ATE121089T1 - Optisch aktives 5h-pyrrolo(3,4-b>pyrazinderivat, seine herstellung und pharmazeutische zubereitungen die es enthalten. - Google Patents

Optisch aktives 5h-pyrrolo(3,4-b>pyrazinderivat, seine herstellung und pharmazeutische zubereitungen die es enthalten.

Info

Publication number: ATE121089T1
Authority: AT; Austria
Prior art keywords: pyrrolo; production; optically active; pharmaceutical preparations; preparations containing
Prior art date: 1991-01-17

Application number

AT92903994T

Other languages

English (en)

Inventor

Claude Cotrel

Gerard Roussel

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-17

Filing date

1992-01-16

Publication date

1995-04-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9408772&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE121089(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-01-16 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1995-04-15 Application granted granted Critical

1995-04-15 Publication of ATE121089T1 publication Critical patent/ATE121089T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT92903994T 1991-01-17 1992-01-16 Optisch aktives 5h-pyrrolo(3,4-b>pyrazinderivat, seine herstellung und pharmazeutische zubereitungen die es enthalten. ATE121089T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9100490A FR2671800B1 (fr)	1991-01-17	1991-01-17	Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.

Publications (1)

Publication Number	Publication Date
ATE121089T1 true ATE121089T1 (de)	1995-04-15

Family

ID=9408772

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92903994T ATE121089T1 (de)	1991-01-17	1992-01-16	Optisch aktives 5h-pyrrolo(3,4-b>pyrazinderivat, seine herstellung und pharmazeutische zubereitungen die es enthalten.

Country Status (29)

Country	Link
US (5)	US6319926B1 (de)
EP (2)	EP0609210B1 (de)
JP (1)	JPH06504548A (de)
AR (1)	AR248024A1 (de)
AT (1)	ATE121089T1 (de)
AU (2)	AU671797B2 (de)
CA (1)	CA2099782C (de)
CZ (1)	CZ281011B6 (de)
DE (1)	DE69202060T2 (de)
DK (1)	DK0609210T3 (de)
ES (1)	ES2071486T3 (de)
FI (1)	FI100331B (de)
FR (1)	FR2671800B1 (de)
HU (1)	HU218928B (de)
IE (1)	IE66110B1 (de)
IL (1)	IL100677A (de)
MA (1)	MA22392A1 (de)
MX (1)	MX9200180A (de)
NO (1)	NO179911C (de)
NZ (1)	NZ241313A (de)
OA (1)	OA09807A (de)
PH (1)	PH30982A (de)
PL (1)	PL166976B1 (de)
RU (1)	RU2110519C1 (de)
SK (1)	SK279060B6 (de)
TN (1)	TNSN92004A1 (de)
WO (1)	WO1992012980A1 (de)
YU (1)	YU48878B (de)
ZA (1)	ZA92302B (de)

Families Citing this family (50)

