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NO179911C - Optisk aktivt 5H-pyrrolo[3,4-bÅpyrazinderivat samt farmasöytiske preparater inneholdende derivatet - Google Patents

Optisk aktivt 5H-pyrrolo[3,4-bÅpyrazinderivat samt farmasöytiske preparater inneholdende derivatet

Info

Publication number
NO179911C
NO179911C NO931919A NO931919A NO179911C NO 179911 C NO179911 C NO 179911C NO 931919 A NO931919 A NO 931919A NO 931919 A NO931919 A NO 931919A NO 179911 C NO179911 C NO 179911C
Authority
NO
Norway
Prior art keywords
derivative
bpyrazine
pyrrolo
well
optically active
Prior art date
Application number
NO931919A
Other languages
English (en)
Norwegian (no)
Other versions
NO931919D0 (no
NO931919L (no
NO179911B (no
Inventor
Claude Cotrel
Gerard Roussel
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9408772&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO179911(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of NO931919D0 publication Critical patent/NO931919D0/no
Publication of NO931919L publication Critical patent/NO931919L/no
Publication of NO179911B publication Critical patent/NO179911B/no
Publication of NO179911C publication Critical patent/NO179911C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
NO931919A 1991-01-17 1993-05-26 Optisk aktivt 5H-pyrrolo[3,4-bÅpyrazinderivat samt farmasöytiske preparater inneholdende derivatet NO179911C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9100490A FR2671800B1 (fr) 1991-01-17 1991-01-17 Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
PCT/FR1992/000031 WO1992012980A1 (fr) 1991-01-17 1992-01-16 DERIVE DE LA 5H-PYRROLO[3,4-b]PYRAZINE OPTIQUEMENT ACTIF, SA PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LE CONTIENNENT

Publications (4)

Publication Number Publication Date
NO931919D0 NO931919D0 (no) 1993-05-26
NO931919L NO931919L (no) 1993-05-26
NO179911B NO179911B (no) 1996-09-30
NO179911C true NO179911C (no) 1997-01-08

Family

ID=9408772

Family Applications (1)

Application Number Title Priority Date Filing Date
NO931919A NO179911C (no) 1991-01-17 1993-05-26 Optisk aktivt 5H-pyrrolo[3,4-bÅpyrazinderivat samt farmasöytiske preparater inneholdende derivatet

Country Status (29)

