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HK1251014A1 - 用於抑制alas1基因表達的組合物和方法 - Google Patents

用於抑制alas1基因表達的組合物和方法

Info

Publication number
HK1251014A1
HK1251014A1 HK18110394.1A HK18110394A HK1251014A1 HK 1251014 A1 HK1251014 A1 HK 1251014A1 HK 18110394 A HK18110394 A HK 18110394A HK 1251014 A1 HK1251014 A1 HK 1251014A1
Authority
HK
Hong Kong
Prior art keywords
compositions
methods
inhibiting expression
alas1 gene
alas1
Prior art date
Application number
HK18110394.1A
Other languages
English (en)
Inventor
Brian Bettencourt
Kevin Fitzgerald
William Querbes
Makiko Yasuda
Robert J Desnick
Original Assignee
Alnylam Pharmaceuticals Inc
Icahn School Med Mount Sinai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48326393&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1251014(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alnylam Pharmaceuticals Inc, Icahn School Med Mount Sinai filed Critical Alnylam Pharmaceuticals Inc
Publication of HK1251014A1 publication Critical patent/HK1251014A1/zh

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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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HK18110394.1A 2012-04-10 2018-08-14 用於抑制alas1基因表達的組合物和方法 HK1251014A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261622288P 2012-04-10 2012-04-10
US13/835,613 US9133461B2 (en) 2012-04-10 2013-03-15 Compositions and methods for inhibiting expression of the ALAS1 gene

Publications (1)

Publication Number Publication Date
HK1251014A1 true HK1251014A1 (zh) 2019-01-18

Family

ID=48326393

Family Applications (2)

Application Number Title Priority Date Filing Date
HK15102374.5A HK1201876A1 (zh) 2012-04-10 2015-03-09 用於抑制 基因表達的組合物和方法
HK18110394.1A HK1251014A1 (zh) 2012-04-10 2018-08-14 用於抑制alas1基因表達的組合物和方法

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HK15102374.5A HK1201876A1 (zh) 2012-04-10 2015-03-09 用於抑制 基因表達的組合物和方法

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US (10) US9133461B2 (zh)
EP (3) EP3284824A1 (zh)
JP (4) JP6422854B2 (zh)
KR (3) KR102423326B1 (zh)
CN (2) CN104540948B (zh)
AR (1) AR090641A1 (zh)
AU (4) AU2013245949A1 (zh)
BR (1) BR112014025020A2 (zh)
CA (2) CA2868290A1 (zh)
CL (2) CL2014002725A1 (zh)
CO (1) CO7121351A2 (zh)
CY (1) CY1119491T1 (zh)
DK (1) DK2836595T3 (zh)
ES (1) ES2640260T3 (zh)
HK (2) HK1201876A1 (zh)
HR (1) HRP20171369T1 (zh)
HU (1) HUE034311T2 (zh)
IL (5) IL281295B (zh)
LT (1) LT2836595T (zh)
ME (1) ME02850B (zh)
MX (3) MX368723B (zh)
PL (1) PL2836595T3 (zh)
PT (1) PT2836595T (zh)
RS (1) RS56428B1 (zh)
RU (2) RU2019111696A (zh)
SI (1) SI2836595T1 (zh)
SM (1) SMT201700428T1 (zh)
WO (1) WO2013155204A2 (zh)
ZA (1) ZA201408111B (zh)

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US9133461B2 (en) * 2012-04-10 2015-09-15 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the ALAS1 gene
KR20210037752A (ko) 2013-05-01 2021-04-06 아이오니스 파마수티컬즈, 인코포레이티드 Hbv 및 ttr 발현을 조절하는 조성물 및 방법
JP6652922B2 (ja) 2013-08-28 2020-02-26 アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． プレカリクレイン（ｐｋｋ）発現の調節
CR20160195A (es) * 2013-10-04 2016-09-05 Alnylam Pharmaceuticals Inc Composiciones y métodos para inhibir la expresión del gen alas 1
US9994846B2 (en) * 2013-10-25 2018-06-12 Regulus Therapeutics Inc. MicroRNA compounds and methods for modulating miR-21 activity
US9701966B2 (en) 2013-12-27 2017-07-11 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of glycolate oxidase (HAO1) by double-stranded RNA
EP3960860A3 (en) * 2014-02-11 2022-06-08 Alnylam Pharmaceuticals, Inc. Ketohexokinase (khk) irna compositions and methods of use thereof
RU2703411C2 (ru) * 2014-05-01 2019-10-16 Ионис Фармасьютикалз, Инк. Композиции и способы модулирования экспрессии пкп
CN111961669A (zh) 2014-05-01 2020-11-20 Ionis制药公司 用于调节血管生成素样蛋白3表达的组合物和方法
AU2015252841B2 (en) * 2014-05-01 2020-03-19 Ionis Pharmaceuticals, Inc. Compositions and methods for modulating growth hormone receptor expression
IL316808A (en) 2014-08-20 2025-01-01 Alnylam Pharmaceuticals Inc Modified double-stranded RNA materials and their uses
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