IT1318539B1 - Composizioni farmaceutiche a rilascio prolungato per lasomministrazione parenterale di sostanze idrofile biologicamente - Google Patents
Composizioni farmaceutiche a rilascio prolungato per lasomministrazione parenterale di sostanze idrofile biologicamenteInfo
- Publication number
- IT1318539B1 IT1318539B1 IT2000MI001173A ITMI20001173A IT1318539B1 IT 1318539 B1 IT1318539 B1 IT 1318539B1 IT 2000MI001173 A IT2000MI001173 A IT 2000MI001173A IT MI20001173 A ITMI20001173 A IT MI20001173A IT 1318539 B1 IT1318539 B1 IT 1318539B1
- Authority
- IT
- Italy
- Prior art keywords
- pharmaceutical compositions
- parenteral administration
- biologically
- hydrophile
- substances
- Prior art date
Links
- 238000007911 parenteral administration Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000002035 prolonged effect Effects 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- 239000004530 micro-emulsion Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 238000001212 derivatisation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (29)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2000MI001173A IT1318539B1 (it) | 2000-05-26 | 2000-05-26 | Composizioni farmaceutiche a rilascio prolungato per lasomministrazione parenterale di sostanze idrofile biologicamente |
US10/258,616 US7157099B2 (en) | 2000-05-26 | 2001-05-23 | Sustained release pharmaceutical compositions for the parenteral administration of hydrophilic compounds |
DK01960242T DK1283700T3 (da) | 2000-05-26 | 2001-05-23 | Farmaceutiske sustained release-præparater til parenteral administration af biologisk aktive hydrofile forbindelser |
CZ20023772A CZ302059B6 (cs) | 2000-05-26 | 2001-05-23 | Stálá biologicky kompatibilní mikroemulze |
RU2002135086/15A RU2272615C2 (ru) | 2000-05-26 | 2001-05-23 | Фармацевтические композиции устойчивого пролонгированного выделения для парентерального введения биологически активных гидрофильных веществ |
PL359601A PL203354B1 (pl) | 2000-05-26 | 2001-05-23 | Trwała, biologicznie kompatybilna, dobrze tolerowana wodno-olejowa mikroemulsja, zawierająca środek powierzchniowo czynny, wodną fazę hydrofilową i olejową fazę hydrofobową i jej zastosowanie |
KR1020027015828A KR100802625B1 (ko) | 2000-05-26 | 2001-05-23 | 생물학적으로 활성인 친수성 화합물의 비경구적 투여를위한 서방성 약제학적 조성물 |
IL15301101A IL153011A0 (en) | 2000-05-26 | 2001-05-23 | Sustained release pharmaceutical compositions for parenteral administration of hydrophilic compounds |
PCT/EP2001/005949 WO2001089479A2 (en) | 2000-05-26 | 2001-05-23 | Sustained release pharmaceutical compositions for parenteral administration of hydrophilic compounds |
HU0301921A HU228926B1 (en) | 2000-05-26 | 2001-05-23 | Sustained release pharmaceutical compositions for paranteral administration of hydrophilic compounds |
MXPA02011539A MXPA02011539A (es) | 2000-05-26 | 2001-05-23 | Composiciones farmaceuticas de liberacion sostenida para la administracion parenteral de compuestos hidrofilicos biologicamente activos. |
CA2409854A CA2409854C (en) | 2000-05-26 | 2001-05-23 | Sustained release pharmaceutical compositions for the parenteral administration of biologically active hydrophilic compounds |
SI200130529T SI1283700T1 (sl) | 2000-05-26 | 2001-05-23 | Farmacevtski sestavki s podaljsanim sproscanjem za parenteralno dajanje hidrofilnih spojin |