Country Link
US (5) US6319926B1 (he)
EP (2) EP0609210B1 (he)
JP (1) JPH06504548A (he)
AR (1) AR248024A1 (he)
AT (1) ATE121089T1 (he)
AU (2) AU671797B2 (he)
CA (1) CA2099782C (he)
CZ (1) CZ281011B6 (he)
DE (1) DE69202060T2 (he)
DK (1) DK0609210T3 (he)
ES (1) ES2071486T3 (he)
FI (1) FI100331B (he)
FR (1) FR2671800B1 (he)
HU (1) HU218928B (he)
IE (1) IE66110B1 (he)
IL (1) IL100677A (he)
MA (1) MA22392A1 (he)
MX (1) MX9200180A (he)
NO (1) NO179911C (he)
NZ (1) NZ241313A (he)
OA (1) OA09807A (he)
PH (1) PH30982A (he)
PL (1) PL166976B1 (he)
RU (1) RU2110519C1 (he)
SK (1) SK279060B6 (he)
TN (1) TNSN92004A1 (he)
WO (1) WO1992012980A1 (he)
YU (1) YU48878B (he)
ZA (1) ZA92302B (he)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
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FR2671800B1 (fr) 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
US5786357A (en) * 1991-12-02 1998-07-28 Sepracor Inc. Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone
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US6339086B1 (en) * 1999-05-14 2002-01-15 Swpracor, Inc. Methods of making and using N-desmethylzopiclone
TW200734459A (en) 1999-10-04 2007-09-16 Ajinomoto Kk Genes for heat resistant enzymes of amino acid biosynthetic pathway derived from thermophilic coryneform bacteria
PL1691811T3 (pl) 2003-12-11 2014-12-31 Sunovion Pharmaceuticals Inc Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
US20050215521A1 (en) * 2003-12-22 2005-09-29 Karim Lalji Modafinil combination therapy for improving sleep quality
US20050164987A1 (en) * 2003-12-24 2005-07-28 Barberich Timothy J. Melatonin combination therapy for improving sleep quality
DE602005018763D1 (de) * 2004-02-18 2010-02-25 Sepracor Inc Dopamin-agonisten-kombinationstherapie mit sedativa zur verbesserung der schlafqualität
WO2005097132A2 (en) * 2004-04-05 2005-10-20 Sepracor Inc. Methods of treatment using eszopiclone
CA2612763A1 (en) * 2005-06-21 2006-12-28 Generics (Uk) Limited Process for enantiomeric separation of zopiclone
MX2008000249A (es) * 2005-07-06 2008-03-18 Sepracor Inc Combinaciones de eszopiclona y o-desmetilvenlafaxina y metodos de tratamiento de menopausia y trastornos del estado de animo, ansiedad y cognitivos.
CA2957667A1 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
US7476737B2 (en) * 2005-09-05 2009-01-13 Dr. Reddy's Laboratories Limited Eszopiclone process
US20070098788A1 (en) * 2005-10-28 2007-05-03 Gore Subhash P Non-benzodiazepine hypnotic compositions
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
WO2007083188A2 (en) * 2006-01-17 2007-07-26 Glenmark Pharmaceuticals Limited Improved process for the preparation of an optically active 5h-pyrrolo [3,4-b] pyrazine derivative
US20070203145A1 (en) * 2006-02-03 2007-08-30 Jie Zhu Zopiclone resolution
WO2007109799A2 (en) * 2006-03-23 2007-09-27 Teva Pharmaceutical Industries Ltd. Polymorphs of eszopiclone malate
EP2007768A2 (en) * 2006-04-20 2008-12-31 Teva Pharmaceutical Industries Ltd Methods for preparing eszopiclone crystalline form a, substantially pure eszopiclone and optically enriched eszopiclone
US20080015197A1 (en) * 2006-06-26 2008-01-17 Alex Mainfeld Process for the preparatrion of zopiclone
US7786304B2 (en) * 2006-11-06 2010-08-31 Centaur Pharmaceutical Pvt. Ltd. Process for the preparation of eszopiclone
US20080287447A1 (en) * 2007-01-31 2008-11-20 Nina Finkelstein Methods for preparing eszopiclone
EP1997482B1 (en) * 2007-05-29 2011-07-06 LEK Pharmaceuticals d.d. A pharmaceutical composition comprising eszopiclone
US20080305171A1 (en) * 2007-06-07 2008-12-11 Kristin Anne Arnold Pyrrolopyrazine, formulations, methods of manufacture, and methods of use there
US20090018336A1 (en) * 2007-06-25 2009-01-15 Nina Finkelstein Racemization process of R-zopiclone
EP2020403A1 (en) 2007-08-02 2009-02-04 Esteve Quimica, S.A. Process for the resolution of zopiclone and intermediate compounds
WO2009063486A2 (en) * 2007-08-06 2009-05-22 Usv Limited Process for preparation of dextrorotatory isomer of 6-(5-chloro-pyrid-2-yi)-5-[(4-methyl -1-piperazinyl) carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo [3,4-b] pyrazine (eszopiclone)
US8212036B2 (en) * 2007-12-19 2012-07-03 Sunovion Pharmaceuticals Inc. Maleate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8269005B2 (en) * 2007-12-19 2012-09-18 Sunovion Pharmaceuticals Inc. L-malate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-Oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US20110053945A1 (en) * 2007-12-19 2011-03-03 Sepracor Inc. Salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihy-dro-5h-pyrrolo[3,4-b]pyrazine
CA2812705C (en) * 2007-12-19 2015-08-18 Sunovion Pharmaceuticals Inc. Maleate, besylate and l-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine
US8268832B2 (en) * 2007-12-19 2012-09-18 Sunovion Pharmaceuticals Inc. Maleate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8198277B2 (en) * 2007-12-19 2012-06-12 Sunovion Pharmaceuticals Inc. L-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8198278B2 (en) 2007-12-19 2012-06-12 Sunovion Pharmaceuticals Inc. Besylate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
WO2009101634A2 (en) * 2008-02-13 2009-08-20 Lupin Limited A novel process for the preparation of eszopiclone
CA2719097A1 (en) * 2008-03-12 2009-09-17 Emory University Use of gabaa receptor antagonists for the treatment of excessive sleepiness and disorders associated with excessive sleepiness
US20090269409A1 (en) * 2008-04-24 2009-10-29 Mukesh Kumar Garg Pharmaceutical compositions comprising eszopiclone
CN101607961B (zh) * 2008-06-18 2011-08-10 天津天士力集团有限公司 一种右佐匹克隆结晶及其组合物
US8461334B2 (en) 2008-11-07 2013-06-11 Cipla Limited Process for resolving zopiclone
EP2370136A4 (en) * 2008-12-01 2015-12-30 Map Pharmaceuticals Inc INHALATIVE RELEASE PROCEDURES AND DEVICES
US8555875B2 (en) 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
JP2012516348A (ja) 2009-01-30 2012-07-19 サノビオン ファーマシューティカルズ インク ６−（５−クロロ−２−ピリジル）−５−［（４−メチル−１−ピペラジニル）カルボニルオキシ］−７−オキソ−６，７−ジヒドロ−５Ｈ−ピロロ［３，４−ｂ］ピラジンの被覆錠剤及びコーティングの効果を測定する方法
WO2010116385A2 (en) 2009-04-08 2010-10-14 Rubicon Research Private Limited Pharmaceutical compositions for alleviating unpleasant taste
EP2345654A1 (en) 2010-01-05 2011-07-20 LEK Pharmaceuticals d.d. Eszopiclone particles and a process for their preparation
EP2345655A1 (en) 2010-01-05 2011-07-20 LEK Pharmaceuticals d.d. A process for racemisation of 6-(5-chloropyridin-2-yl)-7-(4-methyl-1-piperazinyl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
CN103193779B (zh) * 2012-01-05 2016-04-20 成都弘达药业有限公司 一种右佐匹克隆的制备方法
WO2014100418A2 (en) * 2012-12-20 2014-06-26 Kashiv Pharma, Llc Orally disintegrating tablet formulation for enhanced bioavailability
US9636340B2 (en) 2013-11-12 2017-05-02 Ayyappan K. Rajasekaran Kinase inhibitors
JP2020007252A (ja) * 2018-07-05 2020-01-16 アクティブファーマ株式会社 エスゾピクロンジベンゾイル−ｄ−酒石酸塩の製造方法、エスゾピクロンの製造方法、及びエスゾピクロンジベンゾイル−ｄ−酒石酸塩の結晶

