NO179911C - Optisk aktivt 5H-pyrrolo[3,4-bÅpyrazinderivat samt farmasöytiske preparater inneholdende derivatet - Google Patents

Optisk aktivt 5H-pyrrolo[3,4-bÅpyrazinderivat samt farmasöytiske preparater inneholdende derivatet

Info

Publication number: NO179911C
Authority: NO; Norway
Prior art keywords: derivative; bpyrazine; pyrrolo; well; optically active
Prior art date: 1991-01-17

Application number

NO931919A

Other languages

English (en)

Norwegian (no)

Other versions

NO179911B (no

NO931919L (no

NO931919D0 (no

Inventor

Claude Cotrel

Gerard Roussel

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-17

Filing date

1993-05-26

Publication date

1997-01-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9408772&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO179911(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-05-26 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1993-05-26 Publication of NO931919L publication Critical patent/NO931919L/no

1993-05-26 Publication of NO931919D0 publication Critical patent/NO931919D0/no

1996-09-30 Publication of NO179911B publication Critical patent/NO179911B/no

1997-01-08 Publication of NO179911C publication Critical patent/NO179911C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

NO931919A 1991-01-17 1993-05-26 Optisk aktivt 5H-pyrrolo[3,4-bÅpyrazinderivat samt farmasöytiske preparater inneholdende derivatet NO179911C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9100490A FR2671800B1 (fr)	1991-01-17	1991-01-17	Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
PCT/FR1992/000031 WO1992012980A1 (fr)	1991-01-17	1992-01-16	DERIVE DE LA 5H-PYRROLO[3,4-b]PYRAZINE OPTIQUEMENT ACTIF, SA PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LE CONTIENNENT

Publications (4)

Publication Number	Publication Date
NO931919L NO931919L (no)	1993-05-26
NO931919D0 NO931919D0 (no)	1993-05-26
NO179911B NO179911B (no)	1996-09-30
NO179911C true NO179911C (no)	1997-01-08

Family

ID=9408772

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO931919A NO179911C (no)	1991-01-17	1993-05-26	Optisk aktivt 5H-pyrrolo[3,4-bÅpyrazinderivat samt farmasöytiske preparater inneholdende derivatet

Country Status (29)

Country	Link
US (5)	US6319926B1 (fi)
EP (2)	EP0495717A1 (fi)
JP (1)	JPH06504548A (fi)
AR (1)	AR248024A1 (fi)
AT (1)	ATE121089T1 (fi)
AU (2)	AU671797B2 (fi)
CA (1)	CA2099782C (fi)
CZ (1)	CZ281011B6 (fi)
DE (1)	DE69202060T2 (fi)
DK (1)	DK0609210T3 (fi)
ES (1)	ES2071486T3 (fi)
FI (1)	FI100331B (fi)
FR (1)	FR2671800B1 (fi)
HU (1)	HU218928B (fi)
IE (1)	IE66110B1 (fi)
IL (1)	IL100677A (fi)
MA (1)	MA22392A1 (fi)
MX (1)	MX9200180A (fi)
NO (1)	NO179911C (fi)
NZ (1)	NZ241313A (fi)
OA (1)	OA09807A (fi)
PH (1)	PH30982A (fi)
PL (1)	PL166976B1 (fi)
RU (1)	RU2110519C1 (fi)
SK (1)	SK279060B6 (fi)
TN (1)	TNSN92004A1 (fi)
WO (1)	WO1992012980A1 (fi)
YU (1)	YU48878B (fi)
ZA (1)	ZA92302B (fi)

Families Citing this family (50)

