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KR100323043B1 - 생물학적물질의캡슐화를위한고분자겔 - Google Patents

생물학적물질의캡슐화를위한고분자겔 Download PDF

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Publication number
KR100323043B1
KR100323043B1 KR1019940703035A KR19940703035A KR100323043B1 KR 100323043 B1 KR100323043 B1 KR 100323043B1 KR 1019940703035 A KR1019940703035 A KR 1019940703035A KR 19940703035 A KR19940703035 A KR 19940703035A KR 100323043 B1 KR100323043 B1 KR 100323043B1
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South Korea
Prior art keywords
membranes
polymerization
biological
optionally
macromers
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KR1019940703035A
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KR950700054A (ko
Inventor
제프리 에이. 후벨
챈드라셰크하르 피. 페탁
아마프리트 에스. 소니
네일 피. 데사이
제니퍼 엘. 힐
시에드 에프. 에이. 호사이니
Original Assignee
보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템
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Families Citing this family (396)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US20040195710A1 (en) * 1990-10-15 2004-10-07 Hubbell Jeffrey A. Gels for encapsulation of biological materials
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5380536A (en) * 1990-10-15 1995-01-10 The Board Of Regents, The University Of Texas System Biocompatible microcapsules
EP0610441A4 (en) * 1991-10-29 1996-01-10 Clover Cons Ltd CROSSLINKABLE POLYSACCHARIDES, POLYCATIONS AND LIPIDS CAN BE USED TO ENCODE AND DISPENSE MEDICINAL PRODUCTS.
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
DE69329594T2 (de) * 1992-02-28 2001-05-31 Board Of Regents, The University Of Texas System Photopolymerinierbare, biologisch abbaubare hydrogele als gewebekontaktmaterialien und trägerstoffe für kontrollierte freisetzung
US5871710A (en) * 1992-09-04 1999-02-16 The General Hospital Corporation Graft co-polymer adducts of platinum (II) compounds
US5749968A (en) * 1993-03-01 1998-05-12 Focal, Inc. Device for priming for improved adherence of gels to substrates
US5800373A (en) * 1995-03-23 1998-09-01 Focal, Inc. Initiator priming for improved adherence of gels to substrates
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6004547A (en) 1997-09-29 1999-12-21 Focal, Inc. Apparatus and method for local application of polymeric material to tissue
ES2123135T3 (es) * 1993-03-23 1999-01-01 Focal Inc Aparato y metodo para la aplicacion local de material polimerico a tejido.
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5453368A (en) * 1993-08-27 1995-09-26 Brown University Research Foundation Method of encapsulating biological substances in microspheres
US5994318A (en) * 1993-10-04 1999-11-30 Albany Medical College Cochleate delivery vehicles
US6063911A (en) * 1993-12-01 2000-05-16 Marine Polymer Technologies, Inc. Methods and compositions for treatment of cell proliferative disorders
US6743783B1 (en) * 1993-12-01 2004-06-01 Marine Polymer Technologies, Inc. Pharmaceutical compositions comprising poly-β-1→4-N-acetylglucosamine
US5858350A (en) * 1993-12-01 1999-01-12 Marine Polymer Technologies Methods and compositions for poly-β-1→4-N-acetylglucosamine cell therapy system
US6703017B1 (en) 1994-04-28 2004-03-09 Ixion Biotechnology, Inc. Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
US5665063A (en) 1994-06-24 1997-09-09 Focal, Inc. Methods for application of intraluminal photopolymerized gels
DE4426396A1 (de) * 1994-07-26 1996-02-01 Ulrich Prof Dr Zimmermann Verfahren zur Herstellung konzentrierter Lösungen von mikroverkapselten Zellen oder von suspendierten Wirkstoffen in mikroverkapselter Form
USRE38827E1 (en) 1994-07-27 2005-10-11 3M Innovative Properties Company Adhesive sealant composition
US5583114A (en) 1994-07-27 1996-12-10 Minnesota Mining And Manufacturing Company Adhesive sealant composition
US5931165A (en) * 1994-09-06 1999-08-03 Fusion Medical Technologies, Inc. Films having improved characteristics and methods for their preparation and use
US6911216B1 (en) 1994-10-12 2005-06-28 Genzyme Corporation Targeted delivery via biodegradable polymers
US5900245A (en) * 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
DE69637198T2 (de) 1995-03-23 2008-05-08 Genzyme Corp., Cambridge Redox und photoinitiatorsystem zur grundierung von verbesserter adhäsion von gelen zu substraten
CA2215317C (en) 1995-03-24 2002-07-23 Focal, Inc. Reduction of adhesions using controlled delivery of active oxygen inhibitors
GB9506844D0 (en) * 1995-04-03 1995-05-24 Armitage Ian M Pharmaceutical microencapsulation
FR2733230B1 (fr) * 1995-04-20 1997-05-30 Oreal Nouveaux derives d'ornithine, procede de preparation, utilisation et composition les comprenant
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
DE19519804A1 (de) * 1995-05-31 1996-12-05 Juergen Dr Schrezenmeir Bioaktive Kapsel mit veränderlicher Hülle
US6565842B1 (en) * 1995-06-07 2003-05-20 American Bioscience, Inc. Crosslinkable polypeptide compositions
US5827707A (en) * 1995-06-07 1998-10-27 Neocrin Company Method for manufacturing minimal volume capsules containing biological materials
US5779673A (en) * 1995-06-26 1998-07-14 Focal, Inc. Devices and methods for application of intraluminal photopolymerized gels
WO1997013461A1 (en) * 1995-10-11 1997-04-17 Fusion Medical Technologies, Inc. Device and method for sealing tissue
DE69634859D1 (de) * 1995-10-26 2005-07-21 Paul P Latta Induktion von immunologischer toleranz
AU1051597A (en) * 1995-11-09 1997-05-29 University Of Massachusetts Tissue re-surfacing with hydrogel-cell compositions
CN1052915C (zh) * 1995-11-27 2000-05-31 中国医学科学院生物医学工程研究所 用于携载基因的蛋白质涂层医用载体及其制作方法
US5908624A (en) * 1996-06-27 1999-06-01 Albany Medical College Antigenic modulation of cells
US6027721A (en) * 1996-05-20 2000-02-22 Cytotherapeutics, Inc. Device and method for encapsulated gene therapy
US5791352A (en) * 1996-06-19 1998-08-11 Fusion Medical Technologies, Inc. Methods and compositions for inhibiting tissue adhesion
US8007784B1 (en) 1996-06-27 2011-08-30 Albany Medical College Antigenic modulation of cells
US6696499B1 (en) * 1996-07-11 2004-02-24 Life Medical Sciences, Inc. Methods and compositions for reducing or eliminating post-surgical adhesion formation
US6721083B2 (en) * 1996-07-19 2004-04-13 E Ink Corporation Electrophoretic displays using nanoparticles
AU4648697A (en) 1996-09-23 1998-04-14 Chandrashekar Pathak Methods and devices for preparing protein concentrates
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US7009034B2 (en) * 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
US8003705B2 (en) * 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
BR9711537B1 (pt) * 1996-09-23 2010-12-14 macrâmero polimerizÁvel biodegradÁvel, mÉtodo para aumentar a elasticidade de um gel de polÍmero hidrofÍlico e mÉtodo para melhorar a biodegradabilidade de um macrâmero quimicamente reativo compreendendo carbonato.