SK1655-2002A SK16552002A3 (sk) | 2000-05-26 | 2001-05-23 | Stála, biologicky zlúčiteľná, dobre znášateľná mikroemulzia voda v oleji a jej použitie |
CNB018099254A CN100479856C (zh) | 2000-05-26 | 2001-05-23 | 用于亲水性化合物非肠道给药的缓释药物组合物 |
AU8178601A AU8178601A (en) | 2000-05-26 | 2001-05-23 | Sustained release pharmaceutical compositions for the parenteral administration of biologically active hydrophilic compounds |
PT01960242T PT1283700E (pt) | 2000-05-26 | 2001-05-23 | Composicoes farmaceuticas de libertacao prolongada destinadas a administracao por via parental de compostos hidrofilos biologicamente activos |
YU88202A YU88202A (sh) | 2000-05-26 | 2001-05-23 | Farmaceutski preparati sa odloženim oslobađanjem za parenteralno davanje biološki aktivnih hidrofilnih jedinjenja |
AU2001281786A AU2001281786B8 (en) | 2000-05-26 | 2001-05-23 | Sustained release pharmaceutical compositions for parenteral administration of hydrophilic compounds |
EP01960242A EP1283700B1 (en) | 2000-05-26 | 2001-05-23 | Sustained release pharmaceutical compositions for parenteral administration of hydrophilic compounds |
BR0111016-0 BRPI0111016B8 (pt) | 2000-05-26 | 2001-05-23 | microemulsão água em óleo estavel, biologicamente compatível, bem tolerada e uso da mesma |
JP2001585724A JP4954423B2 (ja) | 2000-05-26 | 2001-05-23 | 生物学的に活性な親水性化合物を非経口的に投与するための徐放性薬剤組成物 |
AT01960242T ATE321533T1 (de) | 2000-05-26 | 2001-05-23 | Pharmazeutische zusammensetzungen mit verzögerter freisetzung für die parenterale applikation von hydrophilen wirkstoffen |
ES01960242T ES2257428T3 (es) | 2000-05-26 | 2001-05-23 | Composiciones farmaceuticas de liberacion sostenida para administracion parenteral de compuestos hidrofilos. |
DE60118395T DE60118395T2 (de) | 2000-05-26 | 2001-05-23 | Pharmazeutische zusammensetzungen mit verzögerter freisetzung für die parenterale applikation von hydrophilen wirkstoffen |
HR20020929A HRP20020929A2 (en) | 2000-05-26 | 2002-11-22 | Sustained release pharmaceutical cmpositions for parenteral administration of hydrophilic compounds |
NO20025621A NO334880B1 (no) | 2000-05-26 | 2002-11-22 | Farmasøytisk sammensetning med vedvarende frigjøring for parenteral administrasjon av hydrofile forbindelser |
ZA200209520A ZA200209520B (en) | 2000-05-26 | 2002-11-22 | Sustained release pharmaceutical compositions for parenteral administration of hydrophilic compounds. |
CY20061100724T CY1105262T1 (el) | 2000-05-26 | 2006-06-05 | Φαρμακευτικες συνθεσεις παρατεταμενης απελευθερωσης για την παρεντepικη χορηγηση βιολογικως δραστικων υδροφιλων ενωσεων |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2000MI001173A IT1318539B1 (it) | 2000-05-26 | 2000-05-26 | Composizioni farmaceutiche a rilascio prolungato per lasomministrazione parenterale di sostanze idrofile biologicamente |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI20001173A0 ITMI20001173A0 (it) | 2000-05-26 |
ITMI20001173A1 ITMI20001173A1 (it) | 2001-11-26 |
IT1318539B1 true IT1318539B1 (it) | 2003-08-27 |
Family
ID=11445131
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT2000MI001173A IT1318539B1 (it) | 2000-05-26 | 2000-05-26 | Composizioni farmaceutiche a rilascio prolungato per lasomministrazione parenterale di sostanze idrofile biologicamente |
Country Status (28)
Country | Link |
---|---|
US (1) | US7157099B2 (it) |
EP (1) | EP1283700B1 (it) |
JP (1) | JP4954423B2 (it) |
KR (1) | KR100802625B1 (it) |
CN (1) | CN100479856C (it) |
