US2878264A
(en)
|
|
1959-03-17 |
|
Substituted amino alcohols |
DE1144279B
(de)
|
1957-09-26 |
1963-02-28 |
Robins Co Inc A H |
Verfahren zur Herstellung von 3-Aryl-3-hydroxypyrrolidinen und deren Salzen
|
US3135766A
(en)
|
1961-10-03 |
1964-06-02 |
Mead Johnson & Co |
3-substituted-3-pyrrolidinols
|
US3484473A
(en)
|
1967-05-12 |
1969-12-16 |
Buckman Labor Inc |
Methylene bisesters of thiolsulfonic acids
|
DE1934150A1
(de)
|
1968-07-10 |
1970-01-15 |
Pennwalt Corp |
Neue 1-Alkanoyloxy-1,2,4,5-tetrahydro-3H,3-benzazepine
|
US3687808A
(en)
|
1969-08-14 |
1972-08-29 |
Univ Leland Stanford Junior |
Synthetic polynucleotides
|
US3745162A
(en)
|
1970-08-31 |
1973-07-10 |
Robins Co Inc A H |
1,2,3,4-tetrahydroisoquinoline-2-(thio)-carboxamides
|
GB1448437A
(en)
|
1973-02-24 |
1976-09-08 |
Beecham Group Ltd |
Diphenylpropylamines
|
US4022791A
(en)
|
1975-06-03 |
1977-05-10 |
Pfizer Inc. |
2-Aminomethyl-3,4-dihydronaphthalenes
|
GB1504424A
(en)
|
1975-08-09 |
1978-03-22 |
Beecham Group Ltd |
Isoquinoline-derived aminoethers
|
BR7807288A
(pt)
|
1977-11-08 |
1979-06-12 |
Genentech Inc |
Processo para sintese de polinucleotidos
|
DD133885B1
(de)
|
1978-01-04 |
1981-02-25 |
Hans Lehmann |
Mittel zur bekaempfung von phytopathogenen bakterien und pilzen
|
US5132418A
(en)
|
1980-02-29 |
1992-07-21 |
University Patents, Inc. |
Process for preparing polynucleotides
|
US4500707A
(en)
|
1980-02-29 |
1985-02-19 |
University Patents, Inc. |
Nucleosides useful in the preparation of polynucleotides
|
US4458066A
(en)
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
US4668777A
(en)
|
1981-03-27 |
1987-05-26 |
University Patents, Inc. |
Phosphoramidite nucleoside compounds
|
US4973679A
(en)
|
1981-03-27 |
1990-11-27 |
University Patents, Inc. |
Process for oligonucleo tide synthesis using phosphormidite intermediates
|
US4415732A
(en)
|
1981-03-27 |
1983-11-15 |
University Patents, Inc. |
Phosphoramidite compounds and processes
|
US4542142A
(en)
|
1982-11-22 |
1985-09-17 |
Roussel Uclaf |
Insecticidal cyclopropane carboxylic acid derivatives with 3-unsaturated-side chain
|
DE3329892A1
(de)
|
1983-08-18 |
1985-03-07 |
Köster, Hubert, Prof. Dr., 2000 Hamburg |
Verfahren zur herstellung von oligonucleotiden
|
US5118800A
(en)
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
Oligonucleotides possessing a primary amino group in the terminal nucleotide
|
US5643889A
(en)
|
1984-07-11 |
1997-07-01 |
Temple University-Of The Commonwealth System Of Pennsylvania |
Cholesterol conjugates of 2'5'-oligoadenylate derivatives and antiviral uses thereof
|
FR2567892B1
(fr)
|
1984-07-19 |
1989-02-17 |
Centre Nat Rech Scient |
Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons
|
US5367066A
(en)
|
1984-10-16 |
1994-11-22 |
Chiron Corporation |
Oligonucleotides with selectably cleavable and/or abasic sites
|
FR2575751B1
(fr)
|
1985-01-08 |
1987-04-03 |
Pasteur Institut |
Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques
|
FR2576898B1
(fr)
|
1985-02-01 |
1988-01-08 |
Lafon Labor |
Derives de 3-phenyl-tetrahydropyridine, procede de preparation et utilisation en therapeutique
|
JPH0658512B2
(ja)
|
1985-04-12 |
1994-08-03 |
富士写真フイルム株式会社 |
ハロゲン化銀写真感光材料
|
US4659774A
(en)
|
1985-11-01 |
1987-04-21 |
American Hoechst Corporation |
Support for solid-phase oligonucleotide synthesis
|
US4840956A
(en)
|
1986-02-18 |
1989-06-20 |
Warner-Lambert Company |
Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents
|
US4735949A
(en)
|
1986-02-18 |
1988-04-05 |
Warner-Lambert Company |
Disubstituted-7-pyrrolidinonaphthyridine antibacterial agents
|
IL83663A0
(en)
|
1986-10-27 |
1988-01-31 |
Robins Co Inc A H |
Preparation of 3-pyrrolidinols
|
CA1340032C
(en)
|
1987-06-24 |
1998-09-08 |
Jim Haralambidis |
Lucleoside derivatives
|
US5200553A
(en)
|
1987-07-30 |
1993-04-06 |
Kupat Holim Health Insurance Institution Of The General Federation Of Labor |
Biologically active carboxylic acid esters
|
US4923901A
(en)
|
1987-09-04 |
1990-05-08 |
Millipore Corporation |
Membranes with bound oligonucleotides and peptides
|
US5175273A
(en)
|
1988-07-01 |
1992-12-29 |
Genentech, Inc. |
Nucleic acid intercalating agents
|
US4943629A
(en)
|
1988-08-12 |
1990-07-24 |
American Cyanamid Company |
Antidiabetic alpha-substituted phosphonates
|
US4945158A
(en)
|
1988-08-12 |
1990-07-31 |
American Cyanamid Company |
Antidiabetic phosphonates
|
US5262530A
(en)
|
1988-12-21 |
1993-11-16 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
US5047524A
(en)
|
1988-12-21 |
1991-09-10 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
JP2794461B2
(ja)
|
1989-08-17 |
1998-09-03 |
有機合成薬品工業株式会社 |
ホスホアミダイト化合物及びそれを用いたオリゴリボヌクレオチドの固相合成法
|
US5141813A
(en)
|
1989-08-28 |
1992-08-25 |
Clontech Laboratories, Inc. |
Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
|
US5134066A
(en)
|
1989-08-29 |
1992-07-28 |
Monsanto Company |
Improved probes using nucleosides containing 3-dezauracil analogs
|
CA2029273A1
(en)
|
1989-12-04 |
1991-06-05 |
Christine L. Brakel |
Modified nucleotide compounds
|
WO1991009594A1
(en)
|
1989-12-28 |
1991-07-11 |
Virginia Commonwealth University |
Sigma receptor ligands and the use thereof
|
US5130302A
(en)
|
1989-12-20 |
1992-07-14 |
Boron Bilogicals, Inc. |
Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same
|
US5587361A
(en)
|
1991-10-15 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having phosphorothioate linkages of high chiral purity
|
US5646265A
(en)
|
1990-01-11 |
1997-07-08 |
Isis Pharmceuticals, Inc. |
Process for the preparation of 2'-O-alkyl purine phosphoramidites
|
US5635488A
(en)
|
1991-10-15 |
1997-06-03 |
Isis Pharmaceuticals, Inc. |
Compounds having phosphorodithioate linkages of high chiral purity
|
US5457191A
(en)
|
1990-01-11 |
1995-10-10 |
Isis Pharmaceuticals, Inc. |
3-deazapurines
|
US5587470A
(en)
|
1990-01-11 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
3-deazapurines
|
US7101993B1
(en)
|
1990-01-11 |
2006-09-05 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides containing 2′-O-modified purines
|
US6339066B1
(en)
|
1990-01-11 |
2002-01-15 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotides which have phosphorothioate linkages of high chiral purity and which modulate βI, βII, γ, δ, Ε, ζ and η isoforms of human protein kinase C
|
ATE271064T1
(de)
|
1990-01-11 |
2004-07-15 |
Isis Pharmaceuticals Inc |
Oligonukleotidderivate zur detektieren und modulation von rna aktivität und genexpression
|
US5506212A
(en)
|
1990-01-11 |
1996-04-09 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides with substantially chirally pure phosphorothioate linkages
|
US5212295A
(en)
|
1990-01-11 |
1993-05-18 |
Isis Pharmaceuticals |
Monomers for preparation of oligonucleotides having chiral phosphorus linkages
|
US5459255A
(en)
|
1990-01-11 |
1995-10-17 |
Isis Pharmaceuticals, Inc. |
N-2 substituted purines
|
US5852188A
(en)
*
|
1990-01-11 |
1998-12-22 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having chiral phosphorus linkages
|
US5620963A
(en)
|
1991-10-15 |
1997-04-15 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating protein kinase C having phosphorothioate linkages of high chiral purity
|
US5914396A
(en)
|
1990-01-11 |
1999-06-22 |
Isis Pharmaceuticals, Inc. |
2'-O-modified nucleosides and phosphoramidites
|
US5681941A
(en)
|
1990-01-11 |
1997-10-28 |
Isis Pharmaceuticals, Inc. |
Substituted purines and oligonucleotide cross-linking
|
US5292875A
(en)
|
1990-04-20 |
1994-03-08 |
Lynx Therapeutics, Inc. |
Method of synthesizing sulfurized oligonucleotide analogs
|
US5151510A
(en)
|
1990-04-20 |
1992-09-29 |
Applied Biosystems, Inc. |
Method of synethesizing sulfurized oligonucleotide analogs
|
BR9106486A
(pt)
|
1990-05-23 |
1993-05-25 |
Isis Pharmaceuticals Inc |
Composicao para modulacao da atividade de um rna e processo para tratamento de um organismo que tem uma doenca que se caracteriza para producao indesejada de uma proteina
|
US5223618A
(en)
|
1990-08-13 |
1993-06-29 |
Isis Pharmaceuticals, Inc. |
4'-desmethyl nucleoside analog compounds
|
US5378825A
(en)
|
1990-07-27 |
1995-01-03 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs
|
US5792844A
(en)
|
1990-07-27 |
1998-08-11 |
Isis Pharmaceuticals, Inc. |
Oligonucleoside linkages containing adjacent nitrogen atoms
|
US5677437A
(en)
|
1990-07-27 |
1997-10-14 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
US5623070A
(en)
|
1990-07-27 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
US5618704A
(en)
|
1990-07-27 |
1997-04-08 |
Isis Pharmacueticals, Inc. |
Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
|
WO1994022886A1
(en)
|
1993-03-30 |
1994-10-13 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
US5489677A
(en)
|
1990-07-27 |
1996-02-06 |
Isis Pharmaceuticals, Inc. |
Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
|
US5614617A
(en)
|
1990-07-27 |
1997-03-25 |
Isis Pharmaceuticals, Inc. |
Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression
|
US5608046A
(en)
|
1990-07-27 |
1997-03-04 |
Isis Pharmaceuticals, Inc. |
Conjugated 4'-desmethyl nucleoside analog compounds
|
US5138045A
(en)
|
1990-07-27 |
1992-08-11 |
Isis Pharmaceuticals |
Polyamine conjugated oligonucleotides
|
US5688941A
(en)
|
1990-07-27 |
1997-11-18 |
Isis Pharmaceuticals, Inc. |
Methods of making conjugated 4' desmethyl nucleoside analog compounds
|
US5610289A
(en)
|
1990-07-27 |
1997-03-11 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogues
|
US6087482A
(en)
|
1990-07-27 |
2000-07-11 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
US5998603A
(en)
|
1994-09-29 |
1999-12-07 |
Isis Pharmaceuticals, Inc. |
4'-desmethyl nucleoside analogs, and oligomers thereof
|
US5386023A
(en)
|
1990-07-27 |
1995-01-31 |
Isis Pharmaceuticals |
Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
|
US5834607A
(en)
|
1990-07-27 |
1998-11-10 |
Isis Pharmaceuticals, Inc. |
Amines and methods of making and using the same
|
US5541307A
(en)
|
1990-07-27 |
1996-07-30 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs and solid phase synthesis thereof
|
US6121433A
(en)
|
1990-07-27 |
2000-09-19 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds having nitrogen-containing linkages
|
US5602240A
(en)
|
1990-07-27 |
1997-02-11 |
Ciba Geigy Ag. |
Backbone modified oligonucleotide analogs
|
US5783682A
(en)
|
1990-07-27 |
1998-07-21 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide mimics having nitrogen-containing linkages
|
US5432272A
(en)
|
1990-10-09 |
1995-07-11 |
Benner; Steven A. |
Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
|
JPH04348044A
(ja)
|
1991-02-21 |
1992-12-03 |
Matsushita Electron Corp |
半導体用樹脂封止装置
|
US5512668A
(en)
|
1991-03-06 |
1996-04-30 |
Polish Academy Of Sciences |
Solid phase oligonucleotide synthesis using phospholane intermediates
|
US7015315B1
(en)
|
1991-12-24 |
2006-03-21 |
Isis Pharmaceuticals, Inc. |
Gapped oligonucleotides
|
US20020183502A1
(en)
|
1991-05-21 |
2002-12-05 |
Mesmaeker Alain De |
Backbone-modified oligonucleotide analogs and methods for using same
|
US6414112B1
(en)
|
1991-05-24 |
2002-07-02 |
Ole Buchardt |
Peptide nucleic acids having 2,6-diaminopurine nucleobases
|
JPH04348077A
(ja)
|
1991-05-24 |
1992-12-03 |
Nec Corp |
薄膜トランジスタ
|
AU659649B2
(en)
|
1991-06-10 |
1995-05-25 |
Lucky Limited |
Hepatitis C diagnostics and vaccines
|
US5359052A
(en)
|
1991-08-05 |
1994-10-25 |
Polish Academy Of Sciences |
Chalcophospholanes useful in the synthesis of oligonucleoside phosphorothioates, phosphorodithioates and related selenates
|
US5646267A
(en)
|
1991-08-05 |
1997-07-08 |
Polish Academy Of Sciences |
Method of making oligonucleotides and oligonucleotide analogs using phospholanes and enantiomerically resolved phospholane analogues
|
US6369209B1
(en)
|
1999-05-03 |
2002-04-09 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
|
US7119184B2
(en)
|
1991-08-12 |
2006-10-10 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
|
US5661134A
(en)
|
1991-10-15 |
1997-08-26 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating Ha-ras or Ki-ras having phosphorothioate linkages of high chiral purity
|
US5607923A
(en)
|
1991-10-15 |
1997-03-04 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating cytomegalovirus having phosphorothioate linkages of high chiral purity
|
US5654284A
(en)
|
1991-10-15 |
1997-08-05 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating RAF kinase having phosphorothioate linkages of high chiral purity
|
US5576302A
(en)
|
1991-10-15 |
1996-11-19 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating hepatitis C virus having phosphorothioate linkages of high chiral purity
|
DE69232699T2
(de)
|
1991-10-15 |
2003-02-06 |
Isis Pharmaceutical, Inc. |
Über chirale phosphoratome gebundene oligonukleotide
|
US5599797A
(en)
|
1991-10-15 |
1997-02-04 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having phosphorothioate linkages of high chiral purity
|
DE59208572D1
(de)
|
1991-10-17 |
1997-07-10 |
Ciba Geigy Ag |
Bicyclische Nukleoside, Oligonukleotide, Verfahren zu deren Herstellung und Zwischenprodukte
|
US5594121A
(en)
|
1991-11-07 |
1997-01-14 |
Gilead Sciences, Inc. |
Enhanced triple-helix and double-helix formation with oligomers containing modified purines
|
US6235887B1
(en)
|
1991-11-26 |
2001-05-22 |
Isis Pharmaceuticals, Inc. |
Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
|
US5484908A
(en)
|
1991-11-26 |
1996-01-16 |
Gilead Sciences, Inc. |
Oligonucleotides containing 5-propynyl pyrimidines
|
US5359044A
(en)
|
1991-12-13 |
1994-10-25 |
Isis Pharmaceuticals |
Cyclobutyl oligonucleotide surrogates
|
DE69232032T3
(de)
|
1991-12-24 |
2012-09-13 |
Isis Pharmaceutical, Inc. |
Antisense oligonukleotide
|
GB9213601D0
(en)
|
1992-06-26 |
1992-08-12 |
Mastico Robert A |
Protein based delivery system
|
US7067497B2
(en)
|
1992-09-29 |
2006-06-27 |
Isis Pharmaceuticals, Inc. |
Modulation of telomere length by oligonucleotides having a G-core sequence
|
US6005107A
(en)
|
1992-12-23 |
1999-12-21 |
Biochem Pharma, Inc. |
Antiviral compounds
|
US6444656B1
(en)
|
1992-12-23 |
2002-09-03 |
Biochem Pharma, Inc. |
Antiviral phosphonate nucleotides
|
JPH08508714A
(ja)
|
1993-01-25 |
1996-09-17 |
ハイブライドン インコーポレイテッド |
オリゴヌクレオチド・アルキルホスホネートおよびアルキルホスホノチオエート
|
JPH08508489A
(ja)
|
1993-03-31 |
1996-09-10 |
スターリング ウィンスロップ インコーポレイティド |
二官能価ヌクレオシド、それらのオリゴマーならびにそれらの製造方法及び使用方法
|
EP0691979A1
(en)
|
1993-03-31 |
1996-01-17 |
Sanofi |
Novel 5'-substituted nucleosides and oligomers produced therefrom
|
US5955591A
(en)
|
1993-05-12 |
1999-09-21 |
Imbach; Jean-Louis |
Phosphotriester oligonucleotides, amidites and method of preparation
|
US6015886A
(en)
|
1993-05-24 |
2000-01-18 |
Chemgenes Corporation |
Oligonucleotide phosphate esters
|
DE69412704T2
(de)
|
1993-06-10 |
1999-02-04 |
Idemitsu Petrochemical Co., Ltd., Tokio/Tokyo |
Spritzgiessform
|
US5502177A
(en)
|
1993-09-17 |
1996-03-26 |
Gilead Sciences, Inc. |
Pyrimidine derivatives for labeled binding partners
|
US5643989A
(en)
|
1993-10-29 |
1997-07-01 |
Azdel, Inc. |
Fiber reinforced functionalized polyolefin composites
|
US5457187A
(en)
|
1993-12-08 |
1995-10-10 |
Board Of Regents University Of Nebraska |
Oligonucleotides containing 5-fluorouracil
|
DE4435728A1
(de)
|
1994-01-19 |
1995-07-20 |
Boehringer Mannheim Gmbh |
Biotinsilan-Verbindungen und diese Verbindungen enthaltende Bindematrix
|
US6117679A
(en)
|
1994-02-17 |
2000-09-12 |
Maxygen, Inc. |
Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
|
ATE222604T1
(de)
|
1994-02-22 |
2002-09-15 |
Novozymes As |
Methode zur herstellung einer variante eines lipolytischen enzymes
|
US5596091A
(en)
|
1994-03-18 |
1997-01-21 |
The Regents Of The University Of California |
Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
|
RU2215034C2
(ru)
|
1994-05-11 |
2003-10-27 |
Новосимс А/С |
ФЕРМЕНТ С АКТИВНОСТЬЮ ЭНДО-1,3(4)-β-ГЛЮКАНАЗЫ, КОДИРУЮЩАЯ ЕГО ДНК И СПОСОБ ЕГО ПОЛУЧЕНИЯ
|
US5525711A
(en)
|
1994-05-18 |
1996-06-11 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Pteridine nucleotide analogs as fluorescent DNA probes
|
ES2127966T3
(es)
|
1994-05-31 |
1999-05-01 |
Bayer Ag |
Derivados de amino-benzofurilo y -benzotienilo.
|
HRP950288A2
(en)
|
1994-05-31 |
1997-08-31 |
Bayer Ag |
Oxalylamino-benzofuran- and benzothienyl-derivatives
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
EP1167378B1
(en)
|
1994-07-15 |
2011-05-11 |
University of Iowa Research Foundation |
Immunomodulatory oligonucleotides
|
US6239116B1
(en)
|
1994-07-15 |
2001-05-29 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
AU3675195A
(en)
|
1994-09-07 |
1996-03-27 |
Hybridon, Inc. |
Oligonucleotide prodrugs
|
US5681940A
(en)
|
1994-11-02 |
1997-10-28 |
Icn Pharmaceuticals |
Sugar modified nucleosides and oligonucleotides
|
EP0807171A1
(en)
|
1994-12-22 |
1997-11-19 |
HYBRIDON, Inc. |
Synthesis of stereospecific oligonucleotide phosphorothioates
|
GB9501465D0
(en)
|
1995-01-25 |
1995-03-15 |
King S College London |
Nucleoside phosphorothioate derivatives,synthesis and use thereof
|
US6166197A
(en)
|
1995-03-06 |
2000-12-26 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions
|
WO1996027606A1
(en)
|
1995-03-06 |
1996-09-12 |
Isis Pharmaceuticals, Inc. |
Improved process for the synthesis of 2'-o-substituted pyrimidines and oligomeric compounds therefrom
|
DE69638104D1
(de)
|
1995-04-27 |
2010-02-11 |
Takara Bio Inc |
Für Lacto-N-biosidase kodierendes Gen
|
AU715125B2
(en)
|
1995-05-11 |
2000-01-20 |
Merck Serono Sa |
IL-6 activity inhibitor
|
EP0828729A1
(en)
|
1995-05-19 |
1998-03-18 |
Glycomed Incorporated |
Collection of activated glycoside compounds and their biological use
|
DE69609511T2
(de)
|
1995-05-23 |
2001-03-29 |
Hybridon, Inc. |
Neue Synthons für die stereoselektive Oligonuklodsynthese
|
AU5871196A
(en)
|
1995-05-23 |
1996-12-24 |
Hybridon, Inc. |
Methods and compounds for the synthesis of oligonucleotides and the oligonucleotides thereby produced
|
CA2223103A1
(en)
|
1995-06-06 |
1996-12-12 |
Isis Pharmaceuticals Inc. |
Oligonucleotides having phosphorothioate linkages of high chiral purity
|
US5932450A
(en)
|
1995-06-07 |
1999-08-03 |
Gen-Probe Incorporated |
Enzymatic synthesis of oligonucleotides using digestible templates
|
DE69636649T2
(de)
|
1995-06-29 |
2007-10-04 |
Takara Bio Inc., Otsu |
Für einen Endoglycoceramidase-Aktivator kodierendes Gen
|
DE69635849T2
(de)
|
1995-06-29 |
2006-10-19 |
Takara Bio Inc., Otsu |
Für Endoglycoceramidase kodierendes Gen
|
US6017700A
(en)
|
1995-08-04 |
2000-01-25 |
Bayer Corporation |
Cationic oligonucleotides, and related methods of synthesis and use
|
US5936080A
(en)
|
1996-05-24 |
1999-08-10 |
Genta Incorporated |
Compositions and methods for the synthesis of organophosphorus derivatives
|
WO1997009443A1
(en)
|
1995-09-05 |
1997-03-13 |
Michigan State University |
PROCESS FOR THE ISOLATION AND PURIFICATION OF TAXOL AND TAXANES FROM TAXUS spp
|
US5734041A
(en)
|
1995-10-20 |
1998-03-31 |
Mcgill University |
Preparation of chiral phosphorothioate oligomers
|
US6476216B1
(en)
|
1995-10-20 |
2002-11-05 |
Mcgill University |
Preparation of phosphorothioate oligomers
|
US6160109A
(en)
|
1995-10-20 |
2000-12-12 |
Isis Pharmaceuticals, Inc. |
Preparation of phosphorothioate and boranophosphate oligomers
|
US7018793B1
(en)
|
1995-12-07 |
2006-03-28 |
Diversa Corporation |
Combinatorial screening of mixed populations of organisms
|
CA2246503A1
(en)
|
1996-02-15 |
1997-08-21 |
National Institutes Of Health |
Rnase l activators and antisense oligonucleotides effective to treat rsv infections
|
US6214805B1
(en)
|
1996-02-15 |
2001-04-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
RNase L activators and antisense oligonucleotides effective to treat RSV infections
|
GB9604669D0
(en)
|
1996-03-05 |
1996-05-01 |
Ciba Geigy Ag |
Chemical compounds
|
US5824669A
(en)
|
1996-03-22 |
1998-10-20 |
Nitromed, Inc. |
Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
|
DE69738254T2
(de)
|
1996-05-10 |
2008-08-14 |
Novozymes A/S |
Methode zur bereitstellung von dna sequenzen
|
US5856465A
(en)
|
1996-05-24 |
1999-01-05 |
Polska Akademia Nauk Centrum Badan Molekularnych I Makromolekularnych |
Compositions and methods for the synthesis of chirally pure organophosphorus nucleoside derivatives
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
DE19622783A1
(de)
|
1996-06-07 |
1997-12-11 |
Hoechst Ag |
Isolierung der Biosynthesegene für Pseudo-Oligosaccharide aus Streptomyces glaucescens GLA.O und ihre Verwendung
|
AU726821B2
(en)
|
1996-07-16 |
2000-11-23 |
Gen-Probe Incorporated |
Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific Tm
|
ATE311402T1
(de)
|
1996-07-24 |
2005-12-15 |
Buchardt Dorte |
Peptidnukleinsäuren mit erhöhter bindungsaffinität, sequenzspezifität und löslichkeit
|
AU4156197A
(en)
*
|
1996-08-21 |
1998-03-06 |
Hybridon, Inc. |
Oligonucleotide prodrugs
|
US6056973A
(en)
|
1996-10-11 |
2000-05-02 |
Sequus Pharmaceuticals, Inc. |
Therapeutic liposome composition and method of preparation
|
GB9621522D0
(en)
|
1996-10-16 |
1996-12-04 |
Biocompatibles Ltd |
Synthesis of phosphorus compounds
|
US6639062B2
(en)
|
1997-02-14 |
2003-10-28 |
Isis Pharmaceuticals, Inc. |
Aminooxy-modified nucleosidic compounds and oligomeric compounds prepared therefrom
|
US6172209B1
(en)
|
1997-02-14 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Aminooxy-modified oligonucleotides and methods for making same
|
US6369237B1
(en)
|
1997-03-07 |
2002-04-09 |
President And Fellows Of Harvard College |
DNA glycosylase inhibitors, and uses related thereto
|
US6015887A
(en)
|
1997-04-11 |
2000-01-18 |
Isis Pharmaceuticals, Inc. |
Chiral peptide nucleic acids and methods for preparing same
|
US6468983B2
(en)
|
1997-04-21 |
2002-10-22 |
The Cleveland Clinic Foundation |
RNase L activators and antisense oligonucleotides effective to treat telomerase-expressing malignancies
|
PL184612B1
(pl)
|
1997-04-25 |
2002-11-29 |
Pan |
Sposób wytwarzania modyfikowanych P chiralnych analogów nukleotydów
|
JP2001501975A
(ja)
|
1997-05-28 |
2001-02-13 |
ペーター・エー・ニールセン |
亢進した細胞取り込みを有する結合ペプチド核酸
|
CA2295110A1
(en)
|
1997-06-27 |
1999-01-07 |
The Procter & Gamble Company |
Pro-fragrance cyclic acetals
|
AU8512598A
(en)
|
1997-07-25 |
1999-02-16 |
Hybridon, Inc. |
Oligonuclotides having 3' terminal stereospecific phosphorothioates
|
US6767739B2
(en)
|
2001-07-30 |
2004-07-27 |
Isis Pharmaceuticals Inc. |
Antisense modulation of microsomal triglyceride transfer protein expression
|
GB9717158D0
(en)
|
1997-08-13 |
1997-10-22 |
King S College London |
Solution synthesis of oligonucleotides and their phosphorothioate analogues
|
US6383808B1
(en)
|
2000-09-11 |
2002-05-07 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of clusterin expression
|
US6750344B1
(en)
|
1997-09-05 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Amine compounds and combinatorial libraries comprising same
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
DE19741715A1
(de)
|
1997-09-22 |
1999-03-25 |
Hoechst Ag |
Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
|
US6232463B1
(en)
|
1997-10-09 |
2001-05-15 |
Isis Pharmaceuticals, Inc. |
Substituted purines and oligonucleotide cross-linking
|
US6528640B1
(en)
|
1997-11-05 |
2003-03-04 |
Ribozyme Pharmaceuticals, Incorporated |
Synthetic ribonucleic acids with RNAse activity
|
US6617438B1
(en)
|
1997-11-05 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Oligoribonucleotides with enzymatic activity
|
US6080543A
(en)
|
1997-12-08 |
2000-06-27 |
E. & J. Gallo Winery |
Detection of fungal pathogens
|
US6582936B1
(en)
|
1997-12-12 |
2003-06-24 |
The Regents Of The University Of California |
Methods for making nucleic acids
|
US6248519B1
(en)
|
1998-03-11 |
2001-06-19 |
E & J Gallo Winery |
Detection of fermentation-related microorganisms
|
US7045610B2
(en)
|
1998-04-03 |
2006-05-16 |
Epoch Biosciences, Inc. |
Modified oligonucleotides for mismatch discrimination
|
AU3884199A
(en)
|
1998-05-06 |
1999-11-23 |
Ottawa Health Research Institute |
Methods for the prevention and treatment of parasitic infections and related diseases using cpg oligonucleotides
|
CA2328406A1
(en)
|
1998-05-14 |
1999-11-18 |
Hermann Wagner |
Methods for regulating hematopoiesis using cpg-oligonucleotides
|
US6242589B1
(en)
|
1998-07-14 |
2001-06-05 |
Isis Pharmaceuticals, Inc. |
Phosphorothioate oligonucleotides having modified internucleoside linkages
|
US6867294B1
(en)
|
1998-07-14 |
2005-03-15 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
AU764532B2
(en)
|
1998-07-27 |
2003-08-21 |
University Of Iowa Research Foundation, The |
Stereoisomers of CpG oligonucleotides and related methods
|
DK1104306T3
(da)
|
1998-08-10 |
2006-05-22 |
Antigenics Inc |
Præparater af CpG- og saponinadjuvanser og fremgangsmåder til anvendelse deraf
|
WO2000023444A1
(en)
|
1998-10-21 |
2000-04-27 |
Abbott Laboratories |
5,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds
|
US6995259B1
(en)
|
1998-10-23 |
2006-02-07 |
Sirna Therapeutics, Inc. |
Method for the chemical synthesis of oligonucleotides
|
US6451524B1
(en)
|
1998-11-25 |
2002-09-17 |
Isis Pharmaceuticals, Inc. |
Identification of disease predictive nucleic acids
|
WO2000031110A1
(en)
|
1998-11-25 |
2000-06-02 |
Isis Pharmaceuticals, Inc. |
Identification of disease predictive nucleic acids
|
AU2200100A
(en)
|
1998-12-21 |
2000-07-12 |
Genencor International, Inc. |
Chemically modified enzymes with multiple charged variants
|
WO2000040749A2
(en)
|
1999-01-06 |
2000-07-13 |
Genenews Inc. |
Method for the detection of gene transcripts in blood and uses thereof
|
US6265172B1
(en)
|
1999-02-08 |
2001-07-24 |
University Of Kentucky |
Diagnostic test and therapy for manganese superoxide dismutate (mNsod) associated diseases
|
US6121437A
(en)
|
1999-03-16 |
2000-09-19 |
Isis Pharmaceuticals, Inc. |
Phosphate and thiophosphate protecting groups
|
US6506594B1
(en)
|
1999-03-19 |
2003-01-14 |
Cornell Res Foundation Inc |
Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
|
GB9907245D0
(en)
|
1999-03-29 |
1999-05-26 |
Goldsborough Andrew |
Cleavage of nucleic acids from solid supports
|
JP3072345B1
(ja)
|
1999-03-31 |
2000-07-31 |
農林水産省家畜衛生試験場長 |
豚丹毒菌の組換えサブユニットワクチン
|
US5998148A
(en)
|
1999-04-08 |
1999-12-07 |
Isis Pharmaceuticals Inc. |
Antisense modulation of microtubule-associated protein 4 expression
|
US6977245B2
(en)
|
1999-04-12 |
2005-12-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Oligodeoxynucleotide and its use to induce an immune response
|
US6300069B1
(en)
|
1999-05-03 |
2001-10-09 |
Qiagen Gmbh |
Generation and amplification of nucleic acids from ribonucleic acids
|
US6656730B1
(en)
|
1999-06-15 |
2003-12-02 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides conjugated to protein-binding drugs
|
US6271004B1
(en)
|
1999-06-25 |
2001-08-07 |
Display Systems Biotech A/S |
Method for improved reverse transcription at high temperatures
|
US6066500A
(en)
|
1999-06-25 |
2000-05-23 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Beta catenin expression
|
US6414135B1
(en)
|
1999-07-07 |
2002-07-02 |
Isis Pharmaceuticals, Inc. |
C3′-methylene hydrogen phosphonate monomers and related compounds
|
US20030092647A1
(en)
|
2001-08-08 |
2003-05-15 |
Crooke Rosanne M. |
Antisense modulation of cholesteryl ester transfer protein expression
|
US6147200A
(en)
|
1999-08-19 |
2000-11-14 |
Isis Pharmaceuticals, Inc. |
2'-O-acetamido modified monomers and oligomers
|
US7264932B2
(en)
|
1999-09-24 |
2007-09-04 |
Applera Corporation |
Nuclease inhibitor cocktail
|
DK1221955T3
(da)
|
1999-09-25 |
2006-01-30 |
Univ Iowa Res Found |
Immunstimulerende nukleinsyre
|
ES2265980T5
(es)
|
1999-09-27 |
2010-12-28 |
Coley Pharmaceutical Group, Inc. |
Metodos relacionados con interferón inducido por ácidos nucleicos inmunoestimuladores.
|
US6949520B1
(en)
|
1999-09-27 |
2005-09-27 |
Coley Pharmaceutical Group, Inc. |
Methods related to immunostimulatory nucleic acid-induced interferon
|
US20020082227A1
(en)
|
1999-09-30 |
2002-06-27 |
Scott Henry |
Use of oligonucleotides for inhibition of complement activation
|
WO2001025488A2
(en)
|
1999-10-06 |
2001-04-12 |
Quark Biotech, Inc. |
Method for enrichment of natural antisense messenger rna
|
GB9924285D0
(en)
|
1999-10-14 |
1999-12-15 |
Avecia Ltd |
Process
|
US20010055761A1
(en)
|
1999-10-29 |
2001-12-27 |
Agilent Technologies |
Small scale dna synthesis using polymeric solid support with functionalized regions
|
FR2800750B1
(fr)
|
1999-11-05 |
2003-01-31 |
Centre Nat Rech Scient |
Proteines membranaires ctl (choline transporter like) impliquees dans le transport de la choline
|
AU1656601A
(en)
|
1999-11-12 |
2001-06-12 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
US6322985B1
(en)
|
1999-12-27 |
2001-11-27 |
Technion Research And Development Foundation Ltd. |
Abundant, well distributed and hyperpolymorphic simple sequence repeats in prokaryote genomes and use of same for prokaryote classification and typing
|
US7501091B2
(en)
|
1999-12-30 |
2009-03-10 |
Smiths Detection Inc. |
Sensors with improved properties
|
US7055094B2
(en)
|
1999-12-30 |
2006-05-30 |
Rutgers, The State University Of New Jersey |
Virtual tags and the process of virtual tagging utilizing user feedback in transformation rules
|
US6649750B1
(en)
|
2000-01-05 |
2003-11-18 |
Isis Pharmaceuticals, Inc. |
Process for the preparation of oligonucleotide compounds
|
US6159697A
(en)
|
2000-01-19 |
2000-12-12 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of Smad7 expression
|
US7585847B2
(en)
|
2000-02-03 |
2009-09-08 |
Coley Pharmaceutical Group, Inc. |
Immunostimulatory nucleic acids for the treatment of asthma and allergy
|
US6495677B1
(en)
|
2000-02-15 |
2002-12-17 |
Kanda S. Ramasamy |
Nucleoside compounds
|
EP1130091A3
(en)
|
2000-03-01 |
2001-11-14 |
Message Pharmaceuticals, Inc. |
Bacterial RNaseP Proteins and their use in identifying antibacterial compounds
|
GB0004889D0
(en)
|
2000-03-01 |
2000-04-19 |
Avecia Ltd |
Synthesis of oligonucleotides
|
EP1265840A2
(en)
|
2000-03-17 |
2002-12-18 |
Corixa Corporation |
Novel amphipathic aldehydes and their use as adjuvants and immunoeffectors
|
MXPA02010261A
(es)
|
2000-04-20 |
2003-04-25 |
Hoffmann La Roche |
Derivados de pirrolidina y piperidina y su uso para el tratamiento de transtornos neurodegenerativos.
|
DE10019756A1
(de)
|
2000-04-20 |
2001-10-25 |
Bayer Ag |
Verfahren zur Herstellung von superabsorbierenden Polymeren aus Polyacrylnitrilen
|
US20020013287A1
(en)
|
2000-05-09 |
2002-01-31 |
Reliable Biopharmaceuticals, Inc. St Louis Missouri |
Polymeric compounds useful as prodrugs
|
US6492171B2
(en)
|
2000-05-16 |
2002-12-10 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of TERT expression
|
US6815542B2
(en)
|
2000-06-16 |
2004-11-09 |
Ribapharm, Inc. |
Nucleoside compounds and uses thereof
|
EP1307469B1
(en)
|
2000-08-03 |
2008-01-23 |
Boehringer Mannheim Gmbh |
Nucleic acid binding compounds containing pyrazolo¬3,4-d pyrimidine analogues of purin-2,6-diamine and their uses
|
US6725412B1
(en)
|
2000-08-15 |
2004-04-20 |
Dolby Laboratories Licensing Corporation |
Low latency data encoder
|
US6809195B1
(en)
|
2000-08-16 |
2004-10-26 |
Isis Pharmaceuticals, Inc. |
Process for the preparation of oligonucleotides
|
US6559279B1
(en)
|
2000-09-08 |
2003-05-06 |
Isis Pharmaceuticals, Inc. |
Process for preparing peptide derivatized oligomeric compounds
|
AU2001291096A1
(en)
|
2000-09-15 |
2002-03-26 |
Coley Pharmaceutical Gmbh |
Process for high throughput screening of CpG-based immuno-agonist/antagonist
|
EP1191097A1
(en)
|
2000-09-21 |
2002-03-27 |
Leids Universitair Medisch Centrum |
Induction of exon skipping in eukaryotic cells
|
GB0024752D0
(en)
|
2000-10-10 |
2000-11-22 |
Univ Belfast |
Oxidative halogenation of aromatic compounds
|
DK1326638T3
(da)
|
2000-10-18 |
2008-03-25 |
Glaxosmithkline Biolog Sa |
Vacciner mod cancer
|
US6372492B1
(en)
|
2000-10-30 |
2002-04-16 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of talin expression
|
US6682889B1
(en)
|
2000-11-08 |
2004-01-27 |
Becton, Dickinson And Company |
Amplification and detection of organisms of the Chlamydiaceae family
|
NL1016978C2
(nl)
|
2000-12-22 |
2002-06-25 |
Robert Jan Colenbrander |
Inrichting en werkwijze voor het verpakken en bereiden van voedsel en werkwijze voor het vervaardigen van een dergelijke inrichting.