US20090324721A1 (en) * 1996-09-23 2009-12-31 Jack Kennedy Hydrogels Suitable For Use In Polyp Removal
DE69832288T2 (de) * 1997-03-20 2006-07-13 Genzyme Corp., Cambridge Biologisch abbaubarer gewebespreizer
US5849800A (en) * 1997-03-28 1998-12-15 The Penn State Research Foundation Use of amantadine for treatment of Hepatitis C
US6127520A (en) * 1997-04-15 2000-10-03 Regents Of The University Of Michigan Compositions and methods for the inhibition of neurotransmitter uptake of synaptic vesicles
US5972332A (en) 1997-04-16 1999-10-26 The Regents Of The University Of Michigan Wound treatment with keratinocytes on a solid support enclosed in a porous material
CA2286590C (en) * 1997-04-18 2005-08-02 California Institute Of Technology Multifunctional polymeric tissue coatings
US6015474A (en) 1997-06-20 2000-01-18 Protein Polymer Technologies Methods of using primer molecules for enhancing the mechanical performance of tissue adhesives and sealants
US6211249B1 (en) * 1997-07-11 2001-04-03 Life Medical Sciences, Inc. Polyester polyether block copolymers
US5837752A (en) * 1997-07-17 1998-11-17 Massachusetts Institute Of Technology Semi-interpenetrating polymer networks
EP1512395A1 (en) * 1997-07-18 2005-03-09 Azopax Therapeutics LLC Biodegradable macromers for the controlled release of biologically active substances
CN1271277A (zh) * 1997-07-18 2000-10-25 因菲米德有限公司 用于生物活性物质控释的生物可降解的大分子的单体
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
WO1999006563A1 (en) 1997-07-30 1999-02-11 Emory University Novel bone mineralization proteins, dna, vectors, expression systems
US6471993B1 (en) 1997-08-01 2002-10-29 Massachusetts Institute Of Technology Three-dimensional polymer matrices
ZA987019B (en) * 1997-08-06 1999-06-04 Focal Inc Hemostatic tissue sealants
US6316522B1 (en) 1997-08-18 2001-11-13 Scimed Life Systems, Inc. Bioresorbable hydrogel compositions for implantable prostheses
US5854382A (en) * 1997-08-18 1998-12-29 Meadox Medicals, Inc. Bioresorbable compositions for implantable prostheses
US6458357B1 (en) 1997-09-09 2002-10-01 Myelos Corporation Retro-inverso neurotrophic and analgesic peptides
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
CA2305349A1 (en) * 1997-10-27 1999-05-06 Alexander R. Irvine Methods and pharmaceutical compositions for the closure of retinal breaks
US6872387B1 (en) 1998-02-24 2005-03-29 The Regents Of The University Of Michigan Three-dimensional hydrogel/cell system
US6096726A (en) 1998-03-11 2000-08-01 Surface Solutions Laboratories Incorporated Multicomponent complex for use with substrate
US20020156434A1 (en) * 1998-03-13 2002-10-24 Minimed Inc. Stabilizing catheter for protein drug delivery
US6312685B1 (en) 1998-03-13 2001-11-06 Timothy C. Fisher Red blood cells covalently bound with two different polyethylene glycol derivatives
US6942859B2 (en) 1998-03-13 2005-09-13 University Of Southern California Red blood cells covalently bound with polymers
US6007833A (en) * 1998-03-19 1999-12-28 Surmodics, Inc. Crosslinkable macromers bearing initiator groups
AU768179B2 (en) * 1998-03-19 2003-12-04 Surmodics, Inc. Crosslinkable macromers bearing initiator groups
US7547445B2 (en) * 1998-03-19 2009-06-16 Surmodics, Inc. Crosslinkable macromers
US6410044B1 (en) 1998-03-19 2002-06-25 Surmodics, Inc. Crosslinkable macromers
US6027744A (en) * 1998-04-24 2000-02-22 University Of Massachusetts Medical Center Guided development and support of hydrogel-cell compositions
DE19818360C2 (de) * 1998-04-24 2000-05-31 Suisse Electronique Microtech Dextranbeschichtete Oberfläche
US6171610B1 (en) * 1998-04-24 2001-01-09 University Of Massachusetts Guided development and support of hydrogel-cell compositions
EP1555036B1 (en) 1998-04-27 2010-05-05 Surmodics Inc. Bioactive agent release coating
US5998534A (en) * 1998-06-19 1999-12-07 Ppg Industries Ohio, Inc. Water-soluble or water-dispersible addition copolymer
DE1095076T1 (de) * 1998-07-08 2002-04-04 Sunsoft Corp., Albuquerque Ineinandergreifendes polymernetzwerk aus hydrophilen hydrogelen für kontaktlinsen
ATE377449T1 (de) † 1998-07-15 2007-11-15 Max Planck Gesellschaft Polyelektrolythüllen auf biologischen templaten
US7347850B2 (en) * 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US6818018B1 (en) 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US6605294B2 (en) * 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US20020028783A1 (en) * 1999-09-09 2002-03-07 O'brien John S. Method of stimulating prosaposin receptor activity
US6399649B1 (en) * 1998-09-24 2002-06-04 Boston Medical Center Corporation Compositions and methods for the treatment of chronic lymphocytic leukemia
US6022361A (en) * 1998-10-09 2000-02-08 Biointerventional Corporation Device for introducing and polymerizing polymeric biomaterials in the human body and method
US6454811B1 (en) * 1998-10-12 2002-09-24 Massachusetts Institute Of Technology Composites for tissue regeneration and methods of manufacture thereof
ATE269114T1 (de) * 1998-11-20 2004-07-15 Univ Connecticut Verfahren und vorrichtung zur steuerung der gewebeimplantat-interaktionen
US20030099682A1 (en) * 1998-11-20 2003-05-29 Francis Moussy Apparatus and method for control of tissue/implant interactions
US6864301B2 (en) * 1998-11-30 2005-03-08 The Regents Of The University Of Colorado Preparation and use of photopolymerized microparticles
US20080114092A1 (en) * 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
EP1137373A4 (en) 1998-12-04 2004-05-19 Chandrashekhar P Pathak BIOCOMPATIBLE, CROSSLINKED POLYMERS
US6958212B1 (en) 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
ES2368988T3 (es) 1999-02-01 2011-11-24 Eidgenössische Technische Hochschule Zürich Bio-materiales formados por reacción de adición nucleófila a grupos insaturados conjugados.
