HUP0401748A2 - 2-Amino-4,5-triszubsztituált tiazolilszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
2-Amino-4,5-triszubsztituált tiazolilszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0401748A2 HUP0401748A2 HU0401748A HUP0401748A HUP0401748A2 HU P0401748 A2 HUP0401748 A2 HU P0401748A2 HU 0401748 A HU0401748 A HU 0401748A HU P0401748 A HUP0401748 A HU P0401748A HU P0401748 A2 HUP0401748 A2 HU P0401748A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- amino
- group
- carbonyl
- mono
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000335 thiazolyl group Chemical group 0.000 title 1
- -1 cyano- Chemical class 0.000 abstract 12
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- RLQMACPTWZLKDP-UHFFFAOYSA-N aminomethanediol Chemical group NC(O)O RLQMACPTWZLKDP-UHFFFAOYSA-N 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000005945 imidazopyridyl group Chemical group 0.000 abstract 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány tárgya (I') általános képletű vegyület, N-oxidja,gyógyászatilag elfogadható addíciós sója, kvaterner aminja éssztereokémiai izomer formájának alkalmazása gyulladásos és/vagyautoimmun betegségek kezelésére és gyógyítására, amelyeket TNF-aés/vagy IL-12 közvetít. Az (1) általános képletben Z jelentésehalogénatom, 1-6 szénatomos alkil-, (1-6 szénatomos alkil)-karbonil-,(1-6 szénatomos alkoxi)-karbonil-, amino-karbonit-csoport, vagyhidroxil-, karboxil-, ciano-, amino-, piperidinil-szubsztituáltamino-, 1-4 szénatomos alkilcsoporttal szubsztituáltpiperidinilcsoporttal szubsztituált amino-, mono- vagy di(1-6szénatomos alkil)-amino-, amino-karbonil-, mono- vagy di(1-6szénatomos alkil)-amino-karbonil-, (1-6 szénatomos alkoxi)-karbonil-,1-6 szénatomos alkoxi-, piperidinil-, piperazinil-, morfolinil-, tio-morfolinil-csoporttal szubsztituált 1-6 szénatomos alkilcsoport,továbbá polihalogén-(1-4 szénatomos alkil)-, ciano-, amino-, mono-vagy di(1-6 szénatomos alkil)-amino-karbonil-, (1-6 szénatomosalkoxi)-karbonil-, (1-6 szénatomos alkil)-karbonil-oxi-, amino-S(=O)2,mono- vagy di(1-6 szénatomos alkil)-amino-S(=O)2, -C(=N-Rx)NRyRzcsoport; Q jelentése adott esetben szubsztituált 3-6 szénatomoscikloalkil-, fenil-, piridil-, pirimidinil-, pirazinil-, piridazinil-,benztiazolil- benzoxazolil-, benzimidazolil-, indazolil- vagy imidazo-piridil-csoport, vagy Q jelentése (b-1), (b-2) vagy (b-3) képletűcsoport; L jelentése adott esetben szubsztituált fenil- vagy adottesetben szubsztituált monociklusos, 5- vagy 6-tagú, részben telítettvagy aromás heterociklus, vagy biciklusos, részben telített vagyaromás heterociklusos csoport; aril jelentése adott esetbenszubsztituált fenilcsoport. A vegyületeket gyógyszer előállításáralehet felhasználni gyulladásos betegségek és/vagy autoimmun betegségekkezelésére vagy megelőzésére, amelyeket TNF-a és/vagy IL-12 közvetít.A találmány kiterjed a vegyület előállítására és a vegyületekettartalmazó gyógyszerkészítményekre is. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01203087 | 2001-08-13 | ||
| PCT/EP2002/008955 WO2003015773A2 (en) | 2001-08-13 | 2002-08-09 | 2-amino-4,5-trisubstituted thiazolyl derivatives and their use against autoimmune diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0401748A2 true HUP0401748A2 (hu) | 2004-12-28 |
| HUP0401748A3 HUP0401748A3 (en) | 2011-03-28 |
Family
ID=8180790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401748A HUP0401748A3 (en) | 2001-08-13 | 2002-08-09 | 2-amino-4,5-trisubstituted thiazolyl derivatives, process for their preparation and pharmaceutical compositions containing them |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7232838B2 (hu) |