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FR2671800B1 (fr)	1991-01-17	1993-03-12	Rhone Poulenc Rorer Sa	Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
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US6339086B1 (en) *	1999-05-14	2002-01-15	Swpracor, Inc.	Methods of making and using N-desmethylzopiclone
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DK1691811T3 (da)	2003-12-11	2014-10-20	Sunovion Pharmaceuticals Inc	Kombination af et sedativ og en neurotransmittermodulator og fremgangsmåder til forbedring af søvnkvaliteten og behandling af depression
WO2005063248A1 (en) *	2003-12-22	2005-07-14	Sepracor Inc.	Modafinil combination therapy for improving sleep quality
AU2004308962A1 (en) *	2003-12-24	2005-07-14	Sepracor Inc.	Melatonin combination therapy for improving sleep quality
ES2337700T3 (es) *	2004-02-18	2010-04-28	Sepracor, Inc.	Terapia combinada de agonista de dopamina con sedantes para mejorar la calidad del sueño.
CA2677465A1 (en)	2004-04-05	2005-10-20	Sepracor Inc.	Methods of treatment using eszopiclone
CA2612763A1 (en) *	2005-06-21	2006-12-28	Generics (Uk) Limited	Process for enantiomeric separation of zopiclone
EP1904066B1 (en) *	2005-07-06	2018-05-23	Sunovion Pharmaceuticals Inc.	COMBINATIONS OF ESZOPICLONE AND TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE OR TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPTHALENAMINE, for treating MENOPAUSE, perimenopause AND COGNITIVE DISORDERS
MX2008000249A (es) *	2005-07-06	2008-03-18	Sepracor Inc	Combinaciones de eszopiclona y o-desmetilvenlafaxina y metodos de tratamiento de menopausia y trastornos del estado de animo, ansiedad y cognitivos.
US7476737B2 (en) *	2005-09-05	2009-01-13	Dr. Reddy's Laboratories Limited	Eszopiclone process
US20070098788A1 (en) *	2005-10-28	2007-05-03	Gore Subhash P	Non-benzodiazepine hypnotic compositions
EP2314289A1 (en)	2005-10-31	2011-04-27	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
BRPI0621028A2 (pt) *	2006-01-17	2011-11-29	Glenmark Pharmaceuticals Ltd	processo para a preparação de um derivado de 5h-pirrolo[3,4-b]pirazina oticamente ativo
US20070203145A1 (en) *	2006-02-03	2007-08-30	Jie Zhu	Zopiclone resolution
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US20070270590A1 (en) *	2006-04-20	2007-11-22	Marioara Mendelovici	Methods for preparing eszopiclone crystalline form a, substantially pure eszopiclone and optically enriched eszopiclone
EP1904499A1 (en) *	2006-06-26	2008-04-02	Teva Pharmaceutical Industries Ltd	Process for the preparation of zopiclone
US7786304B2 (en) *	2006-11-06	2010-08-31	Centaur Pharmaceutical Pvt. Ltd.	Process for the preparation of eszopiclone
EP2032557A2 (en) *	2007-01-31	2009-03-11	Teva Pharmaceutical Industries Ltd.	Methods for preparing eszopiclone
ATE515259T1 (de) *	2007-05-29	2011-07-15	Lek Pharmaceuticals	Pharmazeutische zusammensetzung mit eszopiclon
US20080305171A1 (en) *	2007-06-07	2008-12-11	Kristin Anne Arnold	Pyrrolopyrazine, formulations, methods of manufacture, and methods of use there
US20090018336A1 (en) *	2007-06-25	2009-01-15	Nina Finkelstein	Racemization process of R-zopiclone
EP2020403A1 (en)	2007-08-02	2009-02-04	Esteve Quimica, S.A.	Process for the resolution of zopiclone and intermediate compounds
