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DE68913935D1 - Verfahren zur Herstellung von Retro-Inverso-Peptiden und dessen Zwischenprodukte. - Google Patents

Verfahren zur Herstellung von Retro-Inverso-Peptiden und dessen Zwischenprodukte.

Info

Publication number
DE68913935D1
DE68913935D1 DE89203194T DE68913935T DE68913935D1 DE 68913935 D1 DE68913935 D1 DE 68913935D1 DE 89203194 T DE89203194 T DE 89203194T DE 68913935 T DE68913935 T DE 68913935T DE 68913935 D1 DE68913935 D1 DE 68913935D1
Authority
DE
Germany
Prior art keywords
formula
amino acid
retro
preparation
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE89203194T
Other languages
English (en)
Other versions
DE68913935T2 (de
Inventor
Massimo Pinori
Felice Centini
Antonio Silvio Verdini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sclavo SpA
Original Assignee
Sclavo SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sclavo SpA filed Critical Sclavo SpA
Publication of DE68913935D1 publication Critical patent/DE68913935D1/de
Application granted granted Critical
Publication of DE68913935T2 publication Critical patent/DE68913935T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE68913935T 1988-12-23 1989-12-14 Verfahren zur Herstellung von Retro-Inverso-Peptiden und dessen Zwischenprodukte. Expired - Fee Related DE68913935T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8823098A IT1227907B (it) 1988-12-23 1988-12-23 Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento

Publications (2)

Publication Number Publication Date
DE68913935D1 true DE68913935D1 (de) 1994-04-21
DE68913935T2 DE68913935T2 (de) 1994-07-07

Family

ID=11203765

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68913935T Expired - Fee Related DE68913935T2 (de) 1988-12-23 1989-12-14 Verfahren zur Herstellung von Retro-Inverso-Peptiden und dessen Zwischenprodukte.

Country Status (8)

Country Link
US (2) US5061811A (de)
EP (1) EP0375040B1 (de)
JP (1) JPH02221294A (de)
AT (1) ATE102949T1 (de)
CA (1) CA2006560A1 (de)
DE (1) DE68913935T2 (de)
ES (1) ES2061956T3 (de)
IT (1) IT1227907B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200506A (en) * 1987-03-19 1993-04-06 Eniricerche S.P.A. Process for preparing new thymopentin retro-inverso analogs and fragments thereof and the intermediates obtained therein
US5218089A (en) * 1988-12-23 1993-06-08 Sclavo S.P.A. Retro-inverso analogues of thymopentin and the method for their synthesis
IT1227907B (it) * 1988-12-23 1991-05-14 Eniricerche S P A Milano Sclav Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento
AU1194092A (en) * 1991-02-06 1992-09-07 Georgetown University Receptor blocking peptides of fibroblast growth factor receptor
NZ255256A (en) * 1992-08-27 1997-02-24 Deakin Res Ltd Synthetic peptide antigen analogues with retro, inverso or retro-inverso modification, their use and antibodies against them
EP2583675A1 (de) 1998-02-02 2013-04-24 Trustees Of Tufts College Verwendung von Dipetidylpeptidasehemmer zur Regulierung des Glukosemetabolismus
US7396905B1 (en) 1999-05-21 2008-07-08 Mckeon Frank Calcipressins: endogenous inhibitors of calcineurin, uses and reagents related thereto
US20040082509A1 (en) 1999-10-12 2004-04-29 Christophe Bonny Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US8183339B1 (en) 1999-10-12 2012-05-22 Xigen S.A. Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US6610820B1 (en) * 1999-10-12 2003-08-26 University Of Lausanne Cell-permeable peptide inhibitors of the JNK signal transduction pathway
EP2769715A3 (de) 2001-11-26 2014-09-17 Trustees Of Tufts College Verfahren zur Behandlung von Autoimmunkrankheiten und damit zusammenhängende Reagenzien
EP2316470A3 (de) * 2001-11-26 2011-08-24 Trustees Of Tufts College Peptidomimetikuminhibitoren von post-Prolin-spaltenden Enzymen
WO2003051917A2 (en) * 2001-12-18 2003-06-26 Endocube Sas Novel death associated proteins of the thap family and related par4 pathways involved in apoptosis control
US7858297B2 (en) 2001-12-18 2010-12-28 Centre National De La Recherche Scientifique Cnrs Chemokine-binding protein and methods of use
AU2003214558A1 (en) 2002-03-13 2003-09-22 Bayer Cropscience Sa Mutagenesis of aspergillus fungi and identification of genes essential for growth
WO2007031098A1 (en) 2005-09-12 2007-03-22 Xigen S.A. Cell-permeable peptide inhibitors of the jnk signal transduction pathway
US8080517B2 (en) 2005-09-12 2011-12-20 Xigen Sa Cell-permeable peptide inhibitors of the JNK signal transduction pathway
WO2009143865A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2009143864A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases
WO2010072228A1 (en) 2008-12-22 2010-07-01 Xigen S.A. Novel transporter constructs and transporter cargo conjugate molecules
WO2011160653A1 (en) 2010-06-21 2011-12-29 Xigen S.A. Novel jnk inhibitor molecules
JP5857056B2 (ja) 2010-10-14 2016-02-10 ザイジェン インフラメーション エルティーディー 慢性又は非慢性の炎症性眼疾患を治療するためのｊｎｋシグナル伝達経路の細胞透過性ペプチド阻害剤の使用
WO2013091670A1 (en) 2011-12-21 2013-06-27 Xigen S.A. Novel jnk inhibitor molecules for treatment of various diseases
WO2014206427A1 (en) 2013-06-26 2014-12-31 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
AU2014301631A1 (en) 2013-06-26 2015-08-27 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of various diseases
WO2015197097A1 (en) 2014-06-26 2015-12-30 Xigen Inflammation Ltd. New use for jnk inhibitor molecules for treatment of various diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3783280T2 (de) * 1986-07-16 1993-05-06 Eniricerche Spa Teilweise retro-invertierte analoge des tuftsin, methode zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
IT1227907B (it) * 1988-12-23 1991-05-14 Eniricerche S P A Milano Sclav Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento

Also Published As

Publication number Publication date
US5061811A (en) 1991-10-29
US5116947A (en) 1992-05-26
ES2061956T3 (es) 1994-12-16
IT1227907B (it) 1991-05-14
EP0375040A2 (de) 1990-06-27
DE68913935T2 (de) 1994-07-07
ATE102949T1 (de) 1994-04-15
JPH02221294A (ja) 1990-09-04
EP0375040A3 (de) 1991-07-03
EP0375040B1 (de) 1994-03-16
CA2006560A1 (en) 1990-06-23
IT8823098A0 (it) 1988-12-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee