[go: up one dir, main page]

MA46990B1 - Compositions glp-1 et ses utilisations - Google Patents

Compositions glp-1 et ses utilisations

Info

Publication number
MA46990B1
MA46990B1 MA46990A MA46990A MA46990B1 MA 46990 B1 MA46990 B1 MA 46990B1 MA 46990 A MA46990 A MA 46990A MA 46990 A MA46990 A MA 46990A MA 46990 B1 MA46990 B1 MA 46990B1
Authority
MA
Morocco
Prior art keywords
compositions
glp
kits
phenol
preparation
Prior art date
Application number
MA46990A
Other languages
English (en)
Other versions
MA46990A (fr
Inventor
Møller Eva Horn
Sørensen Michael Duelund
Joakim Lundqvist
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59713860&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA46990(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of MA46990A publication Critical patent/MA46990A/fr
Publication of MA46990B1 publication Critical patent/MA46990B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des compositions pharmaceutiques du sémaglutide peptidique glp-1 ne comprenant pas plus de 0,01 % (p/p) de phénol, la préparation de celles-ci, des trousses comprenant de telles compositions ainsi que des utilisations de celles-ci.
MA46990A 2017-08-24 2018-08-24 Compositions glp-1 et ses utilisations MA46990B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17187676 2017-08-24
PCT/EP2018/072835 WO2019038412A1 (fr) 2017-08-24 2018-08-24 Compositions de glp-1 et leurs utilisations

Publications (2)

Publication Number Publication Date
MA46990A MA46990A (fr) 2019-05-01
MA46990B1 true MA46990B1 (fr) 2024-03-29

Family

ID=59713860

Family Applications (1)

Application Number Title Priority Date Filing Date
MA46990A MA46990B1 (fr) 2017-08-24 2018-08-24 Compositions glp-1 et ses utilisations

Country Status (24)

Country Link
US (4) US10888605B2 (fr)
EP (2) EP4360651A3 (fr)
JP (1) JP6633777B2 (fr)
KR (1) KR102665710B1 (fr)
CN (3) CN118903386A (fr)
AR (1) AR112480A1 (fr)
AU (2) AU2018321157B2 (fr)
BR (1) BR112020002804A2 (fr)
CA (1) CA3082033A1 (fr)
CL (2) CL2020000422A1 (fr)
CO (1) CO2020002647A2 (fr)
ES (1) ES2976496T3 (fr)
HR (1) HRP20240485T1 (fr)
HU (1) HUE066356T2 (fr)
IL (1) IL272232B1 (fr)
MA (1) MA46990B1 (fr)
MX (1) MX2020001525A (fr)
PE (1) PE20211202A1 (fr)
PH (1) PH12020550051B1 (fr)
PL (1) PL3474820T3 (fr)
RS (1) RS65380B1 (fr)
SG (1) SG11202000940XA (fr)
TW (3) TWI847306B (fr)
WO (1) WO2019038412A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118903386A (zh) 2017-08-24 2024-11-08 诺和诺德股份有限公司 Glp-1组合物及其用途
BR112020014624A2 (pt) 2018-02-02 2020-12-08 Novo Nordisk A/S Composições sólidas compreendendo agonista de glp-1, sal de ácido n-(8-(2-hidroxibenzoil) amino)caprílico e lubrificante
WO2020127476A1 (fr) * 2018-12-19 2020-06-25 Krka, D.D., Novo Mesto Composition pharmaceutique comprenant un analogue de glp -1
WO2020190757A1 (fr) * 2019-03-15 2020-09-24 Novetide Ltd. Procédés améliorés pour la préparation de semaglutide
EP3938094A1 (fr) 2019-03-15 2022-01-19 Novo Nordisk A/S Procédé de séchage à pulvérisation d'un peptide glp-1
EP3947451A1 (fr) * 2019-04-01 2022-02-09 Novo Nordisk A/S Anticorps dirigés contre le liraglutide et leur utilisation
WO2020208541A1 (fr) * 2019-04-08 2020-10-15 Enzene Biosciences Limited Composition comprenant un analogue de glp-1
WO2021105393A1 (fr) * 2019-11-29 2021-06-03 Novo Nordisk A/S Procédés d'obtention de compositions de glp-1 stables
WO2021123228A1 (fr) * 2019-12-18 2021-06-24 Krka, D.D., Novo Mesto Composition pharmaceutique comprenant un analogue de glp-1
BR112022013746A2 (pt) * 2020-02-18 2022-10-11 Novo Nordisk As Formulação aquosa de cagrilintida, formulação aquosa de semaglutida, dispositivo médico, e, combinação de dose fixa
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
CN114146163B (zh) * 2021-12-07 2023-09-26 苏州天马医药集团天吉生物制药有限公司 司美格鲁肽制剂的制备方法
CN114660214B (zh) * 2022-02-18 2024-04-05 兰州积石药业有限公司 一种司美格鲁肽的液相色谱检测方法及其应用
CN116159027A (zh) * 2022-12-29 2023-05-26 江苏诺泰澳赛诺生物制药股份有限公司 一种司美格鲁肽冻干药物组合物及其制备方法
WO2024148155A1 (fr) 2023-01-06 2024-07-11 Nano Precision Medical, Inc. Formulations, dispositifs et méthodes pour un agoniste de glp-1
KR20240149356A (ko) 2023-04-05 2024-10-14 주식회사 아울바이오 Glp-1 수용체 작용제, gip/glp-1 수용체 이중작용제, 및 glp-1/gip/gcg 수용체 삼중작용제로 이루어진 군으로부터 선택되는 1종 이상을 포함하는 액상 제형 및 미립구 제형을 포함하는 약학 조성물
KR20240173155A (ko) 2023-06-02 2024-12-10 주식회사 아울바이오 Glp-1 수용체 작용제, gip/glp-1 수용체 작용제 및/또는 glp-1/gip/gcg 수용체 삼중작용제를 포함하는 약학적 조성물

