[go: up one dir, main page]

IT1164225B - Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione - Google Patents

Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione

Info

Publication number
IT1164225B
IT1164225B IT8321083A IT2108383A IT1164225B IT 1164225 B IT1164225 B IT 1164225B IT 8321083 A IT8321083 A IT 8321083A IT 2108383 A IT2108383 A IT 2108383A IT 1164225 B IT1164225 B IT 1164225B
Authority
IT
Italy
Prior art keywords
bpp5a
bradichina
pentapeptide
analogs
enhancing
Prior art date
Application number
IT8321083A
Other languages
English (en)
Other versions
IT8321083A1 (it
IT8321083A0 (it
Inventor
Alessandro Sisto
Antonio Silvio Verdini
Antonino Virdia
Original Assignee
Anic Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anic Spa filed Critical Anic Spa
Publication of IT8321083A0 publication Critical patent/IT8321083A0/it
Priority to IT8321083A priority Critical patent/IT1164225B/it
Priority to DE8484200658T priority patent/DE3482589D1/de
Priority to EP84200658A priority patent/EP0128602B1/en
Priority to EP88201526A priority patent/EP0301639A3/en
Priority to AT84200658T priority patent/ATE54154T1/de
Priority to CA000453932A priority patent/CA1252949A/en
Priority to US06/608,985 priority patent/US4522752A/en
Priority to AU27914/84A priority patent/AU571225B2/en
Priority to JP59094760A priority patent/JPH0635477B2/ja
Publication of IT8321083A1 publication Critical patent/IT8321083A1/it
Application granted granted Critical
Publication of IT1164225B publication Critical patent/IT1164225B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT8321083A 1983-05-13 1983-05-13 Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione IT1164225B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT8321083A IT1164225B (it) 1983-05-13 1983-05-13 Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione
AT84200658T ATE54154T1 (de) 1983-05-13 1984-05-08 Retro-inverse analoga des bradykininpotentialisierenden peptids bpp-5a und verfahren zu ihrer herstellung.
EP84200658A EP0128602B1 (en) 1983-05-13 1984-05-08 Retro-inverso analogues of the bradykinin potentiating peptide bpp5a and method for their preparation
EP88201526A EP0301639A3 (en) 1983-05-13 1984-05-08 Analogues of the bradykinin potentiating peptide bpp 5a and methods for their preparation
DE8484200658T DE3482589D1 (de) 1983-05-13 1984-05-08 Retro-inverse analoga des bradykinin-potentialisierenden peptids bpp-5a und verfahren zu ihrer herstellung.
CA000453932A CA1252949A (en) 1983-05-13 1984-05-09 Retro-inverso analogues of the bradykinin potentiating peptide bpp in5a xx and method for their preparation
US06/608,985 US4522752A (en) 1983-05-13 1984-05-10 Retro-inverso analogues of the bradykinin potentiating peptide BPP5a and methods for their preparation
AU27914/84A AU571225B2 (en) 1983-05-13 1984-05-11 Retro-inverso analogues of the bradykinin potentiating peptide bpp 5a
JP59094760A JPH0635477B2 (ja) 1983-05-13 1984-05-14 ペプチド及びその製法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8321083A IT1164225B (it) 1983-05-13 1983-05-13 Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione

Publications (3)

Publication Number Publication Date
IT8321083A0 IT8321083A0 (it) 1983-05-13
IT8321083A1 IT8321083A1 (it) 1984-11-13
IT1164225B true IT1164225B (it) 1987-04-08

Family

ID=11176481

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8321083A IT1164225B (it) 1983-05-13 1983-05-13 Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione

Country Status (8)

