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EA200900741A1 - Способы лечения гиперхолестеринемии - Google Patents

Способы лечения гиперхолестеринемии

Info

Publication number
EA200900741A1
EA200900741A1 EA200900741A EA200900741A EA200900741A1 EA 200900741 A1 EA200900741 A1 EA 200900741A1 EA 200900741 A EA200900741 A EA 200900741A EA 200900741 A EA200900741 A EA 200900741A EA 200900741 A1 EA200900741 A1 EA 200900741A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
antisense compounds
disclosed
antisense
treatment
Prior art date
Application number
EA200900741A
Other languages
English (en)
Inventor
Сьюзан М. Фрайер
Розанн М. Крук
Марк Дж. Грэхем
Кристина Лемонидис Тарбет
Сэнджей Банот
Дайан ТРИББЛ
Эндрю Т. Уоттс
Original Assignee
Айзис Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Айзис Фармасьютикалз, Инк. filed Critical Айзис Фармасьютикалз, Инк.
Publication of EA200900741A1 publication Critical patent/EA200900741A1/ru

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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  • Health & Medical Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В данном описании раскрываются антисмысловые соединения и способы снижения ЛПНП (LDL)-C у индивидуума с повышенным ЛПНП (LDL)-C. Кроме того, раскрываются антисмысловые соединения и способы лечения гиперхолестеринемии или же лечения или предупреждения атеросклероза. Помимо этого раскрываются антисмысловые соединения и способы снижения риска ишемической болезни сердца. Такие способы включают введение нуждающемуся в лечении индивидууму антисмыслового соединения, нацеленного на PCSK9 нуклеиновую кислоту. Вводимые антисмысловые соединения включают гэпмерные антисмысловые олигонуклеотиды.
EA200900741A 2006-11-27 2007-11-27 Способы лечения гиперхолестеринемии EA200900741A1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US86739506P 2006-11-27 2006-11-27
US91289207P 2007-04-19 2007-04-19
US98628607P 2007-11-07 2007-11-07
US98807407P 2007-11-14 2007-11-14
PCT/US2007/024369 WO2008066776A2 (en) 2006-11-27 2007-11-27 Methods for treating hypercholesterolemia

Publications (1)

Publication Number Publication Date
EA200900741A1 true EA200900741A1 (ru) 2010-04-30

Family

ID=39276232

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900741A EA200900741A1 (ru) 2006-11-27 2007-11-27 Способы лечения гиперхолестеринемии

Country Status (13)

Country Link
US (1) US8084437B2 (ru)
EP (3) EP2102340A2 (ru)
JP (1) JP2010510807A (ru)
KR (1) KR20090103894A (ru)
AU (1) AU2007325767A1 (ru)
CA (1) CA2670563A1 (ru)
CO (1) CO6241169A2 (ru)
EA (1) EA200900741A1 (ru)
IL (1) IL198851A0 (ru)
MX (1) MX2009005527A (ru)
NO (1) NO20092150L (ru)
TW (1) TW200838551A (ru)
WO (1) WO2008066776A2 (ru)

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