Family Cites Families (471)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2444570A (en) 1948-07-06 Drive for counter numeral wheels
GB735443A (en) 1952-09-02 1955-08-24 English Numbering Machines Improvements in or relating to counting devices
US2828742A (en) 1957-05-02 1958-04-01 American Home Prod Cartridge-needle unit
BE639963A (fr) 1963-05-02
US3318289A (en) 1965-05-11 1967-05-09 Northern Ind Products Bi-stable mechanism
CH499734A (de) 1968-07-19 1970-11-30 Kienzle Apparate Gmbh Klinkengesperre als Einrichtungs- und Überholkupplung
US3758683A (en) 1971-04-30 1973-09-11 R Jackson Insulin product
US4282316A (en) 1979-09-11 1981-08-04 Modrovich Ivan Endre Stabilized enzymic solutions for determining urea
CS261206B2 (en) 1980-03-21 1989-01-12 Wellcome Found Isotonization and stabilization agent
US4425346A (en) 1980-08-01 1984-01-10 Smith And Nephew Associated Companies Limited Pharmaceutical compositions
GB2109690B (en) 1981-02-12 1985-02-20 Robert Charles Turner Dose metering plunger devices for use with syringes
US4568335A (en) 1981-08-28 1986-02-04 Markwell Medical Institute, Inc. Device for the controlled infusion of medications
DE3204178C2 (de) 1982-02-06 1986-03-20 Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg Pipettiervorrichtung
US4483849A (en) 1983-01-07 1984-11-20 Carter William A Stabilization and purification of interferon with propylene glycol, resulting in a non-toxic product
GB2141799B (en) 1983-06-03 1986-07-16 Diehl Gmbh & Co An adjusting ratchet mechanism for a time switch
EP0143895B1 (fr) 1983-09-07 1987-12-23 Disetronic Ag Dispositif portatif d'infusion
US4468346A (en) 1983-10-27 1984-08-28 The United States Of America As Represented By The Secretary Of Agriculture Monoclonal antibodies to porcine immunoglobulins
JPS60129941U (ja) 1984-02-09 1985-08-31 テルモ株式会社 医療用器具
US4592745A (en) 1984-02-29 1986-06-03 Novo Industri A/S Dispenser
FR2583291A1 (fr) 1985-06-14 1986-12-19 Hazon Bernard Dispositif d'avancement pas a pas du piston de seringues par double vis coaxiale avec controle du debit d'injection. application aux injections medicamenteuses intra-dermiques repetitives
DE3546150A1 (de) 1985-06-24 1987-01-22 Hoechst Ag Membrananker-wirkstoffkonjugat, seine herstellung sowie seine verwendung
AU6541986A (en) 1985-11-08 1987-06-02 Disetronic A.G. Injection instrument
DE3609555A1 (de) 1986-03-21 1987-09-24 Josef Porner Blutentnahmespritze
US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
US5118666A (en) 1986-05-05 1992-06-02 The General Hospital Corporation Insulinotropic hormone
US5120712A (en) 1986-05-05 1992-06-09 The General Hospital Corporation Insulinotropic hormone
EP1498425A1 (fr) 1986-05-05 2005-01-19 The General Hospital Corporation Utilisation de dérivés du glucagon-like peptide-1 (GLP-1) pour la préparation de compositions pharmaceutiques
US4917685A (en) 1986-05-16 1990-04-17 International Minerals & Chem. Corp. Delivery device for the administration of stabilized growth promoting hormones
DE3638984C3 (de) 1986-11-14 1993-11-18 Haselmeier Wilhelm Fa Injektionsgerät
US5716990A (en) 1987-03-09 1998-02-10 Cancer Research Campaign Technology Limited Drug delivery systems
DK177187A (da) 1987-04-07 1988-10-08 Dcp Af 1988 As Doseringsenhed til dosering af et antal afmaalte maengder af en vaeske, saasom insulin, fra en glasampul
DE3715258C2 (de) 1987-05-08 1996-10-31 Haselmeier Wilhelm Fa Injektionsgerät
EP0368864B1 (fr) 1987-05-14 1993-11-03 Commonwealth Scientific And Industrial Research Organisation Fractions proteiques de petit lait
GB8713810D0 (en) 1987-06-12 1987-07-15 Hypoguard Uk Ltd Measured dose dispensing device
FI883338A (fi) 1987-07-16 1989-01-17 Bristol Myers Co Vattenloesningar av doxorubicinhydroklorid.
IT1222331B (it) 1987-08-25 1990-09-05 Bruno Micovilovich Siringa di sicurezza per usi parentali,a disimpegno autonomo e rapido dell'ago dopo l'uso
US4919596A (en) 1987-12-04 1990-04-24 Pacesetter Infusion, Ltd. Fluid delivery control and monitoring apparatus for a medication infusion system
US4833379A (en) 1988-01-13 1989-05-23 Sherwood Medical Company Motor control fail-safe circuit
CH675078A5 (fr) 1988-01-22 1990-08-31 Nosta Ag
DE3900926C2 (de) 1988-02-08 1999-05-12 Disetronic Licensing Ag Spritzenförmiges Injektionsgerät und Injektionsgerätebaukasten
US4973318A (en) 1988-02-10 1990-11-27 D.C.P. Af 1988 A/S Disposable syringe
DK166948B1 (da) 1988-02-10 1993-08-09 Dcp Af 1988 As Doseringsenhed til dosering af et antal afmaalte maengder af en vaeske, saasom insulin, fra en glastubule
EP0422124A4 (en) 1988-06-27 1991-10-16 Genex Corporation Thermal release of recombinant protein into culture media
ES2069558T3 (es) 1988-09-12 1995-05-16 Graesslin Kg Dispositivo para regular el tiempo de un reloj conmutador.
GB8900763D0 (en) 1989-01-13 1989-03-08 Kabi Vitrum Peptide Hormones A Multi-dose syringe
US5216437A (en) 1989-02-02 1993-06-01 Canon Kabushiki Kaisha Ink, and recording method making use of same
DK68789A (da) 1989-02-14 1990-08-15 Novo Nordisk As Injektionspen
HU203372B (en) 1989-02-24 1991-07-29 Richter Gedeon Vegyeszet Process for producing hyaluronic associates and pharmaceutical compositions and cosmetics comprising such active ingredient
WO1990011296A1 (fr) 1989-03-20 1990-10-04 The General Hospital Corporation Hormone insulinotrope
JP2822447B2 (ja) 1989-05-19 1998-11-11 住友電気工業株式会社 酸化物超電導線材の製造方法および装置
US4994033A (en) 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
US5226895A (en) 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
DE3927286C2 (de) 1989-08-18 1997-07-24 Roehm Gmbh Wäßrige Enzym-Flüssigformulierungen
US5216011A (en) 1989-09-01 1993-06-01 Bristol-Myers Squibb Co. Stable solutions of mitomycin c
DE69013471T2 (de) 1989-12-05 1995-03-30 Merck & Co Inc Methode zur Stabilisierung von rekombinanten Hepatitis-B-Virus-Oberflächenproteinen aus Hefe.
DK17890A (da) 1990-01-22 1991-07-23 Novo Nordisk As Fremgangsmaade og apparat til opblanding og injicering af et laegemiddel
DK0512042T3 (da) 1990-01-24 1998-05-11 Douglas I Buckley GLP-1-analoger anvendelige ved diabetesbehandling
US5545618A (en) 1990-01-24 1996-08-13 Buckley; Douglas I. GLP-1 analogs useful for diabetes treatment
DE4002066A1 (de) 1990-01-25 1991-08-01 Basf Ag Verfahren zur abtrennung von riboflavin aus fermentationssuspensionen
GB9007113D0 (en) 1990-03-29 1990-05-30 Sams Bernard Dispensing device
US5207752A (en) 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
US5318540A (en) 1990-04-02 1994-06-07 Pharmetrix Corporation Controlled release infusion device
US5492534A (en) 1990-04-02 1996-02-20 Pharmetrix Corporation Controlled release portable pump
US5226896A (en) 1990-04-04 1993-07-13 Eli Lilly And Company Dose indicating injection pen
IT220491Z2 (it) 1990-04-13 1993-09-24 Stilolinea Srl Penna a sfera del tipo a punta scrivente rientrante
DE69129110T2 (de) 1990-05-10 1998-12-10 Bechgaard International Research And Development A/S, Hellerup Pharmazeutische zubereitung enthaltend n-glykofurole und n-äthylenglykole
US5257987A (en) 1990-05-21 1993-11-02 Pharmetrix Corporation Controlled release osmotic infusion system
WO1992004926A1 (fr) 1990-09-21 1992-04-02 Novo Nordisk A/S Tete d'adaptateur
US5284480A (en) 1990-11-09 1994-02-08 Medtronic, Inc. Inflation/deflation syringe with threaded plunger
GB9026191D0 (en) 1990-12-01 1991-01-16 Harris Pharma Ltd Breath actuated dispensing device
US5331954A (en) 1990-12-21 1994-07-26 Novo Nordisk A/S Device for nasal delivery of liquid medications
US5232706A (en) 1990-12-31 1993-08-03 Esteve Quimica, S.A. Oral pharmaceutical preparation containing omeprazol
AU641206B2 (en) 1991-01-22 1993-09-16 Eli Lilly And Company Multiple dose injection pen
EP0498737B1 (fr) 1991-02-07 1995-07-19 Terumo Kabushiki Kaisha Dispositif de dosage pour injecteur
US5272135A (en) 1991-03-01 1993-12-21 Chiron Ophthalmics, Inc. Method for the stabilization of methionine-containing polypeptides
HU222249B1 (hu) 1991-03-08 2003-05-28 Amylin Pharmaceuticals Inc. Eljárás amilin agonista peptidszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására
WO1992017571A1 (fr) 1991-03-27 1992-10-15 Novo Nordisk A/S Catalase, sa production et son utilisation
US5258377A (en) 1991-04-08 1993-11-02 Taiho Pharmaceutical Co., Ltd. 2-spirocyclopropyl 4-acylcephems
DE4112259A1 (de) 1991-04-15 1992-10-22 Medico Dev Investment Co Injektionsgeraet
