[go: up one dir, main page]

HRP920491B1 - O-methyl derivatives of azithromycin a, process and intermediates for their preparation, and process of preparation and use thereof in the preparation of pharmaceuticals - Google Patents

O-methyl derivatives of azithromycin a, process and intermediates for their preparation, and process of preparation and use thereof in the preparation of pharmaceuticals

Info

Publication number
HRP920491B1
HRP920491B1 HRP-1409/90A HRP920491A HRP920491B1 HR P920491 B1 HRP920491 B1 HR P920491B1 HR P920491 A HRP920491 A HR P920491A HR P920491 B1 HRP920491 B1 HR P920491B1
Authority
HR
Croatia
Prior art keywords
preparation
azithromycin
pharmaceuticals
intermediates
methyl derivatives
Prior art date
Application number
HRP-1409/90A
Other languages
English (en)
Inventor
Slobodan Dokic
Original Assignee
Slobodan Dokic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Slobodan Dokic filed Critical Slobodan Dokic
Priority to HRP-1409/90A priority Critical patent/HRP920491B1/xx
Publication of HRP920491A2 publication Critical patent/HRP920491A2/hr
Publication of HRP920491B1 publication Critical patent/HRP920491B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HRP-1409/90A 1990-07-18 1992-09-25 O-methyl derivatives of azithromycin a, process and intermediates for their preparation, and process of preparation and use thereof in the preparation of pharmaceuticals HRP920491B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HRP-1409/90A HRP920491B1 (en) 1990-07-18 1992-09-25 O-methyl derivatives of azithromycin a, process and intermediates for their preparation, and process of preparation and use thereof in the preparation of pharmaceuticals

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
YU140990 1990-07-18
HRP-1409/90A HRP920491B1 (en) 1990-07-18 1992-09-25 O-methyl derivatives of azithromycin a, process and intermediates for their preparation, and process of preparation and use thereof in the preparation of pharmaceuticals

Publications (2)

Publication Number Publication Date
HRP920491A2 HRP920491A2 (en) 1994-08-31
HRP920491B1 true HRP920491B1 (en) 1998-10-31

Family

ID=25554060

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP-1409/90A HRP920491B1 (en) 1990-07-18 1992-09-25 O-methyl derivatives of azithromycin a, process and intermediates for their preparation, and process of preparation and use thereof in the preparation of pharmaceuticals

Country Status (20)