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FR2671800B1 (fr)	1991-01-17	1993-03-12	Rhone Poulenc Rorer Sa	Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
US5786357A (en)	1991-12-02	1998-07-28	Sepracor Inc.	Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone
ES2101653B1 (es) *	1995-07-10	1998-04-01	Asturpharma S A	(+)-6-(5-cloropirid-2-il)-7-oxo-viniloxicarboniloxi-5,6-dihidropirrolo(3,4b)pirazina y su uso para un procedimiento de preparacion de (+)-6-(5-cloropirid-2-il)-5-(4-metilpiperazin-1-il)-carboniloxi-7-oxo-5,6-dihidropirrolo(3,4b)pirazina.
US6339086B1 (en) *	1999-05-14	2002-01-15	Swpracor, Inc.	Methods of making and using N-desmethylzopiclone
TW200734460A (en)	1999-10-04	2007-09-16	Ajinomoto Kk	Genes for heat resistant enzymes of amino acid biosynthetic pathway derived from thermophilic coryneform bacteria
DK1691811T3 (da) *	2003-12-11	2014-10-20	Sunovion Pharmaceuticals Inc	Kombination af et sedativ og en neurotransmittermodulator og fremgangsmåder til forbedring af søvnkvaliteten og behandling af depression
WO2005063248A1 (en) *	2003-12-22	2005-07-14	Sepracor Inc.	Modafinil combination therapy for improving sleep quality
CA2551637A1 (en) *	2003-12-24	2005-07-14	Sepracor Inc.	Melatonin combination therapy for improving sleep quality
DK1742624T3 (da) *	2004-02-18	2010-03-08	Sepracor Inc	Dopamin-agonist-kombinationsterapi med sedativer til forbedring af søvnkvalitet
EP1732559B1 (de) *	2004-04-05	2017-03-22	Sunovion Pharmaceuticals Inc.	Behandlungsverfahren unter verwendung von eszopiclon
CA2612763A1 (en) *	2005-06-21	2006-12-28	Generics (Uk) Limited	Process for enantiomeric separation of zopiclone
CN101257898A (zh) *	2005-07-06	2008-09-03	塞普拉科公司	艾司佐匹克隆与o-去甲基文拉法辛的组合以及治疗绝经期和心境障碍、焦虑症和认知障碍的方法
WO2007006003A2 (en)	2005-07-06	2007-01-11	Sepracor Inc.	Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
US7476737B2 (en) *	2005-09-05	2009-01-13	Dr. Reddy's Laboratories Limited	Eszopiclone process
US20070098788A1 (en) *	2005-10-28	2007-05-03	Gore Subhash P	Non-benzodiazepine hypnotic compositions
JP2009513672A (ja)	2005-10-31	2009-04-02	ブレインセルス，インコーポレイティド	神経発生のｇａｂａ受容体媒介調節
EP1984368A2 (de) *	2006-01-17	2008-10-29	Glenmark Pharmaceuticals Limited	Verbessertes verfahren zur herstellung eines optisch aktiven 5h-pyrrolo[3,4-b)pyrazinderivats
AR059296A1 (es) *	2006-02-03	2008-03-26	Synthon Bv	Compuesto de l-tartrato de s-zopiclona y proceso para resolver los enantiomeros de zopiclona.
WO2007109799A2 (en) *	2006-03-23	2007-09-27	Teva Pharmaceutical Industries Ltd.	Polymorphs of eszopiclone malate
WO2007124025A2 (en) *	2006-04-20	2007-11-01	Teva Pharmaceutical Industries Ltd.	Methods for preparing eszopiclone crystalline form a, substantially pure eszopiclone and optically enriched eszopiclone
WO2008002629A1 (en) *	2006-06-26	2008-01-03	Teva Pharmaceutical Industries Ltd.	Process for the preparation of zopiclone
US7786304B2 (en) *	2006-11-06	2010-08-31	Centaur Pharmaceutical Pvt. Ltd.	Process for the preparation of eszopiclone
TW200846340A (en) *	2007-01-31	2008-12-01	Teva Pharma	Methods for preparing eszopiclone
ATE515259T1 (de) *	2007-05-29	2011-07-15	Lek Pharmaceuticals	Pharmazeutische zusammensetzung mit eszopiclon
US20080305171A1 (en) *	2007-06-07	2008-12-11	Kristin Anne Arnold	Pyrrolopyrazine, formulations, methods of manufacture, and methods of use there