DK68991D0 (da) 1991-04-17 1991-04-17 Novo Nordisk As Manifold
US5645052A (en) 1991-04-26 1997-07-08 The Boc Group Plc Anaesthetic vaporizer with expandable/contractable reservoir for pumping liquid anaesthetic
SE9101381D0 (sv) 1991-05-07 1991-05-07 Tomas Moks Peptide hormone solution
ATE121953T1 (de) 1991-07-24 1995-05-15 Medico Dev Investment Co Injektor.
DK175491D0 (da) 1991-10-18 1991-10-18 Novo Nordisk As Apparat
US5206219A (en) 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
DK194291D0 (da) 1991-11-29 1991-11-29 Novo Nordisk As Sproejte til automatisk injektion.
EP0614386B1 (fr) 1991-11-29 1996-10-23 Novo Nordisk A/S Seringue en forme de crayon
US5246417A (en) 1991-12-11 1993-09-21 Alza Corporation Indicator for iontophoresis system
US5849700A (en) 1991-12-20 1998-12-15 Novo Nordisk A/S Pharmaceutical formulation
FR2686460B1 (fr) 1992-01-20 1994-03-11 Labinal Precision Mecanique Organe de contact electrique femelle.
US5279585A (en) 1992-02-04 1994-01-18 Becton, Dickinson And Company Medication delivery pen having improved dose delivery features
CH682968B5 (fr) 1992-02-12 1994-06-30 Rolex Montres Procédé de fabrication d'un joint et joint pour dispositif de commande étanche pour montre obtenu selon ce procédé.
CH682806A5 (de) 1992-02-21 1993-11-30 Medimpex Ets Injektionsgerät.
DE4208677A1 (de) 1992-03-18 1993-09-23 Injecta Gmbh Steinach Injektionsvorrichtung, insbesondere fuer sehgeschaedigte diabetiker
DK36492D0 (da) 1992-03-19 1992-03-19 Novo Nordisk As Praeparat
EP0632734B1 (fr) 1992-03-25 1998-06-10 Tebro S.A. Distributeur a jet de poudre pour traitements par inhalation de medicament
DK39892D0 (da) 1992-03-25 1992-03-25 Bernard Thorens Peptid
US5271527A (en) 1992-04-02 1993-12-21 Habley Medical Technology Corporation Reusable pharmaceutical dispenser with full stroke indicator
US5281198A (en) 1992-05-04 1994-01-25 Habley Medical Technology Corporation Pharmaceutical component-mixing delivery assembly
ES2098739T3 (es) 1992-05-13 1997-05-01 Sandoz Ltd Composiciones oftalmicas conteniendo una cyclosporin.
WO1993025579A1 (fr) 1992-06-15 1993-12-23 Pfizer Inc. Derives d'insulinotropine et de peptide analogue au glucagon
UA26190C2 (uk) 1992-07-28 1999-07-19 Сейфтек Ай Лімітед Шприц
GB9219849D0 (en) 1992-09-19 1992-10-28 Hypoguard Uk Ltd Device
EP0649316B2 (fr) 1992-10-15 2013-08-28 The General Hospital Corporation Pompe a perfusion comportant une bibliotheque electronique de medicaments chargeable
US5545147A (en) 1992-10-20 1996-08-13 Eli Lilly And Company Anti-backup improvement for hypodermic syringes
US5378233A (en) 1992-11-18 1995-01-03 Habley Medical Technology Corporation Selected dose pharmaceutical dispenser
US5320609A (en) 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
GB9226423D0 (en) 1992-12-18 1993-02-10 Sams Bernard Incrementing mechanisms
BR9406249A (pt) 1993-02-19 1996-01-02 Medicorp Holding Seringa enchida previamente para armazenagem e transferência de substância medicamentosa líquida e estéril
US5383865A (en) 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
US5584815A (en) 1993-04-02 1996-12-17 Eli Lilly And Company Multi-cartridge medication injection device
ZA941881B (en) 1993-04-02 1995-09-18 Lilly Co Eli Manifold medication injection apparatus and method
US6284727B1 (en) 1993-04-07 2001-09-04 Scios, Inc. Prolonged delivery of peptides
SE9301494D0 (sv) 1993-04-30 1993-04-30 Kabi Pharmacia Ab A device for dosing liquid preparation
DK52393D0 (fr) 1993-05-05 1993-05-05 Novo Nordisk As
AU7531094A (en) 1993-08-24 1995-03-21 Novo Nordisk A/S Protracted glp-1
JP3014764B2 (ja) 1993-09-17 2000-02-28 ノボ ノルディスク アクティーゼルスカブ アシル化インスリン
GB9320782D0 (en) 1993-10-08 1993-12-01 Univ Leeds Innovations Ltd Stabilising of proteins on solution
PT729362E (pt) 1993-11-19 2000-06-30 Searle & Co Composicao transdermica de n-¬n-¬5-¬4-(aminoiminometil)fenil|-1oxopentil|-l-alfa-aspartil|-l-fenillalanina ou esteres e seus sais farmaceuticamente aceitaveis
US5705483A (en) 1993-12-09 1998-01-06 Eli Lilly And Company Glucagon-like insulinotropic peptides, compositions and methods
US5478316A (en) 1994-02-02 1995-12-26 Becton, Dickinson And Company Automatic self-injection device
US5514097A (en) 1994-02-14 1996-05-07 Genentech, Inc. Self administered injection pen apparatus and method
US5562623A (en) 1994-02-14 1996-10-08 Univec Single-use syringe assembly including spring clip lock and plunger
WO1995022560A1 (fr) 1994-02-22 1995-08-24 The Syntex-Synergen Neuroscience Joint Venture Formulations pharmaceutiques comprenant un facteur neurotrophique ciliaire
WO1995029996A1 (fr) 1994-05-03 1995-11-09 Novo Nordisk A/S Glucose-oxydase alcaline
GB9409496D0 (en) 1994-05-12 1994-06-29 London Health Ass Method for improving glycaemic control in diabetes
US5750140A (en) 1994-05-20 1998-05-12 Novo Nordisk A/S Transdermal delivery of tiagabine
US5652216A (en) 1994-05-26 1997-07-29 Novo Nordisk A/S Pharmaceutical preparation
AU1595395A (en) 1994-06-15 1996-01-05 Interventional Research Technologies, Inc. Locking device for syringe or like instrument
US5461031A (en) 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5827232A (en) 1994-06-22 1998-10-27 Becton Dickinson And Company Quick connect medication delivery pen
US5725508A (en) 1994-06-22 1998-03-10 Becton Dickinson And Company Quick connect medication delivery pen
US5440976A (en) 1994-08-23 1995-08-15 Fred Giuliano Adjustable dispensing stirrer for soluble sweeteners
CA2186869A1 (fr) 1994-08-24 1996-02-29 Hideto Yamagata Appareil pour injections
US5549574A (en) 1994-08-30 1996-08-27 Eli Lilly And Company Cartridge assembly for use in a pen-type medicament injector
US5574008A (en) 1994-08-30 1996-11-12 Eli Lilly And Company Biologically active fragments of glucagon-like insulinotropic peptide
ES2211889T3 (es) 1994-08-31 2004-07-16 Mitsubishi Pharma Corporation Procedimiento para la purificacion de albumina de suero recombinante.
CN1157553A (zh) 1994-09-09 1997-08-20 诺沃挪第克公司 清洁、消毒和防护隐形眼镜的方法
US5549575A (en) 1994-09-13 1996-08-27 Becton Dickinson And Company Cartridge retainer assembly for medication delivery pen
US5582598A (en) 1994-09-19 1996-12-10 Becton Dickinson And Company Medication delivery pen with variable increment dose scale
JP3712130B2 (ja) 1994-09-20 2005-11-02 ノボザイムス アクティーゼルスカブ 凝固を引き起こさずにその中の微生物を殺すための水性タンパク質溶液の処理方法
ZA958073B (en) 1994-09-28 1996-04-23 Anthony William Manicom Method of and apparatus for administering a drug to a patient
US5512549A (en) 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
WO1996020005A1 (fr) 1994-12-23 1996-07-04 Novo Nordisk A/S Compositions a base de glp-1 et a action prolongee
CN100419076C (zh) 1995-02-03 2008-09-17 诺沃奇梅兹有限公司 设计具有预定特性的α－淀粉酶突变体的方法
AU695129B2 (en) 1995-02-06 1998-08-06 Genetics Institute, Llc Formulations for IL-12
GB9503969D0 (en) 1995-02-28 1995-04-19 Sams Bernard Incrementing mechanism
WO1996027400A1 (fr) 1995-03-07 1996-09-12 Eli Lilly And Company Distributeur recyclable de medicament
US5869602A (en) 1995-03-17 1999-02-09 Novo Nordisk A/S Peptide derivatives
CA2215694A1 (fr) 1995-03-17 1996-09-26 Novo Nordisk A/S Derives de l'insuline
US5834428A (en) 1995-04-14 1998-11-10 1149336 Ontario Inc. Glucagon-like peptide-2 and its therapeutic use
US6184201B1 (en) 1995-04-14 2001-02-06 Nps Allelix Corp. Intestinotrophic glucagon-like peptide-2 analogs
CA2222411C (fr) 1995-06-02 2007-09-11 Novo Nordisk A/S Retrait automatique de tige de piston
CN1114613C (zh) 1995-06-02 2003-07-16 诺沃奇梅兹有限公司 蛋白质溶液的铝/铁处理和膜浓缩方法
US5631347A (en) 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
JP3895377B2 (ja) 1995-06-13 2007-03-22 ノボザイムス アクティーゼルスカブ 酵素安定剤としての４−置換フェニルボロン酸
US5674204A (en) 1995-09-19 1997-10-07 Becton Dickinson And Company Medication delivery pen cap actuated dose delivery clutch
US5688251A (en) 1995-09-19 1997-11-18 Becton Dickinson And Company Cartridge loading and priming mechanism for a pen injector
JP3060287B2 (ja) 1995-10-09 2000-07-10 参天製薬株式会社 アパファントを主薬とする水性点眼剤
US5899879A (en) 1995-12-19 1999-05-04 Genesis Medical Technologies, Inc. Spring-actuated needleless injector
BR9707598A (pt) 1996-02-23 1999-07-27 Novo Nordisk As Seringa
ATE226450T1 (de) 1996-03-05 2002-11-15 Robert Gurny Gepufferte orthoesterpolymere enthaltende arzneimittel
AU718205B2 (en) 1996-03-12 2000-04-13 Novo Nordisk A/S Injection device with electronic presentation of set doses
JP3741730B2 (ja) 1996-04-02 2006-02-01 テクファーマ・ライセンシング・アクチェンゲゼルシャフト 注射装置
ATE196096T1 (de) 1996-04-24 2000-09-15 Novo Nordisk As Injektionsnadel
DE19616486C5 (de) 1996-04-25 2016-06-30 Royalty Pharma Collection Trust Verfahren zur Senkung des Blutglukosespiegels in Säugern
DK0909175T3 (da) 1996-07-03 2003-09-29 Alza Corp Ikke-vandige, protiske peptidformuleringer
US5932547A (en) 1996-07-03 1999-08-03 Alza Corporation Non-aqueous polar aprotic peptide formulations
DE69724784T2 (de) 1996-07-05 2004-07-15 Novo Nordisk A/S Vorrichtung zur automatischen einführung einer nadel
PL330757A1 (en) 1996-07-05 1999-05-24 Novo Nordisk As Elastic piston rod
HUP9904033A3 (en) 1996-07-05 2000-05-29 Novo Nordisk As Dose setting device
US5981489A (en) 1996-07-18 1999-11-09 Alza Corporation Non-aqueous protic peptide formulations
US5962407A (en) 1996-07-26 1999-10-05 Kelly; Michael T. Loloatin derivatives and analogs
ATE417622T1 (de) 1996-08-08 2009-01-15 Amylin Pharmaceuticals Inc Regulation gastrointestinaler beweglichkeit
JPH10101696A (ja) 1996-08-08 1998-04-21 Shinotesuto:Kk 形質転換体にて発現される蛋白質に含まれる夾雑物質の除去方法及び精製蛋白質
US5843036A (en) 1996-08-23 1998-12-01 Becton Dickinson And Company Non-dosing cartridge for an injection device
US5709662A (en) 1996-08-23 1998-01-20 Becton Dickinson France, S.A. Cartridge for an injection device
US6006753A (en) 1996-08-30 1999-12-28 Eli Lilly And Company Use of GLP-1 or analogs to abolish catabolic changes after surgery
US6458924B2 (en) 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6268343B1 (en) 1996-08-30 2001-07-31 Novo Nordisk A/S Derivatives of GLP-1 analogs
US7235627B2 (en) 1996-08-30 2007-06-26 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6384016B1 (en) 1998-03-13 2002-05-07 Novo Nordisk A/S Stabilized aqueous peptide solutions
HU227021B1 (en) 1996-08-30 2010-05-28 Novo Nordisk As Glp-1 derivatives
US6277819B1 (en) 1996-08-30 2001-08-21 Eli Lilly And Company Use of GLP-1 or analogs in treatment of myocardial infarction
IL128799A (en) 1996-09-13 2004-08-31 Novo Nordisk As Syringe containing a dose setting mechanism
US6379339B1 (en) 1996-09-13 2002-04-30 Nova Nordisk A/S Syringe
US6110149A (en) 1996-09-13 2000-08-29 Novo Nordisk A/S Syringe
US5947934A (en) 1996-09-13 1999-09-07 Novo Nordisk A/S Dose display for an injection syringe
ES2169380T3 (es) 1996-09-20 2002-07-01 Novo Nordisk As Cilindro de maniobra.
US6146361A (en) 1996-09-26 2000-11-14 Becton Dickinson And Company Medication delivery pen having a 31 gauge needle
US5908830A (en) 1996-10-31 1999-06-01 Merck & Co., Inc. Combination therapy for the treatment of diabetes and obesity
UA65549C2 (uk) 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
TW524667B (en) 1996-12-05 2003-03-21 Pfizer Parasiticidal pyrazoles
US5954689A (en) 1996-12-20 1999-09-21 Novo Nordisk A/S Jet injector
CA2277112C (fr) 1997-01-07 2008-08-26 Amylin Pharmaceuticals, Inc. Utilisation d'exendines et de leurs agonistes pour reduire la consommation alimentaire
US7312196B2 (en) 1997-01-08 2007-12-25 Amylin Pharmaceuticals, Inc. Formulations for amylin agonist peptides
US6136784A (en) 1997-01-08 2000-10-24 Amylin Pharmaceuticals, Inc. Amylin agonist pharmaceutical compositions containing insulin
TW503113B (en) 1997-01-16 2002-09-21 Senju Pharma Co Aqueous suspension for nasal administration
US6274553B1 (en) 1997-01-20 2001-08-14 Japan Energy Corporation Method for stabilizing peptides and freeze-dried medicinal compositions containing peptides obtained by using the method
GB2321419B (en) 1997-01-27 2001-02-07 Medic Aid Ltd Atomizer
AU5652098A (en) 1997-02-04 1998-08-25 Novo Nordisk A/S A device for the administration of a liquid medicament suspension
DE29703820U1 (de) 1997-03-03 1998-07-02 Medico Development Investment Co., Ascona Injektionsgerät
US5898028A (en) 1997-03-20 1999-04-27 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
US20010020155A1 (en) 1997-03-25 2001-09-06 Soren Mikkelsen Injection system
AU6586298A (en) 1997-03-31 1998-10-22 Eli Lilly And Company Glucagon-like peptide-1 analogs
CA2236519C (fr) 1997-05-02 2011-09-13 1149336 Ontario Inc. Methodes pour ameliorer le fonctionnement du gros intestin
US7101853B2 (en) 1997-05-06 2006-09-05 Amylin Pharmaceuticals, Inc. Method for treating or preventing gastritis using amylin or amylin agonists
RU2111019C1 (ru) 1997-05-22 1998-05-20 Сергей Александрович Хворостов Универсальный инъектор
ATE277948T1 (de) 1997-05-23 2004-10-15 Predrag Sikiric Bpc peptid salze mit organ-schützender aktivität, deren herstellung und therapeutische verwendung
US7910548B2 (en) 1997-06-06 2011-03-22 Amylin Pharmaceuticals, Inc. Methods for treating obesity
AU7833698A (en) 1997-06-09 1998-12-30 Bridge Pharma, Inc. Compounds with combined antihistaminic and mast cell stabilizing activities, intended for ophthalmic use
US6074372A (en) 1997-06-09 2000-06-13 Novo Nordisk A/S Dose setting mechanism and an injection syringe having such a dose setting mechanism
US6003736A (en) 1997-06-09 1999-12-21 Novo Nordisk A/S Device for controlled dispensing of a dose of a liquid contained in a cartridge
CO4750643A1 (es) 1997-06-13 1999-03-31 Lilly Co Eli Formulacion estable de la insulina que contiene l-arginina y protamina
US6796970B1 (en) 1997-06-17 2004-09-28 Novo Nordisk A/S Dose setting device
US5961496A (en) 1997-06-17 1999-10-05 Novo Nordisk A/S Syringe with tiltable nut for quick piston disengagement
JP3503129B2 (ja) 1997-06-30 2004-03-02 荒川化学工業株式会社 カラーフィルタ層用剥離剤およびカラーフィルタ用ガラス基板の再生方法
AU7331598A (en) 1997-07-11 1999-02-08 Novo Nordisk A/S An apparatus for the registration of the setting of a medical device
EP0996477B1 (fr) 1997-07-14 2004-01-14 Novo Nordisk A/S Element d'injection
EP0996476B1 (fr) 1997-07-14 2003-05-21 Novo Nordisk A/S Ampoule cylindrique
DE19730999C1 (de) 1997-07-18 1998-12-10 Disetronic Licensing Ag Dosierknopfsicherung an einer Vorrichtung zur dosierten Verabreichung eines injizierbaren Produkts
US5921966A (en) 1997-08-11 1999-07-13 Becton Dickinson And Company Medication delivery pen having an improved clutch assembly
FR2767479B1 (fr) 1997-08-22 1999-10-22 Aguettant Lab Dispositif d'injection de medicament
AU9202398A (en) 1997-09-29 1999-04-23 Becton Dickinson & Company Injection device and drug cartridge for preventing cross-use of the device and drug cartridge
JP2001517689A (ja) 1997-10-01 2001-10-09 フレミントン ファーマシューティカル コーポレイション 極性または非極性の、バッカルスプレーまたはカプセル
CN1240718C (zh) 1997-10-24 2006-02-08 诺沃挪第克公司 人胰岛素衍生物的聚集体
AU740665B2 (en) 1997-10-24 2001-11-08 Genentech Inc. Purification of molecules
US6312413B1 (en) 1997-10-30 2001-11-06 Novo Nordisk A/S Cylinder ampoule
WO1999029336A1 (fr) 1997-12-05 1999-06-17 Eli Lilly And Company Formulations de glp-1
MY120063A (en) 1997-12-09 2005-08-30 Lilly Co Eli Stabilized teriparatide solutions
DE29721752U1 (de) 1997-12-09 1998-02-12 Siemens AG, 80333 München Crimpkontakt für Stecksysteme
US6380357B2 (en) 1997-12-16 2002-04-30 Eli Lilly And Company Glucagon-like peptide-1 crystals
JPH11249087A (ja) 1997-12-18 1999-09-17 Tome:Kk コンタクトレンズ用液剤
EP1044015B1 (fr) 1998-01-09 2008-10-08 Amylin Pharmaceuticals, Inc. Formulations de peptides agonistes d'amyline avec d'insuline
WO1999034764A2 (fr) 1998-01-09 1999-07-15 Amylin Pharmaceuticals, Inc. Compositions pharmaceutiques a agoniste d'amyline, contenant de l'insuline
US6004297A (en) 1998-01-30 1999-12-21 Novo Nordisk A/S Injection syringe
EP0978565B1 (fr) 1998-01-30 2007-10-10 Asubio Pharma Co., Ltd. Procede de production de peptide au moyen d'un peptide accessoire
WO1999040788A1 (fr) 1998-02-13 1999-08-19 Amylin Pharmaceuticals, Inc. Effets inotropiques et diuretiques de l'extendine et du gpl-1
KR100637433B1 (ko) 2004-05-24 2006-10-20 삼성에스디아이 주식회사 발광 표시 장치
EP1061987B1 (fr) 1998-02-13 2006-05-17 Bioniche Life Sciences Inc. Dispositif servant a administrer un medicament
AU766653B2 (en) 1998-02-13 2003-10-23 Amylin Pharmaceuticals, Inc. Novel mixed amylin activity compounds
US5961495A (en) 1998-02-20 1999-10-05 Becton, Dickinson And Company Medication delivery pen having a priming mechanism
US6221053B1 (en) 1998-02-20 2001-04-24 Becton, Dickinson And Company Multi-featured medication delivery pen
US6248095B1 (en) 1998-02-23 2001-06-19 Becton, Dickinson And Company Low-cost medication delivery pen
ATE466028T1 (de) 1998-02-27 2010-05-15 Novo Nordisk As N-terminal veränderte glp-1 abkömmlinge
