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TR200100300T2 - Sitokinlerin üretiminde engelleyici olarak kullanışlı amid türevleri - Google Patents

Sitokinlerin üretiminde engelleyici olarak kullanışlı amid türevleri

Info

Publication number
TR200100300T2
TR200100300T2 TR2001/00300T TR200100300T TR200100300T2 TR 200100300 T2 TR200100300 T2 TR 200100300T2 TR 2001/00300 T TR2001/00300 T TR 2001/00300T TR 200100300 T TR200100300 T TR 200100300T TR 200100300 T2 TR200100300 T2 TR 200100300T2
Authority
TR
Turkey
Prior art keywords
alkyl
hydroxy
cytokines
alkylamino
heteroaryl
Prior art date
Application number
TR2001/00300T
Other languages
English (en)
Inventor
Sutherland Brown Dearg
Robert Brown George
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9816838.8A external-priority patent/GB9816838D0/en
Priority claimed from GBGB9824939.4A external-priority patent/GB9824939D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of TR200100300T2 publication Critical patent/TR200100300T2/tr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Bulus, Formül I'in amid türevleri ile ilgili olup, burada R3 (1-6C) alkil veya halojen; Q1 heteroaril olup, istege bagli olarak, hidroksi, halojen, triflüorometil, (1-6C) alkil, (1-6C) alkoksi, hidroksi-(1-6C)alkil, (1-6C) alkoksi, (1-6C)alkil, hidroksi-(2-6C)alkoksi, amino-(2-6C) alkilamino, N-(1-6C) alkil-(1-6C)alkilamino-(2-6C) alkilamino, aril, heteroaril ve heterosiklik gibi, 1,2,3, veya 4 ikame edilen ile ikame edilmistir, p, 0-2'dir ve R2, hidroksi ve halojen gibi bir ikame edilendir; q, 0-4'tür, ve Q2 istege bagli olarak ikame edilmis aril, sikloalkil, heteroaril ve heterosiklil, veya bunun farmasötik olarak kabul edilebilen tuzlarini veya canli olarak ayrilabilir esterlerini, bunlarin hazirlanmasi, için islemler içermektedir, bunlari içeren farmasötik bilesimler ve bunlarin kullanimi sitokinler tarafindan ortaya çikarilan hastaliklarin veya tibbi kosullarin tedavisinde kullanilmaktadir.
TR2001/00300T 1998-08-04 1999-07-29 Sitokinlerin üretiminde engelleyici olarak kullanışlı amid türevleri TR200100300T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9816838.8A GB9816838D0 (en) 1998-08-04 1998-08-04 Amide derivatives
GBGB9824939.4A GB9824939D0 (en) 1998-11-13 1998-11-13 Amide derivatives

Publications (1)

Publication Number Publication Date
TR200100300T2 true TR200100300T2 (tr) 2001-07-23

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TR2001/00300T TR200100300T2 (tr) 1998-08-04 1999-07-29 Sitokinlerin üretiminde engelleyici olarak kullanışlı amid türevleri

Country Status (19)

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US (2) US6432949B1 (tr)
EP (1) EP1102750A1 (tr)
JP (1) JP2002522421A (tr)
KR (1) KR20010099609A (tr)
CN (1) CN1142912C (tr)
AU (1) AU753741B2 (tr)
BR (1) BR9912729A (tr)
CA (1) CA2338121A1 (tr)
HU (1) HUP0103019A3 (tr)
ID (1) ID27652A (tr)
IL (2) IL141183A0 (tr)
MX (1) MXPA01000895A (tr)
NO (1) NO320289B1 (tr)
NZ (1) NZ509318A (tr)
PL (1) PL345817A1 (tr)
RU (1) RU2216541C2 (tr)
SK (1) SK1762001A3 (tr)
TR (1) TR200100300T2 (tr)
WO (1) WO2000007991A1 (tr)

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EP1163237B1 (en) * 1999-03-17 2004-05-06 AstraZeneca AB Amide derivatives
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