PL1766012T3 - Antysensowne, przeciwbakteryjne związki i sposoby - Google Patents
Antysensowne, przeciwbakteryjne związki i sposobyInfo
- Publication number
- PL1766012T3 PL1766012T3 PL05857499T PL05857499T PL1766012T3 PL 1766012 T3 PL1766012 T3 PL 1766012T3 PL 05857499 T PL05857499 T PL 05857499T PL 05857499 T PL05857499 T PL 05857499T PL 1766012 T3 PL1766012 T3 PL 1766012T3
- Authority
- PL
- Poland
- Prior art keywords
- bases
- compound
- bacterial
- antisense compounds
- mrna
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 230000000692 anti-sense effect Effects 0.000 title abstract 4
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- 230000001580 bacterial effect Effects 0.000 abstract 3
- 108020004999 messenger RNA Proteins 0.000 abstract 2
- 230000008685 targeting Effects 0.000 abstract 2
- 108010077805 Bacterial Proteins Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108091081024 Start codon Proteins 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65613—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. cephalosporins and analogs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/314—Phosphoramidates
- C12N2310/3145—Phosphoramidates with the nitrogen in 3' or 5'-position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3233—Morpholino-type ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58511204P | 2004-07-02 | 2004-07-02 | |
| EP05857499A EP1766012B1 (en) | 2004-07-02 | 2005-07-01 | Antisense antibacterial method and compound |
| PCT/US2005/023553 WO2006085973A2 (en) | 2004-07-02 | 2005-07-01 | Antisense antibacterial method and compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1766012T3 true PL1766012T3 (pl) | 2011-11-30 |
Family
ID=36686070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05857499T PL1766012T3 (pl) | 2004-07-02 | 2005-07-01 | Antysensowne, przeciwbakteryjne związki i sposoby |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US8314072B2 (pl) |
| EP (2) | EP2351839A3 (pl) |
| AT (1) | ATE510914T1 (pl) |
| AU (1) | AU2005327188C8 (pl) |
| CA (2) | CA2571593C (pl) |
| CY (1) | CY1111765T1 (pl) |
| DK (1) | DK1766012T3 (pl) |
| ES (1) | ES2367289T3 (pl) |
| PL (1) | PL1766012T3 (pl) |
| PT (1) | PT1766012E (pl) |
| SI (1) | SI1766012T1 (pl) |
| WO (1) | WO2006085973A2 (pl) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050171044A1 (en) * | 2003-12-24 | 2005-08-04 | Stein David A. | Oligonucleotide compound and method for treating nidovirus infections |
| PL1766012T3 (pl) * | 2004-07-02 | 2011-11-30 | Avi Biopharma Inc | Antysensowne, przeciwbakteryjne związki i sposoby |
| US7790694B2 (en) * | 2005-07-13 | 2010-09-07 | Avi Biopharma Inc. | Antisense antibacterial method and compound |
| WO2007009094A2 (en) * | 2005-07-13 | 2007-01-18 | Avi Biopharma, Inc. | Antisense antibacterial method and compound |
| US8067571B2 (en) * | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| AU2007257094B2 (en) * | 2006-05-05 | 2012-10-25 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating expression of SGLT2 |
| JP2010505741A (ja) * | 2006-05-10 | 2010-02-25 | エイブイアイ バイオファーマ， インコーポレイテッド | カチオン性のサブユニット間結合を有するオリゴヌクレオチドアナログ |
| EA200900741A1 (ru) * | 2006-11-27 | 2010-04-30 | Айзис Фармасьютикалз, Инк. | Способы лечения гиперхолестеринемии |
| US8093222B2 (en) | 2006-11-27 | 2012-01-10 | Isis Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia |
| US9050373B2 (en) | 2010-05-13 | 2015-06-09 | The Charlotte-Mecklenburg Hospital Authority | Pharmaceutical compositions comprising antisense oligonucleotides and methods of using same |
| KR20200133284A (ko) | 2010-05-28 | 2020-11-26 | 사렙타 쎄러퓨틱스, 인코퍼레이티드 | 변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체 |