| EP (1) | EP1418909B1 (hu) |
| JP (1) | JP4388805B2 (hu) |
| KR (2) | KR101034489B1 (hu) |
| CN (1) | CN100496493C (hu) |
| AU (1) | AU2002324045C1 (hu) |
| BR (1) | BR0211887A (hu) |
| CA (1) | CA2451980C (hu) |
| EA (1) | EA007717B1 (hu) |
| ES (1) | ES2407807T3 (hu) |
| HK (1) | HK1069997A1 (hu) |
| HR (1) | HRP20040097B1 (hu) |
| HU (1) | HUP0401748A3 (hu) |
| IL (2) | IL160329A0 (hu) |
| MX (1) | MXPA04001399A (hu) |
| NO (1) | NO327409B1 (hu) |
| NZ (1) | NZ530950A (hu) |
| PL (1) | PL368130A1 (hu) |
| UA (1) | UA82176C2 (hu) |
| WO (1) | WO2003015773A2 (hu) |
| ZA (1) | ZA200401162B (hu) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3836019B2 (ja) * | 2001-11-21 | 2006-10-18 | 松下電器産業株式会社 | 受信装置、送信装置及び送信方法 |
| AR044519A1 (es) * | 2003-05-02 | 2005-09-14 | Novartis Ag | Derivados de piridin-tiazol amina y de pirimidin-tiazol amina |
| AU2005209485A1 (en) * | 2004-01-30 | 2005-08-11 | Ab Science | 2-(3-substituted-aryl)amino-4-aryl-thiazoles as tyrosine kinase inhibitors |
| JP2008540537A (ja) | 2005-05-09 | 2008-11-20 | アキリオン ファーマシューティカルズ，インコーポレーテッド | チアゾール化合物および使用方法 |
| US20070032493A1 (en) * | 2005-05-26 | 2007-02-08 | Synta Pharmaceuticals Corp. | Method for treating B cell regulated autoimmune disorders |
| ES2632940T3 (es) | 2005-09-13 | 2017-09-18 | Janssen Pharmaceutica Nv | Derivados de tiazol sustituidos con 2-anilin-4-arilo |
| CN101484433A (zh) | 2006-02-15 | 2009-07-15 | 艾博特公司 | 新的乙酰辅酶a羧化酶(acc)抑制剂及其在糖尿病、肥胖症和代谢综合征中的应用 |
| US8735595B2 (en) * | 2006-02-15 | 2014-05-27 | Abbvie Inc. | Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome |
| WO2007103550A2 (en) * | 2006-03-08 | 2007-09-13 | Achillion Pharmaceuticals, Inc. | Substituted aminothiazole derivatives with anti-hcv activity |
| RU2456273C2 (ru) | 2006-03-31 | 2012-07-20 | Новартис Аг | Новые соединения |
| EA200901573A1 (ru) | 2007-05-22 | 2010-04-30 | Ачиллион Фармасьютикалз, Инк. | Гетероарилзамещенные тиазолы |
| WO2009023402A2 (en) * | 2007-07-17 | 2009-02-19 | Acea Biosciences Inc. | Heterocyclic compounds and uses as anticancer agents |
| AR066169A1 (es) | 2007-09-28 | 2009-07-29 | Novartis Ag | Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat |
| US8440701B2 (en) | 2007-10-18 | 2013-05-14 | Janssen Pharmaceutica Nv | Trisubstituted 1,2,4 triazoles |
| JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
| EP2240475B1 (en) | 2007-12-20 | 2013-09-25 | Novartis AG | Thiazole derivatives used as pi 3 kinase inhibitors |
| US20110105436A1 (en) * | 2008-03-10 | 2011-05-05 | Auckland Uniservices Limited | Heteroaryl compounds, compositions, and methods of use in cancer treatment |
| CN102066343B (zh) | 2008-03-19 | 2013-12-04 | 詹森药业有限公司 | 作为烟碱乙酰胆碱受体调节剂的三取代1，2，4-三唑类 |
| EP2280945B1 (en) | 2008-05-09 | 2014-09-03 | Janssen Pharmaceutica, N.V. | Trisubstituted pyrazoles as acetylcholine receptor modulators |
| US8106209B2 (en) * | 2008-06-06 | 2012-01-31 | Achillion Pharmaceuticals, Inc. | Substituted aminothiazole prodrugs of compounds with anti-HCV activity |
| EP3111956B1 (en) * | 2008-07-01 | 2019-05-08 | PTC Therapeutics, Inc. | Bmi 1 protein expression modulators |
| UA104147C2 (uk) | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| AU2009300317A1 (en) * | 2008-10-01 | 2010-04-08 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
| US8293753B2 (en) * | 2009-07-02 | 2012-10-23 | Novartis Ag | Substituted 2-carboxamide cycloamino ureas |
| PH12014500724A1 (en) | 2011-10-04 | 2014-05-19 | Institute For Hepatitis And Virus Res | Substituted aminothiazoles as inhibitors of cancers, including hepatocellular carcinoma, and as inhibitors of hepatitis virus replication |