AU3247799A (en) 1998-02-27 1999-09-15 Novo Nordisk A/S Glp-1 derivatives of glp-1 and exendin with protracted profile of action
JP2002504518A (ja) 1998-02-27 2002-02-12 ノボ ノルディスク アクティーゼルスカブ 部分的に構造化されたミセルー様凝集体を形成する、２５％を超えるヘリックス−含有率を有するｇｌｐ−１誘導体
EP1056774A1 (fr) 1998-02-27 2000-12-06 Novo Nordisk A/S Derives de glp-1 tronques a l'extremite n-terminale
WO1999043706A1 (fr) 1998-02-27 1999-09-02 Novo Nordisk A/S Derives d'analogues de glp-1
JP4072319B2 (ja) 1998-03-13 2008-04-09 ノヴォ ノルディスク アクティーゼルスカブ 安定化水溶性ペプチド溶液
WO1999057566A1 (fr) 1998-05-01 1999-11-11 The University Of Tennessee Research Corporation Caracterisation des fibrilles amyloides par cytometrie de flux
WO1999063981A2 (fr) 1998-06-11 1999-12-16 Cerus Corporation Inhibition de la proliferation des cellules musculaires lisses arterielles
CN1308550A (zh) 1998-07-08 2001-08-15 诺沃挪第克公司 给药装置和用于该给药装置的药筒组件
AU765584B2 (en) 1998-09-17 2003-09-25 Eli Lilly And Company Protein formulations
US6033376A (en) 1998-09-30 2000-03-07 Allergan Sales, Inc. Wound shaper sleeve
US6489292B1 (en) 1998-11-18 2002-12-03 Novo Nordisk A/S Stable aqueous insulin preparations without phenol and cresol
US6605067B1 (en) 1998-11-20 2003-08-12 Novo Nordisk A/S Injection needle
US6375975B1 (en) 1998-12-21 2002-04-23 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary application
CA2358107C (fr) 1998-12-22 2011-08-23 Eli Lilly And Company Formulation de longue conservation de peptide-1 de type glucagon
DE29900482U1 (de) 1999-01-14 2000-08-31 Medico Development Investment Co., Ascona Injektionsgerät
RU2242244C2 (ru) 1999-01-14 2004-12-20 Амилин Фармасьютикалз, Инк. Новые композиции агонистов эксендина и способы их введения
EP1071517B1 (fr) 1999-02-14 2008-04-02 Ing. Erich Pfeiffer GmbH Distributeur pour milieux coulants
US6258062B1 (en) 1999-02-25 2001-07-10 Joseph M. Thielen Enclosed container power supply for a needleless injector
US6444788B1 (en) 1999-03-15 2002-09-03 Novo Nordisk A/S Ion exchange chromatography of GLP-1, analogs and derivatives thereof
ATE409193T1 (de) 1999-03-17 2008-10-15 Novo Nordisk As Verfahren zur acylierung von peptiden und proteinen
SE9901366D0 (sv) 1999-04-16 1999-04-16 Pharmacia & Upjohn Ab Injector device and method for its operation
FR2793684B1 (fr) 1999-05-17 2001-08-10 Ethypharm Lab Prod Ethiques Utilisation de microspheres biodegradables liberant un agent anticancereux pour le traitement du glioblastome, procede de preparation de ces microspheres et suspension les contenant
US6506724B1 (en) 1999-06-01 2003-01-14 Amylin Pharmaceuticals, Inc. Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus
EP1207753A4 (fr) 1999-06-17 2005-11-30 Univ California Preservation d'organes par perfusion cardiaque continue avec du peg-hb en vue d'une conservation amelioree en hypothermie
DE60036367T2 (de) 1999-06-21 2008-05-29 Eli Lilly And Co., Indianapolis Synergitische verwendung von thiazolidinedionen und glucagon-ähnlichem peptid-1 und dessen agonisten für die behandlung von nicht-insulin-abhängigen diabetes
JP2003503356A (ja) 1999-06-25 2003-01-28 メドトロニック ミニメド インコーポレイテッド 多剤糖尿病治療
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
EP1076066A1 (fr) 1999-07-12 2001-02-14 Zealand Pharmaceuticals A/S Peptides abaissant le taux de glucose sanguin
JP4290366B2 (ja) 1999-08-05 2009-07-01 ベクトン・ディキンソン・アンド・カンパニー 薬剤送出ペン
TW453884B (en) 1999-09-16 2001-09-11 Novo Nordisk As Dose setting limiter
DE60024118T2 (de) 1999-09-20 2006-07-27 Eli Lilly And Co., Indianapolis Verwendung einer parathyroidhormone zur reduktion des krebsrisikos
US6514230B1 (en) 1999-10-12 2003-02-04 Novo Nordisk A/S Air shot mechanism for electronic injection devices
US6569832B1 (en) 1999-11-12 2003-05-27 Novo Nordisk A/S Inhibition of beta cell degeneration
PL355378A1 (en) 1999-12-16 2004-04-19 Eli Lilly And Company Polypeptide compositions with improved stability
US7022674B2 (en) 1999-12-16 2006-04-04 Eli Lilly And Company Polypeptide compositions with improved stability
GB9930882D0 (en) 1999-12-30 2000-02-23 Nps Allelix Corp GLP-2 formulations
EP1250126A2 (fr) 2000-01-11 2002-10-23 Novo Nordisk A/S Distribution transepitheliale de derives de glp-1
WO2001052937A1 (fr) 2000-01-24 2001-07-26 Medtronic Minimed, Inc. Systeme tampon melange pour la stabilisation de preparations pour polypeptides
AU2001232735A1 (en) 2000-01-27 2001-08-07 Eli Lilly And Company Process for solubilizing glucagon-like peptide 1 compounds
EP1396499A3 (fr) 2000-01-27 2004-12-29 Eli Lilly And Company Procédé de solubilisation de composés 1-peptidiques de type glucagon (GLP-1)
US6569901B2 (en) 2000-01-28 2003-05-27 Novo Nordisk A/S Alkynyl-substituted propionic acid derivatives, their preparation and use
US6844321B2 (en) 2000-01-31 2005-01-18 Novo Nordisk A/S Crystallization of a GLP-1 analogue
GB0007071D0 (en) 2000-03-24 2000-05-17 Sams Bernard One-way clutch mechanisms and injector devices
AU2001248277A1 (en) 2000-04-06 2001-10-23 Novo-Nordisk A/S Shock heat treatment of polypeptides
US6692472B2 (en) 2000-05-04 2004-02-17 Novo Nordisk A/S Injection device, a preassembled dose setting and injection mechanism for an injection device, and a method of assembling an injection device
WO2001087322A2 (fr) 2000-05-17 2001-11-22 Bionebraska, Inc. Preparations pharmaceutiques peptidiques
US6716198B2 (en) 2000-05-18 2004-04-06 Novo Nordisk A/S Injection device
US6547763B2 (en) 2000-05-18 2003-04-15 Novo Nordisk A/S Dose display for injection device
US6547764B2 (en) 2000-05-31 2003-04-15 Novo Nordisk A/S Double pointed injection needle
ATE346093T1 (de) 2000-06-16 2006-12-15 Lilly Co Eli Analoge des glucagon ähnlichen peptid-1
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
US6369419B1 (en) 2000-06-23 2002-04-09 International Business Machines Corporation Self-aligned near surface strap for high density trench DRAMS
AU2001278417A1 (en) 2000-07-14 2002-01-30 Novo-Nordisk A/S A liquid medication delivery device and a method of delivering an intended dose
WO2002024257A1 (fr) 2000-09-22 2002-03-28 Novo Nordisk A/S Dispositif pour l'apport d'un medicament
JP4798833B2 (ja) 2000-10-24 2011-10-19 一般財団法人化学及血清療法研究所 加熱処理工程を含むヒト血清アルブミンの製造方法
EA005584B1 (ru) 2000-12-07 2005-04-28 Эли Лилли Энд Компани Слитые белки glp-1
CA2431173A1 (fr) 2000-12-13 2002-06-20 Eli Lilly And Company Regime de traitement chronique utilisant des peptides insulinotropiques du type glucagon
WO2002048192A2 (fr) 2000-12-13 2002-06-20 Eli Lilly And Company Glp-1 amide
US20020151467A1 (en) 2000-12-21 2002-10-17 Leung Frank K. Methods and compositions for oral insulin delivery
US6899699B2 (en) 2001-01-05 2005-05-31 Novo Nordisk A/S Automatic injection device with reset feature
GB2371227A (en) 2001-01-10 2002-07-24 Grandis Biotech Gmbh Crystallisation - resistant aqueous growth hormone formulations
WO2002064196A1 (fr) 2001-02-14 2002-08-22 Novo Nordisk A/S Dispositif d'injection ou d'injection commande electroniquement
PT1360202E (pt) 2001-02-16 2008-09-01 Conjuchem Biotechnologies Inc Peptídeo do tipo glucagon 2 (glp-2) de longa duração para o tratamento de doenças e distúrbios gastrointestinais
JP2004518756A (ja) 2001-03-07 2004-06-24 ノボ　ノルディスク　アクティーゼルスカブ Ｇｌｐ−１類似体およびｐｐａｒリガンドの誘導体の組み合わせ使用
US6573237B2 (en) 2001-03-16 2003-06-03 Eli Lilly And Company Protein formulations
DK1392377T3 (da) 2001-05-16 2007-06-11 Lilly Co Eli Medikamentinjektorapparat med drivanordning, der letter tilbagestilling
US20040156835A1 (en) 2001-05-30 2004-08-12 Taiji Imoto Protein preparation
GB0113881D0 (en) 2001-06-07 2001-08-01 Innovate Biomed Ltd Foil cutting system
US20030119734A1 (en) 2001-06-28 2003-06-26 Flink James M. Stable formulation of modified GLP-1
US6872705B2 (en) 2001-07-13 2005-03-29 Allergan, Inc. Use of antimicrobial peptides as preservatives in ophthalmic preparations, including solutions, emulsions, and suspensions
DE10163326A1 (de) 2001-07-30 2003-02-27 Disetronic Licensing Ag Verabreichungsgerät mit Dosiervorrichtung
CN1335182A (zh) 2001-08-08 2002-02-13 华中科技大学 胰岛素口腔喷剂及其制备工艺
EP1432430A4 (fr) 2001-08-28 2006-05-10 Lilly Co Eli Pre-melanges de polypeptide glp-1 et d'insuline basale
US6676641B2 (en) 2001-09-05 2004-01-13 Futura Medical Technologies, Inc. Retractable hypodermic syringe
MXPA04003553A (es) 2001-10-18 2004-07-22 Bristol Myers Squibb Co Mimeticos del peptido-1 similares aglucagon humano y su uso en tratamiento de diabetes y condiciones relacionadas.