JP4812167B2 (ja) * 1999-02-12 2011-11-09 モレキュラー インサイト ファーマスーティカルズ インコーポレイテッド 薬物輸送用マトリックス、ならびにその作成方法および使用方法
US6849702B2 (en) * 1999-02-26 2005-02-01 Robert W. Callahan Polymer matrix material
US6605391B2 (en) * 1999-02-26 2003-08-12 Reveo, Inc. Solid gel membrane
US6358651B1 (en) * 1999-02-26 2002-03-19 Reveo, Inc. Solid gel membrane separator in rechargeable electrochemical cells
AU3862900A (en) 1999-03-01 2000-09-21 Uab Research Foundation Porous tissue scaffolding materials and uses thereof
US6495161B1 (en) * 1999-03-09 2002-12-17 Vivorx, Inc. Cytoprotective biocompatible containment systems for biologically active materials and methods of making same
AU4173000A (en) * 1999-03-19 2000-10-09 Regents Of The University Of Michigan, The Mineralization and cellular patterning on biomaterial surfaces
US6767928B1 (en) * 1999-03-19 2004-07-27 The Regents Of The University Of Michigan Mineralization and biological modification of biomaterial surfaces
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
EP1168934B1 (en) * 1999-04-12 2008-02-13 Cornell Research Foundation, Inc. Hydrogel-forming system with hydrophobic and hydrophilic components
JP4647792B2 (ja) * 1999-04-28 2011-03-09 イジュノシッヒ テクニッヒ ホッフシューラ チューリッヒ 分析用デバイスおよびセンシングデバイスにおけるポリイオン性コーティング
US20060247665A1 (en) 1999-05-28 2006-11-02 Ferree Bret A Methods and apparatus for treating disc herniation and preventing the extrusion of interbody bone graft
US7273497B2 (en) 1999-05-28 2007-09-25 Anova Corp. Methods for treating a defect in the annulus fibrosis
US20070038231A1 (en) 1999-05-28 2007-02-15 Ferree Bret A Methods and apparatus for treating disc herniation and preventing the extrusion of interbody bone graft
US6579951B1 (en) * 1999-06-08 2003-06-17 Life Medical Sciences, Inc. Chain-extended or crosslinked polyethylene oxide/polypropylene oxide/polyethylene oxide block polymer with optional polyester blocks
US6521431B1 (en) * 1999-06-22 2003-02-18 Access Pharmaceuticals, Inc. Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments
US8188043B2 (en) * 1999-07-28 2012-05-29 The Board Of Trustees Of The Leland Stanford Jr. University Nicotine in therapeutic angiogenesis and vasculogenesis
JP2001048978A (ja) 1999-08-04 2001-02-20 Nano Career Kk オキサゾリン由来のポリマーセグメントを有するブロックコポリマー
US6719797B1 (en) 1999-08-13 2004-04-13 Bret A. Ferree Nucleus augmentation with in situ formed hydrogels
US7056503B2 (en) * 1999-08-19 2006-06-06 Regents Of The University Of Michigan Enclosures housing cell-coated supports for treating tumors
AU7719300A (en) * 1999-09-27 2001-04-30 Ixion Biotechnology, Inc. Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
US6521284B1 (en) * 1999-11-03 2003-02-18 Scimed Life Systems, Inc. Process for impregnating a porous material with a cross-linkable composition
AU1811301A (en) * 1999-12-02 2001-06-12 General Hospital Corporation, The Methods for removal, purification, and concentration of viruses, and methods of therapy based thereupon
US7560275B2 (en) * 1999-12-30 2009-07-14 Vbi Technologies, L.L.C. Compositions and methods for generating skin
US7575921B2 (en) * 1999-12-30 2009-08-18 Vbi Technologies, L.L.C. Spore-like cells and uses thereof
JP2001208754A (ja) * 2000-01-26 2001-08-03 Kazunori Kataoka 生物学的な被検体を検出するための組成物
US20030095993A1 (en) * 2000-01-28 2003-05-22 Hanne Bentz Gel-infused sponges for tissue repair and augmentation
US7039453B2 (en) * 2000-02-08 2006-05-02 Tarun Mullick Miniature ingestible capsule
US6652883B2 (en) * 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
ATE327262T1 (de) * 2000-03-13 2006-06-15 Biocure Inc Zusammensetzungen zur erhöhung des gewebevolumens und beschichtungszusammensetzungen
US6676971B2 (en) 2000-03-13 2004-01-13 Biocure, Inc. Embolic compositions
US8642051B2 (en) 2000-03-21 2014-02-04 Suzanne Jaffe Stillman Method of hydration; infusion packet system(s), support member(s), delivery system(s), and method(s); with business model(s) and Method(s)
AU2001263281A1 (en) * 2000-05-18 2001-11-26 Genetix Pharmaceuticals, Inc. Polyethylene glycol (peg) polymers for the promotion of angiogenesis
US7291673B2 (en) * 2000-06-02 2007-11-06 Eidgenossiche Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
DE10031132A1 (de) * 2000-06-30 2002-01-17 Henkel Kgaa Verfahren zur Herstellung aktivstoffhaltiger Kapseln mit ultradünner Wandschicht
EP1193056A1 (en) * 2000-09-29 2002-04-03 International Business Machines Corporation Silicone elastomer stamp with hydrophilic surfaces and method of making same
CA2426692C (en) * 2000-10-19 2011-01-25 Eidgenossische Technische Hochschule Zurich Block copolymers for multifunctional self-assembled systems
KR100380569B1 (ko) * 2000-10-24 2003-04-26 주식회사 메디프렉스 고분자 결합을 이용한 췌장소도 막의 표면개질 방법
US20020151050A1 (en) * 2000-10-30 2002-10-17 Vacanti Charles A. Isolation of spore-like cells from tissues exposed to extreme conditions
WO2002036072A2 (en) * 2000-11-03 2002-05-10 Biomedicines, Inc. Method for short-term and long-term drug dosimetry
FR2816847B1 (fr) * 2000-11-22 2006-07-14 Assist Publ Hopitaux De Paris Biomateriaux polymeriques poreux, procede de preparation et utilisations
US6596471B2 (en) * 2000-12-21 2003-07-22 Carbomedics Inc. Method of cross-linking tissue with a bis-maleimide compound
FR2820057A1 (fr) * 2001-01-30 2002-08-02 Ct De Transfert De Technologie Membrane pour chambre d'encapsulation de cellules produisant au moins une substance biologiquement active et organe bio-artificiel comprenant une telle membrane
US6518330B2 (en) * 2001-02-13 2003-02-11 Board Of Trustees Of University Of Illinois Multifunctional autonomically healing composite material
US20060287240A1 (en) * 2001-03-09 2006-12-21 O'brien John S Method of stimulating prosaposin receptor activity
FI20010523A0 (fi) * 2001-03-16 2001-03-16 Yli Urpo Antti Soolien, geelien ja niiden seosten käsittely
US7771468B2 (en) 2001-03-16 2010-08-10 Angiotech Biocoatings Corp. Medicated stent having multi-layer polymer coating
WO2002074354A1 (en) * 2001-03-16 2002-09-26 Delsitech Oy Treatment of sols, gels, mixtures or composites of sols and gels, and/or sol-gel derived materials
US20030044468A1 (en) * 2001-03-20 2003-03-06 Francesco Cellesi Two-phase processing of thermosensitive polymers for use as biomaterials
JP2005508663A (ja) * 2001-06-07 2005-04-07 サーモディックス，インコーポレイティド 架橋性マクロマー
US8101196B2 (en) * 2001-06-26 2012-01-24 Biointeractions, Ltd. Polysaccharide biomaterials and methods of use thereof
US6685927B2 (en) * 2001-09-27 2004-02-03 Ceramoptec Industries, Inc. Topical application of chromophores for hair removal
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7795210B2 (en) * 2001-10-10 2010-09-14 Novo Nordisk A/S Protein remodeling methods and proteins/peptides produced by the methods
US8008252B2 (en) 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
MXPA04003333A (es) 2001-10-10 2006-02-22 Neose Technologies Inc Remodelado y glicoconjugacion de peptidos.