|
JP3914156B2
(ja)
|
2001-01-22 |
2007-05-16 |
メルク エンド カムパニー インコーポレーテッド |
Rna依存性rnaウィルスポリメラーゼ阻害薬としてのヌクレオシド誘導体
|
JP2004525624A
(ja)
|
2001-01-25 |
2004-08-26 |
エボルバ バイオテック アクティーゼルスカブ |
細胞コレクションのライブラリー
|
US8008459B2
(en)
|
2001-01-25 |
2011-08-30 |
Evolva Sa |
Concatemers of differentially expressed multiple genes
|
WO2002059294A1
(en)
|
2001-01-26 |
2002-08-01 |
Commonwealth Scientific And Industrial Research O Rganisation |
Methods and means for producing efficient silencing construct using recombinational cloning
|
US20050277133A1
(en)
|
2001-05-18 |
2005-12-15 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
|
US20030207804A1
(en)
|
2001-05-25 |
2003-11-06 |
Muthiah Manoharan |
Modified peptide nucleic acids
|
GB0113523D0
(en)
|
2001-06-04 |
2001-07-25 |
Torotrak Dev Ltd |
An Hydraulic control circuit for a continuosly variable transmission
|
US20030069410A1
(en)
|
2001-06-14 |
2003-04-10 |
Isis Pharmaceuticals, Inc. |
Methods for preparing oligonucleotides having chiral phosphorothioate linkages
|
US20050019915A1
(en)
|
2001-06-21 |
2005-01-27 |
Bennett C. Frank |
Antisense modulation of superoxide dismutase 1, soluble expression
|
CA2451739A1
(en)
|
2001-06-29 |
2003-01-09 |
Chiron Corporation |
Hcv e1e2 vaccine compositions
|
JP2005504020A
(ja)
|
2001-07-03 |
2005-02-10 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
ヌクレアーゼ耐性キメラオリゴヌクレオチド
|
US7205399B1
(en)
|
2001-07-06 |
2007-04-17 |
Sirna Therapeutics, Inc. |
Methods and reagents for oligonucleotide synthesis
|
US6440739B1
(en)
|
2001-07-17 |
2002-08-27 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of glioma-associated oncogene-2 expression
|
US7425545B2
(en)
|
2001-07-25 |
2008-09-16 |
Isis Pharmaceuticals, Inc. |
Modulation of C-reactive protein expression
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
US6455308B1
(en)
|
2001-08-01 |
2002-09-24 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of serum amyloid A4 expression
|
US7888324B2
(en)
|
2001-08-01 |
2011-02-15 |
Genzyme Corporation |
Antisense modulation of apolipoprotein B expression
|
US7227014B2
(en)
|
2001-08-07 |
2007-06-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein (a) expression
|
US7259150B2
(en)
|
2001-08-07 |
2007-08-21 |
Isis Pharmaceuticals, Inc. |
Modulation of apolipoprotein (a) expression
|
AU2002361468A1
(en)
|
2001-08-14 |
2003-03-18 |
The Government Of The United States Of America As Represented By The Secretary Of Health And Human S |
Method for rapid generation of mature dendritic cells
|
CA2458393A1
(en)
|
2001-08-24 |
2003-03-06 |
Massachusetts Institute Of Technology |
Reagents that facilitate the purification of compounds synthesized on a solid support
|
US7049122B2
(en)
|
2001-09-21 |
2006-05-23 |
Academia Sinica |
Mutant-type lipases and applications thereof
|
US6933288B2
(en)
|
2002-02-04 |
2005-08-23 |
Isis Pharmaceuticals, Inc. |
Pyranosyl cytosines: pharmaceutical formulations and methods
|
JP4348044B2
(ja)
|
2002-02-12 |
2009-10-21 |
株式会社キラルジェン |
立体規則性の高いジヌクレオシドホスホロチオエートの製造法
|
US20040149587A1
(en)
|
2002-02-15 |
2004-08-05 |
George Hradil |
Electroplating solution containing organic acid complexing agent
|
US20030159938A1
(en)
|
2002-02-15 |
2003-08-28 |
George Hradil |
Electroplating solution containing organic acid complexing agent
|
US20050096284A1
(en)
|
2002-02-20 |
2005-05-05 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
|
US8232383B2
(en)
|
2002-02-20 |
2012-07-31 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
AU2003217863B9
(en)
|
2002-02-28 |
2009-10-29 |
Biota Scientific Management Pty Ltd |
Nucleotide mimics and their prodrugs
|
CA2477795A1
(en)
|
2002-02-28 |
2003-09-12 |
Kandasamy Sakthivel |
Nucleoside 5'-monophosphate mimics and their prodrugs
|
US7288376B2
(en)
|
2002-03-22 |
2007-10-30 |
Council Of Scientific And Industrial Research |
Method of detection of SP-A2 gene variants useful for prediction of predisposition to aspergillosis
|
US20040102394A1
(en)
|
2002-11-23 |
2004-05-27 |
Isis Pharmaceuticals Inc. |
Modulation of huntingtin interacting protein 2 expression
|
US7247621B2
(en)
|
2002-04-30 |
2007-07-24 |
Valeant Research & Development |
Antiviral phosphonate compounds and methods therefor
|
WO2003097662A1
(en)
|
2002-05-15 |
2003-11-27 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein b expression
|
WO2003100017A2
(en)
|
2002-05-24 |
2003-12-04 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having modified nucleoside units
|
AU2003237249A1
(en)
|
2002-05-24 |
2003-12-12 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having modified nucleoside units
|
US7507808B2
(en)
|
2002-12-12 |
2009-03-24 |
Isis Pharmaceuticals, Inc. |
Modulation of endothelial lipase expression
|
WO2003106477A1
(en)
|
2002-06-01 |
2003-12-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds that include carbocyclic nucleosides and their use in gene modulation
|
EP1513552B1
(en)
|
2002-06-20 |
2010-12-01 |
Cytos Biotechnology AG |
Packaged virus-like particles in combination with cpg for use as adjuvants with allergens : method of preparation and use
|
WO2004003228A1
(en)
|
2002-07-01 |
2004-01-08 |
Unisearch Limited |
Genotyping method
|
EP2333062A1
(en)
|
2002-07-10 |
2011-06-15 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
RNA-interference by single-stranded RNA molecules
|
US20040023905A1
(en)
|
2002-07-31 |
2004-02-05 |
Isis Pharmaceuticals Inc. |
Antisense modulation of LAR expression
|
US20080274989A1
(en)
|
2002-08-05 |
2008-11-06 |
University Of Iowa Research Foundation |
Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof
|
US20050255086A1
(en)
|
2002-08-05 |
2005-11-17 |
Davidson Beverly L |
Nucleic acid silencing of Huntington's Disease gene
|
US20050042646A1
(en)
|
2002-08-05 |
2005-02-24 |
Davidson Beverly L. |
RNA interference suppresion of neurodegenerative diseases and methods of use thereof
|
WO2004014933A1
(en)
|
2002-08-07 |
2004-02-19 |
University Of Massachusetts |
Compositions for rna interference and methods of use thereof
|
AU2003259735A1
(en)
|
2002-08-08 |
2004-02-25 |
Sirna Therapeutics, Inc. |
Small-mer compositions and methods of use
|
AR040996A1
(es)
|
2002-08-19 |
2005-04-27 |
Coley Pharm Group Inc |
Acidos nucleicos inmunoestimuladores
|
US7414116B2
(en)
|
2002-08-23 |
2008-08-19 |
Illumina Cambridge Limited |
Labelled nucleotides
|
WO2004024919A1
(en)
*
|
2002-09-13 |
2004-03-25 |
Replicor, Inc. |
Non-sequence complementary antiviral oligonucleotides
|
US7030230B2
(en)
|
2002-10-25 |
2006-04-18 |
Isis Pharmaceuticals, Inc. |
Process of purifying phosphoramidites
|
DK2241325T3
(da)
|
2002-10-29 |
2012-04-10 |
Coley Pharm Group Inc |
Anvendelse af CPG-oligonukleotider til behandling af Hepatitis Cvirusinfektion
|
WO2004042018A2
(en)
|
2002-11-01 |
2004-05-21 |
The Regents Of The University Of Colorado |
Dopamine neurons from human embryonic stem cells
|
AU2003291755A1
(en)
|
2002-11-05 |
2004-06-07 |
Isis Pharmaceuticals, Inc. |
Oligomers comprising modified bases for binding cytosine and uracil or thymine and their use
|
WO2004044141A2
(en)
|
2002-11-05 |
2004-05-27 |
Isis Pharmaceuticals, Inc. |
Conjugated oligomeric compounds and their use in gene modulation
|
WO2004044134A2
(en)
|
2002-11-05 |
2004-05-27 |
Isis Pharmaceuticals, Inc. |
Phosphorous-linked oligomeric compounds and their use in gene modulation
|
WO2004041889A2
(en)
|
2002-11-05 |
2004-05-21 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
US7381527B2
(en)
|
2002-11-06 |
2008-06-03 |
Council Of Scientific And Industrial Research |
Method of detection of SP-A2 gene variants
|
WO2004044181A2
(en)
|
2002-11-13 |
2004-05-27 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein b expression
|
US7511131B2
(en)
|
2002-11-13 |
2009-03-31 |
Genzyme Corporation |
Antisense modulation of apolipoprotein B expression
|
WO2004045543A2
(en)
|
2002-11-14 |
2004-06-03 |
Dharmacon, Inc. |
Functional and hyperfunctional sirna
|
DK2216407T3
(en)
|
2003-03-07 |
2016-03-29 |
Alnylam Pharmaceuticals Inc |
therapeutic compositions
|
AU2003225705A1
(en)
|
2003-03-07 |
2004-09-30 |
Ribapharm Inc. |
Cytidine analogs and methods of use
|
WO2004083432A1
(en)
|
2003-03-21 |
2004-09-30 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
|
GB0306657D0
(en)
|
2003-03-24 |
2003-04-30 |
Avecia Ltd |
Process and compounds
|
EP1605972A2
(en)
|
2003-03-26 |
2005-12-21 |
Cytos Biotechnology AG |
Hiv-peptide-carrier-conjugates
|
US7537767B2
(en)
|
2003-03-26 |
2009-05-26 |
Cytis Biotechnology Ag |
Melan-A- carrier conjugates
|
ITRM20030149A1
(it)
|
2003-04-02 |
2004-10-03 |
Giuliani Spa |
Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico
|
US7598227B2
(en)
|
2003-04-16 |
2009-10-06 |
Isis Pharmaceuticals Inc. |
Modulation of apolipoprotein C-III expression
|
US20050261237A1
(en)
|
2003-04-25 |
2005-11-24 |
Boojamra Constantine G |
Nucleoside phosphonate analogs
|
WO2004096233A2
(en)
|
2003-04-25 |
2004-11-11 |
Gilead Sciences, Inc. |
Nucleoside phosphonate conjugates
|
US7470724B2
(en)
|
2003-04-25 |
2008-12-30 |
Gilead Sciences, Inc. |
Phosphonate compounds having immuno-modulatory activity
|
US7452901B2
(en)
|
2003-04-25 |
2008-11-18 |
Gilead Sciences, Inc. |
Anti-cancer phosphonate analogs
|
US20090247488A1
(en)
|
2003-04-25 |
2009-10-01 |
Carina Cannizzaro |
Anti-inflammatory phosphonate compounds
|
CN101410120A
(zh)
|
2003-04-25 |
2009-04-15 |
吉里德科学公司 |
抗炎的膦酸酯化合物
|
WO2005002626A2
(en)
|
2003-04-25 |
2005-01-13 |
Gilead Sciences, Inc. |
Therapeutic phosphonate compounds
|
US7432261B2
(en)
|
2003-04-25 |
2008-10-07 |
Gilead Sciences, Inc. |
Anti-inflammatory phosphonate compounds
|
US7407965B2
(en)
|
2003-04-25 |
2008-08-05 |
Gilead Sciences, Inc. |
Phosphonate analogs for treating metabolic diseases
|
PT1628685E
(pt)
|
2003-04-25 |
2011-03-16 |
Gilead Sciences Inc |
Análogos de fosfonatos antivirais
|
AU2004233989A1
(en)
|
2003-04-25 |
2004-11-11 |
Gilead Sciences, Inc. |
Anti-cancer phosphonate analogs
|
US7045306B2
(en)
|
2003-04-28 |
2006-05-16 |
The General Hospital Corporation |
Method for identifying compounds in vitro that modulate the dysregulation of transcription of transcription mediated by mutant huntingtin protein
|
US7214491B2
(en)
|
2003-05-07 |
2007-05-08 |
E. I. Du Pont De Nemours And Company |
Δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts
|
US7589189B2
(en)
|
2003-05-14 |
2009-09-15 |
Japan Science And Technology Agency |
Inhibition of the expression of huntingtin gene
|
JP4579911B2
(ja)
|
2003-06-03 |
2010-11-10 |
アイシス・ファーマシューティカルズ・インコーポレイテッド |
スルビビン発現の調節
|
AU2004257149A1
(en)
|
2003-06-20 |
2005-01-27 |
Coley Pharmaceutical Gmbh |
Small molecule toll-like receptor (TLR) antagonists
|
US8969314B2
(en)
|
2003-07-31 |
2015-03-03 |
Regulus Therapeutics, Inc. |
Methods for use in modulating miR-122a
|
EP1648914A4
(en)
|
2003-07-31 |
2009-12-16 |
Regulus Therapeutics Inc |
OLIGOMERIC COMPOUNDS AND COMPOSITIONS USEFUL FOR MODULATING SMALL NON-CODING RNA
|
JP2011088935A
(ja)
|
2003-08-08 |
2011-05-06 |
Chiralgen Ltd |
リン原子修飾ヌクレオチド類縁体の製造のための光学活性ヌクレオシド3’−ホスホロアミダイト
|
JP2005089441A
(ja)
|
2003-08-08 |
2005-04-07 |
Toudai Tlo Ltd |
立体規則性の高いリン原子修飾ヌクレオチド類縁体の製造法
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
BRPI0413682A
(pt)
|
2003-08-21 |
2006-10-24 |
Univ Griffith |
compostos, composição farmacêutica e respectivos métodos de preparação, de tratamento de infecção microbiana e de extermìnio de microrganismo e usos
|
EP1664072A1
(en)
|
2003-08-21 |
2006-06-07 |
Griffith University |
Novel sulfenamides
|
AU2004269026B2
(en)
|
2003-08-27 |
2010-02-25 |
Biota Scientific Management Pty Ltd |
Novel tricyclic nucleosides or nucleotides as therapeutic agents
|
JP4731324B2
(ja)
|
2003-08-28 |
2011-07-20 |
武 今西 |
N−o結合性架橋構造型新規人工核酸
|
WO2005023828A1
(ja)
|
2003-09-02 |
2005-03-17 |
Takeshi Wada |
リボヌクレオチド又はリボヌクレオチド誘導体の製造方法
|
JP4616175B2
(ja)
|
2003-09-02 |
2011-01-19 |
株式会社キラルジェン |
5’−ホスフィチル化モノマーおよびh−ホスホネートオリゴヌクレオチド誘導体の製造方法
|
KR20060132802A
(ko)
|
2003-09-09 |
2006-12-22 |
제론 코포레이션 |
텔로머라제 억제를 위한 변형 올리고뉴클레오티드
|
US20050074801A1
(en)
|
2003-09-09 |
2005-04-07 |
Monia Brett P. |
Chimeric oligomeric compounds comprising alternating regions of northern and southern conformational geometry
|
US20050053981A1
(en)
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
WO2008005562A2
(en)
|
2006-07-07 |
2008-01-10 |
University Of Massachusetts |
Rna silencing compositions and methods for the treatment of huntington's disease
|
PT2821085T
(pt)
|
2003-09-12 |
2020-07-28 |
Univ Massachusetts |
Interferência de arn para o tratamento de distúrbios de ganho de função
|
US8680063B2
(en)
|
2003-09-12 |
2014-03-25 |
University Of Massachusetts |
RNA interference for the treatment of gain-of-function disorders
|
GB0323968D0
(en)
|
2003-10-13 |
2003-11-19 |
Glaxosmithkline Biolog Sa |
Immunogenic compositions
|
BRPI0416079A
(pt)
|
2003-10-30 |
2007-01-02 |
Coley Pharm Gmbh |
análogos de oligonucleotìdeos de classe c com uma potência imunoestimuladora aumentada
|
WO2005042716A2
(en)
|
2003-10-31 |
2005-05-12 |
President And Fellows Of Harvard College |
Nucleic acid binding oligonucleotides
|
US7846436B2
(en)
*
|
2003-11-28 |
2010-12-07 |
Chemgenes Corporation |
Oligonucleotides and related compounds
|
AU2003300239A1
(en)
|
2003-12-29 |
2005-07-21 |
Galapagos Genomics N.V. |
Modulators of bone homeostasis identified in a high-throughput screen
|
JP4945129B2
(ja)
|
2004-01-27 |
2012-06-06 |
株式会社キラルジェン |
フルオラス担体およびそれを用いたオリゴヌクレオチド誘導体の製造方法
|
US20050176045A1
(en)
|
2004-02-06 |
2005-08-11 |
Dharmacon, Inc. |
SNP discriminatory siRNA
|
WO2005076744A2
(en)
|
2004-02-18 |
2005-08-25 |
Frutarom Ltd. |
Method for the preparation of peptide-oligonucleotide conjugates
|
JP3976742B2
(ja)
|
2004-02-27 |
2007-09-19 |
江守商事株式会社 |
インターフェロンアルファを誘導する免疫刺激オリゴヌクレオチド
|
WO2005085272A1
(ja)
|
2004-03-05 |
2005-09-15 |
Takeshi Wada |
ボラノホスフェートモノマーおよびそれを用いたオリゴヌクレオチド誘導体の製造方法
|
JP4865544B2
(ja)
|
2004-03-25 |
2012-02-01 |
株式会社キラルジェン |
立体規則性の高いリボヌクレオチド類縁体及びデオキシリボヌクレオチド類縁体の製造法
|
US20050267300A1
(en)
|
2004-04-05 |
2005-12-01 |
Muthiah Manoharan |
Processes and reagents for oligonucleotide synthesis and purification
|
US20050244869A1
(en)
|
2004-04-05 |
2005-11-03 |
Brown-Driver Vickie L |
Modulation of transthyretin expression
|
TWI350168B
(en)
|
2004-05-07 |
2011-10-11 |
Incyte Corp |
Amido compounds and their use as pharmaceuticals
|
WO2005116268A2
(en)
|
2004-05-27 |
2005-12-08 |
The Government Of The United States Of America As Represented By The Secretary, Department Of Health |
Differential expression of molecules associated with acute stroke
|
US7759318B1
(en)
|
2004-05-28 |
2010-07-20 |
Isis Pharmaceuticals, Inc. |
Identification of novel pathways, genes and promoter motifs regulating adipogenesis
|
WO2005121372A2
(en)
|
2004-06-03 |
2005-12-22 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
DK1766010T3
(da)
|
2004-06-28 |
2011-06-06 |
Univ Western Australia |
Antisense-oligonukleotider til induktion af exon-skipping og fremgangsmåder til anvendelse deraf
|
EP2409713B1
(en)
|
2004-08-10 |
2015-07-22 |
Genzyme Corporation |
Oligonucleotides for use in modulating lipoprotein and cholesterol levels in humans
|
AU2005275801B2
(en)
|
2004-08-26 |
2012-05-10 |
Nippon Shinyaku Co., Ltd. |
Phosphoramidite compound and method for producing oligo-RNA
|
EP1791557A4
(en)
|
2004-09-07 |
2009-09-23 |
Archemix Corp |
MEDICAL CHEMISTRY USING APTAMERS
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
WO2006031461A2
(en)
|
2004-09-09 |
2006-03-23 |
Isis Pharmaceuticals, Inc. |
Pyrrolidinyl groups for attaching conjugates to oligomeric compounds
|
EP2397563A3
(en)
|
2004-09-17 |
2012-07-18 |
Isis Pharmaceuticals, Inc. |
Enhanced antisense oligonucleotides
|
JP4944034B2
(ja)
|
2004-10-13 |
2012-05-30 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
Ptp1b発現のアンチセンス調節
|
AU2005301957B2
(en)
|
2004-11-03 |
2012-02-23 |
Department Of Health And Human Services |
Novobiocin analogues as anticancer agents
|
US7622451B2
(en)
|
2004-11-03 |
2009-11-24 |
University Of Kansas |
Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
|
US8212011B2
(en)
|
2004-11-03 |
2012-07-03 |
University Of Kansas |
Novobiocin analogues
|
US9120774B2
(en)
|
2004-11-03 |
2015-09-01 |
University Of Kansas |
Novobiocin analogues having modified sugar moieties
|
WO2010096650A1
(en)
|
2009-02-20 |
2010-08-26 |
University Of Kansas |
Novobiocin analogues having modified sugar moieties
|
US8212012B2
(en)
|
2004-11-03 |
2012-07-03 |
University Of Kansas |
Novobiocin analogues having modified sugar moieties
|
KR100721928B1
(ko)
|
2004-11-05 |
2007-05-28 |
주식회사 바이오씨에스 |
CpG 올리고데옥시뉴클레오티드를 함유하는 피부질환의치료 또는 예방용 약학적 조성물
|
EP1657307A1
(en)
|
2004-11-16 |
2006-05-17 |
Immunotech S.A. |
Oligonucleotides that induce the secretion of GM-CSF
|
EP1819365B1
(en)
|
2004-12-09 |
2014-07-02 |
Alnylam Pharmaceuticals Inc. |
Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering RNAs
|
WO2006065751A2
(en)
|
2004-12-13 |
2006-06-22 |
Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Cpg oligonucleotide prodrugs, compositions thereof and associated therapeutic methods
|
WO2006066260A2
(en)
|
2004-12-17 |
2006-06-22 |
Thiosense, Inc. |
Compositions of and methods for producing phosphorus-chiral monomers and oligomers
|
US20070099851A1
(en)
|
2004-12-30 |
2007-05-03 |
Linn Gregory S |
Stable analogues of ribose-1-phosphate and methods for treating diabetes and other metabolic disorders
|
US20060183763A1
(en)
|
2004-12-31 |
2006-08-17 |
Pfizer Inc |
Novel pyrrolidyl derivatives of heteroaromatic compounds
|
CA2549423C
(en)
|
2005-01-28 |
2012-10-02 |
Hyung-Joo Kwon |
Oligonucleotides derived from mycobacterium for stimulating immune function, treating immune-related diseases, atopic dermatitis and/or protecting normal immune cell
|
EP1851314A2
(en)
|
2005-02-24 |
2007-11-07 |
Coley Pharmaceutical Group, Inc. |
Immunostimulatory oligonucleotides
|
CN101189249B
(zh)
|
2005-04-01 |
2013-04-17 |
加利福尼亚大学董事会 |
膦酰基-戊-2-烯-1-基核苷和类似物
|
JP4977035B2
(ja)
|
2005-05-05 |
2012-07-18 |
アンティセンス ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング |
腫瘍の治療における、TGF−β、VEGF、インターロイキン−10、C−JUN、C−FOSまたはプロスタグランジンE2遺伝子にアンチセンスなオリゴヌクレオチドの低適用量の使用
|
US20060257912A1
(en)
|
2005-05-06 |
2006-11-16 |
Medtronic, Inc. |
Methods and sequences to suppress primate huntington gene expression
|
US7902352B2
(en)
|
2005-05-06 |
2011-03-08 |
Medtronic, Inc. |
Isolated nucleic acid duplex for reducing huntington gene expression
|
EP3470072A1
(en)
|
2005-06-23 |
2019-04-17 |
Biogen MA Inc. |
Compositions and methods for modulation of smn2 splicing
|
US9133517B2
(en)
|
2005-06-28 |
2015-09-15 |
Medtronics, Inc. |
Methods and sequences to preferentially suppress expression of mutated huntingtin
|
ATE522626T1
(de)
|
2005-06-28 |
2011-09-15 |
Medtronic Inc |
Verfahren und nukleotid-sequenzen, die bevorzugt die expression eines mutierten huntingtin-genes unterdrücken
|
WO2007005941A2
(en)
|
2005-07-05 |
2007-01-11 |
President And Fellows Of Harvard College |
Liver targeted conjugates
|
JP4984634B2
(ja)
|
2005-07-21 |
2012-07-25 |
ソニー株式会社 |
物理情報取得方法および物理情報取得装置
|
EP1924252B1
(en)
|
2005-07-28 |
2011-09-07 |
ID-Fish Technology, Inc. |
Method for improving cell permeability to foreign particles
|
WO2007028065A2
(en)
|
2005-08-30 |
2007-03-08 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds for modulation of splicing
|
US7700567B2
(en)
|
2005-09-29 |
2010-04-20 |
Supergen, Inc. |
Oligonucleotide analogues incorporating 5-aza-cytosine therein
|
US20070077993A1
(en)
|
2005-09-30 |
2007-04-05 |
Midgley Timothy M |
Method and apparatus for collecting user game play data and crediting users in a gaming environment
|
AU2006304205C1
(en)
|
2005-10-12 |
2012-11-15 |
Idera Pharmaceuticals, Inc. |
Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
|
US9308252B2
(en)
|
2005-10-27 |
2016-04-12 |
Cook Biotech, Inc. |
Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins
|
CA2627025A1
(en)
|
2005-10-28 |
2007-05-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of huntingtin gene
|
CA2627134A1
(en)
|
2005-10-28 |
2007-05-03 |
Tosoh Corporation |
Method of preparing carotenoid synthesizing microorganism and method of producing carotenoids
|
BRPI0618473A2
(pt)
*
|
2005-11-11 |
2011-08-30 |
Pfizer |
combinações e métodos de uso de um oligodeoxinucleotìdeo imunomodulador
|
WO2007064291A1
(en)
|
2005-11-30 |
2007-06-07 |
Jyoti Chattopadhyaya |
Method and compounds for rna synthesis
|
ES2707787T3
(es)
|
2005-12-02 |
2019-04-05 |
Ionis Pharmaceuticals Inc |
Análogos antibacterianos de aminoglucósido 4,5-sustituidos que tienen sustituyentes múltiples
|
US8076303B2
(en)
|
2005-12-13 |
2011-12-13 |
Spring Bank Pharmaceuticals, Inc. |
Nucleotide and oligonucleotide prodrugs
|
NZ568692A
(en)
|
2005-12-21 |
2011-07-29 |
Pfizer Prod Inc |
Carbonylamino pyrrolopyrazoles, potent kinase inhibitors
|
ES2744098T3
(es)
|
2006-01-26 |
2020-02-21 |
Ionis Pharmaceuticals Inc |
Composiciones y sus usos dirigidos a la huntingtina
|
KR20130042043A
(ko)
|
2006-01-27 |
2013-04-25 |
아이시스 파마수티컬즈 인코포레이티드 |
6-변형된 바이시클릭 핵산 유사체
|
PT1991678E
(pt)
|
2006-02-15 |
2015-11-25 |
Adiutide Pharmaceuticals Gmbh |
Composições e métodos para formulações de oligonucleótidos
|
US7759470B2
(en)
|
2006-02-20 |
2010-07-20 |
Roche Diagnostics Operations, Inc. |
Labeling reagent
|
US8383660B2
(en)
|
2006-03-10 |
2013-02-26 |
Pfizer Inc. |
Dibenzyl amine compounds and derivatives
|
CA2647827A1
(en)
|
2006-03-31 |
2007-10-11 |
Applied Biosystems Inc. |
Reagents useful for synthesizing rhodamine-labeled oligonucleotides
|
WO2007118222A2
(en)
|
2006-04-06 |
2007-10-18 |
Ibis Biosciences, INC |
Compositions for the use in identification of fungi
|
ES2348122T3
(es)
|
2006-04-20 |
2010-11-30 |
F. Hoffmann-La Roche Ag |
Derivados de diazepano moduladores de receptores de quimioquina.