| CN103159695B (zh) * | 2011-12-08 | 2015-08-12 | 首都师范大学 | 可抑制hiv复制并对耐药hiv病毒株有效的噻唑类化合物及其制备方法和用途 |
| CN102863435B (zh) * | 2012-09-25 | 2015-02-18 | 盐城工学院 | 一种2-[[4-氟-3-(三氟甲基)苯基]氨基]-4-吡啶基-5-噻唑甲醛及其还原产物的制备方法 |
| US9453002B2 (en) | 2013-08-16 | 2016-09-27 | Janssen Pharmaceutica Nv | Substituted imidazoles as N-type calcium channel blockers |
| WO2016138533A2 (en) * | 2015-02-27 | 2016-09-01 | The Regents Of The University Of California | Small molecules that enable cartilage rejuvanation |
| KR20170001969U (ko) | 2015-11-27 | 2017-06-07 | 주식회사 바이오해저드특수청소 | 조류 퇴치기 |
| CN105524056A (zh) * | 2016-01-05 | 2016-04-27 | 中山大学肿瘤防治中心 | 一种氨基噻唑化合物及其制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3459731A (en) | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
| BE795907A (fr) * | 1972-02-25 | 1973-06-18 | Luso Farmaco Inst | 2-amino-4-arylthiazoles 5-substitues et leur preparation |
| US4649146A (en) * | 1983-01-31 | 1987-03-10 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole derivatives and pharmaceutical composition comprising the same |
| DE3486009T2 (de) * | 1983-09-09 | 1993-04-15 | Takeda Chemical Industries Ltd | 5-pyridyl-1,3-thiazol-derivate, ihre herstellung und anwendung. |
| DE3406232A1 (de) | 1984-02-21 | 1985-08-29 | Bayer Ag, 5090 Leverkusen | Faserreaktive formazanfarbstoffe |
| DE3406329A1 (de) * | 1984-02-22 | 1985-08-22 | Merck Patent Gmbh, 6100 Darmstadt | Pyridone |
| JPS6267022A (ja) | 1985-09-18 | 1987-03-26 | Otsuka Pharmaceut Factory Inc | 抗炎症剤 |
| US5000775A (en) * | 1985-12-31 | 1991-03-19 | Monsanto Company | 2-amino-4,5-disubstituted-oxazole/thiazole compounds as herbicide antidotes |
| JPH07149745A (ja) | 1993-11-30 | 1995-06-13 | Hisamitsu Pharmaceut Co Inc | 新規な２−アミノチアゾール誘導体 |
| AU689972B2 (en) * | 1994-11-29 | 1998-04-09 | Hisamitsu Pharmaceutical Co., Inc. | Antibacterial preparation or bactericide comprising 2-aminothiazole derivative and/or salt thereof |
| WO1997018839A1 (en) | 1995-11-23 | 1997-05-29 | Janssen Pharmaceutica N.V. | Solid mixtures of cyclodextrins prepared via melt-extrusion |
| WO1999064418A1 (en) | 1998-06-05 | 1999-12-16 | Novartis Ag | Aryl pyridinyl thiazoles |
| WO2001064674A1 (en) * | 2000-03-01 | 2001-09-07 | Janssen Pharmaceutica N.V. | 2,4-disubstituted thiazolyl derivatives |
| US6403588B1 (en) * | 2000-04-27 | 2002-06-11 | Yamanouchi Pharmaceutical Co., Ltd. | Imidazopyridine derivatives |
| WO2002034748A1 (en) | 2000-10-24 | 2002-05-02 | Sankyo Company, Limited | Imidazopyridine derivatives |
-
2002
- 2002-08-09 HU HU0401748A patent/HUP0401748A3/hu unknown
- 2002-08-09 BR BR0211887-4A patent/BR0211887A/pt not_active IP Right Cessation
- 2002-08-09 KR KR1020107011315A patent/KR101034489B1/ko active IP Right Grant
- 2002-08-09 EP EP02758455A patent/EP1418909B1/en not_active Expired - Lifetime
- 2002-08-09 ES ES02758455T patent/ES2407807T3/es not_active Expired - Lifetime
- 2002-08-09 KR KR1020037017268A patent/KR100979988B1/ko active IP Right Grant
- 2002-08-09 US US10/486,819 patent/US7232838B2/en not_active Expired - Lifetime
- 2002-08-09 CA CA2451980A patent/CA2451980C/en not_active Expired - Lifetime
- 2002-08-09 EA EA200400306A patent/EA007717B1/ru not_active IP Right Cessation
- 2002-08-09 WO PCT/EP2002/008955 patent/WO2003015773A2/en active Application Filing
- 2002-08-09 IL IL16032902A patent/IL160329A0/xx unknown
- 2002-08-09 JP JP2003520732A patent/JP4388805B2/ja not_active Expired - Fee Related
- 2002-08-09 CN CNB028157990A patent/CN100496493C/zh not_active Expired - Fee Related
- 2002-08-09 PL PL02368130A patent/PL368130A1/xx not_active Application Discontinuation