EP1536839B1 (en) * 2001-11-09 2010-09-15 Intarcia Therapeutics, Inc Combination therapy comprising omega-interferon for treating infection with hepatitis c virus or yellow fever virus
FR2833961B1 (fr) * 2001-12-20 2004-04-02 Virsol Procede de preparation de films a base de poly(oxyde d'ethylene) reticule
US20040266026A1 (en) * 2002-01-10 2004-12-30 Amiji Mansoor M. Hybrid immobilized catalytic system with controlled permeability
US20030229333A1 (en) * 2002-02-22 2003-12-11 Control Delivery Systems, Inc. Methods for treating otic disorders
ITPD20020064A1 (it) * 2002-03-12 2003-09-12 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
US6616954B1 (en) * 2002-03-14 2003-09-09 Balchem Corporation Solvent released encapsulated yeast
US20030179692A1 (en) * 2002-03-19 2003-09-25 Yoshitaka Ohotomo Storage medium
US8282912B2 (en) * 2002-03-22 2012-10-09 Kuros Biosurgery, AG Compositions for tissue augmentation
US7419947B2 (en) * 2002-03-27 2008-09-02 Novozymes A/S Process for preparing granules with filamentous coatings
WO2003094898A2 (en) * 2002-05-07 2003-11-20 Mcmaster University Microcapsules containing biomedical materials
MXPA04012496A (es) 2002-06-21 2005-09-12 Novo Nordisk Healthcare Ag Glicoformos del factor vii pegilados.
US7217254B2 (en) 2002-09-20 2007-05-15 Genzyme Corporation Multi-pressure biocompatible agent delivery device and method
US7862831B2 (en) * 2002-10-09 2011-01-04 Synthasome, Inc. Method and material for enhanced tissue-biomaterial integration
US20050069572A1 (en) * 2002-10-09 2005-03-31 Jennifer Elisseeff Multi-layered polymerizing hydrogels for tissue regeneration
NZ539713A (en) * 2002-10-11 2008-07-31 Novocell Inc Implantation of encapsulated biological materials for treating diseases
WO2004046200A1 (ja) * 2002-11-21 2004-06-03 Chugai Seiyaku Kabushiki Kaisha 薬物徐放担体
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
US7420024B2 (en) * 2003-01-16 2008-09-02 Cornell Research Foundation, Inc. Partially biodegradable temperature and pH sensitive hydrogel
ATE531447T1 (de) * 2003-01-17 2011-11-15 Cornell Res Foundation Inc Injizierbare hydrogel-microsphären aus wässrigem zwei-phasen-system
US7393493B2 (en) * 2003-02-27 2008-07-01 A Enterprises, Inc. Crosslinkable polymeric materials and their applications
US20060052471A1 (en) * 2003-02-27 2006-03-09 A Enterprises, Inc. Initiators and crosslinkable polymeric materials
NZ542094A (en) 2003-03-14 2008-12-24 Neose Technologies Inc Branched polymer conjugates comprising a peptide and water-soluble polymer chains
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
PL1615945T3 (pl) 2003-04-09 2012-03-30 Ratiopharm Gmbh Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami
US7585499B2 (en) * 2003-04-10 2009-09-08 Surmodics, Inc. Method for encapsulation of cellular material using a charged initiator polymer
US7820158B2 (en) * 2003-04-10 2010-10-26 Surmodics, Inc. Ligand-coupled initiator polymers and methods of use
JP2007523630A (ja) * 2003-05-09 2007-08-23 ネオス テクノロジーズ インコーポレイテッド ヒト成長ホルモングリコシル化突然変異体の組成と調合法
US7251893B2 (en) * 2003-06-03 2007-08-07 Massachusetts Institute Of Technology Tribological applications of polyelectrolyte multilayers
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
AU2004272081A1 (en) * 2003-09-12 2005-03-24 Bankruptcy Estate Of Ferx, Inc. Magnetically targetable particles comprising magnetic components and biocompatible polymers for site-specific delivery of biologically active agents
US20050282747A1 (en) * 2003-10-01 2005-12-22 The Research Foundation Of State University Of New York At Stony Brook Methods and compositions for wound healing
US7128931B2 (en) * 2003-10-17 2006-10-31 Francois Leblond Semi-permeable microcapsule with covalently linked layers and method for producing same
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US7846333B2 (en) * 2003-11-24 2010-12-07 Effendorf AG Porous media
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US8202833B2 (en) * 2003-11-26 2012-06-19 Surmodics, Inc. Composition containing biocompatible polymerization accelerator and polymerizable material
US20060040856A1 (en) * 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
US7956032B2 (en) 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
US7842667B2 (en) 2003-12-22 2010-11-30 Regentis Biomaterials Ltd. Matrix composed of a naturally-occurring protein backbone cross linked by a synthetic polymer and methods of generating and using same
WO2005061018A1 (en) * 2003-12-22 2005-07-07 Regentis Biomaterials Ltd. Matrix comprising naturally-occurring protein backbone
US7846137B2 (en) * 2003-12-26 2010-12-07 Medtronic Minimed, Inc. Modular catheter system
US20050148928A1 (en) * 2003-12-31 2005-07-07 Medtronic Minimed, Inc. Multiple layer tubing and method of making same
US8361961B2 (en) 2004-01-08 2013-01-29 Biogenerix Ag O-linked glycosylation of peptides
US20050180957A1 (en) * 2004-01-16 2005-08-18 Scharp David W. Method of using fibrin-bound angiogenic factors to stimulate vascularization of transplant site of encapsulated cells
US20050202096A1 (en) * 2004-03-09 2005-09-15 Jun Li Microcapsules for encapsulation of bioactive substances
US7205145B2 (en) * 2004-03-24 2007-04-17 Zefon International, Inc. Gas-borne matter collection device
WO2005099787A1 (en) 2004-04-06 2005-10-27 Surmodics, Inc. Coating compositions for bioactive agents
US7566747B2 (en) * 2004-05-07 2009-07-28 The Board Of Trustees Of The University Of Illinois Wax particles for protection of activators, and multifunctional autonomically healing composite materials
US20050266415A1 (en) * 2004-05-28 2005-12-01 Zefon International, Inc. Method for sampling gas-borne matter
US20050271727A1 (en) * 2004-06-07 2005-12-08 Callisyn Pharmaceuticals, Inc. Biodegradable and biocompatible crosslinked polymer hydrogel prepared from PVA and/or PEG macromer mixtures
US7723086B2 (en) 2004-06-16 2010-05-25 Agency For Science, Technology + Research Apparatus for encapsulating cells
WO2006004941A2 (en) * 2004-06-29 2006-01-12 Biocure, Inc. Biomaterial
WO2006010143A2 (en) 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
US20090292110A1 (en) * 2004-07-23 2009-11-26 Defrees Shawn Enzymatic modification of glycopeptides
US7964219B2 (en) * 2004-08-12 2011-06-21 Qps, Llc Pharmaceutical compositions for controlled release delivery of biologically active compounds