US20090018336A1 (en) *	2007-06-25	2009-01-15	Nina Finkelstein	Racemization process of R-zopiclone
EP2020403A1 (de)	2007-08-02	2009-02-04	Esteve Quimica, S.A.	Verfahren zur Auflösung von Zopiclon und Zwischenprodukten
WO2009063486A2 (en) *	2007-08-06	2009-05-22	Usv Limited	Process for preparation of dextrorotatory isomer of 6-(5-chloro-pyrid-2-yi)-5-[(4-methyl -1-piperazinyl) carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo [3,4-b] pyrazine (eszopiclone)
CA2747008C (en) *	2007-12-19	2017-12-12	Richard Hsia	Salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine
CA2812705C (en) *	2007-12-19	2015-08-18	Sunovion Pharmaceuticals Inc.	Maleate, besylate and l-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine
US8212036B2 (en)	2007-12-19	2012-07-03	Sunovion Pharmaceuticals Inc.	Maleate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8268832B2 (en) *	2007-12-19	2012-09-18	Sunovion Pharmaceuticals Inc.	Maleate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8269005B2 (en) *	2007-12-19	2012-09-18	Sunovion Pharmaceuticals Inc.	L-malate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-Oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8198278B2 (en) *	2007-12-19	2012-06-12	Sunovion Pharmaceuticals Inc.	Besylate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8198277B2 (en)	2007-12-19	2012-06-12	Sunovion Pharmaceuticals Inc.	L-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
WO2009101634A2 (en) *	2008-02-13	2009-08-20	Lupin Limited	A novel process for the preparation of eszopiclone
AU2009223153A1 (en)	2008-03-12	2009-09-17	Emory University	Use of GABAa receptor antagonists for the treatment of excessive sleepiness and disorders associated with excessive sleepiness
US20090269409A1 (en) *	2008-04-24	2009-10-29	Mukesh Kumar Garg	Pharmaceutical compositions comprising eszopiclone
CN101607961B (zh) *	2008-06-18	2011-08-10	天津天士力集团有限公司	一种右佐匹克隆结晶及其组合物
US8461334B2 (en)	2008-11-07	2013-06-11	Cipla Limited	Process for resolving zopiclone
WO2010065547A1 (en) *	2008-12-01	2010-06-10	Map Pharmaceuticals, Inc.	Inhalation delivery methods and devices
US8555875B2 (en) *	2008-12-23	2013-10-15	Map Pharmaceuticals, Inc.	Inhalation devices and related methods for administration of sedative hypnotic compounds
EP3632417A1 (de)	2009-01-30	2020-04-08	Sunovion Pharmaceuticals Inc.	Dragees mit 6-(5-chloro-2-pyridyl) -5-[ (4-methyl-1-piperazinyl) carbonyloxy]-7-oxo-6, 7-dihydro-5h-pyrrolo [3,4-b] pyrazin
WO2010116385A2 (en)	2009-04-08	2010-10-14	Rubicon Research Private Limited	Pharmaceutical compositions for alleviating unpleasant taste
EP2345655A1 (de)	2010-01-05	2011-07-20	LEK Pharmaceuticals d.d.	Verfahren zur Racemisierung von 6-(5-Chlorpyridin-2-yl)-7-(4-methyl-1-piperazinyl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin
EP2345654A1 (de)	2010-01-05	2011-07-20	LEK Pharmaceuticals d.d.	Eszopiclon-Teilchen und Verfahren zu deren Herstellung
CN103193779B (zh) *	2012-01-05	2016-04-20	成都弘达药业有限公司	一种右佐匹克隆的制备方法
EP2934486A2 (de) *	2012-12-20	2015-10-28	Kashiv Pharma, LLC	Schmelztablettenformulierung zur erhöhten bioverfügbarkeit
US9636340B2 (en)	2013-11-12	2017-05-02	Ayyappan K. Rajasekaran	Kinase inhibitors
JP2020007252A (ja) *	2018-07-05	2020-01-16	アクティブファーマ株式会社	エスゾピクロンジベンゾイル−ｄ−酒石酸塩の製造方法、エスゾピクロンの製造方法、及びエスゾピクロンジベンゾイル−ｄ−酒石酸塩の結晶

