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IT1227907B - Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento - Google Patents

Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento

Info

Publication number
IT1227907B
IT1227907B IT8823098A IT2309888A IT1227907B IT 1227907 B IT1227907 B IT 1227907B IT 8823098 A IT8823098 A IT 8823098A IT 2309888 A IT2309888 A IT 2309888A IT 1227907 B IT1227907 B IT 1227907B
Authority
IT
Italy
Prior art keywords
procedure
formula
amino acid
retro
synthesis
Prior art date
Application number
IT8823098A
Other languages
English (en)
Other versions
IT8823098A0 (it
Inventor
Massimo Pinori
Felice Centini
Antonio Silvio Verdini
Original Assignee
Eniricerche S P A Milano Sclav
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eniricerche S P A Milano Sclav filed Critical Eniricerche S P A Milano Sclav
Publication of IT8823098A0 publication Critical patent/IT8823098A0/it
Priority to IT8823098A priority Critical patent/IT1227907B/it
Priority to AT89203194T priority patent/ATE102949T1/de
Priority to US07/450,572 priority patent/US5061811A/en
Priority to DE68913935T priority patent/DE68913935T2/de
Priority to EP89203194A priority patent/EP0375040B1/en
Priority to ES89203194T priority patent/ES2061956T3/es
Priority to CA002006560A priority patent/CA2006560A1/en
Priority to JP1336182A priority patent/JPH02221294A/ja
Application granted granted Critical
Publication of IT1227907B publication Critical patent/IT1227907B/it
Priority to US07/742,873 priority patent/US5116947A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT8823098A 1988-12-23 1988-12-23 Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento IT1227907B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT8823098A IT1227907B (it) 1988-12-23 1988-12-23 Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento
EP89203194A EP0375040B1 (en) 1988-12-23 1989-12-14 Process for the preparation of retro-inverso peptides and new intermediates thereof
US07/450,572 US5061811A (en) 1988-12-23 1989-12-14 Process for the preparation of retro-inverso peptides and 1,3-dioxane-4,6-dione intermediates thereof
DE68913935T DE68913935T2 (de) 1988-12-23 1989-12-14 Verfahren zur Herstellung von Retro-Inverso-Peptiden und dessen Zwischenprodukte.
AT89203194T ATE102949T1 (de) 1988-12-23 1989-12-14 Verfahren zur herstellung von retro-inversopeptiden und dessen zwischenprodukte.
ES89203194T ES2061956T3 (es) 1988-12-23 1989-12-14 Procedimiento para la preparacion de peptidos retro-inversos y nuevos compuestos intermedios de los mismos.
CA002006560A CA2006560A1 (en) 1988-12-23 1989-12-22 Process for the preparation of retro-inverso peptides and new intermediates thereof
JP1336182A JPH02221294A (ja) 1988-12-23 1989-12-25 ペプチド合成法
US07/742,873 US5116947A (en) 1988-12-23 1991-08-09 Process for the preparation of retro-inverso peptides and new intermediates thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8823098A IT1227907B (it) 1988-12-23 1988-12-23 Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento

Publications (2)

Publication Number Publication Date
IT8823098A0 IT8823098A0 (it) 1988-12-23
IT1227907B true IT1227907B (it) 1991-05-14

Family

ID=11203765

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8823098A IT1227907B (it) 1988-12-23 1988-12-23 Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento

Country Status (8)