EP1796693A2 (en) * 2004-08-26 2007-06-20 Chandrashekhar P. Pathak Implantable tissue compositions and method
US8268967B2 (en) 2004-09-10 2012-09-18 Novo Nordisk A/S Glycopegylated interferon α
AU2005299672A1 (en) * 2004-10-22 2006-05-04 Benitec, Inc. Therapeutic RNAi agents for treating psoriasis
EP2586456B1 (en) 2004-10-29 2016-01-20 ratiopharm GmbH Remodeling and glycopegylation of fibroblast growth factor (FGF)
JP2008526864A (ja) * 2005-01-06 2008-07-24 ネオス テクノロジーズ インコーポレイテッド 糖断片を用いる糖結合
AU2006203792B2 (en) 2005-01-10 2011-11-03 Ratiopharm Gmbh Glycopegylated Granulocyte Colony Stimulating Factor
US20060239986A1 (en) * 2005-01-26 2006-10-26 Perez-Luna Victor H Method for the formation of hydrogel multilayers through surface initiated photopolymerization
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
EP1846505B1 (en) * 2005-02-09 2015-11-11 Covidien LP Synthetic sealants
CA2598268C (en) * 2005-02-18 2011-01-04 Synthasome Inc. Synthetic structure for soft tissue repair
WO2006099137A1 (en) * 2005-03-10 2006-09-21 Uab Research Foundation Endothelial predecessor cell seeded wound healing scaffold
US20060228734A1 (en) * 2005-03-18 2006-10-12 Applera Corporation Fluid processing device with captured reagent beads
US20060222596A1 (en) 2005-04-01 2006-10-05 Trivascular, Inc. Non-degradable, low swelling, water soluble radiopaque hydrogel polymer
WO2006121569A2 (en) 2005-04-08 2006-11-16 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US7612152B2 (en) * 2005-05-06 2009-11-03 The Board Of Trustees Of The University Of Illinois Self-healing polymers
US20110003744A1 (en) * 2005-05-25 2011-01-06 Novo Nordisk A/S Glycopegylated Erythropoietin Formulations
JP5216580B2 (ja) 2005-05-25 2013-06-19 ノヴォ ノルディスク アー／エス グリコペグ化第ｉｘ因子
WO2006127910A2 (en) * 2005-05-25 2006-11-30 Neose Technologies, Inc. Glycopegylated erythropoietin formulations
JP5329949B2 (ja) * 2005-05-31 2013-10-30 エコーレ ポリテクニーク フェデラーレ デ ローザンヌ 遺伝子に基づいた薬物の細胞質送達のためのトリブロックコポリマー
WO2006138542A2 (en) * 2005-06-15 2006-12-28 Surmodics, Inc. Macromer composition including light activated initiator
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
WO2007048105A2 (en) * 2005-10-19 2007-04-26 A Enterprises, Inc. Curable bone substitute
US8318973B2 (en) * 2005-10-21 2012-11-27 Bezwada Biomedical, Llc Functionalized sinapic acid and methyl sinapate
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
TWI285100B (en) * 2005-12-27 2007-08-11 Ind Tech Res Inst Surface modification of polysaccharide, the modified polysaccharide, and method of culturing and recovery cells using the same
US20070149641A1 (en) * 2005-12-28 2007-06-28 Goupil Dennis W Injectable bone cement
WO2007082153A2 (en) 2006-01-05 2007-07-19 The Board Of Trustees Of The University Of Illinois Self-healing coating system
SI1984009T1 (sl) * 2006-01-18 2013-02-28 Qps, Llc Farmacevtski sestavki z izboljĺ ano stabilnostjo
US20070212385A1 (en) * 2006-03-13 2007-09-13 David Nathaniel E Fluidic Tissue Augmentation Compositions and Methods
DE102006014862A1 (de) * 2006-03-30 2007-10-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Abdeckmaterial für Biomasse und Verfahren zu dessen Herstellung
US20070237749A1 (en) * 2006-04-07 2007-10-11 Wang Taylor G Multi-membrane immunoisolation system for cellular transplant
WO2007127198A2 (en) * 2006-04-24 2007-11-08 Incept, Llc Protein crosslinkers, crosslinking methods and applications thereof
DK2020990T3 (da) 2006-05-30 2010-12-13 Intarcia Therapeutics Inc Strømningsmodulator med en indre kanal til et todelt osmotisk fremføringssystem
US7872068B2 (en) * 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
US20070280986A1 (en) * 2006-06-01 2007-12-06 Carlos Gil Intra-operative coating of implants
US7569625B2 (en) * 2006-06-02 2009-08-04 The Board Of Trustees Of The University Of Illinois Self-healing elastomer system
US8821549B2 (en) 2006-06-13 2014-09-02 Anova Corporation Methods and apparatus for anulus repair
US8834496B2 (en) 2006-06-13 2014-09-16 Bret A. Ferree Soft tissue repair methods and apparatus
US9232938B2 (en) 2006-06-13 2016-01-12 Anova Corp. Method and apparatus for closing fissures in the annulus fibrosus
US8764835B2 (en) 2006-06-13 2014-07-01 Bret A. Ferree Intervertebral disc treatment methods and apparatus
WO2007147086A2 (en) * 2006-06-14 2007-12-21 Brigham Young University Adsorption-resistant acrylic copolymer for fluidic devices
FR2902661B1 (fr) * 2006-06-22 2011-05-13 Orthomed Tubes de collagene
US20100038311A1 (en) * 2006-07-06 2010-02-18 Hitachi Plant Technologies, Ltd. Entrapping immobilization pellets, wastewater treatment system using the entrapping immobilization pellets and wastewater treatment method
US20080242607A1 (en) 2006-07-21 2008-10-02 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
US20100215720A1 (en) 2006-08-08 2010-08-26 Fundacion Inasmet Implantable optical system, method for developing it and applications
KR101200728B1 (ko) 2006-08-09 2012-11-13 인타르시아 세라퓨틱스 인코포레이티드 삼투성 전달 시스템 및 피스톤 조립체
KR100783228B1 (ko) 2006-08-29 2007-12-06 가톨릭대학교 산학협력단 세포배양용 폴리비닐알코올-콜라겐 하이드로젤 스캐폴드 및그 제조방법
EP2061483A1 (en) * 2006-09-07 2009-05-27 McGill University Oral polymeric membrane feruloyl esterase producing bacteria formulation
US8969532B2 (en) 2006-10-03 2015-03-03 Novo Nordisk A/S Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
SI2068907T1 (en) 2006-10-04 2018-01-31 Novo Nordisk A/S Pegylated sugars and glycopeptides are associated with glycerol
JP4386061B2 (ja) * 2006-10-06 2009-12-16 株式会社豊田中央研究所 固形複合材料及びその製造方法
US7926368B2 (en) * 2006-11-01 2011-04-19 Zefon International, Inc. Humidity-controlled gas-borne matter collection device
US7935363B2 (en) 2006-12-12 2011-05-03 Synthasome, Inc. Composite material for tissue repair
US20100196439A1 (en) * 2006-12-22 2010-08-05 Medtronic, Inc. Angiogenesis Mechanism and Method, and Implantable Device
US20080215090A1 (en) * 2007-02-14 2008-09-04 Entrigue Surgical, Inc. Method and System for Tissue Fastening
EP2478922B1 (en) 2007-02-19 2017-02-01 Marine Polymer Technologies, Inc. Hemostatic compositions and therapeutic regimens
US20090227689A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20090227981A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
CA2682897C (en) 2007-04-03 2016-11-22 Biogenerix Ag Methods of treatment using glycopegylated g-csf
MX2009011005A (es) * 2007-04-13 2009-11-02 Kuros Biosurgery Ag Sellador polimerico para tejido.
ES2402172T3 (es) 2007-04-23 2013-04-29 Intarcia Therapeutics, Inc Formulación en suspensión de péptidos insulinotrópicos y usos de los mismos
US20080299391A1 (en) * 2007-05-31 2008-12-04 White Scott R Capsules, methods for making capsules, and self-healing composites including the same
CN101778859B (zh) 2007-06-12 2014-03-26 诺和诺德公司 改良的用于生产核苷酸糖的方法
US8133553B2 (en) 2007-06-18 2012-03-13 Zimmer, Inc. Process for forming a ceramic layer
US8309521B2 (en) 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
US7968811B2 (en) * 2007-06-29 2011-06-28 Harley-Davidson Motor Company Group, Inc. Integrated ignition and key switch
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US8067028B2 (en) * 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
WO2009025866A1 (en) 2007-08-23 2009-02-26 Intrexon Corporation Methods and compositions for diagnosing disease
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
US20110136935A1 (en) * 2007-08-30 2011-06-09 National University Of Singapore Bone and/or dental cement composition and uses thereof
US8217134B2 (en) 2007-08-30 2012-07-10 Bezwada Biomedical, Llc Controlled release of biologically active compounds
US8026285B2 (en) * 2007-09-04 2011-09-27 Bezwada Biomedical, Llc Control release of biologically active compounds from multi-armed oligomers
US8048980B2 (en) 2007-09-17 2011-11-01 Bezwada Biomedical, Llc Hydrolysable linkers and cross-linkers for absorbable polymers
US8093038B2 (en) * 2007-09-17 2012-01-10 Illinois Institute Of Technology Apparatus and method for encapsulating pancreatic cells
JP2010540696A (ja) * 2007-09-25 2010-12-24 サーモディクス，インコーポレイティド 耐久性のある膨潤性ヒドロゲルマトリックス及び方法
US8053591B2 (en) 2007-09-26 2011-11-08 Bezwada Biomedical, Llc Functionalized biodegradable triclosan monomers and oligomers for controlled release
US20090136465A1 (en) 2007-09-28 2009-05-28 Intrexon Corporation Therapeutic Gene-Switch Constructs and Bioreactors for the Expression of Biotherapeutic Molecules, and Uses Thereof
US20090088723A1 (en) * 2007-09-28 2009-04-02 Accessclosure, Inc. Apparatus and methods for treating pseudoaneurysms
US8608049B2 (en) 2007-10-10 2013-12-17 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
US20090123519A1 (en) * 2007-11-12 2009-05-14 Surmodics, Inc. Swellable hydrogel matrix and methods
US20090143348A1 (en) * 2007-11-30 2009-06-04 Ahmet Tezel Polysaccharide gel compositions and methods for sustained delivery of drugs
US20090181254A1 (en) * 2008-01-15 2009-07-16 The Board Of Trustees Of The University Of Illinois Multi-capsule system and its use for encapsulating active agents
RU2530653C2 (ru) * 2008-01-24 2014-10-10 Юниверсити Оф Юта Рисерч Фаундейшн Адгезивные комплексные коацерваты и способы их получения и применения
US8283384B2 (en) 2008-01-24 2012-10-09 University Of Utah Research Foundation Adhesive complex coacervates and methods of making and using thereof
US20090196854A1 (en) * 2008-02-04 2009-08-06 Kytos Biosystems S.A. Methods and compositions for use of crl 5803 cells for expression of biotherapeutics and encapsulated cell-based delivery
DK2240155T3 (da) 2008-02-13 2012-09-17 Intarcia Therapeutics Inc Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler
AU2009219232B2 (en) 2008-02-27 2014-02-27 Novo Nordisk A/S Conjugated Factor VIII molecules
US20090238815A1 (en) * 2008-03-18 2009-09-24 Medtronic Vascular, Inc. Nondegradable Hydrogels For Medical Device Application
EP2271312A4 (en) * 2008-03-19 2013-12-11 Univ Florida NERVOUS REPAIR WITH A HYDROGEL AND AN OPTIONAL ADHESIVE
GB2459438B (en) * 2008-04-10 2010-10-06 Kythera Biopharmaceuticals Inc Systems and methods for transdermal photo-polymerization
JP2011518940A (ja) * 2008-04-28 2011-06-30 サーモディクス，インコーポレイティド ヒドラジド架橋を有するポリ−α（１→４）グルコピラノース−ベースのマトリクス
US9694055B2 (en) * 2008-05-09 2017-07-04 Wake Forest University Health Sciences Renal tissue regeneration
US8367747B2 (en) 2008-05-23 2013-02-05 Bezwada Biomedical, Llc Bioabsorbable polymers from bioabsorbable polyisocyanates and uses thereof
US20090294049A1 (en) * 2008-06-02 2009-12-03 Medtronic Vascular, Inc. Biodegradable Adhesive Hydrogels
WO2010042943A1 (en) * 2008-10-10 2010-04-15 Massachusetts Institute Of Technology Tunable hydrogel microparticles
EP2356227B1 (en) 2008-11-14 2018-03-28 Viacyte, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells
EP2356228B1 (en) 2008-11-25 2023-05-03 École Polytechnique Fédérale de Lausanne (EPFL) Block copolymers and uses thereof
US9198872B2 (en) 2008-12-08 2015-12-01 University Of Miami Dendritic and hyperbranched polymers for cellular encapsulation and functionalization
US8728520B2 (en) * 2008-12-08 2014-05-20 University Of Miami Cross-linked alginate-polyalkylene glycol polymer coatings for encapsulation and methods of making the same
AU2010213612B2 (en) 2009-02-12 2015-04-30 Incept, Llc Drug delivery through hydrogel plugs
US9259507B2 (en) * 2009-04-21 2016-02-16 Warsaw Orthopedic, Inc. Tissue augmentation with active agent for wound healing
US9109245B2 (en) 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
EP3904505A1 (en) 2009-04-22 2021-11-03 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
US20120108514A1 (en) 2009-07-09 2012-05-03 University Of Iowa Research Foundation Long acting atrial natriuretic peptide (la-anp) and methods for use thereof
US9597430B2 (en) * 2009-07-31 2017-03-21 Synthasome, Inc. Synthetic structure for soft tissue repair
US9024766B2 (en) * 2009-08-28 2015-05-05 The Invention Science Fund, Llc Beverage containers with detection capability
US8810417B2 (en) 2009-08-28 2014-08-19 The Invention Science Fund I, Llc Beverage immersate with detection capability
RU2753280C2 (ru) 2009-09-28 2021-08-12 Интарсия Терапьютикс, Инк. Быстрое достижение и/или прекращение существенной стабильной доставки лекарственного средства
KR102081356B1 (ko) 2009-11-12 2020-02-25 브이셀 세라퓨틱스 인코포레이티드 포자를 닮은 세포들의 계군 및 그 용도
EP3583960A1 (en) 2009-12-15 2019-12-25 Incept, LLC Implants and biodegradable fiducial markers
US20110223314A1 (en) * 2010-03-10 2011-09-15 Xiaoxiao Zhang Efficient microencapsulation
US9045657B2 (en) 2010-03-24 2015-06-02 The Board Of Trustees Of The University Of Illinois Viscoelastic ink for direct writing of hydrogel structures