- 2002-08-09 AU AU2002324045A patent/AU2002324045C1/en not_active Ceased
- 2002-08-09 MX MXPA04001399A patent/MXPA04001399A/es active IP Right Grant
- 2002-08-09 NZ NZ530950A patent/NZ530950A/xx not_active IP Right Cessation
- 2002-09-08 UA UA2004031904A patent/UA82176C2/uk unknown
-
2004
- 2004-01-29 HR HRP20040097AA patent/HRP20040097B1/hr not_active IP Right Cessation
- 2004-02-11 IL IL160329A patent/IL160329A/en active IP Right Grant
- 2004-02-12 NO NO20040632A patent/NO327409B1/no not_active IP Right Cessation
- 2004-02-12 ZA ZA2004/01162A patent/ZA200401162B/en unknown
-
2005
- 2005-04-01 HK HK05102761.8A patent/HK1069997A1/xx not_active IP Right Cessation
-
2007
- 2007-05-01 US US11/742,741 patent/US7803823B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0401748A2 (hu) | 2-Amino-4,5-triszubsztituált tiazolilszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0401160A2 (hu) | Gyulladásgátló 2,4,5-triszubsztituált tiazolilszármazékok, előállításuk és az ezeket tartalmazó gyógyszerkészítmények | |
| HUP0301382A2 (hu) | Alfa-aril-etanol-amin-származékok és e vegyületeket tartalmazó béta-3 adrenergiás receptor agonista hatású gyógyászati készítmények | |
| CA2450922A1 (en) | Piperidines for use as orexin receptor antagonists | |
| MY135686A (en) | Indole derivatives useful as histamine h3 antagonists | |
| HUP0100860A2 (hu) | Retinsav utánzó anilidek, eljárás az előállításukra valamint ezeket tartalmazó gyógyászati készítmények | |
| HUP0203142A2 (hu) | Benzodiazepinszármazékok, eljárás a vegyületek előállítására, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| HUP0401729A2 (hu) | IV típusú foszfodiészteráz inhibitor hatású alkin-aril-naftiridin-4(1H)-on-származékok és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0202682A2 (hu) | Tirozin kináz inhibitorok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| NZ332240A (en) | Substituted indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) and are therefor useful for treating inflammatory diseases | |
| HUP0203228A2 (hu) | Szubsztituált indolszármazékok az NFKB-aktivitás módosítására, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| DE69206820D1 (de) | 1,3-Dihydro-2H-Imidano 4,5-b-quinolin-2-ein Derivate als Phosphodiestenase Hemmer | |
| TR200100300T2 (tr) | Sitokinlerin üretiminde engelleyici olarak kullanışlı amid türevleri | |
| HUP0101204A2 (hu) | HIV-gátló pirimidinszármazékok és a vegyületeket tartalmazó gyógyászati készítmények | |
| DE69633607D1 (de) | Piperidinderivate mit tachykinin-antagonistischer wirkung | |
| CA2492723A1 (en) | Novel 2,5-disubstituted pyrimidine derivatives | |
| JP2012512886A5 (hu) | ||
| HUP0203323A2 (hu) | Tirozin kináz inhibitorok és ilyen vegyületeket tartalmazó gyógyászati készítmények | |
| NO179695C (no) | Anvendelse av æomega-[4-(2-pyrimidinyl)-1-piperazinylÅalkylå-1H-azol-derivater for fremstilling av medisinske produkter beregnet til behandling av forstyrrelser i kognitive funksjoner | |
| HUP0400966A2 (hu) | NK3 receptor antagonisták alkalmazása megváltozott bélműködéssel és/vagy visceralis fájdalommal jellemzett állapotok kezelésére és/vagy megelőzésére | |
| FR2844270B1 (fr) | Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent | |
| NO20051754D0 (no) | Quinolylpropylpiperidinderivater, fremgangsmate for fremstilling derav og mellomprodukter og preparater inneholdende slike derivater | |
| NO962543L (no) | Cykliske amid-derivater som neurokinin A-antagonister | |
| HUP0000426A2 (hu) | Új benzonaftiridinek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| YU40998A (sh) | Derivati supstituisanog 1,2,3,4-tetrahidronaftalina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |