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MX9804416A - Diaminopirimidinas, composiciones farmaceuticas que las contienen y su uso como antibacterianos. - Google Patents

Diaminopirimidinas, composiciones farmaceuticas que las contienen y su uso como antibacterianos.

Info

Publication number
MX9804416A
MX9804416A MX9804416A MX9804416A MX9804416A MX 9804416 A MX9804416 A MX 9804416A MX 9804416 A MX9804416 A MX 9804416A MX 9804416 A MX9804416 A MX 9804416A MX 9804416 A MX9804416 A MX 9804416A
Authority
MX
Mexico
Prior art keywords
alkyl
diaminopyrimidines
signifies
antibacterial
pharmaceutical compositions
Prior art date
Application number
MX9804416A
Other languages
English (en)
Inventor
Raffaello Masciadri
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4255709&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9804416(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX9804416A publication Critical patent/MX9804416A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invencion se refiere a diaminopirimidinas de la Formula General (I), en donde ya sea R1 representa un radical alquilo de 5 a 10 átomos de carbono de cadena recta, alquilo de 3 a 5 átomos de carbono de cadena ramificada, cicloalquilo de 3 a 6 átomos de carbono o w-carboxialquilo de 3 a 5 átomos de carbono y R2 y R3 representan un radical alquilo de 1 a 5 átomos de carbono; o bien, R1 representa un átomo de hidrogeno, R2 representa un radical w-carboxialquilo de 3 a 5 átomos de carbono y R3 representa un radical alquilo de 1 a 5 átomos de carbono; y a sus sales de adicion ácida farmacéuticamente aceptables, las cuales tienen propiedades antibioticas y se pueden utilizar en el control o prevencion de enfermedades infecciosas.
MX9804416A 1995-12-04 1998-06-03 Diaminopirimidinas, composiciones farmaceuticas que las contienen y su uso como antibacterianos. MX9804416A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH342595 1995-12-04

Publications (1)

Publication Number Publication Date
MX9804416A true MX9804416A (es) 1998-09-30

Family

ID=4255709

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9804416A MX9804416A (es) 1995-12-04 1998-06-03 Diaminopirimidinas, composiciones farmaceuticas que las contienen y su uso como antibacterianos.

Country Status (16)

Country Link
US (1) US5773446A (es)
EP (2) EP0866791B1 (es)
JP (1) JP3309340B2 (es)
KR (1) KR100417207B1 (es)
CN (1) CN1092194C (es)
AT (1) ATE212629T1 (es)
AU (1) AU708578B2 (es)
BR (1) BR9611871B1 (es)
CA (1) CA2238521C (es)
DE (1) DE69618986T2 (es)
DK (1) DK0866791T3 (es)
ES (1) ES2169272T3 (es)
MX (1) MX9804416A (es)
PT (1) PT866791E (es)
TR (1) TR199801014T2 (es)
WO (1) WO1997020839A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW438796B (en) * 1996-05-15 2001-06-07 Hoffmann La Roche 2,4-diaminopyrimidine derivatives, the manufacture process thereof, and the antibiotically-active pharmaceutical composition containing the same
JP4033676B2 (ja) * 2000-04-27 2008-01-16 バジリア ファルマスーチカ アーゲー 抗菌剤としてのクロメニルメチルピリミジンジアミン類
WO2002010156A1 (en) * 2000-07-29 2002-02-07 Arpida Ag Benzofuran derivatives and their use as antibacterial agents
WO2005014586A1 (en) * 2003-08-08 2005-02-17 Arpida Ag Novel process for the preparation of 2h-chromenes
CN102079727A (zh) * 2005-02-18 2011-06-01 阿皮德公开股份有限公司 用于制备2h-色烯的方法
US20090069357A1 (en) * 2007-09-09 2009-03-12 Protia, Llc Deuterium-enriched iclaprim
AU2008354622A1 (en) * 2008-04-08 2009-10-15 Acino Pharma Ag Aqueous pharmaceutical formulation
US7947293B2 (en) 2008-04-08 2011-05-24 Arpida Ag Aqueous pharmaceutical formulation
US10076522B2 (en) 2016-05-04 2018-09-18 Motif BioSciences Inc. Systems and methods for treating bacterial infection
US20180133218A1 (en) * 2016-11-11 2018-05-17 Motif Biosciences, Inc. Formulations, methods, kit, and dosage forms for treating bacterial infection
CN110498812B (zh) * 2018-05-17 2021-08-24 上海医药工业研究院 一种艾拉普林的中间体化合物的制备方法
CN110606831A (zh) * 2018-06-14 2019-12-24 上海度德医药科技有限公司 一种Iclaprim的新中间体及其制备方法和应用
CN110818693B (zh) * 2018-08-07 2023-06-02 上海度德医药科技有限公司 一种艾拉普林甲磺酸盐晶型b及其制备方法
WO2020161284A1 (en) 2019-02-07 2020-08-13 Sandoz Ag Crystalline form of iclaprim mesylate
CN109988156B (zh) * 2019-03-12 2021-12-28 广东中科药物研究有限公司 一种氨基嘧啶化合物
CN113493461A (zh) * 2020-04-01 2021-10-12 上海医药工业研究院 一种七元杂环化合物或其盐、其制备方法及应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438267A (en) * 1980-11-11 1984-03-20 Daluge Susan M Monoheteroring compounds and their use

Also Published As

Publication number Publication date
WO1997020839A1 (en) 1997-06-12
DE69618986T2 (de) 2002-06-20
ATE212629T1 (de) 2002-02-15
CN1203600A (zh) 1998-12-30
EP0866791A1 (en) 1998-09-30
DE69618986D1 (de) 2002-03-14
CN1092194C (zh) 2002-10-09
BR9611871A (pt) 1999-02-17
PT866791E (pt) 2002-05-31
AU708578B2 (en) 1999-08-05
EP0866791B1 (en) 2002-01-30
KR19990071912A (ko) 1999-09-27
DK0866791T3 (da) 2002-04-22
JP2000501399A (ja) 2000-02-08
AU7696396A (en) 1997-06-27
ES2169272T3 (es) 2002-07-01
US5773446A (en) 1998-06-30
BR9611871B1 (pt) 2010-11-03
JP3309340B2 (ja) 2002-07-29
CA2238521C (en) 2005-08-16
EP1149834A1 (en) 2001-10-31
KR100417207B1 (ko) 2004-04-17
TR199801014T2 (xx) 1998-09-21
CA2238521A1 (en) 1997-06-12

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