AT (1) | ATE321533T1 (it) |
AU (2) | AU2001281786B8 (it) |
BR (1) | BRPI0111016B8 (it) |
CA (1) | CA2409854C (it) |
CY (1) | CY1105262T1 (it) |
CZ (1) | CZ302059B6 (it) |
DE (1) | DE60118395T2 (it) |
DK (1) | DK1283700T3 (it) |
ES (1) | ES2257428T3 (it) |
HR (1) | HRP20020929A2 (it) |
HU (1) | HU228926B1 (it) |
IL (1) | IL153011A0 (it) |
IT (1) | IT1318539B1 (it) |
MX (1) | MXPA02011539A (it) |
NO (1) | NO334880B1 (it) |
PL (1) | PL203354B1 (it) |
PT (1) | PT1283700E (it) |
RU (1) | RU2272615C2 (it) |
SI (1) | SI1283700T1 (it) |
SK (1) | SK16552002A3 (it) |
WO (1) | WO2001089479A2 (it) |
YU (1) | YU88202A (it) |
ZA (1) | ZA200209520B (it) |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
US8119159B2 (en) | 1999-02-22 | 2012-02-21 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
PT1787658E (pt) | 2005-11-10 | 2012-06-22 | Chemi Spa | Formulações de libertação sustentada de análogos de somatostatina inibidores da hormona do crescimento |
EP2007397B1 (en) | 2006-04-07 | 2013-07-24 | Merrion Research III Limited | Solid oral dosage form containing an enhancer |
KR100816065B1 (ko) * | 2006-11-27 | 2008-03-24 | 동국제약 주식회사 | 초기 방출억제 특성이 우수한 서방출성 마이크로캡슐의제조방법 및 이에 의해 제조되는 마이크로캡슐 |
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EP2576579B1 (en) | 2010-06-02 | 2018-08-08 | Alnylam Pharmaceuticals, Inc. | Compositions and methods directed to treating liver fibrosis |
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US9107822B2 (en) | 2010-09-03 | 2015-08-18 | Santen Sas | Water-in oil type emulsion for treating a disease of the eye |
SG188272A1 (en) | 2010-09-03 | 2013-04-30 | Novagali Pharma Sa | A water-in-oil type emulsion for treating a disease of the eye |
US9193973B2 (en) | 2010-12-10 | 2015-11-24 | Alynylam Pharmaceuticals, Inc. | Compositions and methods for increasing erythropoietin (EPO) production |
WO2012079046A2 (en) | 2010-12-10 | 2012-06-14 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of klf-1 and bcl11a genes |
CN103476419A (zh) | 2011-01-07 | 2013-12-25 | 梅里翁第三研究有限公司 | 口服投药的含铁药物组合物 |
CA2831284C (en) | 2011-03-29 | 2023-12-12 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of tmprss6 gene |
SG10201805199RA (en) | 2011-06-02 | 2018-07-30 | Harvard College | Methods and Uses for Ex Vivo Tissue Culture Systems |
SG10201913683WA (en) | 2011-06-21 | 2020-03-30 | Alnylam Pharmaceuticals Inc | Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof |
WO2012177906A1 (en) | 2011-06-21 | 2012-12-27 | Alnylam Pharmaceuticals, Inc. | Assays and methods for determining activity of a therapeutic agent in a subject |
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WO2013019857A2 (en) | 2011-08-01 | 2013-02-07 | Alnylam Pharmaceuticals, Inc. | Method for improving the success rate of hematopoietic stem cell transplants |
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AU2013230085B2 (en) * | 2012-03-05 | 2016-04-28 | Archer Daniels Midland Company | Microemulsions and uses thereof as delivery systems |
US9133461B2 (en) | 2012-04-10 | 2015-09-15 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of the ALAS1 gene |
US9127274B2 (en) | 2012-04-26 | 2015-09-08 | Alnylam Pharmaceuticals, Inc. | Serpinc1 iRNA compositions and methods of use thereof |
EP3336187A1 (en) | 2012-12-05 | 2018-06-20 | Alnylam Pharmaceuticals, Inc. | Pcsk9 irna compositions and methods of use thereof |
