27 Rhone Poulenc Ind Procedimiento para obtener nuevos derivados de la((acil-4piperazinil-1)carboniloxi-5 pirrolinona-2)
US4962124A (en) 1987-11-17 1990-10-09 Analgesic Associates Onset-hastened/enhanced antipyretic response
US4868214A (en) 1987-11-17 1989-09-19 Analgesic Associates Onset-hastened/enhanced analgesia
US5102890A (en) 1989-09-05 1992-04-07 Rhone-Poulenc Sante Pyrrole derivatives, their preparation and pharmaceutical compositions which contain them
FR2671800B1 (fr) 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
US5786357A (en) * 1991-12-02 1998-07-28 Sepracor Inc. Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone
AU3275993A (en) 1991-12-02 1993-06-28 Sepracor, Inc. Methods and compositions for treating sleep disorders, convulsive seizures, and other disorders using optically pure (-) zopiclone
US5331000A (en) 1992-03-09 1994-07-19 Sepracor Inc. Antipyretic and analgesic methods and compositions containing optically pure R(-) ketoprofen
US6436926B1 (en) * 1999-05-10 2002-08-20 Medpointe, Inc. Compositions and methods for treating superficial fungal infections
US7476737B2 (en) * 2005-09-05 2009-01-13 Dr. Reddy's Laboratories Limited Eszopiclone process
AR059296A1 (es) * 2006-02-03 2008-03-26 Synthon Bv Compuesto de l-tartrato de s-zopiclona y proceso para resolver los enantiomeros de zopiclona.

Also Published As

Publication number Publication date
CZ281011B6 (cs) 1996-05-15
WO1992012980A1 (fr) 1992-08-06
IE66110B1 (en) 1995-12-13
TNSN92004A1 (fr) 1993-06-08
HU9302063D0 (en) 1993-10-28
IE920126A1 (en) 1992-07-29
NO931919D0 (no) 1993-05-26
MA22392A1 (fr) 1992-10-01
IL100677A0 (en) 1992-09-06
OA09807A (fr) 1994-04-15
NO931919L (no) 1993-05-26
CA2099782A1 (fr) 1992-07-18
SK71993A3 (en) 1993-12-08
FI100331B (fi) 1997-11-14
YU48878B (sh) 2002-09-19
NO179911C (no) 1997-01-08
US20050043311A1 (en) 2005-02-24
CA2099782C (fr) 2002-12-03
US20020193378A1 (en) 2002-12-19
AU1226492A (en) 1992-08-27
IL100677A (en) 1995-11-27
ES2071486T3 (es) 1995-06-16
US7381724B2 (en) 2008-06-03
HU218928B (hu) 2000-12-28
US6319926B1 (en) 2001-11-20
EP0495717A1 (fr) 1992-07-22
EP0609210B1 (fr) 1995-04-12
DE69202060D1 (de) 1995-05-18
EP0609210A1 (fr) 1994-08-10
AU3032195A (en) 1995-11-09
RU2110519C1 (ru) 1998-05-10
DK0609210T3 (da) 1995-07-03
FR2671800B1 (fr) 1993-03-12
PH30982A (en) 1997-12-23
FR2671800A1 (fr) 1992-07-24
US6444673B1 (en) 2002-09-03
ZA92302B (en) 1992-10-28
SK279060B6 (sk) 1998-06-03
US7125874B2 (en) 2006-10-24
EP0609210A4 (fr) 1993-09-17
MX9200180A (es) 1992-07-01
ATE121089T1 (de) 1995-04-15
NZ241313A (en) 1993-03-26
AU671797B2 (en) 1996-09-12
DE69202060T2 (de) 1995-10-26
JPH06504548A (ja) 1994-05-26
NO179911B (no) 1996-09-30
YU5592A (sh) 1994-11-15
FI933248L (fi) 1993-07-16
US6864257B2 (en) 2005-03-08
CZ138093A3 (en) 1994-02-16
US20060194806A1 (en) 2006-08-31
PL166976B1 (pl) 1995-07-31
HUT68915A (en) 1995-08-28
FI933248A0 (fi) 1993-07-16

Similar Documents

Publication Publication Date Title
AR248024A1 (es) Preparacion del isomero dextrogiro de la (cloro-5 piridil-2)-6 (metil-4 piperazinil-1) carboniloxi-5 oxo-7 hihidro-6, 7 5h-pirrolo ¡3, 4-b¿pirazina, y sus sales farmaceuticamente aceptables.
ES2193142T3 (es) Uso de benzotiofenos para el tratamiento de hipercolesterolemia.
IE820308L (en) Pharmaceutical composition
AR015987A1 (es) DERIVADOS DE PLEUROMUTILINA, COMPOSICIoN FARMACÉUTICA QUE LOS CONTIENE, Y, SU USO PARA LA ELABORACIoN DE UN MEDICAMENTO.
ECSP034563A (es) Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti-inflamatorios y analgesicos
PT100631A (pt) Antagonistas biciclicos de fibrinogenio, seu uso e composicoes farmaceuticas que os contem
ES2183935T3 (es) Isoxazoles sustituidos para el tratamiento de la inflamacion.
DK0440885T3 (da) Blandinger af forbindelser isoleret fra Curcuma Spp. som antiinflammatoriske midler
CO5160323A1 (es) Formulaciones farmaceuticas mejoradas vir en combinacion con otros inhibidores de proteasa vih
ES2104134T3 (es) Mejoras en composiciones para limpieza o relativas a ellas.
AR034370A1 (es) Una preparacion farmaceutica acuosa de cilostazol para uso parenteral
AR017189A1 (es) Antagonistas del receptor de trombina triciclico sustituido, composicion farmaceutica que lo contiene y su uso para la manufactura de un medicamento
MX9306311A (es) Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
LV10446A (lv) Jauni tetrazola atvasinajumi to iegusanas panemiens un farmaceitiskas kompozicijas uz to bazes
AR029758A1 (es) Un derivado del grupo a de las estreptograminas, su preparacion y las composiciones farmaceuticas que los contienen
AR003107A1 (es) Derivados de vitamina d para uso dermatologico, composiciones farmaceuticas que los contienen y procedimiento para la preparacion de dichos derivados.
GT199800203A (es) Compuestos de triazina.
ES2038656T3 (es) Derivados de la tiometilpenicilina substituidos en beta y su preparacion y uso.
DE59209855D1 (de) Fettsäureester, welche einen Pyrimidinring enthalten als Komponenten flüssigkristalliner Gemische
PE20001377A1 (es) Una composicion de alta pureza de (7alfa,17alfa)-17-hidroxi-7-metil-19-nor-17-pregn-5(10)-en-20-in-3-ona
AR053303A1 (es) Derivados de 4-fenil-pirimidina-2-carbonitrilo y su uso en el tratamiento de enfermedades relacionadas con catepsina k y catepsina s
JPS6431727A (en) Dissolution of argininamide and drug composition containing argininamides
MX9301721A (es) Derivados, composiciones de carbinol de bis-arilo sin puente, y metodos de uso.
MX9700497A (es) Derivado de acido trifluorometilquinolinocarboxilico.
AR005820A1 (es) Derivados de heterociclil-ergolina, composicion farmaceutica que los contiene y procedimiento para la preparacion de dichos derivados