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
OA04285A (fr) * 1972-01-07 1979-12-31 Rhone Poulenc Sa Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation.
AR208414A1 (es) * 1974-11-07 1976-12-27 Rhone Poulenc Ind Procedimiento para obtener nuevos derivados de la((acil-4piperazinil-1)carboniloxi-5 pirrolinona-2)
US4962124A (en) 1987-11-17 1990-10-09 Analgesic Associates Onset-hastened/enhanced antipyretic response
US4868214A (en) 1987-11-17 1989-09-19 Analgesic Associates Onset-hastened/enhanced analgesia
US5102890A (en) 1989-09-05 1992-04-07 Rhone-Poulenc Sante Pyrrole derivatives, their preparation and pharmaceutical compositions which contain them
FR2671800B1 (fr) 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
WO1993010788A1 (en) 1991-12-02 1993-06-10 Sepracor, Inc. Methods and compositions for treating sleep disorders, convulsive seizures, and other disorders using optically pure (-) zopiclone
US5786357A (en) 1991-12-02 1998-07-28 Sepracor Inc. Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone
US5331000A (en) 1992-03-09 1994-07-19 Sepracor Inc. Antipyretic and analgesic methods and compositions containing optically pure R(-) ketoprofen
US6436926B1 (en) * 1999-05-10 2002-08-20 Medpointe, Inc. Compositions and methods for treating superficial fungal infections
US7476737B2 (en) * 2005-09-05 2009-01-13 Dr. Reddy's Laboratories Limited Eszopiclone process
US20070203145A1 (en) * 2006-02-03 2007-08-30 Jie Zhu Zopiclone resolution

Also Published As

Publication number Publication date
HU9302063D0 (en) 1993-10-28
IL100677A0 (en) 1992-09-06
ATE121089T1 (de) 1995-04-15
SK71993A3 (en) 1993-12-08
HU218928B (hu) 2000-12-28
AU1226492A (en) 1992-08-27
DK0609210T3 (da) 1995-07-03
FI933248L (fi) 1993-07-16
WO1992012980A1 (fr) 1992-08-06
MA22392A1 (fr) 1992-10-01
EP0609210B1 (fr) 1995-04-12
US6864257B2 (en) 2005-03-08
NO931919D0 (no) 1993-05-26
AU671797B2 (en) 1996-09-12
NO931919L (no) 1993-05-26
PH30982A (en) 1997-12-23
US20060194806A1 (en) 2006-08-31
CA2099782C (fr) 2002-12-03
US7125874B2 (en) 2006-10-24
AR248024A1 (es) 1995-05-31
FR2671800A1 (fr) 1992-07-24
SK279060B6 (sk) 1998-06-03
US7381724B2 (en) 2008-06-03
OA09807A (fr) 1994-04-15
US6319926B1 (en) 2001-11-20
FI100331B (fi) 1997-11-14
DE69202060T2 (de) 1995-10-26
US6444673B1 (en) 2002-09-03
HUT68915A (en) 1995-08-28
AU3032195A (en) 1995-11-09
IL100677A (he) 1995-11-27
EP0609210A1 (fr) 1994-08-10
EP0495717A1 (fr) 1992-07-22
US20020193378A1 (en) 2002-12-19
ZA92302B (en) 1992-10-28
IE66110B1 (en) 1995-12-13
PL166976B1 (pl) 1995-07-31
FR2671800B1 (fr) 1993-03-12
DE69202060D1 (de) 1995-05-18
JPH06504548A (ja) 1994-05-26
NO179911B (no) 1996-09-30
YU5592A (sh) 1994-11-15
YU48878B (sh) 2002-09-19
US20050043311A1 (en) 2005-02-24
CZ281011B6 (cs) 1996-05-15
IE920126A1 (en) 1992-07-29
CA2099782A1 (fr) 1992-07-18
ES2071486T3 (es) 1995-06-16
FI933248A0 (fi) 1993-07-16
MX9200180A (es) 1992-07-01
RU2110519C1 (ru) 1998-05-10
EP0609210A4 (fr) 1993-09-17
NZ241313A (en) 1993-03-26
CZ138093A3 (en) 1994-02-16
TNSN92004A1 (fr) 1993-06-08

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