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KR950702839A - 레트로, 인버소-, 및 레트로- 인버소 합성 펩티드 유사체(retro-, inverso-, and retro-inverso synthetic peptide analogues) - Google Patents

레트로, 인버소-, 및 레트로- 인버소 합성 펩티드 유사체(retro-, inverso-, and retro-inverso synthetic peptide analogues) Download PDF

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KR950702839A
KR950702839A KR1019950700754A KR19950700754A KR950702839A KR 950702839 A KR950702839 A KR 950702839A KR 1019950700754 A KR1019950700754 A KR 1019950700754A KR 19950700754 A KR19950700754 A KR 19950700754A KR 950702839 A KR950702839 A KR 950702839A
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retro
inverso
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코미스 알피오
피셔 피터
이사벨 타일러 마가렛
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스티븐 딕
데킨 리서치 리미티드(Deakin Research Limited)
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Abstract

부분적인 또는 완전한 레트로, 인버소 또는 레트로-인버소 변형을 갖는 천연펩티드 항원의 합성펩티드 항원유사체가 제공된다. 면역능력있는 숙주에 면역원으로서 투여했을때 합성펩티드 항원 유사체는 천연펩티드 항원을 인식하는 항체의 생성을 유도한다. 또한 이러한 유사체의 이용, 백신 및 이 항원 유사체를 함유하는 백신의 제조방법, 그리고 이 항원 유사체를 이용하여 생성된 항체가 제공된다.

Description

레트로, 인버소-, 및 레트로- 인버소 합성 펩티드 유사체(RETRO-, INVERSO-, AND RETRO-INVERSO SYNTHETIC PEPTIDE ANALOGUES)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본발명에 따라서 아미노산 서열에 행해질 수 있는 변형을 예시한다. R1, R2, R3및 R4는 아미노산 측쇄를 나타내고, Xaa는 어떤 아미노산 잔기를 나타낸다.
제2도는 여러가지의 고정화된 펩티드-BSA에 대한 레트로-인버소 모델(mod) 펩티드-KLH 항혈청의 ELISA의 결과를 나타낸다-noMod(□), riMod(+), reMod(◇), inMod(△), 콘트롤1(X), 콘트롤2(▽),
제3도는 펩티드-BSA에 대한 말라리아(Ma ℓ)-펩티드 항혈청(경구 면역화)의 ELISA의 결과를 나타낸다-혈청/고정화된 항원 : riMa ℓ/riMa ℓ(△), riMa ℓ/moMa ℓ(+), noMa ℓ/noMa ℓ(□), noMa ℓ/riMa ℓ(◇), 비-면역혈청/noMa ℓ(X).
제4도는 고정화된 펩티드-BSA에 대한 디프테리아(DIP) 펩티드-KLH 항혈청의 ELISA의 결과를 나타낸다-혈청/고정화된 항원:riDip/riDiP(△), riDip/noDip(+), noDip/noDip(□), noDip/riDip(◇), 비-면역/noDip(X).
제5도는고정화된 디프테리아 독소에 대한 디프테리아(Dip) 펩티드-KLH 항혈청의 ELISA의 결과를 나타낸다-항-riDip(+), 항-noDip(□), 비-면역혁청(◇).
제6도는 고종화된 디프테리아 독소에 대해 경구적으로 유도된 디프테리아(Dip) 펩티드 항혈청의 ELISA의 결과를 나타낸다-항-noDip, 2주일(□), 항-riDip, 2주일(+), 항-riDip, 8주일(◇).

Claims (19)

  1. 천연펩티드 항원의 합성펩티드 항원 유사체에서, 이 유사체는 천연항원에 대해서 부분적으로 또는 완전히 레트로 변형된 것을 특징으로 하는 합성펩티드 항원 유사체.
  2. 천연펩티드 항원의 합성펩티드 항원 유사체에서, 이 유사체는 천연항원에 대해서 부분적으로 또는 완전히 인버소 변형된 것을 특징으로 하는 합성펩티드 항원 유사체.
  3. 천연펩티드 항원의 합성펩티드 항원 유사체에서, 이 유사체는 천연항원에 대해서 부분적으로 또는 완전히 레트로-인버소 변형된 것을 특징으로 하는 합성펩티드 항원 유사체.
  4. 제3항에 있어서, 레트로-인버소 변형된 서열의 측면부의 아미노산 잔기가 측쇄-유사한 α-치환된 게니말-디아미노메틴 및 말로네이트에 의해 치환된 것을 특징으로 하는 항원 유사체.
  5. 제1항 내지 제4항중 어느 한항에 있어서, 면역능력있는 숙주를 면역화시키는데 사용되는 것을 특징으로 하는 합성 펩티드 항원 유사체.
  6. 제1항 내지 제5항중 어느 한항에 있어서, 천연항원은 천연적으로 존재하는 폴리펩티드 또는 그것의 항원성 단편인 것을 특징으로 하는 항원 유사체.
  7. 제1항 내지 제6항중 어느 한항에 있어서, 항원 유사체는 P.falciparum 스포로 조이트의 스포로조이트 주위 외피단백질의 면역우세 에피토프, 또는 디프테리아 독소항원, 또는 로부스톡신, 또는 간염 바이러스 항원, 또는 HIV항원의 유사체인 것을 특징으로 하는 항원 유사체.
  8. 제2항 또는 제3항에 있어서, 대응하는 천연항원으로 얻어지는 면역반응보다 더 오래 지속되는 면역반응을 일으킬 수 있는 것을 특징으로 하는 항원 유사체.
  9. 제약학적으로 허용가능한 담체, 희석제, 부형제 및/또는 보조제와 함께 제1항 내지 제8항중 어느 한 항에 따른 항원 유사체를 함유하는 백신.
  10. 숙주에 투여하는데 적당한 담체분자와 컨쥬게이션된 제1항 내지 제8항중 어느 한항에 따른 항원유사체를 함유하는 백신.
  11. 제3항에 따른 항원 유사체를 함유하는 백신에서, 그 유사체 에피토프의 유사체이고, C 및 N 말단을 보호하도록 유사체가 변형된 것을 특징으로 하는 백신.
  12. 제1항 내지 제8항중 어느 한항에 따른 항원유사체 또는 제9항 내지 제11항중 어느 한항에 따른 백신에 대해서 만들어진 항체.
  13. 백신 접종치료가 필요한 숙주의 백신접종방법에서, 이 방법은 제1항 내지 제8항중 어느 한항에 따른 항원유사체 또는 제9항 내지 제12항중 어느한 항에 따른 백신의 유효량을 숙주에 투여하는 것으로 이루어지는 것을 특징으로 하는 방법.
  14. 포지티브 및 네가티브 콘트롤 표준물과 함께 제12항에 따른 항체 또는 제1항 내지 제8항중 어느 한 항에 따른 항원 유사체를 함유하는 진단 키트.
  15. 천연 펩티드 항원의 유사체를 제조하는 방법에서, 천연펩티드 항원의 부분적인 또는 완전한 레트로, 인버소 또는 레트로-인버소 유사체를 합성하는 것으로 이루어지는 방법.
  16. 천연 펩티드 항원에 대한 백신의 제조방법에서, 천연펩티드 항원의 레트로, 인버소 또는 레트로-인버소 유사체를 제공하고 제약학적으로 또는 수의학적으로 허용가능한 담체, 희석제, 부형제 및/또는 보조제와 함께 항원 유사체의 유효량을 혼합하는 것으로 이루어지는 것을 특징으로 하는 방법.
  17. 제15항에 있어서, 이 방법은 부가적으로 항원 유사체를 적당한 담체분자에 컨쥬게이션시키는 것을 포함하는 것을 특징으로 하는 방법.
  18. 천연펩티드 항원에 대해 샘플을 분석하는 방법에서, 그 항원을 인식하는 제12항에 따른 항체의 사용을 포함하는 것을 특징으로 하는 방법.
  19. 항체에 대해 샘플을 분석하는 방법에서, 그 항체에 결합할 수 있는 제1항 내지 제8항중 어느 한항에 따른 항원 유사체의 사용을 포함하는 것을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950700754A 1992-08-27 1993-08-27 레트로, 인버소-, 및 레트로- 인버소 합성 펩티드 유사체(retro-, inverso-, and retro-inverso synthetic peptide analogues) Withdrawn KR950702839A (ko)

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ATE258188T1 (de) 2004-02-15
EP0667786A4 (en) 1997-08-06
HU9500571D0 (en) 1995-04-28
JPH08500829A (ja) 1996-01-30
BR9306984A (pt) 1999-01-12
OA10129A (en) 1996-12-18
CN1091138A (zh) 1994-08-24
DE69333397T2 (de) 2004-12-09
HUT71860A (en) 1996-02-28
DE69333397D1 (de) 2004-02-26
CA2143823A1 (en) 1994-03-17
CA2143823C (en) 2005-07-26
EP0667786A1 (en) 1995-08-23
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