| HUE054179T2 (hu) * | 2010-06-23 | 2021-08-30 | Curna Inc | Nátriumcsatornás, feszültségfüggõ, alfa alegységgel (SCNA) kapcsolatos betegségek kezelése a természetes antiszensz (SCNA)-transzkripció gátlásával |
| WO2012031243A2 (en) | 2010-09-03 | 2012-03-08 | Avi Biopharma, Inc. | dsRNA MOLECULES COMPRISING OLIGONUCLEOTIDE ANALOGS HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS |
| CA2817090A1 (en) * | 2010-11-12 | 2012-05-18 | Sarepta Therapeutics, Inc. | Antisense antibacterial compounds and methods |
| MX2013009191A (es) | 2011-02-08 | 2013-11-04 | Charlotte Mecklenburg Hospital | Oligonucleotidos antisentido. |
| BR112014011875B1 (pt) | 2011-11-18 | 2022-01-04 | Sarepta Therapeutics, Inc | Oligonucleotídeos funcionalmente modificados e subunidades dos mesmos |
| BR112014023347A2 (pt) | 2012-03-20 | 2017-07-18 | Sarepta Therapeutics Inc | conjugados de ácido borônico de análogos oligonucleotídeos |
| EP3143141B1 (en) | 2014-05-16 | 2019-10-02 | Oregon State University | Antisense antibacterial compounds and methods |
| JP6687542B2 (ja) | 2014-05-19 | 2020-04-22 | オレゴン ステート ユニバーシティ | アンチセンス抗菌化合物および方法 |
| WO2016003816A1 (en) * | 2014-07-01 | 2016-01-07 | The University Of North Carolina At Chapel Hill | Small molecules that enhance the activity of oligonucleotides |
| EP3240794A4 (en) * | 2014-12-31 | 2018-10-31 | Oregon State University | Antisense antibacterial compounds and methods |
| EP3302489A4 (en) | 2015-06-04 | 2019-02-06 | Sarepta Therapeutics, Inc. | METHOD AND COMPOUNDS FOR THE TREATMENT OF DISEASES AND SUFFERING IN CONNECTION WITH LYMPHOCYTES |
| CA3010084A1 (en) | 2015-12-23 | 2017-06-29 | Oregon State University | Antisense antibacterial compounds and methods |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5185444A (en) | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
| US5521063A (en) | 1985-03-15 | 1996-05-28 | Antivirals Inc. | Polynucleotide reagent containing chiral subunits and methods of use |
| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5217866A (en) | 1985-03-15 | 1993-06-08 | Anti-Gene Development Group | Polynucleotide assay reagent and method |
| EP0216860B1 (en) | 1985-03-15 | 1992-10-28 | SUMMERTON, James | Stereoregular polynucleotide-binding polymers |
| US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| US5749847A (en) * | 1988-01-21 | 1998-05-12 | Massachusetts Institute Of Technology | Delivery of nucleotides into organisms by electroporation |
| DE69034213T2 (de) | 1989-12-20 | 2006-08-24 | Avi Biopharma, Inc., Portland | Ungeladene, auf morpholin basierende polymere mit chiralen, phosphor enthaltenden brücken zwischen den untereinheiten |
| US5852188A (en) | 1990-01-11 | 1998-12-22 | Isis Pharmaceuticals, Inc. | Oligonucleotides having chiral phosphorus linkages |
| JPH06501843A (ja) | 1990-08-14 | 1994-03-03 | アイシス・ファーマシューティカルス・インコーポレーテッド | アンチセンスオリゴヌクレオチドによるインフルエンザａ型ウイルス，アン・アーバｈ２ｎ２株の阻害 |
| AU659482B2 (en) | 1991-06-28 | 1995-05-18 | Massachusetts Institute Of Technology | Localized oligonucleotide therapy |
| US6030954A (en) | 1991-09-05 | 2000-02-29 | University Of Connecticut | Targeted delivery of poly- or oligonucleotides to cells |
| US5821052A (en) | 1992-04-16 | 1998-10-13 | University Of Medicine And Dentistry Of New Jersey | Control of the synthesis of proteins by anitisense RNA-tRNA complex |
| US6174868B1 (en) | 1992-09-10 | 2001-01-16 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of hepatitis C virus-associated diseases |
| US6060456A (en) | 1993-11-16 | 2000-05-09 | Genta Incorporated | Chimeric oligonucleoside compounds |
| US5479847A (en) * | 1994-11-07 | 1996-01-02 | Marlen Research Corporation | Dual-piston pump apparatus |