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FR2671800B1 (fr)	1991-01-17	1993-03-12	Rhone Poulenc Rorer Sa	Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
US5786357A (en) *	1991-12-02	1998-07-28	Sepracor Inc.	Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone
AU3275993A (en)	1991-12-02	1993-06-28	Sepracor, Inc.	Methods and compositions for treating sleep disorders, convulsive seizures, and other disorders using optically pure (-) zopiclone
US5331000A (en)	1992-03-09	1994-07-19	Sepracor Inc.	Antipyretic and analgesic methods and compositions containing optically pure R(-) ketoprofen
US6436926B1 (en) *	1999-05-10	2002-08-20	Medpointe, Inc.	Compositions and methods for treating superficial fungal infections
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AR059296A1 (es) *	2006-02-03	2008-03-26	Synthon Bv	Compuesto de l-tartrato de s-zopiclona y proceso para resolver los enantiomeros de zopiclona.

1991
- 1991-01-17 FR FR9100490A patent/FR2671800B1/fr not_active Expired - Fee Related
1992
- 1992-01-15 NZ NZ241313A patent/NZ241313A/xx not_active IP Right Cessation
- 1992-01-15 MA MA22677A patent/MA22392A1/fr unknown
- 1992-01-15 ZA ZA92302A patent/ZA92302B/xx unknown
- 1992-01-16 HU HU9302063A patent/HU218928B/hu unknown
- 1992-01-16 CZ CS931380A patent/CZ281011B6/cs not_active IP Right Cessation
- 1992-01-16 DE DE69202060T patent/DE69202060T2/de not_active Expired - Lifetime
- 1992-01-16 DK DK92903994.9T patent/DK0609210T3/da active
- 1992-01-16 ES ES92903994T patent/ES2071486T3/es not_active Expired - Lifetime
- 1992-01-16 JP JP4504006A patent/JPH06504548A/ja active Pending
- 1992-01-16 PH PH43784A patent/PH30982A/en unknown
- 1992-01-16 EP EP92903994A patent/EP0609210B1/de not_active Expired - Lifetime
- 1992-01-16 IL IL10067792A patent/IL100677A/en not_active IP Right Cessation
- 1992-01-16 AR AR92321649A patent/AR248024A1/es active
- 1992-01-16 AT AT92903994T patent/ATE121089T1/de not_active IP Right Cessation
- 1992-01-16 AU AU12264/92A patent/AU671797B2/en not_active Expired
- 1992-01-16 WO PCT/FR1992/000031 patent/WO1992012980A1/fr not_active Ceased
- 1992-01-16 SK SK719-93A patent/SK279060B6/sk not_active IP Right Cessation
- 1992-01-16 RU RU93051787A patent/RU2110519C1/ru active
- 1992-01-16 MX MX9200180A patent/MX9200180A/es unknown
- 1992-01-16 IE IE920126A patent/IE66110B1/en not_active IP Right Cessation
- 1992-01-16 PL PL92299834A patent/PL166976B1/pl unknown
- 1992-01-16 EP EP92400111A patent/EP0495717A1/de active Pending
- 1992-01-16 CA CA002099782A patent/CA2099782C/fr not_active Expired - Fee Related
- 1992-01-17 YU YU5592A patent/YU48878B/sh unknown
- 1992-01-17 TN TNTNSN92004A patent/TNSN92004A1/fr unknown
1993
- 1993-05-26 NO NO931919A patent/NO179911C/no not_active IP Right Cessation
- 1993-06-17 OA OA60387A patent/OA09807A/fr unknown
- 1993-07-16 FI FI933248A patent/FI100331B/fi active
1995
- 1995-08-30 AU AU30321/95A patent/AU3032195A/en not_active Abandoned
1998
- 1998-07-29 US US09/124,651 patent/US6319926B1/en not_active Expired - Fee Related
2000
- 2000-11-28 US US09/722,438 patent/US6444673B1/en not_active Expired - Lifetime
2002
- 2002-07-23 US US10/200,510 patent/US6864257B2/en not_active Expired - Fee Related
2004
- 2004-09-28 US US10/951,844 patent/US7125874B2/en not_active Expired - Fee Related
2006
- 2006-05-03 US US11/416,570 patent/US7381724B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CZ281011B6 (cs)	1996-05-15
WO1992012980A1 (fr)	1992-08-06
IE66110B1 (en)	1995-12-13
TNSN92004A1 (fr)	1993-06-08
HU9302063D0 (en)	1993-10-28
IE920126A1 (en)	1992-07-29
NO931919D0 (no)	1993-05-26
MA22392A1 (fr)	1992-10-01
IL100677A0 (en)	1992-09-06
OA09807A (fr)	1994-04-15
NO931919L (no)	1993-05-26
CA2099782A1 (fr)	1992-07-18
SK71993A3 (en)	1993-12-08
FI100331B (fi)	1997-11-14
YU48878B (sh)	2002-09-19
NO179911C (no)	1997-01-08
US20050043311A1 (en)	2005-02-24
CA2099782C (fr)	2002-12-03
US20020193378A1 (en)	2002-12-19
AU1226492A (en)	1992-08-27
IL100677A (en)	1995-11-27
ES2071486T3 (es)	1995-06-16
US7381724B2 (en)	2008-06-03
HU218928B (hu)	2000-12-28
US6319926B1 (en)	2001-11-20
EP0495717A1 (de)	1992-07-22
EP0609210B1 (de)	1995-04-12
DE69202060D1 (de)	1995-05-18
AR248024A1 (es)	1995-05-31
EP0609210A1 (de)	1994-08-10
AU3032195A (en)	1995-11-09
RU2110519C1 (ru)	1998-05-10
DK0609210T3 (da)	1995-07-03
FR2671800B1 (fr)	1993-03-12
PH30982A (en)	1997-12-23
FR2671800A1 (fr)	1992-07-24
US6444673B1 (en)	2002-09-03
ZA92302B (en)	1992-10-28
SK279060B6 (sk)	1998-06-03
US7125874B2 (en)	2006-10-24
EP0609210A4 (de)	1993-09-17
MX9200180A (es)	1992-07-01
NZ241313A (en)	1993-03-26
AU671797B2 (en)	1996-09-12
DE69202060T2 (de)	1995-10-26
JPH06504548A (ja)	1994-05-26
NO179911B (no)	1996-09-30
YU5592A (sh)	1994-11-15
FI933248L (fi)	1993-07-16
US6864257B2 (en)	2005-03-08
CZ138093A3 (en)	1994-02-16
US20060194806A1 (en)	2006-08-31
PL166976B1 (pl)	1995-07-31
HUT68915A (en)	1995-08-28
FI933248A0 (fi)	1993-07-16

Publication	Publication Date	Title
ATE121089T1 (de)	1995-04-15	Optisch aktives 5h-pyrrolo(3,4-b>pyrazinderivat, seine herstellung und pharmazeutische zubereitungen die es enthalten.
ATE109145T1 (de)	1994-08-15	Heterozyklische acylaminothiazolderivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen.
DE10199027I1 (de)	2001-08-02	Fluorcytidinderivate deren Herstellung und Arzneimittel die diese Derivate enthalten
ATE98480T1 (de)	1994-01-15	Arzneimittelformulierungen.
DE69015842D1 (de)	1995-02-23	Nicotinsäurederivate und diese enthaltende pharmazeutische Zusammensetzungen.
DE3679920D1 (de)	1991-08-01	Spiro-3-heteroazolidinverbindungen und ihre salze, ihre herstellung und diese enthaltende pharmazeutische mittel.
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