EP3312281A3 (en) | 2013-03-14 | 2018-06-27 | Alnylam Pharmaceuticals, Inc. | Complement component c5 irna compositions and methods of use thereof |
WO2014160871A2 (en) | 2013-03-27 | 2014-10-02 | The General Hospital Corporation | Methods and agents for treating alzheimer's disease |
WO2014182661A2 (en) | 2013-05-06 | 2014-11-13 | Alnylam Pharmaceuticals, Inc | Dosages and methods for delivering lipid formulated nucleic acid molecules |
JP6495250B2 (ja) | 2013-05-22 | 2019-04-03 | アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. | SERPINA1 iRNA組成物およびその使用方法 |
EP3587578A1 (en) | 2013-05-22 | 2020-01-01 | Alnylam Pharmaceuticals, Inc. | Tmprss6 irna compositions and methods of use thereof |
AU2014278011B2 (en) | 2013-06-14 | 2020-03-19 | Alyssum Therapeutics, Inc. | Lipid-based platinum compounds and nanoparticles |
EP2823808A1 (en) * | 2013-07-09 | 2015-01-14 | Ipsen Pharma S.A.S. | Pharmaceutical composition for a sustained release of lanreotide |
EP2832361A1 (en) * | 2013-07-29 | 2015-02-04 | Ipsen Pharma S.A.S. | Aqueous sustained release compositions of LHRH analogs |
MX385871B (es) | 2013-10-02 | 2025-03-18 | Alnylam Pharmaceuticals Inc | Composiciones y metodos para inhibir la expresion del gen lect2. |
KR20220159478A (ko) | 2013-10-04 | 2022-12-02 | 알닐람 파마슈티칼스 인코포레이티드 | Alas1 유전자의 발현을 억제하기 위한 조성물 및 방법 |
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CN118845818A (zh) | 2014-02-11 | 2024-10-29 | 阿尔尼拉姆医药品有限公司 | 己酮糖激酶(KHK)iRNA组合物及其使用方法 |
WO2015175510A1 (en) | 2014-05-12 | 2015-11-19 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for treating a serpinc1-associated disorder |
SG11201609376SA (en) | 2014-05-22 | 2016-12-29 | Alnylam Pharmaceuticals Inc | Angiotensinogen (agt) irna compositions and methods of use thereof |
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WO2016040589A1 (en) | 2014-09-12 | 2016-03-17 | Alnylam Pharmaceuticals, Inc. | Polynucleotide agents targeting complement component c5 and methods of use thereof |
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JOP20200092A1 (ar) | 2014-11-10 | 2017-06-16 | Alnylam Pharmaceuticals Inc | تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها |
WO2016081444A1 (en) | 2014-11-17 | 2016-05-26 | Alnylam Pharmaceuticals, Inc. | Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof |
TW201702218A (zh) | 2014-12-12 | 2017-01-16 | 美國杰克森實驗室 | 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法 |
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ES2975708T3 (es) | 2015-01-29 | 2024-07-12 | Novo Nordisk As | Comprimidos que comprenden agonista del GLP-1 y recubrimiento entérico |
CA2976445A1 (en) | 2015-02-13 | 2016-08-18 | Alnylam Pharmaceuticals, Inc. | Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof |
MX2017012610A (es) | 2015-04-08 | 2018-03-16 | Alnylam Pharmaceuticals Inc | Composiciones y metodos para inhibir la expresion del gen lect2. |
TWI723986B (zh) | 2015-04-13 | 2021-04-11 | 美商阿尼拉製藥公司 | 類血管生成素3(ANGPTL3)iRNA組成物及其用途方法 |
CA2984636A1 (en) | 2015-05-06 | 2016-11-10 | Alnylam Pharmaceuticals, Inc. | Factor xii (hageman factor) (f12), kallikrein b, plasma (fletcher factor) 1 (klkb1), and kininogen 1 (kng1) irna compositions and methods of use thereof |
EP3307316A1 (en) | 2015-06-12 | 2018-04-18 | Alnylam Pharmaceuticals, Inc. | Complement component c5 irna compositions and methods of use thereof |
