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HRP20040097B1 - 2-amino-4,5-trisupstituirani derivati tiazolila - Google Patents

2-amino-4,5-trisupstituirani derivati tiazolila

Info

Publication number
HRP20040097B1
HRP20040097B1 HRP20040097AA HRP20040097A HRP20040097B1 HR P20040097 B1 HRP20040097 B1 HR P20040097B1 HR P20040097A A HRP20040097A A HR P20040097AA HR P20040097 A HRP20040097 A HR P20040097A HR P20040097 B1 HRP20040097 B1 HR P20040097B1
Authority
HR
Croatia
Prior art keywords
amino
calkyl
aminocarbonyl
mono
optionally substituted
Prior art date
Application number
HRP20040097AA
Other languages
English (en)
Inventor
Christopher John Love
Guy Rosalia Eugeen Van Lommen
Julien Georges Pierre-Olivier Doyon
Jean-Pierre Andre Marc Bongartz
Marcel Jozef Maria Van Der Aa
Robert Jozef Maria Hendrickx
Peter Jacobus Johannes Anto Buijnsters
Ludwig Paul Cooymans
Nele Vandermaesen
Erwin Coesemans
Gustaaf Maria Boeckx
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of HRP20040097A2 publication Critical patent/HRP20040097A2/hr
Publication of HRP20040097B1 publication Critical patent/HRP20040097B1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Ovaj izum bavi se uporabom spoja formule (I'), njegovog N-oksida, farmaceutski prihvatljive adicijske soli, kvaternog amina i stereokemijski izomorfnog oblika, pri čemu Z je halo; Calkil; Calkilkarbonil; Calkiloksikarbonil; aminokarbonil; Calkil supstituiran s hidroksi, karboksilom, cijano, amino, amino supstituiranim s piperidinilom, amino supstituiranim s Calkilom supstituiranim piperidinilom, mono- ili di(Calkil)amino, aminokarbonilom, mono- ili di(Calkil)aminokarbonilom, Calkiloksikarbonilom, Calkiloksi, piperidinilom, piperazinilom, morfolinilom, tiomorfolinilom; polihaloCalkil; cijano; amino; mono- ili di (Calkil)aminokarbonil; Calkiloksikarbonil; Calkilkarboniloksi; amino-S(=O)-, mono- ili di(Calkil)amino-S(=O); -C(=N-R)NRR; Q je moguće supstituirani C-ecikloalkil, fenil, piridil, pirimidinil, pirazinil, piridazinil, benztiazolil, benzoksazolil, benzimidazolil, indazolil, ili imidazopiridil, ili je Q radikal formule (b-1), (b-2) ili (b-3), L je moguće supstituirani fenil ili moguće supstituirani monociklički 5 ili 6-eročlani djelomično zasićeni ili aromatski heterocikl ili biciklički djelomično zasićeni ili aromatski heterocikl; aril je moguće supstituirani fenil; za izradu lijeka za sprječavanje ili liječenje upalnih i/ili autoimunih bolesti nastalih posredovanjem TNF-α i/ili IL-12.
HRP20040097AA 2001-08-13 2002-08-09 2-amino-4,5-trisupstituirani derivati tiazolila HRP20040097B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01203087 2001-08-13
PCT/EP2002/008955 WO2003015773A2 (en) 2001-08-13 2002-08-09 2-amino-4,5-trisubstituted thiazolyl derivatives and their use against autoimmune diseases

Publications (2)

Publication Number Publication Date
HRP20040097A2 HRP20040097A2 (en) 2004-06-30
HRP20040097B1 true HRP20040097B1 (hr) 2013-10-11

Family

ID=8180790

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20040097AA HRP20040097B1 (hr) 2001-08-13 2002-08-09 2-amino-4,5-trisupstituirani derivati tiazolila

Country Status (20)

Country Link
US (2) US7232838B2 (hr)
EP (1) EP1418909B1 (hr)
JP (1) JP4388805B2 (hr)
KR (2) KR101034489B1 (hr)
CN (1) CN100496493C (hr)
AU (1) AU2002324045C1 (hr)
BR (1) BR0211887A (hr)
CA (1) CA2451980C (hr)
EA (1) EA007717B1 (hr)
ES (1) ES2407807T3 (hr)
HR (1) HRP20040097B1 (hr)
HU (1) HUP0401748A3 (hr)
IL (2) IL160329A0 (hr)
MX (1) MXPA04001399A (hr)
NO (1) NO327409B1 (hr)
NZ (1) NZ530950A (hr)
PL (1) PL368130A1 (hr)
UA (1) UA82176C2 (hr)
WO (1) WO2003015773A2 (hr)
ZA (1) ZA200401162B (hr)

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JP2008540537A (ja) 2005-05-09 2008-11-20 アキリオン ファーマシューティカルズ，インコーポレーテッド チアゾール化合物および使用方法
WO2006128172A2 (en) * 2005-05-26 2006-11-30 Synta Pharmaceuticals Corp. Method for treating b cell regulated autoimmune disorders
CA2617394C (en) 2005-09-13 2014-06-03 Janssen Pharmaceutica N.V. 2-aniline-4-aryl substituted thiazole derivatives
JP5369257B2 (ja) 2006-02-15 2013-12-18 アッヴィ・インコーポレイテッド 新規なアセチル−ＣｏＡカルボキシラーゼ（ＡＣＣ）阻害薬およびそれらの糖尿病、肥満および代謝症候群での使用
CA2641766A1 (en) * 2006-02-15 2007-08-23 Abbott Laboratories Novel acetyl-coa carboxylase (acc) inhibitors and their use in diabetes, obesity and metabolic syndrome
AU2007223797A1 (en) * 2006-03-08 2007-09-13 Achillion Pharmaceuticals, Inc. Substituted aminothiazole derivatives with anti-HCV activity
CN101415683B (zh) 2006-03-31 2013-07-17 诺瓦提斯公司 新化合物
KR20100020484A (ko) 2007-05-22 2010-02-22 아칠리온 파르마세우티칼스 인코포레이티드 헤테로아릴 치환된 티아졸 그리고 항-바이러스제로서의 그들의 사용
JP5457344B2 (ja) * 2007-07-17 2014-04-02 アセア バイオサイエンシズ インコーポレイテッド 複素環式化合物および抗がん剤としての使用
AR066169A1 (es) 2007-09-28 2009-07-29 Novartis Ag Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat
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JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
BRPI0820722A2 (pt) 2007-12-20 2015-06-16 Novartis Ag Derivados de tiazol usados como inibidores de pi 3 cinases
WO2009114552A1 (en) * 2008-03-10 2009-09-17 The Board Of Trustees Of The Leland Stanford Junior University Heteroaryl compounds, compositions, and methods of use in cancer treatment
CN102066343B (zh) 2008-03-19 2013-12-04 詹森药业有限公司 作为烟碱乙酰胆碱受体调节剂的三取代1，2，4-三唑类
WO2009135944A1 (en) 2008-05-09 2009-11-12 Janssen Pharmaceutica Nv Trisubstituted pyrazoles as acetylcholine receptor modulators
US8106209B2 (en) * 2008-06-06 2012-01-31 Achillion Pharmaceuticals, Inc. Substituted aminothiazole prodrugs of compounds with anti-HCV activity
EP2306836B1 (en) * 2008-07-01 2016-09-07 PTC Therapeutics, Inc. Bmi-1 protein expression modulators
UA104147C2 (uk) 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
JP2012504604A (ja) * 2008-10-01 2012-02-23 シンタ ファーマシューティカルズ コーポレーション 炎症および免疫関連使用のための化合物
US8293753B2 (en) * 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
EP2763674A4 (en) * 2011-10-04 2015-04-29 Inst Hepatitis & Virus Res SUBSTITUTED AMINOTHIAZOLE AS ANTIBODIES OF CANCER CELLS INCLUDING HEPATOCELLULAR CARCINOMA AND AS HEPATITIS VIRUS REPLICATION INHIBITORS
CN103159695B (zh) * 2011-12-08 2015-08-12 首都师范大学 可抑制hiv复制并对耐药hiv病毒株有效的噻唑类化合物及其制备方法和用途
CN102863435B (zh) * 2012-09-25 2015-02-18 盐城工学院 一种2-[[4-氟-3-(三氟甲基)苯基]氨基]-4-吡啶基-5-噻唑甲醛及其还原产物的制备方法
US9453002B2 (en) 2013-08-16 2016-09-27 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers
AU2016224975B2 (en) * 2015-02-27 2020-10-22 The Regents Of The University Of California Small molecules that enable cartilage rejuvanation
KR20170001969U (ko) 2015-11-27 2017-06-07 주식회사 바이오해저드특수청소 조류 퇴치기
CN105524056A (zh) * 2016-01-05 2016-04-27 中山大学肿瘤防治中心 一种氨基噻唑化合物及其制备方法和应用