Country Link
US (2) US5061811A (it)
EP (1) EP0375040B1 (it)
JP (1) JPH02221294A (it)
AT (1) ATE102949T1 (it)
CA (1) CA2006560A1 (it)
DE (1) DE68913935T2 (it)
ES (1) ES2061956T3 (it)
IT (1) IT1227907B (it)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200506A (en) * 1987-03-19 1993-04-06 Eniricerche S.P.A. Process for preparing new thymopentin retro-inverso analogs and fragments thereof and the intermediates obtained therein
IT1227907B (it) * 1988-12-23 1991-05-14 Eniricerche S P A Milano Sclav Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento
US5218089A (en) * 1988-12-23 1993-06-08 Sclavo S.P.A. Retro-inverso analogues of thymopentin and the method for their synthesis
AU1194092A (en) * 1991-02-06 1992-09-07 Georgetown University Receptor blocking peptides of fibroblast growth factor receptor
WO1994005311A1 (en) 1992-08-27 1994-03-17 Deakin Research Limited Retro-, inverso-, and retro-inverso synthetic peptide analogues
CA2819705C (en) 1998-02-02 2014-07-08 Trustees Of Tufts College Method of regulating glucose metabolism, and reagents related thereto
US7396905B1 (en) 1999-05-21 2008-07-08 Mckeon Frank Calcipressins: endogenous inhibitors of calcineurin, uses and reagents related thereto
US20040082509A1 (en) 1999-10-12 2004-04-29 Christophe Bonny Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US8183339B1 (en) 1999-10-12 2012-05-22 Xigen S.A. Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US6610820B1 (en) * 1999-10-12 2003-08-26 University Of Lausanne Cell-permeable peptide inhibitors of the JNK signal transduction pathway
JP2005511636A (ja) 2001-11-26 2005-04-28 トラスティーズ オブ タフツ カレッジ 自己免疫疾患の治療方法及びそれに関する試薬
EP2316470A3 (en) * 2001-11-26 2011-08-24 Trustees Of Tufts College Peptidomimetic inhibitors of post-proline cleaving enzymes
US7858297B2 (en) 2001-12-18 2010-12-28 Centre National De La Recherche Scientifique Cnrs Chemokine-binding protein and methods of use
US7572886B2 (en) * 2001-12-18 2009-08-11 Centre National De La Recherche Scientifique Death associated proteins, and THAP1 and PAR4 pathways in apoptosis control
AU2003214558A1 (en) 2002-03-13 2003-09-22 Bayer Cropscience Sa Mutagenesis of aspergillus fungi and identification of genes essential for growth
US8080517B2 (en) 2005-09-12 2011-12-20 Xigen Sa Cell-permeable peptide inhibitors of the JNK signal transduction pathway
WO2007031098A1 (en) 2005-09-12 2007-03-22 Xigen S.A. Cell-permeable peptide inhibitors of the jnk signal transduction pathway
WO2009143865A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2009143864A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases
WO2010072228A1 (en) 2008-12-22 2010-07-01 Xigen S.A. Novel transporter constructs and transporter cargo conjugate molecules
WO2011160653A1 (en) 2010-06-21 2011-12-29 Xigen S.A. Novel jnk inhibitor molecules
JP5857056B2 (ja) 2010-10-14 2016-02-10 ザイジェン インフラメーション エルティーディー 慢性又は非慢性の炎症性眼疾患を治療するためのｊｎｋシグナル伝達経路の細胞透過性ペプチド阻害剤の使用
WO2013091670A1 (en) 2011-12-21 2013-06-27 Xigen S.A. Novel jnk inhibitor molecules for treatment of various diseases
WO2014206427A1 (en) 2013-06-26 2014-12-31 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
JP2016523274A (ja) 2013-06-26 2016-08-08 ザイジェン インフラメーション リミテッド 種々の疾患を処置するためのｊｎｋシグナル伝達経路の新規の細胞透過性ペプチド阻害剤の使用
WO2015197097A1 (en) 2014-06-26 2015-12-30 Xigen Inflammation Ltd. New use for jnk inhibitor molecules for treatment of various diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0253190B1 (en) * 1986-07-16 1992-12-30 ENIRICERCHE S.p.A. Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them
IT1227907B (it) * 1988-12-23 1991-05-14 Eniricerche S P A Milano Sclav Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento

Also Published As

Publication number Publication date
EP0375040B1 (en) 1994-03-16
US5061811A (en) 1991-10-29
DE68913935T2 (de) 1994-07-07
DE68913935D1 (de) 1994-04-21
US5116947A (en) 1992-05-26
CA2006560A1 (en) 1990-06-23
IT8823098A0 (it) 1988-12-23
EP0375040A3 (en) 1991-07-03
JPH02221294A (ja) 1990-09-04
ES2061956T3 (es) 1994-12-16
EP0375040A2 (en) 1990-06-27
ATE102949T1 (de) 1994-04-15

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19931230