US9012415B2 (en) * 2010-03-26 2015-04-21 Stemmatters, Biotecnologia E Medicina Regenerativa S.A. Photo-crosslinked gellan gum-based hydrogels: preparation methods and uses thereof
BR112012025844A2 (pt) 2010-04-15 2017-07-18 Marine Polymer Tech Inc uso de nanofibras snag
JP2013526393A (ja) 2010-05-24 2013-06-24 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション 強化された接着複合コアセルベートならびにその作製方法および使用方法
US9232805B2 (en) 2010-06-29 2016-01-12 Biocure, Inc. In-situ forming hydrogel wound dressings containing antimicrobial agents
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
JP2014502296A (ja) 2010-11-12 2014-01-30 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション 単純接着剤コアセルベートならびにその製造方法および使用
US10669522B2 (en) * 2011-02-07 2020-06-02 Life Technologies Corporation Compositions and methods for stabilizing susceptible compounds
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
EP2680862B1 (en) 2011-03-04 2016-07-20 Wake Forest University Health Sciences Encapsulated cells for hormone replacement therapy
AU2012242479B2 (en) 2011-04-15 2015-04-16 Marine Polymer Technologies, Inc. Treatment of disease with poly-n-acetylglucosamine nanofibers
ES2637640T3 (es) 2011-04-29 2017-10-16 Converge Biotech Inc. Recubrimiento conformal de células para inmunoaislamiento
CN107090028A (zh) 2011-08-30 2017-08-25 梅约医学教育与研究基金会 利钠多肽
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
CN109200013A (zh) 2011-12-05 2019-01-15 因赛普特有限责任公司 医用有机凝胶方法和组合物
WO2013103896A1 (en) 2012-01-06 2013-07-11 Mayo Foundation For Medical Education And Research Treating cardiovascular or renal diseases
KR101327630B1 (ko) * 2012-03-05 2013-11-13 울산대학교 산학협력단 아텔로콜라겐을 이용한 췌도세포 이식용 담체의 제조방법 그리고 이를 이용하여 제조된 인공췌장
CN102697731B (zh) * 2012-05-10 2013-12-25 华东医院 5-氨基酮戊酸纳米粒及其制备方法和装置
US9255281B2 (en) 2012-06-15 2016-02-09 Microvi Biotech Inc. Bioconversion processes using water-insoluble liquids
SG11201408356VA (en) 2012-06-15 2015-03-30 Microvi Biotech Inc Novel biocatalyst compositions and processes for use
US9752164B2 (en) 2012-06-15 2017-09-05 Microvi Biotech, Inc. Enhanced efficiency ethanol and sugar conversion processes
US9334507B2 (en) 2012-06-15 2016-05-10 Microvi Biotech, Inc. Bioprocesses for making butanol
CN102827310B (zh) * 2012-09-24 2014-08-27 上海交通大学 光化学引发系统及采用其的引发透明体系或不透明体系光聚合或包埋的方法
EP2922919B1 (en) 2012-11-21 2020-03-25 University Of Louisville Research Foundation, Inc. Compositions and methods for reducing oxidative damage
EP2953992B1 (en) 2013-02-06 2021-11-24 3M Innovative Properties Company Polymers, preparation and use thereof
US10624865B2 (en) 2013-03-14 2020-04-21 Pathak Holdings Llc Methods, compositions, and devices for drug/live cell microarrays
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
CN105142570B (zh) 2013-04-24 2018-06-22 雀巢产品技术援助有限公司 包封装置
CN105555296A (zh) 2013-05-15 2016-05-04 小利兰·斯坦福大学托管委员会 用于鼓膜愈合的肝素结合表皮生长因子活性的调节
EP2821060B1 (de) 2013-07-01 2016-09-21 PM-International AG Kosmetisches Kühlgel
US10711106B2 (en) 2013-07-25 2020-07-14 The University Of Chicago High aspect ratio nanofibril materials
US9392814B2 (en) 2014-06-06 2016-07-19 Nicholas J. Singer Delivery system for drinks
CA2955048C (en) 2014-07-14 2020-11-03 University Of Utah Research Foundation In situ solidifying compositions and methods of making and using therof
WO2016033295A1 (en) * 2014-08-27 2016-03-03 The Regents Of The University Of Colorado, A Body Corporate Multilayer polymeric matrix based medical devices
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US20160121027A1 (en) * 2014-10-23 2016-05-05 South Dakota Board Of Regents Formulations for Tailored Drug Release
CA3014030C (en) 2015-02-09 2023-10-03 Ori Braun Ophthalmic compositions and methods for reducing oxidative damage to an eye lens
KR102650751B1 (ko) 2015-06-03 2024-03-22 인타르시아 세라퓨틱스 인코포레이티드 임플란트 배치 및 제거 시스템들
USD773313S1 (en) 2015-06-23 2016-12-06 Nicholas J. Singer Package
GB201519811D0 (en) * 2015-11-10 2015-12-23 Univ Belfast Ocular compositions
US20170173209A1 (en) * 2015-12-18 2017-06-22 Rousseau Research, Inc. Wound closure compositions and method
US20170252304A1 (en) 2016-03-01 2017-09-07 Prodo Laboratories, Inc. Encapsulation Methods and Compositions
TWI814219B (zh) 2016-05-16 2023-09-01 美商因塔希亞治療公司 升糖素受體選擇性多肽和彼之使用方法
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
EP3538131B1 (en) 2016-11-09 2025-05-07 Mayo Foundation for Medical Education and Research Manp analogues
US11623023B2 (en) 2016-11-10 2023-04-11 Viacyte, Inc. PDX1 pancreatic endoderm cells in cell delivery devices and methods thereof
US10835580B2 (en) 2017-01-03 2020-11-17 Intarcia Therapeutics, Inc. Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug
AR111216A1 (es) 2017-02-23 2019-06-19 Japan Vam & Poval Co Ltd Dispositivo de integración celular o tisular
JP2019083794A (ja) * 2017-11-10 2019-06-06 永嶋　良一 担体の製造方法、および担体
CN108159023A (zh) * 2017-12-22 2018-06-15 杭州高斯博医疗用品有限公司 一种冷敷用水凝胶贴的制备方法及产品
EP3743120A4 (en) 2018-01-26 2021-10-13 Fluidx Medical Technology, LLC APPARATUS AND METHOD FOR USING COMPLEX IN SITU SOLIDIFICATION COACERVATS FOR VASCULAR OCCLUSION
CN108548656B (zh) * 2018-03-29 2021-08-03 昂纳信息技术（深圳）有限公司 一种用于to-can激光器的测试装置和测试系统
WO2021016055A1 (en) * 2019-07-19 2021-01-28 The Secant Group, Llc Poly(glycerol sebacate)-infused hollow lumen composite graft
US20210063402A1 (en) * 2019-08-29 2021-03-04 AbulKalam Mohammed Shamsuddin Screening method, device and kit for detecting mucosal carbohydrates and associated conditions
WO2021048250A1 (en) * 2019-09-10 2021-03-18 Fundació Institut De Bioenginyeria De Catalunya Multi-layered cell capsules and uses thereof
CN110755628B (zh) * 2019-11-13 2023-06-20 华南协同创新研究院 一种乏氧响应性壳聚糖药物载体及其制备方法与应用
CN111318237B (zh) * 2020-03-20 2022-07-05 武汉轻工大学 一种胶原-壳聚糖水凝胶及其制备方法
US11866523B2 (en) 2020-04-06 2024-01-09 The Secant Group, Llc Water-mediated polyester (meth)acrylation systems
US20230165669A1 (en) 2020-04-28 2023-06-01 University Of Miami Conformal coating of cells for immunoisolation
JPWO2022092211A1 (ko) * 2020-10-28 2022-05-05
MX2022005428A (es) 2021-05-07 2022-11-08 Abulkalam Mohammed Shamsuddin Metodo, dispositivo y kit para clasificacion de poblacion para cancer, recurrencia de cancer y condiciones precancerosas en individuos sin sintomas.