|
US8206923B2
(en)
|
2006-04-24 |
2012-06-26 |
Elvira Garza Gonzalez |
Method for detection and multiple, simultaneous quantification of pathogens by means of real-time polymerase chain reaction
|
EP2018436A2
(en)
|
2006-04-25 |
2009-01-28 |
Immune Disease Institute Inc. |
Targeted delivery to leukocytes using non-protein carriers
|
GB0608838D0
(en)
|
2006-05-04 |
2006-06-14 |
Novartis Ag |
Organic compounds
|
WO2007131232A2
(en)
|
2006-05-05 |
2007-11-15 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to ptpr alpha
|
WO2007131238A2
(en)
|
2006-05-05 |
2007-11-15 |
Isis Pharmaceuticals , Inc. |
Compounds and methods for modulating expression apob
|
US20090012120A1
(en)
|
2006-05-10 |
2009-01-08 |
Board Of Trustees Of Michigan State University |
Synthesis of N-heterocycles, beta-amino acids, and allyl amines via aza-payne mediated reaction of ylides and hydroxy aziridines
|
US7666854B2
(en)
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
JP5441688B2
(ja)
|
2006-05-11 |
2014-03-12 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
5’修飾二環式核酸類似体
|
US8592566B2
(en)
|
2006-05-31 |
2013-11-26 |
Toray Industries, Inc. |
Immunostimulatory oligonucleotides and use thereof in pharmaceuticals
|
US8097596B2
(en)
|
2006-06-30 |
2012-01-17 |
Lakewood-Amedex, Inc. |
Compositions and methods for the treatment of muscle wasting
|
EP2046964B1
(en)
|
2006-07-12 |
2018-07-04 |
The Regents of The University of California |
Transducible delivery of nucleic acids by reversible phosphotriester charge neutralization protecting groups
|
EP2051977A2
(en)
|
2006-07-20 |
2009-04-29 |
Amgen Inc. |
SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF LLbeta-HSD-1
|
GB0614947D0
(en)
|
2006-07-27 |
2006-09-06 |
Isis Innovation |
Epitope reduction therapy
|
US8101585B2
(en)
|
2006-08-04 |
2012-01-24 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for the modulation of JNK proteins
|
AT504194B1
(de)
|
2006-09-07 |
2008-07-15 |
Oesterr Rotes Kreuz |
Bakteriennachweis
|
US8138330B2
(en)
|
2006-09-11 |
2012-03-20 |
Sigma-Aldrich Co. Llc |
Process for the synthesis of oligonucleotides
|
PT2078080E
(pt)
|
2006-09-27 |
2015-09-18 |
Coley Pharm Gmbh |
Análogos dos oligonucleotídeos cpg que contêm análogos t hidrofóbicos com atividade imunoestimulante potenciada
|
AU2007310989B2
(en)
|
2006-10-18 |
2014-05-29 |
Isis Pharmaceuticals, Inc. |
Antisense compounds
|
WO2008051763A1
(en)
|
2006-10-23 |
2008-05-02 |
Irm Llc |
Cathepsin proteases inhibitors
|
US20100144846A1
(en)
*
|
2006-10-26 |
2010-06-10 |
Coley Pharmaceutical Gmbh |
Oligoribonucleotides and uses thereof
|
FR2908414B1
(fr)
|
2006-11-13 |
2012-01-20 |
Centre Nat Rech Scient |
Immobilisation de proteines membranaires sur un support par l'intermediaire d'une molecule amphiphile
|
EP2099454A4
(en)
|
2006-11-17 |
2010-11-10 |
Abbott Lab |
AMINOPYRROLIDINES AS CHEMOKINE RECEPTOR ANTAGONISTS
|
US8093222B2
(en)
|
2006-11-27 |
2012-01-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
EA200900741A1
(ru)
|
2006-11-27 |
2010-04-30 |
Айзис Фармасьютикалз, Инк. |
Способы лечения гиперхолестеринемии
|
AU2007333146A1
(en)
|
2006-12-12 |
2008-06-19 |
Idera Pharmaceuticals, Inc. |
Synthetic agonists of TLR9
|
UY30892A1
(es)
|
2007-02-07 |
2008-09-02 |
Smithkline Beckman Corp |
Inhibidores de la actividad akt
|
EP2125852B1
(en)
|
2007-02-15 |
2016-04-06 |
Ionis Pharmaceuticals, Inc. |
5'-substituted-2'-f modified nucleosides and oligomeric compounds prepared therefrom
|
RU2015127794A
(ru)
|
2007-03-24 |
2018-12-21 |
Касл Терапьютикс, ЭлЭлСи |
Введение антисмысловых олигонуклеотидов, комплементарных человеческому аполипопротеину в
|
US7960353B2
(en)
|
2007-05-10 |
2011-06-14 |
University Of Kansas |
Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
|
EP2158316B1
(en)
|
2007-05-11 |
2015-04-15 |
Adynxx, Inc. |
Gene expression and pain
|
CA2688008A1
(en)
|
2007-05-24 |
2008-11-27 |
Kyorin Pharmaceutical Co., Ltd. |
Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
|
GB0710186D0
(en)
|
2007-05-29 |
2007-07-04 |
Texas Instr Denmark |
PWM loop with minimum allasing error property
|
EP2170917B1
(en)
|
2007-05-30 |
2012-06-27 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
JP5444535B2
(ja)
|
2007-06-05 |
2014-03-19 |
インテグレイティブ・リサーチ・ラボラトリーズ・スウェーデン・アーベー |
皮質カテコールアミン作動性神経伝達の調節物質としての新規な二置換フェニルピロリジン
|
EP2173760B2
(en)
|
2007-06-08 |
2015-11-04 |
Isis Pharmaceuticals, Inc. |
Carbocyclic bicyclic nucleic acid analogs
|
US20100298280A1
(en)
|
2007-06-13 |
2010-11-25 |
Petra Kioschis-Schneider |
Compounds for the Modulation of Huntingtin Aggregation, Methods and Means for Identifying Such Compounds
|
ATE462787T1
(de)
|
2007-06-18 |
2010-04-15 |
Commissariat Energie Atomique |
Reversibles sirna-silencing eines mutierten und endogenen huntington-wildtypgens und dessen anwendung zur behandlung von morbus huntington
|
GB0712494D0
(en)
|
2007-06-27 |
2007-08-08 |
Isis Innovation |
Substrate reduction therapy
|
ES2376507T5
(es)
|
2007-07-05 |
2015-08-31 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos 6-disustituidos
|
US8188261B2
(en)
|
2007-07-09 |
2012-05-29 |
Idera Pharmaceuticals, Inc. |
Stabilized immune modulatory RNA (SIMRA) compounds
|
TWI413530B
(zh)
|
2007-07-20 |
2013-11-01 |
Kao Corp |
有機聚矽氧
|
US8008011B2
(en)
|
2007-07-31 |
2011-08-30 |
University Of Saskatchewan |
Genetic variation in pro-melanin-concentrating hormone gene affects carcass traits in cattle
|
US7812003B2
(en)
|
2007-08-02 |
2010-10-12 |
Safe Stephen H |
Antisense microRNA and uses therefor
|
WO2009023819A2
(en)
|
2007-08-15 |
2009-02-19 |
Idera Pharmaceuticals, Inc. |
Toll like receptor modulators
|
US8486904B2
(en)
|
2007-10-01 |
2013-07-16 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of fibroblast growth factor receptor 4 expression
|
KR100886139B1
(ko)
|
2007-11-13 |
2009-02-27 |
주식회사 삼천리제약 |
올리고뉴클레오타이드의 제조방법
|
PE20091669A1
(es)
|
2007-12-21 |
2009-12-06 |
Exelixis Inc |
Benzofuropirimidinonas
|
TWI340765B
(en)
|
2007-12-26 |
2011-04-21 |
Ind Tech Res Inst |
Oligonucleotide sequences and dna chip for identifying filamentous microorganisms and the identification method thereof
|
WO2009089659A1
(en)
|
2008-01-18 |
2009-07-23 |
Shanghai Targetdrug Co., Ltd. |
Pyrollidine-based compounds
|
WO2009098197A1
(en)
|
2008-02-04 |
2009-08-13 |
Biofocus Dpi B.V. |
Target sequences and methods to identify the same, useful in treatment of neurodegenerative diseases
|
JP2009190983A
(ja)
|
2008-02-12 |
2009-08-27 |
Tokyo Institute Of Technology |
オリゴヌクレオチド誘導体
|
EP2282744B1
(en)
|
2008-03-21 |
2018-01-17 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising tricyclic nucleosides and methods for their use
|
US20110269814A1
(en)
|
2008-03-26 |
2011-11-03 |
Alnylam Pharamaceuticals, Inc. |
2'-f modified rna interference agents
|
KR101806314B1
(ko)
|
2008-04-03 |
2017-12-07 |
스프링 뱅크 파마슈티칼스, 인크. |
바이러스 감염증을 치료하기 위한 조성물 및 방법
|
EP2285819B1
(en)
|
2008-04-04 |
2013-10-16 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising neutrally linked terminal bicyclic nucleosides
|
WO2009121347A1
(de)
|
2008-04-04 |
2009-10-08 |
Universität Hamburg |
Verfahren zur stereoselektiven synthese von phosphorverbindungen
|
AU2009244013B2
(en)
|
2008-05-09 |
2015-06-25 |
The University Of British Columbia |
Methods and compositions for the treatment of Huntington's disease
|
US8679750B2
(en)
|
2008-05-09 |
2014-03-25 |
The University Of British Columbia |
Methods and compositions for the treatment of Huntington'S disease
|
EP2300102B1
(en)
|
2008-05-15 |
2014-01-08 |
Dynavax Technologies Corporation |
Immunostimulatory sequences containing CpG for use in the treatment of allergic rhinitis
|
WO2009143391A2
(en)
|
2008-05-22 |
2009-11-26 |
Isis Pharmaceuticals, Inc |
Methods for modulation expression of creb
|
WO2009143390A2
(en)
|
2008-05-22 |
2009-11-26 |
Isis Pharmaceuticals, Inc. |
Methods for modulating expression of rbp4
|
US8541387B2
(en)
|
2008-05-22 |
2013-09-24 |
Isis Pharmaceuticals, Inc. |
Modulation of SMRT expression
|
WO2009148605A2
(en)
|
2008-06-04 |
2009-12-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
JP2011526931A
(ja)
|
2008-07-03 |
2011-10-20 |
エグゼリクシス, インコーポレイテッド |
Cdkモジュレーター
|
WO2010030849A1
(en)
|
2008-09-12 |
2010-03-18 |
University Of Louisville Research Foundation, Inc. |
Compositions and methods for treating cancer,inhibiting proliferation, and inducing cell death
|
WO2010030858A1
(en)
|
2008-09-15 |
2010-03-18 |
Enanta Pharmaceuticals, Inc. |
4'-allene-substituted nucleoside derivatives
|
WO2010039543A2
(en)
|
2008-09-23 |
2010-04-08 |
Traversa Therapeutics, Inc. |
Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating rna interference
|
WO2010036698A1
(en)
|
2008-09-24 |
2010-04-01 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-l-bicyclic nucleosides
|
DK2361256T3
(da)
|
2008-09-24 |
2013-07-01 |
Isis Pharmaceuticals Inc |
Cyclohexenyl-nukleinsyreanaloger
|
US20110257251A1
(en)
|
2008-10-07 |
2011-10-20 |
Presidents And Fellows Of Harvard College |
Telomerase inhibitors and methods of use thereof
|
EP2350279B1
(en)
|
2008-10-22 |
2016-01-27 |
Quark Pharmaceuticals, Inc. |
Methods for treating eye disorders
|
WO2010048552A2
(en)
|
2008-10-24 |
2010-04-29 |
Isis Pharmaceuticals, Inc. |
Methods of using oligomeric compounds comprising 2'-substituted nucleosides
|
EP2358398A2
(en)
|
2008-10-24 |
2011-08-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
US9394333B2
(en)
|
2008-12-02 |
2016-07-19 |
Wave Life Sciences Japan |
Method for the synthesis of phosphorus atom modified nucleic acids
|
WO2010072831A1
(en)
|
2008-12-23 |
2010-07-01 |
Girindus America, Inc |
Sulfurizing reagents and their use for oligonucleotides synthesis
|
WO2010080953A1
(en)
|
2009-01-08 |
2010-07-15 |
Isis Pharmaceuticals, Inc. |
Transgenic murine model of human lipoprotein metabolism, hypercholesterolemia and cardiovascular disease
|
KR20100087540A
(ko)
|
2009-01-28 |
2010-08-05 |
삼성전자주식회사 |
잉크젯 기록용 잉크 조성물
|
WO2010091301A1
(en)
|
2009-02-06 |
2010-08-12 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and excipients
|
MX2011008383A
(es)
|
2009-02-10 |
2011-09-06 |
Idera Pharmaceuticals Inc |
Agonistas basados en acido ribonucleico sintetico de receptor 7 tipo toll.
|
EP2669290A1
(en)
|
2009-03-02 |
2013-12-04 |
Alnylam Pharmaceuticals Inc. |
Nucleic Acid Chemical Modifications
|
WO2010107838A1
(en)
|
2009-03-16 |
2010-09-23 |
Isis Pharmaceuticals, Inc. |
Targeting apolipoprotein b for the reduction of apolipoprotein c-iii
|
JP5685526B2
(ja)
|
2009-03-31 |
2015-03-18 |
武田薬品工業株式会社 |
ヌクレオシドの製造方法
|
WO2010118263A1
(en)
|
2009-04-08 |
2010-10-14 |
University Of Massachusetts |
Single-nucleotide polymorphism (snp) targeting therapies for the treatment of huntington's disease
|
CA2759098A1
(en)
|
2009-04-14 |
2010-10-21 |
Smith Holdings, Llc |
Methods and compositions for the treatment of medical conditions involving cellular programming
|
WO2010129853A2
(en)
|
2009-05-07 |
2010-11-11 |
The Regents Of The University Of California |
TRANSDUCIBLE DELIVERY OF NUCLEIC ACIDS USING MODIFIED dsRNA BINDING DOMAINS
|
AU2010256836A1
(en)
|
2009-06-01 |
2012-01-19 |
The Regents Of The University Of California |
Nucleic acid delivery compositions and methods of use thereof
|
PL2437753T3
(pl)
|
2009-06-05 |
2017-03-31 |
Infectious Disease Research Institute |
Syntetyczne adiuwanty glukopiranozylolipidowe oraz zawierające je kompozycje szczepionek
|
KR20170054537A
(ko)
|
2009-06-17 |
2017-05-17 |
바이오젠 엠에이 인코포레이티드 |
대상에게서 smn2 스플라이싱을 조정하기 위한 조성물 및 방법
|
JP5670097B2
(ja)
|
2009-06-19 |
2015-02-18 |
花王株式会社 |
二層分離型毛髪化粧料
|
EP2447273A4
(en)
|
2009-06-23 |
2013-06-19 |
Takeda Pharmaceutical |
PROCESS FOR SYNTHETIZING NUCLEIC ACID
|
US8329024B2
(en)
|
2009-07-06 |
2012-12-11 |
Ada Technologies, Inc. |
Electrochemical device and method for long-term measurement of hypohalites
|
RU2612521C2
(ru)
|
2009-07-06 |
2017-03-09 |
Онтории, Инк. |
Новые пролекарства нуклеиновых кислот и способы их применения
|
WO2011005860A2
(en)
|
2009-07-07 |
2011-01-13 |
Alnylam Pharmaceuticals, Inc. |
5' phosphate mimics
|
WO2011005942A2
(en)
|
2009-07-08 |
2011-01-13 |
Idera Pharmaceuticals, Inc. |
Oligonucleotide-based compounds as inhibitors of toll-like receptors
|
WO2011010706A1
(ja)
|
2009-07-23 |
2011-01-27 |
武田薬品工業株式会社 |
Fgf21シスエレメント結合物質
|
WO2011015572A1
(en)
|
2009-08-03 |
2011-02-10 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases
|
WO2011015573A1
(en)
|
2009-08-03 |
2011-02-10 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases
|
UA107360C2
(en)
|
2009-08-05 |
2014-12-25 |
Biogen Idec Inc |
Bicyclic aryl sphingosine 1-phosphate analogs
|
WO2011017521A2
(en)
|
2009-08-06 |
2011-02-10 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
US8927553B2
(en)
|
2009-08-10 |
2015-01-06 |
Daljit Singh Dhanoa |
Deuterium-enriched alkyl sulfonamides and uses thereof
|
KR20170102069A
(ko)
|
2009-09-11 |
2017-09-06 |
아이오니스 파마수티컬즈, 인코포레이티드 |
헌팅틴 발현의 조절
|
WO2011034072A1
(ja)
|
2009-09-16 |
2011-03-24 |
株式会社キラルジェン |
Rna及びその誘導体合成のための新規保護基
|
US20120270929A1
(en)
|
2009-09-25 |
2012-10-25 |
Isis Pharmaceuticals, Inc. |
Modulation of ttc39 expression to increase hdl
|
PE20121077A1
(es)
|
2009-10-15 |
2012-08-10 |
Pfizer |
Compuestos de pirrolo[2,3-d]pirimidina
|
TWI475051B
(zh)
|
2009-11-18 |
2015-03-01 |
Kao Corp |
Organic polysiloxane
|
JP5809408B2
(ja)
|
2009-11-25 |
2015-11-10 |
花王株式会社 |
毛髪化粧料
|
WO2011075560A1
(en)
|
2009-12-17 |
2011-06-23 |
Merck Sharp & Dohme Corp. |
Aminopyrimidines as syk inhibitors
|
JP2013515953A
(ja)
|
2009-12-28 |
2013-05-09 |
アチラ ラボズ プライベート リミテッド |
診断用ゲル組成物、前記診断用ゲル組成物の製造方法
|
DK2521556T3
(en)
|
2010-01-08 |
2018-08-13 |
Ionis Pharmaceuticals Inc |
MODULATION OF ANGIOPOIETIN-LIKE 3 EXPRESSION
|
US8750507B2
(en)
|
2010-01-25 |
2014-06-10 |
Cisco Technology, Inc. |
Dynamic group creation for managed key servers
|
AU2011213562B2
(en)
|
2010-02-08 |
2016-07-07 |
Ionis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
EP3208347B1
(en)
|
2010-02-08 |
2019-08-14 |
Ionis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
CA2786973C
(en)
|
2010-02-10 |
2018-04-10 |
Robert Hermann Gibbon |
6-amino-2-{[(1s)-1-methylbutyl] oxy}-9-[5-(1-piperidinyl)-7,9-dihydro-8h-purin-8-one maleate
|
WO2011108682A1
(ja)
|
2010-03-05 |
2011-09-09 |
国立大学法人 東京大学 |
リボヌクレオシドホスホロチオエートの製造方法
|
WO2011127175A1
(en)
|
2010-04-06 |
2011-10-13 |
Isis Pharmaceuticals, Inc. |
Modulation of cd130 (gp130) expression
|
AU2011237426A1
(en)
|
2010-04-07 |
2012-11-22 |
Isis Pharmaceuticals, Inc. |
Modulation of CETP expression
|
US9725479B2
(en)
|
2010-04-22 |
2017-08-08 |
Ionis Pharmaceuticals, Inc. |
5′-end derivatives
|
WO2011139699A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
5' modified nucleosides and oligomeric compounds prepared therefrom
|
CN103154014B
(zh)
|
2010-04-28 |
2015-03-25 |
Isis制药公司 |
修饰核苷、其类似物以及由它们制备的寡聚化合物
|
US20130156845A1
(en)
|
2010-04-29 |
2013-06-20 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
EP2563921B1
(en)
|
2010-04-30 |
2016-11-23 |
Cellectis |
Method for modulating double-strand break-induced homologous recombination
|
GB201008902D0
(en)
|
2010-05-27 |
2010-07-14 |
Imp Innovations Ltd |
Membrane enhanced polymer sythesis
|
EP2611927B1
(en)
|
2010-08-31 |
2018-08-01 |
Sirna Therapeutics, Inc. |
Novel single chemical entities and methods for delivery of oligonucleotides
|
EP2620428B1
(en)
|
2010-09-24 |
2019-05-22 |
Wave Life Sciences Ltd. |
Asymmetric auxiliary group
|
CN103080314B
(zh)
|
2010-09-30 |
2016-04-13 |
Lsip基金运营联合公司 |
显性突变基因表达抑制剂
|
KR101381048B1
(ko)
|
2010-10-20 |
2014-04-14 |
씨제이제일제당 (주) |
O-포스포세린 생산 균주 및 이로부터 생산된 o-포스포세린으로부터 l-시스테인 또는 이의 유도체의 생산방법
|
EP3766975A1
(en)
|
2010-10-29 |
2021-01-20 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
|
DK2638163T3
(en)
|
2010-11-12 |
2017-07-24 |
Massachusetts Gen Hospital |
POLYCOMB-ASSOCIATED NON-CODING RNAs
|
JP6093924B2
(ja)
|
2010-11-30 |
2017-03-15 |
株式会社Wave Life Sciences Japan |
2’−o−修飾rna
|
US20140050778A1
(en)
|
2010-12-28 |
2014-02-20 |
University Of Rochester |
Nucleic acid binding compounds, methods of making, and use thereof
|
EP3067421B1
(en)
|
2011-02-08 |
2018-10-10 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
WO2012109667A1
(en)
|
2011-02-12 |
2012-08-16 |
University Of Iowa Research Foundation |
Therapeutic compounds
|
WO2012151324A1
(en)
|
2011-05-02 |
2012-11-08 |
Isis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with usher syndrome
|
FR2975600B1
(fr)
|
2011-05-24 |
2013-07-05 |
Assist Publ Hopitaux De Paris |
Agents pour le traitement de tumeurs
|
EP2734525A4
(en)
|
2011-07-19 |
2015-03-04 |
Univ Idaho |
EMBODIMENTS OF A PROBE AND METHOD OF AIMING NUCLEIC ACIDS
|
JP6128529B2
(ja)
|
2011-07-19 |
2017-05-17 |
ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. |
官能化核酸の合成のための方法
|
WO2013022990A1
(en)
|
2011-08-11 |
2013-02-14 |
Isis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
WO2013033223A1
(en)
|
2011-08-29 |
2013-03-07 |
Isis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
US20140080896A1
(en)
|
2011-08-30 |
2014-03-20 |
The Regents Of The University Of California |
Identification of small molecules that facilitate therapeutic exon skipping
|
DK2751284T3
(en)
|
2011-08-31 |
2017-03-27 |
Univ Manchester |
PROCEDURE FOR DIAGNOSTICING A NEURODEGENERATIVE DISEASE
|
WO2013036833A1
(en)
|
2011-09-09 |
2013-03-14 |
Mayo Foundation For Medical Education And Research |
Detecting frontotemporal dementia and amyotrophic lateral sclerosis
|
EP2785729B1
(en)
|
2011-11-30 |
2020-11-04 |
Sarepta Therapeutics, Inc. |
Oligonucleotides for treating expanded repeat diseases
|
KR200460641Y1
(ko)
|
2011-12-07 |
2012-06-04 |
이형호 |
휴대가 용이한 와인 잔
|
DK2790736T3
(en)
|
2011-12-12 |
2018-05-07 |
Oncoimmunin Inc |
In vivo delivery of oligonucleotides
|
EP2791335B1
(en)
|
2011-12-16 |
2018-11-14 |
National University Corporation Tokyo Medical and Dental University |
Chimeric double-stranded nucleic acid
|
CN102675386B
(zh)
|
2011-12-24 |
2014-07-02 |
河南科技大学 |
一种龙胆苦苷分离提纯方法
|
US8957042B2
(en)
|
2012-03-07 |
2015-02-17 |
The Texas A&M University System |
Cancer treatment targeting non-coding RNA overexpression
|
EP2834258B1
(en)
|
2012-03-13 |
2017-01-04 |
Gilead Sciences, Inc. |
2'- substituted carba-nucleoside analogs for antiviral treatment
|
KR20130114435A
(ko)
|
2012-04-09 |
2013-10-17 |
삼성전자주식회사 |
다수의 전극을 갖는 생분자 검출 장치
|
DK2841578T3
(en)
|
2012-04-23 |
2017-07-31 |
Biomarin Tech Bv |
RNA modulating oligonucleotides with improved properties for the treatment of neuromuscular diseases
|
BR112014029115A8
(pt)
|
2012-05-22 |
2018-04-03 |
Idenix Pharmaceuticals Inc |
Composto, composição farmacêutica, e, uso de um composto ou composição
|
DK2857412T3
(en)
|
2012-05-30 |
2017-04-03 |
Hokkaido System Science Co Ltd |
Method for Oligonucleotide Synthesis Using High-Resolution Liquid Phase Carrier
|
KR101835401B1
(ko)
|
2012-07-13 |
2018-03-08 |
신 니뽄 바이오메디칼 라보라토리즈, 엘티디. |
키랄 핵산 어쥬번트
|
WO2014012081A2
(en)
|
2012-07-13 |
2014-01-16 |
Ontorii, Inc. |
Chiral control
|
CN104684893B
(zh)
|
2012-07-13 |
2016-10-26 |
日本波涛生命科学公司 |
不对称辅助基团
|
WO2014025805A1
(en)
|
2012-08-06 |
2014-02-13 |
Alnylam Pharmaceuticals, Inc. |
Carbohydrate conjugated rna agents and process for their preparation
|
CN104736551B
(zh)
|
2012-08-15 |
2017-07-28 |
Ionis制药公司 |
使用改进的封端方案制备寡聚化合物的方法
|
EP2906256B1
(en)
|
2012-10-12 |
2018-08-22 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
WO2014062736A1
(en)
|
2012-10-15 |
2014-04-24 |
Isis Pharmaceuticals, Inc. |
Methods for monitoring c9orf72 expression
|
CN104968783B
(zh)
|
2012-10-15 |
2019-12-10 |
Ionis制药公司 |
用于调节c9orf72表达的组合物
|
PT2906696T
(pt)
|
2012-10-15 |
2019-12-16 |
Univ California |
Métodos para modular a expressão de c9orf72
|
WO2014070771A1
(en)
|
2012-10-29 |
2014-05-08 |
Rfs Pharma, Llc |
Pyrimidine nucleotides and their monophosphate prodrugs for treatment of viral infections and cancer
|
EP2725029A1
(en)
|
2012-10-29 |
2014-04-30 |
Laboratoire Biodim |
New antibacterial compounds and biological applications thereof
|
EP2915815B1
(en)
|
2012-10-31 |
2018-01-17 |
Takeda Pharmaceutical Company Limited |
New modified nucleic acid
|
SG11201503821YA
(en)
|
2012-11-15 |
2015-06-29 |
Roche Innovation Ct Copenhagen As |
Oligonucleotide conjugates
|
CA2889993A1
(en)
|
2012-11-26 |
2014-05-30 |
Roche Innovation Center Copenhagen A/S |
Compositions and methods for modulation of fgfr3 expression
|
EP2935304A1
(en)
|
2012-12-19 |
2015-10-28 |
IDENIX Pharmaceuticals, Inc. |
4'-fluoro nucleosides for the treatment of hcv
|
US20150368642A1
(en)
|
2013-01-30 |
2015-12-24 |
Hoffmann-La Roche Inc. |
Lna oligonucleotide carbohydrate conjugates
|
WO2014118272A1
(en)
|
2013-01-30 |
2014-08-07 |
Santaris Pharma A/S |
Antimir-122 oligonucleotide carbohydrate conjugates
|
EP2951304B1
(en)
|
2013-02-04 |
2020-07-08 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
CA2900238A1
(en)
|
2013-02-22 |
2014-08-28 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) molecules containing a 2' internucleoside linkage
|
JP6440170B2
(ja)
|
2013-03-01 |
2018-12-19 |
国立大学法人 東京医科歯科大学 |
キメラ一本鎖アンチセンスポリヌクレオチドおよび二本鎖アンチセンス剤
|
US20160050929A1
(en)
|
2013-03-28 |
2016-02-25 |
Syngenta Limited |
Methods of controlling neonicotinoid resistant pests
|
MX2015013568A
(es)
|
2013-03-28 |
2016-02-05 |
Syngenta Participations Ag |
Metodos para controlar las plagas resistentes a neonicotinoides.