MXPA04003569A (es) 2001-10-19 2004-07-23 Lilly Co Eli Mezclas bifasicas de glp-1 e insulina.
NZ534125A (en) 2002-02-20 2006-11-30 Emisphere Tech Inc A formulation comprising a GLP-1 compound and a delivery agent
JP2005527508A (ja) 2002-03-07 2005-09-15 ヴェクトゥラ　リミテッド 経口デリバリー用急速溶融多粒子製剤
EP1344533B1 (fr) 2002-03-15 2006-08-23 Natimmune A/S Compositions pharmaceutique comprenant une lectine liant le mannose
JP2005535569A (ja) 2002-04-04 2005-11-24 ノボ・ノルデイスク・エー／エス Ｇｌｐ−１アゴニスト及び心臓血管合併症
CN1668332A (zh) 2002-07-09 2005-09-14 桑多斯股份公司 包含苯酚的含高浓度人生长激素的液体制剂
US6945961B2 (en) 2002-07-10 2005-09-20 Novo Nordisk A/S Injection device
WO2004007003A1 (fr) 2002-07-10 2004-01-22 Novo Nordisk A/S Dispositif d'injection a limiteur de dosage
EP1391794A1 (fr) 2002-07-23 2004-02-25 Novo Nordisk A/S Dispositif muni d'indicateur de temps
ATE331542T1 (de) 2002-08-29 2006-07-15 Novo Nordisk As Injektionsvorrichtung mit frontladung
US7112187B2 (en) 2002-09-24 2006-09-26 Shl Medical Ab Injecting device
ES2308029T3 (es) 2002-09-25 2008-12-01 Novo Nordisk A/S Proceso de purificacion que comprende una microfiltracion a temperaturas elevadas.
US7273921B2 (en) 2002-09-25 2007-09-25 Novo Nordisk A/S Method for producing acylated peptides
WO2004037168A2 (fr) 2002-10-18 2004-05-06 Amylin Pharmaceuticals, Inc. Traitement de la pancreatite avec de l'amyline
US6969702B2 (en) 2002-11-20 2005-11-29 Neuronova Ab Compounds and methods for increasing neurogenesis
EP1610811A4 (fr) 2002-12-17 2008-03-26 Amylin Pharmaceuticals Inc Prevention et traitement d'arythmies cardiaques
WO2004066939A2 (fr) 2003-01-27 2004-08-12 Sarnoff Corporation Systeme d'administration de medicament a liberation controlee
GB0304823D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0304824D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0304822D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0306642D0 (en) 2003-03-22 2003-04-30 Dca Design Int Ltd Improvements in and relating to an injector for a medical product
GB0308267D0 (en) 2003-04-10 2003-05-14 Dca Design Int Ltd Improvements in and relating to a pen-type injector
WO2004089985A1 (fr) 2003-04-11 2004-10-21 Novo Nordisk A/S Compositions pharmaceutiques stables
US8008255B2 (en) 2003-05-30 2011-08-30 Amylin Pharmaceuticals, Inc. Methods and compositions for enhanced transmucosal delivery of peptides and proteins
EP1633390B1 (fr) 2003-06-03 2012-01-18 Novo Nordisk A/S Compositions pharmaceutiques de peptides glp-1 stabilisees
CN1812807A (zh) * 2003-06-03 2006-08-02 诺沃挪第克公司 稳定化的药物肽组合物
ATE541582T1 (de) 2003-06-03 2012-02-15 Novo Nordisk As Stabilisierte pharmazeutische glp-1 peptid zusammensetzungen
EP1656170B1 (fr) 2003-08-12 2019-03-13 Eli Lilly And Company Appareil de distribution de medicaments a triple filetage presentant un avantage mecanique
WO2005021026A2 (fr) 2003-08-29 2005-03-10 Amylin Pharmaceuticals, Inc. Procedes pour traiter ou ameliorer des maladies et des troubles associes a la ghreline
AU2004273573B2 (en) 2003-09-19 2010-04-22 Novo Nordisk A/S Albumin-binding derivatives of therapeutic peptides
PE20050444A1 (es) 2003-10-31 2005-08-09 Takeda Pharmaceutical Compuestos de piridina como inhibidores de la peptidasa
PT1682180E (pt) 2003-11-04 2010-02-10 Novartis Vaccines & Diagnostic Anticorpos monoclonais antagonistas anti-cd40 e métodos para a sua utilização
AU2004316290C1 (en) 2003-11-06 2012-02-02 Seagen Inc. Monomethylvaline compounds capable of conjugation to ligands
US20060287221A1 (en) 2003-11-13 2006-12-21 Novo Nordisk A/S Soluble pharmaceutical compositions for parenteral administration comprising a GLP-1 peptide and an insulin peptide of short time action for treatment of diabetes and bulimia
ES2373660T3 (es) 2003-11-13 2012-02-07 Novo Nordisk A/S Composición farmacéutica que comprende un análogo insulinotrópico de glp-1 (7-37), insulina asp(b28) y un tensioactivo.
SI1687019T1 (en) 2003-11-20 2018-04-30 Novo Nordisk A/S Propylene glycol-containing peptide formulations which are optimal for production and for use in injection devices
JP2007514752A (ja) 2003-12-16 2007-06-07 ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス Ｇｌｐ−１医薬組成物
JP2007537141A (ja) 2003-12-18 2007-12-20 ノボ　ノルディスク　アクティーゼルスカブ 新規なｇｌｐ−１化合物
US20060286129A1 (en) 2003-12-19 2006-12-21 Emisphere Technologies, Inc. Oral GLP-1 formulations
US20050143303A1 (en) 2003-12-26 2005-06-30 Nastech Pharmaceutical Company Inc. Intranasal administration of glucose-regulating peptides
BRPI0507623A (pt) 2004-02-11 2007-07-03 Amylin Pharmaceuticals Inc peptìdeos da famìlia da amilina e métodos para prepará-los e empregá-los
EP1765406A4 (fr) 2004-05-21 2012-11-28 Mediplex Corp Delivrance d'agents permettant d'ameliorer l'absorption mucosale d'agents therapeutiques
US7448385B2 (en) 2004-06-07 2008-11-11 Purepharm Inc. Nasal adaptation of an oral inhaler device
EP1758575A1 (fr) 2004-06-11 2007-03-07 Novo Nordisk A/S Remede contre l'obesite induite par les medicaments au moyen d'agonistes glp-1
JP2008504249A (ja) 2004-06-28 2008-02-14 ノボ　ノルディスク　アクティーゼルスカブ 糖尿病を治療するための方法
WO2006025882A2 (fr) 2004-08-25 2006-03-09 The Uab Research Foundation Substances ameliorant l'absorption destinees a l'administration de medicaments
EP2286838A3 (fr) 2004-11-01 2013-09-04 Amylin Pharmaceuticals, LLC Traitement de l'obésité et de maladies liés à l'obésité
US20090011976A1 (en) 2004-11-12 2009-01-08 Novo Nordisk A/S Stable Formulations Of Peptides
CN101056650A (zh) 2004-11-12 2007-10-17 诺和诺德公司 促胰岛素肽的稳定制剂
US7910577B2 (en) 2004-11-16 2011-03-22 Elan Pharma International Limited Injectable nanoparticulate olanzapine formulations
US7833707B2 (en) 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
AU2006207744B2 (en) 2005-01-21 2011-08-11 Novo Nordisk A/S An automatic injection device with a top release mechanism
AU2006214443C1 (en) 2005-02-15 2011-11-24 Alkermes Pharma Ireland Limited Aerosol and injectable formulations of nanoparticulate benzodiazepine
EP1868646A2 (fr) 2005-03-08 2007-12-26 Pharmacia & Upjohn Company LLC Compositions d'anticorps contre m-csf
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
TWI362392B (en) * 2005-03-18 2012-04-21 Novo Nordisk As Acylated glp-1 compounds
WO2007014051A2 (fr) 2005-07-22 2007-02-01 Amylin Pharmaceuticals, Inc. Utilisation d'amyline et d'agonistes d'amyline comme agents cardioprotecteurs ou myoprotecteurs
US8389472B2 (en) 2005-08-19 2013-03-05 Amylin Pharmaceuticals, Llc Exendin-4 to treat nonalcoholic steatohepatitis and nonalcoholic fatty liver disease
EP1978926A2 (fr) 2005-12-19 2008-10-15 Comentis, Inc. Preparations de mecamylamine topique pour administration oculaire et utilisations de celles-ci
EP2374475A1 (fr) 2005-12-29 2011-10-12 Boehringer Ingelheim Vetmedica, Inc. Utilisation d'une composition immunogène PCV2 pour diminuer les symptômes cliniques chez les porcs
AU2007238574B2 (en) 2006-04-13 2011-08-18 Ipsen Pharma S.A.S. Pharmaceutical compositions of hGLP-1, exendin-4 and analogs thereof
MX2009000748A (es) 2006-07-18 2009-03-31 Centocor Inc Mimeticuerpos de peptido-1 similar a glucagon de humano, composiciones, metodos y usos.
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
AR064623A1 (es) 2006-12-21 2009-04-15 Centocor Inc Uso de agonistas del receptor de glp -1 de accion prolongada para mejorar la sensibilidad a la insulina y los perfiles lipidicos
GB0704846D0 (en) 2007-03-13 2007-04-18 Futura Medical Dev Ltd Topical pharmaceutical formulation
AU2008244523B2 (en) 2007-04-23 2012-02-16 Intarcia Therapeutics, Inc. Suspension formulations of insulinotropic peptides and uses thereof
US20080293814A1 (en) 2007-05-22 2008-11-27 Deepak Tiwari Concentrate esmolol
EP2190460B1 (fr) 2007-09-05 2014-12-17 Novo Nordisk A/S Peptides dérivés avec a-b-c-d et utilisation thérapeutique de ceux-ci
JP2010539058A (ja) 2007-09-11 2010-12-16 モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト 治療剤としてのｔｒａｐ−１４
WO2009051992A1 (fr) 2007-10-19 2009-04-23 Bausch & Lomb Incorporated Compositions et procédés de traitement de maladies mettant en jeu une angiogenèse oculaire par inhibition d'une ou plusieurs tyrosine kinases de récepteurs sélectionnés
MX2010005345A (es) 2007-11-14 2010-08-31 Amylin Pharmaceuticals Inc Metodos para el tratamiento de la obesidad y enfermedades y trastornos relacionados con la obesidad.
EP2231191A2 (fr) 2007-12-11 2010-09-29 ConjuChem Biotechnologies Inc. Formulation de conjugués de peptides insulinotropes