US20250152755A1 (en) * 2022-01-06 2025-05-15 Case Western Reserve University Systems and methods of generating lipid, protein, and/or protein shelled bubbles
EP4482465A2 (en) 2022-02-25 2025-01-01 ViaCyte, Inc. Multilayer implantable cell encapsulation devices and methods thereof
CN118416015B (zh) * 2024-07-04 2024-09-06 西部生科生物医学科技(成都)有限公司 一种富含脂肪干细胞外泌体的组合物及其应用

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4193845A (en) * 1973-11-15 1980-03-18 Japan Atomic Energy Research Institute Immobilization of enzymes or bacterial cells
JPS5126285A (en) * 1974-08-30 1976-03-04 Japan Atomic Energy Res Inst Koso mataha kintaiofukunda soseibutsu no seizohoho
DE2633259C3 (de) * 1975-07-23 1984-11-15 Japan Atomic Energy Research Institute, Tokio/Tokyo Verfahren zum Unbeweglichmachen von Enzymen oder enzymhaltigen Zellen
US4195129A (en) * 1975-11-26 1980-03-25 Kansai Paint Co., Ltd. Method for immobilizing enzymes and microbial cells
JPS5296791A (en) * 1976-02-09 1977-08-13 Japan Atom Energy Res Inst Preparation of composition including enzymes or microorganisms
CA1125698A (en) * 1978-03-09 1982-06-15 Masaru Yoshida Process for preparing a polymer composition
US4329332A (en) * 1978-07-19 1982-05-11 Patrick Couvreur Biodegradable submicroscopic particles containing a biologically active substance and compositions containing them
FR2433949A1 (fr) * 1978-08-25 1980-03-21 Commissariat Energie Atomique Substrat hydrophobe apte a liberer une substance chimique
US4352883A (en) 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US4298002A (en) * 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
JPS5911563B2 (ja) * 1980-02-27 1984-03-16 日本原子力研究所 多層構造の徐放性複合体を製造する方法
US4376059A (en) * 1980-04-11 1983-03-08 Exxon Research And Engineering Co. Process for preparing artificial red cells
US4390521A (en) * 1980-04-11 1983-06-28 Exxon Research And Engineering Co. Artificial red cells
FR2485370A1 (fr) * 1980-06-30 1981-12-31 Commissariat Energie Atomique Support inerte en copolymere reticule, son procede de preparation et son utilisation pour la realisation de medicaments retard
SE441009B (sv) * 1982-03-08 1985-09-02 Kjell Nilsson Sett att immobilisera levande biomaterial i perlformiga polymerer
US4652443A (en) * 1983-06-07 1987-03-24 Japan Atomic Energy Research Institute Slow-release composite and process for producing the same
US4511478A (en) * 1983-11-10 1985-04-16 Genetic Systems Corporation Polymerizable compounds and methods for preparing synthetic polymers that integrally contain polypeptides
US4605622A (en) * 1983-11-15 1986-08-12 Kansai Paint Co., Ltd. Process for producing granular fixed enzymes or microorganisms
EP0160260A3 (de) * 1984-05-02 1986-10-08 Bayer Ag Verfahren zur Immobilisierung von biologischem Material
JPS6132271A (ja) * 1984-07-24 1986-02-14 Canon Inc 記録装置
DE3617875C2 (de) 1985-06-28 1993-10-14 Hitachi Plant Eng & Constr Co Verfahren zum Immobilisieren von Mikroorganismen
SE459005B (sv) * 1985-07-12 1989-05-29 Aake Rikard Lindahl Saett att framstaella sfaeriska polymerpartiklar
JPS6214781A (ja) * 1985-07-15 1987-01-23 Taiyo Kagaku Kk リパ−ゼの固定化方法
US4931279A (en) * 1985-08-16 1990-06-05 Bausch & Lomb Incorporated Sustained release formulation containing an ion-exchange resin
US4889722A (en) * 1985-12-16 1989-12-26 Ethicon, Inc. Method for inhibiting post-surgical adhesion formation by the topical administration of tissue plasminogen activator
US5160745A (en) * 1986-05-16 1992-11-03 The University Of Kentucky Research Foundation Biodegradable microspheres as a carrier for macromolecules
US5037656A (en) * 1986-12-04 1991-08-06 Millipore Corporation Porous membrane having hydrophilic and cell growth promotions surface and process
US5288500A (en) * 1987-03-13 1994-02-22 Benzon Pharma A/S Oral composition containing particles comprising an active substance
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US5268182A (en) * 1988-06-24 1993-12-07 Abbott Laboratories Sustained-release drug dosage units of terazosin
US5271961A (en) * 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
JP2651516B2 (ja) * 1989-12-13 1997-09-10 国立循環器病センター総長 ハイブリッド型人工膵臟
US5104957A (en) * 1990-02-28 1992-04-14 Autogenesis Technologies, Inc. Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom
US5183690A (en) * 1990-06-25 1993-02-02 The United States Of America, As Represented By The Secretary Of Agriculture Starch encapsulation of biologically active agents by a continuous process
US5143724A (en) 1990-07-09 1992-09-01 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use
US5071644A (en) 1990-08-07 1991-12-10 Mediventures, Inc. Topical drug delivery with thermo-irreversible gels
US5110605A (en) 1990-08-21 1992-05-05 Oramed, Inc. Calcium polycarbophil-alginate controlled release composition and method
US5149543A (en) * 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
KR930006431B1 (ko) 1990-10-11 1993-07-16 재단법인 한국화학연구소 약물의 미세캡슐화 방법
US5232984A (en) * 1990-10-15 1993-08-03 The Board Of The Regents The University Of Texas Biocompatible microcapsules
US5529914A (en) * 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5219895A (en) * 1991-01-29 1993-06-15 Autogenesis Technologies, Inc. Collagen-based adhesives and sealants and methods of preparation and use thereof
JP3184555B2 (ja) 1991-05-28 2001-07-09 松下電工株式会社 吸湿器
EP0610441A4 (en) * 1991-10-29 1996-01-10 Clover Cons Ltd CROSSLINKABLE POLYSACCHARIDES, POLYCATIONS AND LIPIDS CAN BE USED TO ENCODE AND DISPENSE MEDICINAL PRODUCTS.
WO1994015589A1 (en) * 1992-12-30 1994-07-21 Clover Consolidated, Limited Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials
US5545423A (en) * 1991-11-25 1996-08-13 Vivorx, Inc. Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials
DE69329594T2 (de) * 1992-02-28 2001-05-31 Board Of Regents, The University Of Texas System Photopolymerinierbare, biologisch abbaubare hydrogele als gewebekontaktmaterialien und trägerstoffe für kontrollierte freisetzung
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5578442A (en) * 1992-03-23 1996-11-26 Vivorx, Inc. Graft copolymers of polycationic species and water-soluble polymers, and use therefor
US5334640A (en) * 1992-04-08 1994-08-02 Clover Consolidated, Ltd. Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
US5286495A (en) * 1992-05-11 1994-02-15 University Of Florida Process for microencapsulating cells
US5762959A (en) * 1992-05-29 1998-06-09 Vivorx, Inc. Microencapsulation of cells
AU4406793A (en) * 1992-06-04 1993-12-30 Clover Consolidated, Limited Water-soluble polymeric carriers for drug delivery
AU5728994A (en) * 1992-11-24 1994-06-22 Clover Consolidated, Limited Cytoprotective, biocompatible, retrievable macrocapsules

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AU3780993A (en) 1993-09-13
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US5529914A (en) 1996-06-25
ATE266389T1 (de) 2004-05-15
US6258870B1 (en) 2001-07-10
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US20020058318A1 (en) 2002-05-16
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