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EP0154190A1 (de) * 1984-02-22 1985-09-11 MERCK PATENT GmbH Pyridone
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US3933838A (en) * 1972-02-25 1976-01-20 Instituto Luso Farmaco D'italia S.R.L. 5-Substituted 2-amino-4-arylthiazoles
US4649146A (en) * 1983-01-31 1987-03-10 Fujisawa Pharmaceutical Co., Ltd. Thiazole derivatives and pharmaceutical composition comprising the same
EP0154190A1 (de) * 1984-02-22 1985-09-11 MERCK PATENT GmbH Pyridone
US5000775A (en) * 1985-12-31 1991-03-19 Monsanto Company 2-amino-4,5-disubstituted-oxazole/thiazole compounds as herbicide antidotes
EP0790057A1 (en) * 1994-11-29 1997-08-20 Hisamitsu Pharmaceutical Co., Inc. Antibacterial or bactericide comprising 2-aminothiazole derivative and salts thereof

Also Published As

Publication number Publication date
CA2451980C (en) 2012-12-11
IL160329A0 (en) 2004-07-25
MXPA04001399A (es) 2004-05-27
ZA200401162B (en) 2005-07-27
AU2002324045B2 (en) 2007-10-04
KR101034489B1 (ko) 2011-05-17
NZ530950A (en) 2006-03-31
CA2451980A1 (en) 2003-02-27
US20070203189A1 (en) 2007-08-30
IL160329A (en) 2010-05-31
US7803823B2 (en) 2010-09-28
BR0211887A (pt) 2004-09-21
HUP0401748A3 (en) 2011-03-28
ES2407807T3 (es) 2013-06-14
JP4388805B2 (ja) 2009-12-24
EA200400306A1 (ru) 2004-08-26
US7232838B2 (en) 2007-06-19
EP1418909B1 (en) 2013-02-20
KR20040031712A (ko) 2004-04-13
EP1418909A2 (en) 2004-05-19
KR100979988B1 (ko) 2010-09-03
NO20040632L (no) 2004-03-11
EA007717B1 (ru) 2006-12-29
WO2003015773A2 (en) 2003-02-27
HK1069997A1 (en) 2005-06-10
NO327409B1 (no) 2009-06-22
HUP0401748A2 (hu) 2004-12-28
JP2005501099A (ja) 2005-01-13
CN1541097A (zh) 2004-10-27
CN100496493C (zh) 2009-06-10
AU2002324045C1 (en) 2008-05-29
PL368130A1 (en) 2005-03-21
HRP20040097A2 (en) 2004-06-30
WO2003015773A3 (en) 2003-12-18
US20040254191A1 (en) 2004-12-16
KR20100076043A (ko) 2010-07-05
UA82176C2 (en) 2008-03-25

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