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MXPA05008156A - Inmunizacion activa para generar anticuerpos para beta-a soluble. - Google Patents

Inmunizacion activa para generar anticuerpos para beta-a soluble.

Info

Publication number
MXPA05008156A
MXPA05008156A MXPA05008156A MXPA05008156A MXPA05008156A MX PA05008156 A MXPA05008156 A MX PA05008156A MX PA05008156 A MXPA05008156 A MX PA05008156A MX PA05008156 A MXPA05008156 A MX PA05008156A MX PA05008156 A MXPA05008156 A MX PA05008156A
Authority
MX
Mexico
Prior art keywords
beta
soluble
fragments
antibodies
disease
Prior art date
Application number
MXPA05008156A
Other languages
English (en)
Inventor
Bard Frederique
Original Assignee
Neuralab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32850829&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA05008156(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Neuralab Ltd filed Critical Neuralab Ltd
Publication of MXPA05008156A publication Critical patent/MXPA05008156A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0007Nervous system antigens; Prions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invencion proporciona metodos utiles para efectuar la profilaxis o el tratamiento de la enfermedad de Alzheimer. Tales metodos implican la administracion de fragmentos BETA-A de las region central o C-terminal de beta-A. Tales fragmentos pueden inducir una mezcla policlonal de anticuerpos que se enlazan especificamente a BETA-A soluble sin enlazarse a las placas. Los anticuerpos pueden inhibir la formacion de depositos amiloides de BETA-A en el cerebro de un paciente a partir de A( soluble previniendo o tratando asi la enfermedad. El fragmento BETA-A 15-24 y los subfragmentos de 5-10 aminoacidos contiguos del mismo son los inmunogenos preferidos debido a su capacidad para generar una alta valoracion de anticuerpos.
MXPA05008156A 2003-02-01 2004-01-31 Inmunizacion activa para generar anticuerpos para beta-a soluble. MXPA05008156A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44415003P 2003-02-01 2003-02-01
PCT/US2004/002856 WO2004069182A2 (en) 2003-02-01 2004-01-31 Active immunization to generate antibodies to soluble a-beta

Publications (1)

Publication Number Publication Date
MXPA05008156A true MXPA05008156A (es) 2005-09-30

Family

ID=32850829

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05008156A MXPA05008156A (es) 2003-02-01 2004-01-31 Inmunizacion activa para generar anticuerpos para beta-a soluble.

Country Status (20)

Country Link
US (3) US20060188512A1 (es)
EP (1) EP1594969B1 (es)
JP (1) JP2006516639A (es)
KR (1) KR20050118669A (es)
CN (1) CN1745175A (es)
AU (1) AU2004209981B2 (es)
BR (1) BRPI0407058A (es)
CA (1) CA2513722A1 (es)
CR (1) CR7922A (es)
EC (1) ECSP055939A (es)
ES (1) ES2545765T3 (es)
HR (1) HRP20050670A2 (es)
MX (1) MXPA05008156A (es)
NO (1) NO20053862L (es)
NZ (1) NZ567324A (es)
PL (1) PL378571A1 (es)
RU (1) RU2390350C2 (es)
UA (1) UA87453C2 (es)
WO (1) WO2004069182A2 (es)
ZA (1) ZA200505782B (es)

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