WO2009063486A2 (en) *	2007-08-06	2009-05-22	Usv Limited	Process for preparation of dextrorotatory isomer of 6-(5-chloro-pyrid-2-yi)-5-[(4-methyl -1-piperazinyl) carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo [3,4-b] pyrazine (eszopiclone)
US8269005B2 (en) *	2007-12-19	2012-09-18	Sunovion Pharmaceuticals Inc.	L-malate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-Oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
CA2812705C (en) *	2007-12-19	2015-08-18	Sunovion Pharmaceuticals Inc.	Maleate, besylate and l-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine
US8212036B2 (en) *	2007-12-19	2012-07-03	Sunovion Pharmaceuticals Inc.	Maleate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
WO2009085988A1 (en) *	2007-12-19	2009-07-09	Sepracor Inc.	Salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7- dihydro-5h-pyrrolo[3,4-b]pyrazine
US8268832B2 (en) *	2007-12-19	2012-09-18	Sunovion Pharmaceuticals Inc.	Maleate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8198277B2 (en)	2007-12-19	2012-06-12	Sunovion Pharmaceuticals Inc.	L-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8198278B2 (en)	2007-12-19	2012-06-12	Sunovion Pharmaceuticals Inc.	Besylate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
WO2009101634A2 (en) *	2008-02-13	2009-08-20	Lupin Limited	A novel process for the preparation of eszopiclone
WO2009114740A2 (en) *	2008-03-12	2009-09-17	Emory University	USE OF GABAa RECEPTOR ANTAGONISTS FOR THE TREATMENT OF EXCESSIVE SLEEPINESS AND DISORDERS ASSOCIATED WITH EXCESSIVE SLEEPINESS
US20090269409A1 (en) *	2008-04-24	2009-10-29	Mukesh Kumar Garg	Pharmaceutical compositions comprising eszopiclone
CN101607961B (zh) *	2008-06-18	2011-08-10	天津天士力集团有限公司	一种右佐匹克隆结晶及其组合物
EP2356121A1 (en)	2008-11-07	2011-08-17	Cipla Limited	Process for resolving zopiclone
US20100196286A1 (en) *	2008-12-01	2010-08-05	Armer Thomas A	Inhalation delivery methods and devices
US8555875B2 (en) *	2008-12-23	2013-10-15	Map Pharmaceuticals, Inc.	Inhalation devices and related methods for administration of sedative hypnotic compounds
EP2391354B1 (en)	2009-01-30	2019-11-27	Sunovion Pharmaceuticals Inc.	Coated tablets of 6-(5-chloro-2-pyridyl) -5-[ (4-methyl-1-piperazinyl) carbonyloxy]-7-oxo-6, 7-dihydro-5h-pyrrol o [3,4-b] pyrazine and process for preparation thereof
WO2010116385A2 (en)	2009-04-08	2010-10-14	Rubicon Research Private Limited	Pharmaceutical compositions for alleviating unpleasant taste
EP2345655A1 (en)	2010-01-05	2011-07-20	LEK Pharmaceuticals d.d.	A process for racemisation of 6-(5-chloropyridin-2-yl)-7-(4-methyl-1-piperazinyl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
EP2345654A1 (en)	2010-01-05	2011-07-20	LEK Pharmaceuticals d.d.	Eszopiclone particles and a process for their preparation
CN103193779B (zh) *	2012-01-05	2016-04-20	成都弘达药业有限公司	一种右佐匹克隆的制备方法
RU2015128794A (ru) *	2012-12-20	2017-01-25	КАШИВ ФАРМА, ЭлЭлСи	Композиция перорально распадающейся таблетки, обеспечивающая повышенную биодоступность
US9636340B2 (en)	2013-11-12	2017-05-02	Ayyappan K. Rajasekaran	Kinase inhibitors
JP2020007252A (ja) *	2018-07-05	2020-01-16	アクティブファーマ株式会社	エスゾピクロンジベンゾイル−ｄ−酒石酸塩の製造方法、エスゾピクロンの製造方法、及びエスゾピクロンジベンゾイル−ｄ−酒石酸塩の結晶

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
OA04285A (fr) *	1972-01-07	1979-12-31	Rhone Poulenc Sa	Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation.
AR208414A1 (es) *	1974-11-07	1976-12-27	Rhone Poulenc Ind	Procedimiento para obtener nuevos derivados de la((acil-4piperazinil-1)carboniloxi-5 pirrolinona-2)
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US4962124A (en)	1987-11-17	1990-10-09	Analgesic Associates	Onset-hastened/enhanced antipyretic response
US5102890A (en)	1989-09-05	1992-04-07	Rhone-Poulenc Sante	Pyrrole derivatives, their preparation and pharmaceutical compositions which contain them
FR2671800B1 (fr)	1991-01-17	1993-03-12	Rhone Poulenc Rorer Sa	Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
US5786357A (en) *	1991-12-02	1998-07-28	Sepracor Inc.	Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone
AU3275993A (en)	1991-12-02	1993-06-28	Sepracor, Inc.	Methods and compositions for treating sleep disorders, convulsive seizures, and other disorders using optically pure (-) zopiclone
US5331000A (en)	1992-03-09	1994-07-19	Sepracor Inc.	Antipyretic and analgesic methods and compositions containing optically pure R(-) ketoprofen
US6436926B1 (en) *	1999-05-10	2002-08-20	Medpointe, Inc.	Compositions and methods for treating superficial fungal infections
US7476737B2 (en) *	2005-09-05	2009-01-13	Dr. Reddy's Laboratories Limited	Eszopiclone process
US20070203145A1 (en) *	2006-02-03	2007-08-30	Jie Zhu	Zopiclone resolution