Country Link
US (1) US4522752A (it)
EP (2) EP0301639A3 (it)
JP (1) JPH0635477B2 (it)
AT (1) ATE54154T1 (it)
AU (1) AU571225B2 (it)
CA (1) CA1252949A (it)
DE (1) DE3482589D1 (it)
IT (1) IT1164225B (it)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1178789B (it) * 1984-12-21 1987-09-16 Assorenti Peptidi retro-invertiti analoghi del potenziatore della bradichinina bpp 5a
IT1184317B (it) * 1985-02-05 1987-10-28 Eniricerche Spa Retro-inverso analoghi del peptide potenziatore della bradichina bpp5a
IT1184164B (it) * 1985-03-19 1987-10-22 Eniricerche Spa Triptidi ad azione ipotensiva e procedimento per la loro sintesi
IT1190389B (it) * 1985-09-19 1988-02-16 Eniricerche Spa Esapeptidi ad attivita' ipotensiva
US6261569B1 (en) * 1992-08-27 2001-07-17 Deakin Research Limited Retro-, inverso- and retro-inverso synthetic peptide analogues
US5968895A (en) 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
WO1999038501A2 (en) 1998-02-02 1999-08-05 Trustees Of Tufts College Method of regulating glucose metabolism, and reagents related thereto
US6465495B1 (en) 1998-07-30 2002-10-15 Osi Pharmaceuticals, Inc. Preparation of pyridone-based phosphotyrosine mimetics and uses thereof
US6984719B1 (en) 1998-09-17 2006-01-10 Hospital Sainte-Justine Peptide antagonists of prostaglandin F2α receptor
US7396905B1 (en) 1999-05-21 2008-07-08 Mckeon Frank Calcipressins: endogenous inhibitors of calcineurin, uses and reagents related thereto
US20040235749A1 (en) * 1999-09-15 2004-11-25 Sylvain Chemtob G-protein coupled receptor antagonists
US6865492B2 (en) * 2000-01-24 2005-03-08 The Cielo Institute, Inc. Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins
US6560542B1 (en) * 2000-01-24 2003-05-06 The Cielo Institute Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins
US20050119454A1 (en) * 2000-01-24 2005-06-02 The Cielo Institute, Inc. Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins
BR0101088A (pt) * 2001-03-19 2003-03-18 Biolab Sanus Farmaceutica Ltda Processo de isolamento e purificação de peptìdeos inibidores das vasopeptidases, com especificidade para o sìtio carboxìlico da enzima conversora da angiotensina, secretados pelas glândulas do veneno de serpentes (bpps), particularmente bothrops jararaca, ou produzidos endogenamente (evasins) possuindo ação vasodilatadora e anti-hipertensiva; processo de determinação da sequência de amido-ácidos dos peptìdios inibidores secretados pela glândula de veneno de serpentes (bpps) ou endógenos (evasins); processo de determinação da sequência de aminoácidos dos bpps por dedução do cdna dos precursores dessas moléculas expressos em tecidos de serpentes, especificamente bothrops jararaca. processo de determinação da sequência de aminoácidos dos evasins por dedução do cdna dos precursores dessas moléculas expressos em tecidos de serpentes, especificamente bothrops jararaca, processo de amplificação do cdna a partir das bibliotecas de cdna de pâncreas e/ou cérebro de serpentes, especificamente bothrops jararaca; processo de sìntese em fase sólida de peptìdeos inibidores das vasopeptidases com ação vasodilatadora e anti-hipertensiva, peptìdeos inibidores das vasopeptidases com ação anti-hipertensiva; utilização dos peptìdeos inibidores das vaso peptidases com ação vasodilatadora e anti-hipertensiva na obtenção de composições farmacêuticas; processo de determinação da atividade inibitória sobre as vasopeptidases e de atividade biológica sobre músculo liso, sistema cardiovascular e microcirculatório.
HUP0401863A3 (en) 2001-10-03 2012-09-28 Harvard College Amino acid-copolymers for suppression of autoimmune diseases, and methods of use
EP1469873A4 (en) * 2001-11-26 2007-10-03 Tufts College PEPTIDOMIMETIC INHIBITORS FROM BEHIND PROLIN SPLENDING ENZYMES
WO2003045228A2 (en) * 2001-11-26 2003-06-05 Trustees Of Tufts College Methods for treating autoimmune disorders, and reagents related thereto
US6935959B2 (en) * 2002-05-16 2005-08-30 Microsoft Corporation Use of multiple player real-time voice communications on a gaming device
US7521530B2 (en) * 2002-06-11 2009-04-21 Universite De Montreal Peptides and peptidomimetics useful for inhibiting the activity of prostaglandin F2α receptor
US7521481B2 (en) 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
AU2004299457B2 (en) 2003-12-12 2011-03-24 Government Of The United States Of America, As Represented By The Secretary Department Of Health And Human Services A human cytotoxic T-lymphocyte epitope and its agonist epitope from the non-variable number of tandem repeat sequence of MUC-1
US7491263B2 (en) 2004-04-05 2009-02-17 Technology Innovation, Llc Storage assembly
JP2008506703A (ja) 2004-07-14 2008-03-06 ユニバーシティ オブ ユタ リサーチ ファウンデーション ネトリン関連化合物および用途
DE102004037356B4 (de) * 2004-07-30 2017-11-23 Ansaldo Energia Ip Uk Limited Wandstruktur zur Begrenzung eines Heißgaspfads
BRPI0517733A (pt) 2004-11-17 2008-10-21 Joanne Mclaurin composições compreendendo derivados de scilo-inositol e métodos para tratar transtornos de agregação de proteìna
GB0426146D0 (en) 2004-11-29 2004-12-29 Bioxell Spa Therapeutic peptides and method
EP2796146B1 (en) 2005-02-25 2016-11-09 University of Utah Research Foundation Tropoelastin for promoting endothelial cell adhesion or migration
EP2298792A3 (en) 2005-08-05 2011-10-19 Pharmagap Inc. Peptides targeted to protein kinase C isoforms and uses thereof
WO2007109583A2 (en) 2006-03-17 2007-09-27 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Compositions and methods for prevention or treatment of neoplastic disease in a mammalian subject
US8470963B2 (en) 2006-06-30 2013-06-25 Sku Asset Management Gmbh Multifunctional compounds for pharmaceutical purposes
ES2425264T3 (es) 2007-04-12 2013-10-14 Waratah Pharmaceuticals, Inc. Uso de derivados de ciclohexanohexol en el tratamiento de enfermedades oculares
KR20150083931A (ko) * 2007-06-27 2015-07-20 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 올리고펩티드 티로시나제 억제제 및 그의 용도
CN103864892A (zh) * 2007-06-27 2014-06-18 里兰斯坦福初级大学理事会 肽酪氨酸酶抑制剂及其应用
WO2009013319A1 (en) * 2007-07-23 2009-01-29 Bioxell Spa Screening, therapy and diagnosis
GB0821941D0 (en) 2008-12-01 2009-01-07 Renovo Ltd Non-surgical improvements of scars
JP2013532172A (ja) 2010-07-09 2013-08-15 ダナ ファーバー キャンサー インスティテュート インコーポレイテッド 安定化したインスリン分泌促進ペプチド及び使用方法
CA2861392C (en) 2012-01-26 2021-08-17 Christopher J. Soares Peptide antagonists of the calcitonin cgrp family of peptide hormones and their use
US9637527B2 (en) 2012-03-13 2017-05-02 James Cook University Method for treating inflammation with an Ac-TMP-2 protein
CA2902209A1 (en) 2013-03-15 2014-09-18 The Regents Of The University Of California Peptides having reduced toxicity that stimulate cholesterol efflux
WO2015039188A1 (en) 2013-09-18 2015-03-26 James Cook University Anti-inflammatory proteins and methods of use
EP4509188A2 (en) 2013-09-18 2025-02-19 James Cook University Modified anti-inflammatory proteins and method of use
CN115925878A (zh) 2015-06-05 2023-04-07 艾比欧公司 用于治疗纤维化的内皮抑素片段和变体
GB201609083D0 (en) 2016-05-24 2016-07-06 Syntab Therapeutics Gmbh Synthetic compound
CN109922820A (zh) 2016-09-02 2019-06-21 克里斯托弗·J·索尔斯 Cgrp受体拮抗剂在神经保护和神经系统疾病中的应用
US11858974B2 (en) 2017-05-22 2024-01-02 Resq Biotech Macrocyclic modulators of disease associated protein misfolding and aggregation
US12129302B2 (en) 2021-08-25 2024-10-29 Ibio, Inc. Anti-CD-25 antibody

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH568964A5 (it) * 1972-06-01 1975-11-14 Squibb & Sons Inc
HU185263B (en) * 1981-06-12 1984-12-28 Richter Gedeon Vegyeszet Process for producing peptides effective on the immuncontroll analogous with the tp5
IT1212508B (it) * 1981-12-22 1989-11-22 Anic Spa Analoghi retro - invertiti dei penta - ed esapeptidi c - terminali della sostanza p. utili come vasodilatatori
IT1190891B (it) * 1982-06-24 1988-02-24 Anic Spa Metodo per la sintesi in fase solida di polipeptidi retroinvertiti
ZA838780B (en) * 1982-11-26 1985-01-30 Nyegaard & Co As Peptide compounds
IT1164240B (it) * 1983-05-25 1987-04-08 Anic Spa Decapeptide parzialmente retro-invertito inibitore specifico della renina con elevata resistenza alla idrolisi enzimatica
IT1206339B (it) * 1984-01-13 1989-04-14 Anic Spa Analoghi retro-invertiti esapeptidici c-terminali della sostanza p.

Also Published As

Publication number Publication date
CA1252949A (en) 1989-04-18
EP0128602B1 (en) 1990-06-27
EP0301639A3 (en) 1989-10-18
IT8321083A1 (it) 1984-11-13
JPH0635477B2 (ja) 1994-05-11
EP0128602A3 (en) 1987-01-14
US4522752A (en) 1985-06-11
ATE54154T1 (de) 1990-07-15
IT8321083A0 (it) 1983-05-13
AU571225B2 (en) 1988-04-14
JPS59212453A (ja) 1984-12-01
DE3482589D1 (de) 1990-08-02
AU2791484A (en) 1984-11-15
EP0301639A2 (en) 1989-02-01
EP0128602A2 (en) 1984-12-19

Similar Documents

Publication Publication Date Title
IT1164225B (it) Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione
EA199800752A1 (ru) Пентафторбензолсульфонамиды и их аналоги
CY1107051T1 (el) Αντι-διηθητικα και αντι-αγγειογενετικα θραυσματα ουροκινασης και η χρηση τους
HUP0204136A2 (hu) Eljárások az interleukin-2 tüdőbe juttatására
ES2060951T3 (es) Azaindenos.
TR200100894T2 (tr) Aril ikameli propanolamin türevleri, imalat yöntemleri, ilaç maddeleri, kullanımları.
CY1116164T1 (el) Προδρομη 4-σουλφαταση ν-ακετυλογαλακτο σαμινης, μεθοδοι θεραπευτικης αγωγης που χρησιμοποιουν το εν λογω ενζυμο και μεθοδοι για παραγωγη και καθαρισμο του εν λογω ενζυμου
ES2158452T3 (es) Uso de agonistas y antagonistas de estrogenos en la fabricacion de un medicamento para el tratamiento de la ateroesclerosis, independientemente de la disminucion de lipidos.
EA200000785A1 (ru) Новые сульфонамидные производные в качестве ингибиторов рассасывания костной ткани и ингибиторов адгезии клеток
TR200101633T2 (tr) Farmasötik bileşim
NO882239L (no) Fremgangsmaate for fremstilling av terapeutisk aktive cykliske peptider.
NO882238D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive cykliske peptider.
EA200500882A1 (ru) N-арилсульфонил-3-аминоалкоксииндолы
EA200000996A1 (ru) Конденсированные с арилом азаполициклические соединения
ATE84545T1 (de) Derivate des alpha-anp und ihre herstellung.
NZ225715A (en) Cyclic peptides as promoters of absorption of peptides and proteins on administration onto the mucosa
IT1307786B1 (it) Analoghi di ceramidi, processo per la loro preparazione e loro usocome antitumorali.
MY104088A (en) Peptide-drugs compositions containing (alpha)-aminoboroic acid derivatives.
TR200100887T2 (tr) LH-RH analoglarının ağız yoluyla verilmesi için alfa-siklodekstrin esaslı farmasötik terkipler