Country Link
US (1) US5250518A (cs)
EP (1) EP0467331B1 (cs)
JP (1) JP2657132B2 (cs)
CN (1) CN1029738C (cs)
AT (1) ATE129715T1 (cs)
BG (1) BG60593B1 (cs)
CA (1) CA2046956C (cs)
CZ (1) CZ280640B6 (cs)
DE (1) DE69114198T2 (cs)
DK (1) DK0467331T3 (cs)
ES (1) ES2081397T3 (cs)
GR (1) GR3018330T3 (cs)
HR (1) HRP920491B1 (cs)
HU (4) HU215158B (cs)
PL (1) PL166379B1 (cs)
RO (1) RO109338B1 (cs)
RU (1) RU2045533C1 (cs)
SI (1) SI9011409A (cs)
SK (1) SK279075B6 (cs)
UA (1) UA27105A1 (cs)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
US5605889A (en) * 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
ES2279242T3 (es) * 1997-10-16 2007-08-16 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Nuevos 3,6-hemicetales de la clase de las 9a-azalidas.
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
UA70972C2 (uk) 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
HRP980646B1 (en) * 1998-12-30 2008-02-29 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. Novel oleandomycin derivatives
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
HRP990116B1 (en) * 1999-04-20 2007-10-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
CA2419873A1 (en) 2000-08-23 2002-02-28 Wockhardt Limited Process for preparation of anhydrous azithromycin
HRP20010301A2 (en) * 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
US7271154B2 (en) 2002-02-15 2007-09-18 Merckle Gmbh Antibiotic conjugates
AU2003215245A1 (en) 2002-02-15 2003-09-09 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
AU2003219770B2 (en) 2002-02-15 2008-10-09 Merckle Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
ITMI20022292A1 (it) * 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
US7435805B2 (en) 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
AU2003264910A1 (en) * 2003-05-30 2005-01-21 Pliva - Istrazivacki Institut D.O.O. Process for selective alkylation of macrolide and azalide derivatives
WO2005021567A1 (en) * 2003-09-02 2005-03-10 Pliva - Istrazivacki Institut D.O.O. O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US8080529B2 (en) * 2005-01-13 2011-12-20 Glaxo Group Limited Macrolides with anti-inflammatory activity
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
EP2384332A1 (en) 2009-01-30 2011-11-09 Glaxo Group Limited 9-deoxo- 9a-methyl- 9a- aza- 9a-h0m0erythr0mycin a derivatives for the treatment of neutrophil dominated inflammatory diseases
MA32997B1 (fr) * 2009-01-30 2012-01-02 Glaxo Group Ltd Macrolide anti-inflammatoire
CN101830949B (zh) * 2009-03-13 2012-05-23 上海医药工业研究院 一种阿奇霉素衍生物、其中间体及其制备方法和应用
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
CN102952166A (zh) * 2011-08-28 2013-03-06 山东方明药业集团股份有限公司 聚合物支载硼氢阴离子还原剂合成阿奇霉素中间体的方法
WO2013148874A1 (en) 2012-03-27 2013-10-03 Burnet Michael W Anti-inflammatory macrolides
GB201608236D0 (en) 2016-05-11 2016-06-22 Fidelta D O O Seco macrolide compounds
WO2018193117A1 (en) * 2017-04-20 2018-10-25 Novintum Biotechnology Gmbh Azithromycin derivatives containing a phosphonium ion as anticancer agents
JP2020517749A (ja) * 2017-04-20 2020-06-18 ライジング タイド ファウンデーション 抗がん剤としてホスホニウムイオンを含むアジスロマイシン誘導体
WO2018195446A1 (en) 2017-04-21 2018-10-25 Lisanti Michael P Targeting hypoxic cancer stem cells (cscs) with doxycycline: implications for improving anti-angiogenic therapy
CA3060510A1 (en) 2017-04-21 2018-10-25 Lunella Biotech, Inc. Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs)
EP3624897A4 (en) 2017-05-19 2021-07-14 Lunella Biotech, Inc. COMPANION DIAGNOSIS FOR MITOCHONDRIAL INHIBITORS
CA3063717C (en) 2017-05-19 2021-08-24 Lunella Biotech, Inc. Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
AU2018292283B2 (en) 2017-06-26 2020-07-23 Lunella Biotech, Inc. Mitoketoscins: mitochondrial-based therapeutics targeting ketone metabolism in cancer cells

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
EP0184921A3 (en) * 1984-12-08 1986-10-29 Beecham Group Plc Erythromycin derivatives
US4833236A (en) * 1986-05-02 1989-05-23 Taisho Pharmaceutical Co., Ltd. Erythromycin derivatives
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents

Also Published As

Publication number Publication date
CZ280640B6 (cs) 1996-03-13
GR3018330T3 (en) 1996-03-31
CN1029738C (zh) 1995-09-13
HU9202619D0 (en) 1992-12-28
RU2045533C1 (ru) 1995-10-10
HRP920491A2 (en) 1994-08-31
HUT59935A (en) 1992-07-28
HU9802439D0 (en) 1998-12-28
PL166379B1 (en) 1995-05-31
BG60593B1 (bg) 1995-09-29
US5250518A (en) 1993-10-05
CA2046956C (en) 1999-01-05
ES2081397T3 (es) 1996-03-01
DE69114198T2 (de) 1996-06-27
JP2657132B2 (ja) 1997-09-24
CA2046956A1 (en) 1992-01-19
EP0467331B1 (en) 1995-11-02
CS219591A3 (en) 1992-03-18
HU221803B1 (hu) 2003-01-28
SI9011409A (en) 1995-10-31
HU215158B (hu) 1998-12-28
ATE129715T1 (de) 1995-11-15
SK279075B6 (sk) 1998-06-03
PL291130A1 (en) 1992-11-16
HUT62307A (en) 1993-04-28
CN1059728A (zh) 1992-03-25
DK0467331T3 (da) 1996-02-05
EP0467331A1 (en) 1992-01-22
RO109338B1 (ro) 1995-01-30
BG94837A (bg) 1993-12-24
DE69114198D1 (de) 1995-12-07
HU912408D0 (en) 1991-12-30
JPH05132497A (ja) 1993-05-28
UA27105A1 (uk) 2000-02-28
HU211659A9 (en) 1995-12-28

Similar Documents

Publication Publication Date Title
HRP920491B1 (en) O-methyl derivatives of azithromycin a, process and intermediates for their preparation, and process of preparation and use thereof in the preparation of pharmaceuticals
IL89831A (en) Process for preparing derivatives of baccatine iii and of 10-deacetyl baccatine iii
DE3270317D1 (en) Derivatives of amino acids and their therapeutic use
CA2146852A1 (en) New substituted pyrazole derivatives, processes for their preparation and their use as herbicides
FI111263B (fi) Uudet erytromysiinijohdannaiset, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeinä sekä menetelmässä käytettävät välituoteamiinit
DK1040107T3 (da) 6-O-alkyl-derivater af erythronolid B
PL295030A1 (en) Method of obtaining substituted derivatives of 2-cyclohexan-1-yl amine
NZ233735A (en) Heterocyclic substituted aminophenol derivatives
NO890567D0 (no) Anthracyklin-derivater.
NO961356L (no) Antracyklinonderivater, samt anvendelse derav ved amyloidose
CA2148595A1 (en) Molecule labelling using 2-hydrazinopyridine derivatives
KR950700762A (ko) 제약학적 조성물(Pharmaceutical composition)
MY132057A (en) Quinoxalinones, a process for their preparation and their use
DE69025505D1 (de) Tylosin-Derivate
ATE63921T1 (de) 6-amino-anthracycline, verfahren zu ihrer herstellung und ihre verwendung.
TW350840B (en) N-acylpiperazine derivative, antibacterial drug and anti-ulcer drug
FI913699A0 (fi) Menetelmä farmaseuttisesti käyttökelpoisten 4'-epi-4'-aminoantrasykliinien valmistamiseksi sekä menetelmässä käytettävät välituotteet
PT86702A (pt) Process for preparing substituted methanesulphonamidophenethylamines
ES8107249A1 (es) Un procedimiento para la preparacion de derivados de 2-epi- fortimicina.
MY115291A (en) New substituted pyrazole derivatives, processes for their preparation nad their use as herbicides
JPS6479196A (en) Novel anthracycline derivative
PT84061A (en) Process for the preparation of monosulfactams
HUT57718A (en) Process for producing thiourea derivative
MX9802933A (es) Derivados novedosos de amina de 2", 3"-didesoxiglicosidos de epipodofilotoxina, metodo de preparacion de los mismos y uso de los mismos con un farmaco y para tratamientos anticancer.
FI921696A0 (fi) 20-metyl-5,7-pregnadien-3b,21- diolderivat.

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
PNAN Change of the applicant name, address/residence

Owner name: GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O.,

PPPP Transfer of rights

Owner name: PLIVA-ISTRAZIVACKI INSTITUT D.O.O., HR

ODRP Renewal fee for the maintenance of a patent

Payment date: 20070713

Year of fee payment: 18

PBON Lapse due to non-payment of renewal fee

Effective date: 20080719