| GB9505438D0 (en) | 1995-03-17 | 1995-05-03 | Sod Conseils Rech Applic | Antisense oligonucleotides |
| GB9510718D0 (en) * | 1995-05-26 | 1995-07-19 | Sod Conseils Rech Applic | Antisense oligonucleotides |
| AU729643B2 (en) | 1996-05-01 | 2001-02-08 | Antivirals Inc. | Polypeptide conjugates for transporting substances across cell membranes |
| AU3811897A (en) | 1996-07-24 | 1998-02-10 | Oglios Therapeutics, Inc. | Antisense oligonucleotides as antibacterial agents |
| US6124271A (en) | 1997-01-24 | 2000-09-26 | Avi Biopharma, Inc. | Method and conjugate for treating H. pylori infection |
| EP0975370B9 (en) | 1997-05-21 | 2004-11-03 | The Board Of Trustees Of The Leland Stanford Junior University | Composition and method for enhancing transport across biological membranes |
| US6204019B1 (en) | 1997-06-04 | 2001-03-20 | Smithkline Beecham Corporation | Sec A2 from Streptococcus pneumoniae |
| US6610539B1 (en) | 1997-07-10 | 2003-08-26 | Genesense Technologies, Inc. | Antisense oligonucleotide sequences as inhibitors of microorganisms |
| EP0894857A3 (en) | 1997-08-01 | 2001-09-26 | Smithkline Beecham Corporation | SecA gene from Streptococcus pneumoniae |
| US6133246A (en) * | 1997-08-13 | 2000-10-17 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide compositions and methods for the modulation of JNK proteins |
| US6228579B1 (en) | 1997-11-14 | 2001-05-08 | San Diego State University Foundation | Method for identifying microbial proliferation genes |
| US6548651B1 (en) | 1998-11-11 | 2003-04-15 | Pantheco A/S | Modified peptide nucleic acid (PNA) molecules |
| JP2002535015A (ja) | 1999-01-29 | 2002-10-22 | エイブイアイ バイオファーマ， インコーポレイテッド | 標的ｒｎａを検出するための非侵襲性方法 |
| US7094765B1 (en) | 1999-01-29 | 2006-08-22 | Avi Biopharma, Inc. | Antisense restenosis composition and method |
| US6521438B1 (en) * | 1999-11-05 | 2003-02-18 | North Carolina State University | Chemoreceptors in plant parasitic nematodes |
| US20030095953A1 (en) * | 1999-11-12 | 2003-05-22 | Myles C. Cabot | Methods of reversing drug resistance in cancer cells |
| US6677153B2 (en) | 1999-11-29 | 2004-01-13 | Avi Biopharma, Inc. | Antisense antibacterial method and composition |
| JP2003518946A (ja) * | 2000-01-04 | 2003-06-17 | エイブイアイ バイオファーマ， インコーポレイテッド | アンチセンス抗細菌性細胞分裂組成物、およびその方法 |
| US7833992B2 (en) | 2001-05-18 | 2010-11-16 | Merck Sharpe & Dohme | Conjugates and compositions for cellular delivery |
| EP1296718A1 (en) | 2000-04-06 | 2003-04-02 | Pantheco A/S | Pharmaceutical composition of modified pna molecules |
| JP2003533986A (ja) * | 2000-05-04 | 2003-11-18 | エイブイアイ バイオファーマ， インコーポレイテッド | スプライス領域アンチセンス組成物および方法 |
| US6841542B2 (en) | 2000-07-06 | 2005-01-11 | Avi Biopharma, Inc. | Transforming growth factor beta (TGF-β) blocking agent-treated stem cell composition and method |
| AU2002214127B2 (en) * | 2000-10-27 | 2007-06-07 | J. Craig Venter Institute, Inc. | Nucleic acids and proteins from streptococcus groups A and B |
| WO2002079467A2 (en) | 2001-03-29 | 2002-10-10 | Københavns Universitet | Antibiotic-free bacterial strain selection with antisense molecules |
| US20030125241A1 (en) * | 2001-05-18 | 2003-07-03 | Margit Wissenbach | Therapeutic uses of LNA-modified oligonucleotides in infectious diseases |
| US20030224353A1 (en) * | 2001-10-16 | 2003-12-04 | Stein David A. | Antisense antiviral agent and method for treating ssRNA viral infection |
| US6828105B2 (en) | 2001-10-16 | 2004-12-07 | Avi Biopharma, Inc. | Antisense antiviral agent and method for treating ssRNA viral infection |
| WO2004041854A2 (en) * | 2002-11-05 | 2004-05-21 | Affinium Pharmaceuticals, Inc. | Essential novel bacterial polypeptides |
| US7468418B2 (en) | 2003-04-29 | 2008-12-23 | Avi Biopharma., Inc. | Compositions for enhancing transport of molecules into cells |