1991
- 1991-01-17 FR FR9100490A patent/FR2671800B1/fr not_active Expired - Fee Related
1992
- 1992-01-15 MA MA22677A patent/MA22392A1/fr unknown
- 1992-01-15 NZ NZ241313A patent/NZ241313A/xx not_active IP Right Cessation
- 1992-01-15 ZA ZA92302A patent/ZA92302B/xx unknown
- 1992-01-16 PH PH43784A patent/PH30982A/en unknown
- 1992-01-16 SK SK719-93A patent/SK279060B6/sk not_active IP Right Cessation
- 1992-01-16 PL PL92299834A patent/PL166976B1/pl unknown
- 1992-01-16 JP JP4504006A patent/JPH06504548A/ja active Pending
- 1992-01-16 AU AU12264/92A patent/AU671797B2/en not_active Expired
- 1992-01-16 HU HU9302063A patent/HU218928B/hu unknown
- 1992-01-16 DK DK92903994.9T patent/DK0609210T3/da active
- 1992-01-16 EP EP92400111A patent/EP0495717A1/fr active Pending
- 1992-01-16 WO PCT/FR1992/000031 patent/WO1992012980A1/fr active IP Right Grant
- 1992-01-16 CZ CS931380A patent/CZ281011B6/cs not_active IP Right Cessation
- 1992-01-16 MX MX9200180A patent/MX9200180A/es unknown
- 1992-01-16 IE IE920126A patent/IE66110B1/en not_active IP Right Cessation
- 1992-01-16 AR AR92321649A patent/AR248024A1/es active
- 1992-01-16 CA CA002099782A patent/CA2099782C/fr not_active Expired - Fee Related
- 1992-01-16 AT AT92903994T patent/ATE121089T1/de not_active IP Right Cessation
- 1992-01-16 DE DE69202060T patent/DE69202060T2/de not_active Expired - Lifetime
- 1992-01-16 ES ES92903994T patent/ES2071486T3/es not_active Expired - Lifetime
- 1992-01-16 EP EP92903994A patent/EP0609210B1/fr not_active Expired - Lifetime
- 1992-01-16 RU RU93051787A patent/RU2110519C1/ru active
- 1992-01-16 IL IL10067792A patent/IL100677A/en not_active IP Right Cessation
- 1992-01-17 TN TNTNSN92004A patent/TNSN92004A1/fr unknown
- 1992-01-17 YU YU5592A patent/YU48878B/sh unknown
1993
- 1993-05-26 NO NO931919A patent/NO179911C/no not_active IP Right Cessation
- 1993-06-17 OA OA60387A patent/OA09807A/fr unknown
- 1993-07-16 FI FI933248A patent/FI100331B/fi active
1995
- 1995-08-30 AU AU30321/95A patent/AU3032195A/en not_active Abandoned
1998
- 1998-07-29 US US09/124,651 patent/US6319926B1/en not_active Expired - Fee Related
2000
- 2000-11-28 US US09/722,438 patent/US6444673B1/en not_active Expired - Lifetime
2002
- 2002-07-23 US US10/200,510 patent/US6864257B2/en not_active Expired - Fee Related
2004
- 2004-09-28 US US10/951,844 patent/US7125874B2/en not_active Expired - Fee Related
2006
- 2006-05-03 US US11/416,570 patent/US7381724B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PH30982A (en)	1997-12-23
AR248024A1 (es)	1995-05-31
DE69202060T2 (de)	1995-10-26
PL166976B1 (pl)	1995-07-31
US6444673B1 (en)	2002-09-03
US6864257B2 (en)	2005-03-08
SK279060B6 (sk)	1998-06-03
OA09807A (fr)	1994-04-15
MA22392A1 (fr)	1992-10-01
US20060194806A1 (en)	2006-08-31
FI100331B (fi)	1997-11-14
CA2099782A1 (fr)	1992-07-18
IL100677A (en)	1995-11-27
EP0495717A1 (fr)	1992-07-22
TNSN92004A1 (fr)	1993-06-08
ZA92302B (en)	1992-10-28
MX9200180A (es)	1992-07-01
JPH06504548A (ja)	1994-05-26
HUT68915A (en)	1995-08-28
US7125874B2 (en)	2006-10-24
EP0609210A4 (fr)	1993-09-17
NO179911B (no)	1996-09-30
US6319926B1 (en)	2001-11-20
WO1992012980A1 (fr)	1992-08-06
YU48878B (sh)	2002-09-19
HU9302063D0 (en)	1993-10-28
CZ281011B6 (cs)	1996-05-15
YU5592A (sh)	1994-11-15
AU671797B2 (en)	1996-09-12
HU218928B (hu)	2000-12-28
FR2671800A1 (fr)	1992-07-24
IE66110B1 (en)	1995-12-13
DK0609210T3 (da)	1995-07-03
IE920126A1 (en)	1992-07-29
ATE121089T1 (de)	1995-04-15
EP0609210B1 (fr)	1995-04-12
CA2099782C (fr)	2002-12-03
US20020193378A1 (en)	2002-12-19
NZ241313A (en)	1993-03-26
EP0609210A1 (fr)	1994-08-10
AU1226492A (en)	1992-08-27
RU2110519C1 (ru)	1998-05-10
IL100677A0 (en)	1992-09-06
NO931919L (no)	1993-05-26
FI933248A (fi)	1993-07-16
US7381724B2 (en)	2008-06-03
ES2071486T3 (es)	1995-06-16
FR2671800B1 (fr)	1993-03-12
DE69202060D1 (de)	1995-05-18
FI933248A0 (fi)	1993-07-16
NO931919D0 (no)	1993-05-26
SK71993A3 (en)	1993-12-08
CZ138093A3 (en)	1994-02-16
US20050043311A1 (en)	2005-02-24
AU3032195A (en)	1995-11-09

Publication	Publication Date	Title
NO179911C (no)	1997-01-08	Optisk aktivt 5H-pyrrolo[3,4-bÅpyrazinderivat samt farmasöytiske preparater inneholdende derivatet
NO965377D0 (no)	1996-12-13	Indolinonforbindelser samt farmasöytiske preparater inneholdende forbindelsene
ATE98480T1 (de)	1994-01-15	Arzneimittelformulierungen.
MX9102473A (es)	1992-06-01	Agentes farmaceuticos.
ATE74125T1 (de)	1992-04-15	Didehydro-vitamin d3-derivate.
IT8921442A0 (it)	1989-08-03	Complesso di vite prigioniero.
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