|
KR20210037752A
(ko)
|
2013-05-01 |
2021-04-06 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Hbv 및 ttr 발현을 조절하는 조성물 및 방법
|
CN105247052A
(zh)
|
2013-05-24 |
2016-01-13 |
罗氏创新中心哥本哈根有限公司 |
B-细胞cll/淋巴瘤11a(bcl11a)的寡核苷酸调节剂及其用途
|
EP3015467B1
(en)
|
2013-05-24 |
2024-12-04 |
Ajinomoto Co., Inc. |
Morpholino oligonucleotide manufacturing method
|
WO2014192310A1
(en)
|
2013-05-30 |
2014-12-04 |
National University Corporation Tokyo Medical And Dental University |
Double-stranded agents for delivering therapeutic oligonucleotides
|
CN105324119A
(zh)
|
2013-06-16 |
2016-02-10 |
国立大学法人东京医科齿科大学 |
具有外显子跳跃效应的双链反义核酸
|
WO2014205451A2
(en)
|
2013-06-21 |
2014-12-24 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation of target nucleic acids
|
US9879265B2
(en)
|
2013-06-27 |
2018-01-30 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide conjugates
|
TWI702046B
(zh)
|
2013-07-19 |
2020-08-21 |
美商Ionis製藥公司 |
用於調節τ蛋白表現之組合物
|
CN105579582A
(zh)
|
2013-07-25 |
2016-05-11 |
埃克西奎雷股份有限公司 |
用于预防和治疗用途的作为免疫刺激剂的基于球形核酸的构建体
|
US10435430B2
(en)
|
2013-07-31 |
2019-10-08 |
Ionis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
US20160214974A1
(en)
|
2013-09-06 |
2016-07-28 |
Syngenta Participations Ag |
Insecticidal compounds
|
EP3052511A4
(en)
|
2013-10-02 |
2017-05-31 |
Moderna Therapeutics, Inc. |
Polynucleotide molecules and uses thereof
|
BR112016007255A2
(pt)
|
2013-10-03 |
2017-09-12 |
Moderna Therapeutics Inc |
polinucleotídeos que codificam receptor de lipoproteína de baixa densidade
|
US9988627B2
(en)
|
2013-10-04 |
2018-06-05 |
Novartis Ag |
Formats for organic compounds for use in RNA interference
|
KR20160062069A
(ko)
|
2013-10-11 |
2016-06-01 |
아이오니스 파마수티컬즈, 인코포레이티드 |
C9orf72 발현을 조절하기 위한 조성물
|
EP3058068B1
(en)
|
2013-10-14 |
2019-04-24 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
CA2926341A1
(en)
|
2013-10-14 |
2015-04-23 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating expression of c9orf72 antisense transcript
|
KR102431079B1
(ko)
|
2013-11-11 |
2022-08-11 |
상가모 테라퓨틱스, 인코포레이티드 |
헌팅턴병을 치료하기 위한 방법 및 조성물
|
EP3068885A1
(en)
|
2013-11-14 |
2016-09-21 |
Roche Innovation Center Copenhagen A/S |
Apob antisense conjugate compounds
|
US20150167017A1
(en)
|
2013-12-13 |
2015-06-18 |
Moderna Therapeutics, Inc. |
Alternative nucleic acid molecules and uses thereof
|
US10149905B2
(en)
|
2014-01-15 |
2018-12-11 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
|
WO2015108047A1
(ja)
|
2014-01-15 |
2015-07-23 |
株式会社新日本科学 |
免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
|
JPWO2015108046A1
(ja)
|
2014-01-15 |
2017-03-23 |
株式会社新日本科学 |
抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
|
EP3094728B1
(en)
|
2014-01-16 |
2022-03-09 |
Wave Life Sciences Ltd. |
Chiral design
|
EP3750907A3
(en)
|
2014-03-18 |
2021-04-28 |
University of Massachusetts |
Raav-based compositions and methods for treating amyotrophic lateral sclerosis
|
EP3137476B1
(en)
|
2014-04-28 |
2019-10-09 |
Ionis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds
|
CN111961669A
(zh)
|
2014-05-01 |
2020-11-20 |
Ionis制药公司 |
用于调节血管生成素样蛋白3表达的组合物和方法
|
BR112016025849A2
(pt)
|
2014-05-08 |
2017-10-17 |
Chdi Foundation Inc |
métodos e composições para o tratamento da doença de huntington
|
CA2949437C
(en)
|
2014-05-20 |
2023-08-15 |
University Of Iowa Research Foundation |
Huntington's disease therapeutic compounds
|
US20160017327A1
(en)
|
2014-07-11 |
2016-01-21 |
The Johns Hopkins University |
Phosphorodiamidate morpholino oligomers (pmos) and their use in suppression of mutant huntingtin expression and attenuation of neurotoxicity
|
WO2016011226A1
(en)
|
2014-07-16 |
2016-01-21 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
EP2982758A1
(en)
|
2014-08-04 |
2016-02-10 |
Centre Hospitalier Universitaire Vaudois (CHUV) |
Genome editing for the treatment of huntington's disease
|
CN106573877B
(zh)
|
2014-08-07 |
2021-04-13 |
武田药品工业株式会社 |
阳离子脂质
|
WO2016024205A1
(en)
|
2014-08-15 |
2016-02-18 |
Pfizer Inc. |
Oligomers targeting hexanucleotide repeat expansion in human c9orf72 gene
|
WO2016027168A2
(en)
|
2014-08-20 |
2016-02-25 |
Lifesplice Pharma Llc |
Splice modulating oligonucleotides and methods of use thereof
|
WO2016037191A1
(en)
|
2014-09-05 |
2016-03-10 |
Health Research, Inc. |
Use of huntingtin-derived plasmids and peptides for active immunization as a huntington's disease (hd) therapeutic
|
WO2016081444A1
(en)
|
2014-11-17 |
2016-05-26 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
|
WO2016079181A1
(en)
|
2014-11-19 |
2016-05-26 |
Roche Innovation Center Copenhagen A/S |
Lna gapmer oligonucleotides comprising chiral phosphorothioate linkages
|
US10815481B2
(en)
|
2014-12-16 |
2020-10-27 |
Roche Innovation Center Copenhagen A/S |
Chiral library screen
|
LT3237618T
(lt)
|
2014-12-24 |
2019-07-10 |
Uniqure Ip B.V. |
Rnri sukeltas hantingtino geno slopinimas
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
WO2016112132A1
(en)
|
2015-01-06 |
2016-07-14 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
JP2018505676A
(ja)
|
2015-02-04 |
2018-03-01 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
タウアンチセンスオリゴマー及びその使用
|
ES2893114T3
(es)
|
2015-02-04 |
2022-02-08 |
Bristol Myers Squibb Co |
Métodos para seleccionar moléculas terapéuticas
|
US20180023081A1
(en)
|
2015-02-04 |
2018-01-25 |
Bristol-Myers Squibb Company |
Lna oligonucleotides with alternating flanks
|
WO2016130589A2
(en)
|
2015-02-10 |
2016-08-18 |
Genzyme Corporation |
VARIANT RNAi
|
JP2018510621A
(ja)
|
2015-02-13 |
2018-04-19 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
パタチン様ホスホリパーゼドメイン含有3(PNPLA3)iRNA組成物およびその使用方法
|
EP3262174A4
(en)
|
2015-02-23 |
2018-10-17 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for increasing antisense activity
|
EP3265098B1
(en)
|
2015-03-03 |
2025-03-26 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating mecp2 expression
|
WO2016145142A1
(en)
|
2015-03-10 |
2016-09-15 |
Emory University |
Nucleotide and nucleoside therapeutics compositions and uses related thereto
|
WO2016154096A1
(en)
|
2015-03-20 |
2016-09-29 |
Ionis Pharmaceuticals, Inc. |
Modulation of smggds expression
|
SMT202000454T1
(it)
|
2015-04-03 |
2020-11-10 |
Univ Massachusetts |
Cmposti oligonucleotidici per bersagliare l'mrn della huntingtina
|
US10851371B2
(en)
|
2015-04-10 |
2020-12-01 |
Ionis Pharmaceuticals, Inc. |
Modulation of SMN expression
|
US10407678B2
(en)
|
2015-04-16 |
2019-09-10 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
MX366128B
(es)
|
2015-04-16 |
2019-06-28 |
Ionis Pharmaceuticals Inc |
Composiciones para modular la expresion de c90rf72.
|
WO2016209862A1
(en)
|
2015-06-23 |
2016-12-29 |
Alnylam Pharmaceuticals, Inc. |
Glucokinase (gck) irna compositions and methods of use thereof
|
US11414657B2
(en)
|
2015-06-29 |
2022-08-16 |
Ionis Pharmaceuticals, Inc. |
Modified CRISPR RNA and modified single CRISPR RNA and uses thereof
|
IL256622B2
(en)
|
2015-07-10 |
2023-09-01 |
Ionis Pharmaceuticals Inc |
Modulators of diacyglycerol acyltransferase 2 (dgat2)
|
WO2017011286A1
(en)
|
2015-07-10 |
2017-01-19 |
Alnylam Pharmaceuticals, Inc. |
Insulin-like growth factor binding protein, acid labile subunit (igfals) and insulin-like growth factor 1 (igf-1) irna compositions and methods of use thereof
|
EP3919619A1
(en)
|
2015-07-17 |
2021-12-08 |
Alnylam Pharmaceuticals, Inc. |
Multi-targeted single entity conjugates
|
MA43072A
(fr)
|
2015-07-22 |
2018-05-30 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
TW201718620A
(zh)
|
2015-07-27 |
2017-06-01 |
阿尼拉製藥公司 |
黃嘌呤脫氫酶(XDH)iRNA組成物及其使用方法
|
IL313082A
(en)
|
2015-07-31 |
2024-07-01 |
Alnylam Pharmaceuticals Inc |
Transthyretin (TTR) iRNA compositions and methods of using them for the treatment or prevention of TTR-related diseases
|
US20190055550A1
(en)
|
2015-08-24 |
2019-02-21 |
Roche Innovation Center Copenhagen A/S |
LNA-G Process
|
CN114469984A
(zh)
|
2015-08-25 |
2022-05-13 |
阿尔尼拉姆医药品有限公司 |
用于治疗前蛋白转化酶枯草杆菌蛋白酶kexin(pcsk9)基因相关障碍的方法和组合物
|
EP4393495A3
(en)
|
2015-09-02 |
2024-09-25 |
Alnylam Pharmaceuticals, Inc. |
Programmed cell death 1 ligand 1 (pd-l1) irna compositions and methods of use thereof
|
EP3350328A1
(en)
|
2015-09-14 |
2018-07-25 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting patatin-like phospholipase domain containing 3 (pnpla3) and methods of use thereof
|
WO2017059446A1
(en)
|
2015-10-01 |
2017-04-06 |
Memorial Sloan-Kettering Cancer Center |
Anthranilyl-adenosinemonosulfamate analogs and uses thereof
|
US20180273573A1
(en)
|
2015-10-01 |
2018-09-27 |
Memorial Sloan-Kettering Cancer Center |
Inhibitors of menaquinone biosynthesis
|
WO2017055423A1
(en)
|
2015-10-02 |
2017-04-06 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide conjugation process
|
IL258230B
(en)
|
2015-10-09 |
2022-09-01 |
Wave Life Sciences Ltd |
Oligonucleotide compositions and methods thereof
|
EP3394258B1
(en)
|
2015-10-22 |
2021-09-22 |
Roche Innovation Center Copenhagen A/S |
In vitro toxicity screening assay
|
WO2017068087A1
(en)
|
2015-10-22 |
2017-04-27 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide detection method
|
WO2017079291A1
(en)
|
2015-11-02 |
2017-05-11 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating c90rf72
|
PE20210451A1
(es)
|
2015-11-12 |
2021-03-08 |
Hoffmann La Roche |
Oligonucleotidos para inducir la expresion paterna de ube3a
|
MA43822A
(fr)
|
2016-03-13 |
2018-11-28 |
Wave Life Sciences Ltd |
Compositions et procédés de synthèse de phosphoramidite et d'oligonucléotides
|
WO2017157899A1
(en)
|
2016-03-14 |
2017-09-21 |
F. Hoffmann-La Roche Ag |
Oligonucleotides for reduction of pd-l1 expression
|
CN108779139A
(zh)
|
2016-03-18 |
2018-11-09 |
罗氏创新中心哥本哈根有限公司 |
酰基保护的l-lna-鸟嘌呤核苷单体
|
US11963972B2
(en)
|
2016-03-23 |
2024-04-23 |
Emory University |
Antiviral agents and nucleoside analogs for treatment of Zika virus
|
ES2933435T3
(es)
|
2016-04-13 |
2023-02-08 |
Ionis Pharmaceuticals Inc |
Métodos para reducir la expresión de C9ORF72
|
US11248019B2
(en)
|
2016-04-14 |
2022-02-15 |
Hoffmann-La Roche Inc. |
Trityl-mono-GalNAc compounds and their use
|
MA45270A
(fr)
|
2016-05-04 |
2017-11-09 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
MA45290A
(fr)
|
2016-05-04 |
2019-03-13 |
Wave Life Sciences Ltd |
Procédés et compositions d'agents biologiquement actifs
|
DK3455232T3
(da)
|
2016-05-12 |
2020-07-06 |
Roche Innovation Ct Copenhagen As |
Forbedret kobling af stereodefinerede oxazaphospholidin-phosphoramidit-monomerer til nukleosid eller oligonukleotid
|
JP7083756B2
(ja)
|
2016-05-13 |
2022-06-13 |
エフ.ホフマン-ラ ロシュ アーゲー |
タンパク質系試料回収マトリックス及び装置
|
US10882884B2
(en)
|
2016-05-18 |
2021-01-05 |
Eth Zurich |
Stereoselective synthesis of phosphorothioate oligoribonucleotides
|
EP3463386A4
(en)
|
2016-06-03 |
2020-03-04 |
Wave Life Sciences Ltd. |
OLIGONUCLEOTIDES, COMPOSITIONS AND ASSOCIATED METHODS
|
CN109310765A
(zh)
|
2016-06-20 |
2019-02-05 |
领先基因生物技术股份有限公司 |
抗体-药物偶联物
|
WO2018022473A1
(en)
|
2016-07-25 |
2018-02-01 |
Wave Life Sciences Ltd. |
Phasing
|
WO2018098264A1
(en)
|
2016-11-23 |
2018-05-31 |
Wave Life Sciences Ltd. |
Compositions and methods for phosphoramidite and oligonucleotide synthesis
|