ES2662501T3 (es) 2008-10-21 2018-04-06 Novo Nordisk A/S Derivados de amilina
US8748375B2 (en) 2009-03-17 2014-06-10 Amylin Pharmaceuticals, Llc Methods for affecting body composition using amylin agonists
EP2437816B1 (fr) 2009-06-04 2013-04-24 Novo Nordisk Health Care AG Dispositif de mélange avec un piston/inter-verrouillage de tige de piston
KR101759499B1 (ko) 2009-07-31 2017-07-19 사노피-아벤티스 도이칠란트 게엠베하 지속형 인슐린 조성물
MA33467B1 (fr) 2009-07-31 2012-07-03 Sanofi Aventis Deutschland Promédicaments comprenant un conjugué insuline-lieur
WO2011050008A2 (fr) 2009-10-19 2011-04-28 Amylin Pharmaceuticals, Inc. Polythérapie comprenant l'administration d'un amylinomimétique et d'un peptidomimétique de pyy pour obtenir une perte de poids et pour traiter l'obésité et les états pathologiques et les troubles métaboliques associés
KR20120104316A (ko) 2009-12-10 2012-09-20 메르크 파텐트 게엠베하 올리고펩티드, 바람직하게는 실렌기티드를 포함하는 약학 조성물
US8648041B2 (en) 2009-12-16 2014-02-11 Novo Nordisk A/S Double-acylated GLP-1 derivatives
EP2539364A1 (fr) 2010-02-26 2013-01-02 Novo Nordisk A/S Peptides de traitement de l'obésité
WO2011109784A1 (fr) 2010-03-05 2011-09-09 Conjuchem, Llc Formulation de conjugués peptidiques insulinotropiques
WO2011109787A1 (fr) 2010-03-05 2011-09-09 Conjuchem, Llc Méthodes d'administration de peptides insulinotropes
CA2792663A1 (fr) 2010-03-26 2011-09-29 Novo Nordisk A/S Nouveaux analogues du glucagon
KR20130101005A (ko) 2010-07-28 2013-09-12 아밀린 파마슈티칼스, 엘엘씨. 안정화된 영역을 갖는 glp-1 수용체 효능제 화합물
EP2438930A1 (fr) 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Promédicaments comprenant un conjugué de liaison d'exendine
JP6231386B2 (ja) 2010-11-09 2017-11-15 ノヴォ ノルディスク アー／エス リンカーを有する二重アシル化されたｇｌｐ−１誘導体
RU2600440C3 (ru) 2010-12-16 2021-12-10 Ново Нордиск А/С Твердые композиции, содержащие агонист glp-1 и соль n-(8-(2-гидроксибензоил)амино)каприловой кислоты
CN103298457A (zh) 2011-01-19 2013-09-11 诺沃—诺迪斯克有限公司 Glp-1组合物
US20140004198A1 (en) 2011-01-19 2014-01-02 Novo Nordisk A/S Glp-1 particles and compositions
AU2012213217B2 (en) 2011-02-04 2017-04-20 Infirst Healthcare Limited Compositions and methods for treating cardiovascular diseases
US20130035281A1 (en) 2011-02-09 2013-02-07 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
EP3225631B1 (fr) 2011-04-12 2019-01-09 Novo Nordisk A/S Dérivés glp-1 double-acylates
EP2696847A1 (fr) 2011-04-14 2014-02-19 Novo Nordisk A/S Acides aminés acylés par un acide gras pour l'administration de peptides par voie orale
UA116189C2 (uk) 2011-05-02 2018-02-26 Мілленніум Фармасьютікалз, Інк. КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА
US8722849B2 (en) 2011-06-10 2014-05-13 Novo Nordisk A/S Polypeptides
US20140256621A1 (en) 2011-07-08 2014-09-11 Astrazeneca Pharmaceuticals Lp Engineered poypeptides having enhanced duration of action and reduced immunogenicity
US20140221490A1 (en) 2011-07-20 2014-08-07 Hospira, Inc. Methods of treating pain
US9132170B2 (en) 2011-07-29 2015-09-15 Case Western Reserve University Compositions and methods for treating cognitive deficits
CN104039822A (zh) 2011-09-06 2014-09-10 诺沃—诺迪斯克有限公司 Glp-1衍生物
TWI679212B (zh) 2011-11-15 2019-12-11 美商安進股份有限公司 針對ｂｃｍａ之e3以及ｃｄ３的結合分子
CN104244981A (zh) 2011-12-09 2014-12-24 诺和诺德A/S Glp-1激动剂
WO2013127779A1 (fr) 2012-03-01 2013-09-06 Novo Nordisk A/S Promédicaments à base de glp-1
CN102579350B (zh) 2012-03-02 2013-04-24 海南灵康制药有限公司 右旋布洛芬脂质体固体制剂
EP3488857B9 (fr) 2012-03-22 2023-10-04 Novo Nordisk A/S Compositions de peptides glp-1 et leur préparation
US9192651B2 (en) 2012-04-02 2015-11-24 Moderna Therapeutics, Inc. Modified polynucleotides for the production of secreted proteins
CA2868688A1 (fr) 2012-04-03 2013-10-10 Trustees Of Boston University Compositions, procedes et dosages comprenant de l'amyline ou des analogues de l'amlyine pour troubles a mediation par le peptide a-beta
EP2838914B1 (fr) 2012-04-19 2017-06-14 Novo Nordisk A/S Analogues de l'amyline humaine
JP6366575B2 (ja) 2012-05-08 2018-08-01 ノヴォ ノルディスク アー／エス 二重アシル化されたｇｌｐ−１誘導体
WO2013167454A1 (fr) 2012-05-08 2013-11-14 Novo Nordisk A/S Dérivés du glp-1 à double acylation
WO2013177565A1 (fr) 2012-05-25 2013-11-28 Amylin Pharmaceuticals, Llc Compositions d'insuline/pramlintide et leurs procédés de fabrication et d'utilisation
EP2861608B8 (fr) 2012-06-19 2019-06-19 Debiopharm International SA Dérivés de type promédicament du (e)-n-méthyl-n-((3-méthylbenzofuran-2-yl) méthyl)-3-(7-oxo-5,6,7,8-tétrahydro-l,8-naphtyridin-3-yl)acrylamide
CA2877056A1 (fr) 2012-07-01 2014-01-09 Novo Nordisk A/S Utilisation de peptides glp-1 a action longue
WO2014010586A1 (fr) 2012-07-10 2014-01-16 武田薬品工業株式会社 Préparation pharmaceutique pour l'injection
AR094821A1 (es) 2012-07-25 2015-09-02 Hanmi Pharm Ind Co Ltd Formulación líquida de un conjugado de péptido insulinotrópico de acción prolongada
EP2908844A1 (fr) * 2012-10-17 2015-08-26 Novo Nordisk A/S Acides aminés acylés par un acide gras pour l'administration de peptides par voie orale
US20140187635A1 (en) 2012-12-28 2014-07-03 Themis Medicare Limited Diclofenac compositions
WO2014144842A2 (fr) 2013-03-15 2014-09-18 Rhythm Metabolic, Inc. Compositions pharmaceutiques
PL2991671T3 (pl) 2013-05-02 2019-01-31 Novo Nordisk As Doustne dawkowanie związków glp-1
WO2014182950A1 (fr) 2013-05-10 2014-11-13 Nimbus Apollo, Inc. Inhibiteurs de l'acc et utilisations associées
US20160136246A1 (en) 2013-06-21 2016-05-19 Novo Nordisk A/S Novel Uses of GLP-1 Receptor Agonists in Patients Treated with Insulin and/or Suffering from Type 1 Diabetes
MX2015016875A (es) 2013-07-04 2016-04-07 Novo Nordisk As Derivados de peptidos similares a peptido similar a glucagon 1 (glp-1) y sus usos.
JO3425B1 (ar) 2013-07-15 2019-10-20 Novartis Ag مشتقات البابيريدينيل-اندول واستخدامها كعامل متمم لمثبطات b
CN103405753B (zh) * 2013-08-13 2016-05-11 上海仁会生物制药股份有限公司 稳定的促胰岛素分泌肽水针药物组合物
EP3033112B1 (fr) 2013-08-15 2020-10-07 Novo Nordisk A/S Dérivés glp-1 et leurs utilisations
MX369818B (es) 2013-11-15 2019-11-22 Novo Nordisk As Compuestos selectivos de peptido yy (pyy) y usos de los mismos.
EP3129041B1 (fr) 2014-04-07 2019-06-12 Novo Nordisk A/S Composés glp-1 acylés doubles
EP3160491A4 (fr) 2014-06-25 2018-01-17 GlaxoSmithKline LLC Compositions pharmaceutiques
WO2016001862A1 (fr) 2014-07-04 2016-01-07 Wockhardt Limited Formulations à libération prolongée d'insulines
WO2016038521A1 (fr) 2014-09-08 2016-03-17 Sun Pharmaceutical Industries Limited Compositions pharmaceutiques de liraglutide
DK3006045T3 (en) 2014-10-07 2017-07-17 Cyprumed Gmbh Pharmaceutical formulations for oral administration of peptide or protein drugs
ES2739289T3 (es) * 2014-11-27 2020-01-30 Novo Nordisk As Derivados de GLP-1 y sus usos
CN105777872B (zh) * 2014-12-16 2019-06-07 深圳翰宇药业股份有限公司 一种萨摩鲁肽的纯化方法
JOP20200119A1 (ar) 2015-01-09 2017-06-16 Lilly Co Eli مركبات مساعد مشترك من gip وglp-1
CN107249620B (zh) 2015-05-13 2018-06-26 杭州九源基因工程有限公司 一种包含glp-1类似物的药物制剂及其制备方法
TW201706291A (zh) 2015-07-10 2017-02-16 賽諾菲公司 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物
EP3423481B1 (fr) 2016-03-03 2020-10-07 Novo Nordisk A/S Dérivés glp-1 et leurs utilisations
CN105963257B (zh) 2016-04-26 2021-01-22 广州帝奇医药技术有限公司 一种缓释微粒的制备方法
JP7221694B2 (ja) 2016-04-28 2023-02-14 ノヴォ ノルディスク アー／エス 心血管状態におけるセマグルチド
WO2018055539A1 (fr) 2016-09-22 2018-03-29 Wockhardt Limited Composition pharmaceutique contenant de l'insuline glargine tamponnée et un analogue de glp-1
US20190374613A1 (en) 2016-11-22 2019-12-12 Biocon Research Limited Pharmaceutical compositions of glp-1 analogues
GB201621987D0 (en) 2016-12-22 2017-02-08 Archer Virgil L See Archer Sheri A Arecor Ltd Novel composition
KR20190124704A (ko) 2017-01-24 2019-11-05 마크레젠, 인크. 아포지질단백질 모방체를 이용하는, 나이 관련 황반 변성 및 기타 안질환의 치료
CN118903386A (zh) * 2017-08-24 2024-11-08 诺和诺德股份有限公司 Glp-1组合物及其用途
AR114162A1 (es) 2017-12-21 2020-07-29 Sanofi Sa Composición farmacéutica líquida
TWI705820B (zh) 2018-06-22 2020-10-01 美商美國禮來大藥廠 Gip/glp1促效劑組合物
KR20210024082A (ko) 2018-06-25 2021-03-04 제이씨알 파마 가부시키가이샤 단백질 함유 수성 액제
RS64438B1 (sr) 2018-10-26 2023-09-29 Novo Nordisk As Stabilne kompozicije semaglutida i njihova upotreba
JP2022543239A (ja) 2019-08-02 2022-10-11 アボット ダイアベティス ケア インコーポレイテッド 薬剤用量ガイダンスに関連するシステム、デバイスおよび方法
BR112022013746A2 (pt) 2020-02-18 2022-10-11 Novo Nordisk As Formulação aquosa de cagrilintida, formulação aquosa de semaglutida, dispositivo médico, e, combinação de dose fixa