| US7666612B2 (en) * | 2003-05-23 | 2010-02-23 | Epfl-Ecole Polytechnique Federale De Lausanne | Methods for protein labeling based on acyl carrier protein |
| EP1654363B1 (en) | 2003-08-05 | 2010-12-15 | AVI BioPharma, Inc. | Oligonucleotide analog and method for treating flavivirus infections |
| US7402574B2 (en) | 2004-03-12 | 2008-07-22 | Avi Biopharma, Inc. | Antisense composition and method for treating cancer |
| PL1766012T3 (pl) | 2004-07-02 | 2011-11-30 | Avi Biopharma Inc | Antysensowne, przeciwbakteryjne związki i sposoby |
| US8357664B2 (en) | 2004-10-26 | 2013-01-22 | Avi Biopharma, Inc. | Antisense antiviral compound and method for treating influenza viral infection |
| US7524829B2 (en) | 2004-11-01 | 2009-04-28 | Avi Biopharma, Inc. | Antisense antiviral compounds and methods for treating a filovirus infection |
| US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| US7790694B2 (en) | 2005-07-13 | 2010-09-07 | Avi Biopharma Inc. | Antisense antibacterial method and compound |
| WO2007009094A2 (en) | 2005-07-13 | 2007-01-18 | Avi Biopharma, Inc. | Antisense antibacterial method and compound |
| JP2010505741A (ja) | 2006-05-10 | 2010-02-25 | エイブイアイ バイオファーマ， インコーポレイテッド | カチオン性のサブユニット間結合を有するオリゴヌクレオチドアナログ |
| US10100305B2 (en) | 2011-07-15 | 2018-10-16 | Sarepta Therapeutics, Inc. | Methods and compositions for manipulating translation of protein isoforms from alternative initiation of start sites |
-
2005
- 2005-07-01 PL PL05857499T patent/PL1766012T3/pl unknown
- 2005-07-01 CA CA 2571593 patent/CA2571593C/en not_active Expired - Fee Related
- 2005-07-01 EP EP10013182A patent/EP2351839A3/en not_active Withdrawn
- 2005-07-01 EP EP05857499A patent/EP1766012B1/en active Active
- 2005-07-01 AU AU2005327188A patent/AU2005327188C8/en not_active Ceased
- 2005-07-01 DK DK05857499.7T patent/DK1766012T3/da active
- 2005-07-01 PT PT05857499T patent/PT1766012E/pt unknown
- 2005-07-01 SI SI200531354T patent/SI1766012T1/sl unknown
- 2005-07-01 WO PCT/US2005/023553 patent/WO2006085973A2/en active Application Filing
- 2005-07-01 US US11/173,847 patent/US8314072B2/en not_active Expired - Fee Related
- 2005-07-01 CA CA2875436A patent/CA2875436A1/en not_active Abandoned
- 2005-07-01 ES ES05857499T patent/ES2367289T3/es active Active
- 2005-07-01 AT AT05857499T patent/ATE510914T1/de active
-
2006
- 2006-05-10 US US11/432,216 patent/US7625873B2/en not_active Expired - Fee Related
-
2009
- 2009-11-05 US US12/613,428 patent/US20100137408A1/en not_active Abandoned
-
2011
- 2011-08-18 CY CY20111100790T patent/CY1111765T1/el unknown
-
2012
- 2012-11-19 US US13/680,790 patent/US9534220B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005327188A1 (en) | 2006-08-17 |
| EP1766012B1 (en) | 2011-05-25 |
| CY1111765T1 (el) | 2015-10-07 |
| DK1766012T3 (da) | 2011-09-19 |
| ATE510914T1 (de) | 2011-06-15 |
| SI1766012T1 (sl) | 2011-10-28 |
| US7625873B2 (en) | 2009-12-01 |
| CA2571593A1 (en) | 2006-08-17 |
| AU2005327188B2 (en) | 2011-03-17 |
| WO2006085973A2 (en) | 2006-08-17 |
| EP2351839A3 (en) | 2011-10-05 |
| CA2571593C (en) | 2015-04-21 |
| US20070049542A1 (en) | 2007-03-01 |
| AU2005327188C1 (en) | 2011-07-07 |
| AU2005327188C9 (en) | 2011-09-22 |
| US20130289091A1 (en) | 2013-10-31 |
| US9534220B2 (en) | 2017-01-03 |
| ES2367289T3 (es) | 2011-11-02 |
| CA2875436A1 (en) | 2006-08-17 |
| EP1766012A2 (en) | 2007-03-28 |
| EP2351839A2 (en) | 2011-08-03 |
| AU2005327188C8 (en) | 2011-09-22 |
| WO2006085973A3 (en) | 2007-04-12 |
| US20100137408A1 (en) | 2010-06-03 |
| US20070021362A1 (en) | 2007-01-25 |
| PT1766012E (pt) | 2011-09-05 |
| US8314072B2 (en) | 2012-11-20 |
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