WO2016205323A1 (en) | 2015-06-18 | 2016-12-22 | Alnylam Pharmaceuticals, Inc. | Polynucleotde agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof |
WO2016209862A1 (en) | 2015-06-23 | 2016-12-29 | Alnylam Pharmaceuticals, Inc. | Glucokinase (gck) irna compositions and methods of use thereof |
US10494632B2 (en) | 2015-07-10 | 2019-12-03 | Alnylam Pharmaceuticals, Inc. | Insulin-like growth factor binding protein, acid labile subunit (IGFALS) compositions and methods of use thereof |
JP7028764B2 (ja) | 2015-09-02 | 2022-03-02 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | プログラム細胞死1リガンド1(PD-L1)iRNA組成物およびその使用方法 |
WO2017048620A1 (en) | 2015-09-14 | 2017-03-23 | Alnylam Pharmaceuticals, Inc. | Polynucleotide agents targeting patatin-like phospholipase domain containing 3 (pnpla3) and methods of use thereof |
WO2017048843A1 (en) | 2015-09-14 | 2017-03-23 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of the alas1 gene |
WO2017064657A1 (en) | 2015-10-16 | 2017-04-20 | Invictus Oncology Pvt. Ltd. | Fluorescent anticancer platinum drugs |
EP3386518A1 (en) | 2015-12-07 | 2018-10-17 | Genzyme Corporation | Methods and compositions for treating a serpinc1-associated disorder |
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JP2019518028A (ja) | 2016-06-10 | 2019-06-27 | アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. | 補体成分C5iRNA組成物及び発作性夜間血色素尿症(PNH)を処置するためのその使用方法 |
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WO2018112320A1 (en) | 2016-12-16 | 2018-06-21 | Alnylam Pharmaceuticals, Inc. | Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions |
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US11987792B2 (en) | 2018-08-16 | 2024-05-21 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of the LECT2 gene |
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US20230159933A1 (en) | 2020-04-07 | 2023-05-25 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for silencing scn9a expression |
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US20230183707A1 (en) | 2020-05-21 | 2023-06-15 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting marc1 gene expression |
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EP4217489A1 (en) | 2020-09-24 | 2023-08-02 | Alnylam Pharmaceuticals, Inc. | Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof |
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TW202237150A (zh) | 2020-12-01 | 2022-10-01 | 美商艾拉倫製藥股份有限公司 | 用於抑制hao1(羥基酸氧化酶1(乙醇酸氧化酶))基因表現的方法及組成物 |
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EP4321152A1 (en) * | 2021-04-08 | 2024-02-14 | Tionlab Therapeutics | Sustained-release lipid pre-concentrate |
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EP4469575A2 (en) | 2022-01-24 | 2024-12-04 | Alnylam Pharmaceuticals, Inc. | Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof |
TW202424193A (zh) | 2022-09-15 | 2024-06-16 | 美商艾拉倫製藥股份有限公司 | 第13型17β-羥基類固醇去氫酶(HSD17B13)iRNA組成物及其使用方法 |
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JPH08505367A (ja) * | 1992-10-16 | 1996-06-11 | スミスクライン・ビーチャム・コーポレイション | 医薬用エマルジョン組成物 |
SE512663C2 (sv) * | 1997-10-23 | 2000-04-17 | Biogram Ab | Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer |
AU1198599A (en) | 1997-10-24 | 1999-05-17 | Neorx Corporation | Delivery vehicles for bioactive agents and uses thereof |
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