Also Published As

Publication number Publication date
BR112020002804A2 (pt) 2020-07-28
US20200164042A1 (en) 2020-05-28
TW201912147A (zh) 2019-04-01
HRP20240485T1 (hr) 2024-07-05
CA3082033A1 (fr) 2019-02-28
SG11202000940XA (en) 2020-02-27
ES2976496T3 (es) 2024-08-02
RU2020109402A3 (fr) 2022-01-25
AU2018321157B2 (en) 2024-03-28
CL2020000422A1 (es) 2020-07-10
TWI783890B (zh) 2022-11-11
EP3474820B1 (fr) 2024-02-07
AU2024204151A1 (en) 2024-07-11
IL272232B1 (en) 2023-03-01
MA46990A (fr) 2019-05-01
CN111050750B (zh) 2024-09-24
PH12020550051B1 (en) 2024-01-31
US20240016896A1 (en) 2024-01-18
WO2019038412A1 (fr) 2019-02-28
US10888605B2 (en) 2021-01-12
AR112480A1 (es) 2019-10-30
EP3474820C0 (fr) 2024-02-07
HUE066356T2 (hu) 2024-07-28
RS65380B1 (sr) 2024-04-30
EP3474820A1 (fr) 2019-05-01
JP2019528237A (ja) 2019-10-10
US12214017B2 (en) 2025-02-04
EP4360651A3 (fr) 2024-07-17
CN111050750A (zh) 2020-04-21
IL272232A (en) 2020-03-31
CN118903386A (zh) 2024-11-08
RU2020109402A (ru) 2021-09-03
US11752198B2 (en) 2023-09-12
PH12020550051A1 (en) 2020-10-19
KR20200044016A (ko) 2020-04-28
PL3474820T3 (pl) 2024-05-13
CL2021001430A1 (es) 2021-11-12
US20240216475A1 (en) 2024-07-04
KR102665710B1 (ko) 2024-05-14
PE20211202A1 (es) 2021-07-05
MX2020001525A (es) 2020-03-20
JP6633777B2 (ja) 2020-01-22
CO2020002647A2 (es) 2020-06-09
EP4360651A2 (fr) 2024-05-01
CN118903385A (zh) 2024-11-08
AU2018321157A1 (en) 2020-03-19
US20210085755A1 (en) 2021-03-25
TWI847306B (zh) 2024-07-01
TWI762706B (zh) 2022-05-01
TW202304501A (zh) 2023-02-01
TW202224670A (zh) 2022-07-01

Similar Documents

Publication Publication Date Title
MA46990B1 (fr) Compositions glp-1 et ses utilisations
WO2020106647A3 (fr) Polythérapie comprenant un inhibiteur de krasg12c et un ou plusieurs principes pharmaceutiquement actifs supplémentaires pour le traitement de cancers
CL2019003892A1 (es) Nuevos derivados de azaquinolina.
DOP2019000117A (es) Nuevos derivados de quinolina
MX2020006957A (es) Composicion de liberacion modificada que comprende un cannabinoide.
MA40814A1 (fr) Compositions pharmaceutiques pour thérapie combinée
UY37831A (es) Nuevos derivados de quinolina
MA41060A (fr) Compositions comprenant des souches bactériennes
MA41010A (fr) Compositions comprenant des souches bactériennes
WO2015070224A3 (fr) Polythérapie comprenant un inhibiteur de mdm2 et un ou plusieurs principes pharmaceutiquement actifs supplémentaires pour le traitement de cancers
PH12021550705A1 (en) Stable semaglutide compositions and uses thereof
MA43409B1 (fr) Composés polycycliques à utiliser en tant qu'inhibiteurs de la tyrosine kinase de bruton
MX2022009844A (es) Composiciones y usos del peptido similar al glucagon-1 (glp-1).
MX2023013577A (es) Composiciones de bismuto-tiol y metodos de uso.
BR112018072034A2 (pt) compostos mic-1 e usos dos mesmos
MX2019001121A (es) Nuevas formulaciones y composiciones de cannabis en comprimidos y metodos para su elaboracion.
MX2020008125A (es) Composiciones que comprenden berberina.
CR20230100A (es) Compuestos fosfolípidos y usos de los mismos
MX2020012800A (es) Cannabinoides y usos de los mismos.
FR3058059B1 (fr) Composition pharmaceutique comprenant le beta-elemene, le lupeol et le 2-hydroxycinnamaldehyde et/ou le 2'-benzoyloxycinnalmaldehyde et/ou le beta-sitosterol et/ou la curcumine.
CO2021014260A2 (es) Formas sólidas de un inhibidor de glyt1
EA202092695A1 (ru) Композиции, содержащие глюкозу и гемицеллюлозу, и их применение
FR3064264B1 (fr) Composition a base de tetrafluoropropene
MX2021015289A (es) Metiltioninio como mejorador de la funcion cognitiva.
PH12020551618A1 (en) Erenumab compositions and uses thereof