[go: up one dir, main page]

IT1318539B1 - Composizioni farmaceutiche a rilascio prolungato per lasomministrazione parenterale di sostanze idrofile biologicamente - Google Patents

Composizioni farmaceutiche a rilascio prolungato per lasomministrazione parenterale di sostanze idrofile biologicamente

Info

Publication number
IT1318539B1
IT1318539B1 IT2000MI001173A ITMI20001173A IT1318539B1 IT 1318539 B1 IT1318539 B1 IT 1318539B1 IT 2000MI001173 A IT2000MI001173 A IT 2000MI001173A IT MI20001173 A ITMI20001173 A IT MI20001173A IT 1318539 B1 IT1318539 B1 IT 1318539B1
Authority
IT
Italy
Prior art keywords
pharmaceutical compositions
parenteral administration
biologically
hydrophile
substances
Prior art date
Application number
IT2000MI001173A
Other languages
English (en)
Inventor
Francesco Autuori
Carlo Bianchini
Giuseppe Bottoni
Flavio Leoni
Paolo Mascagni
Walmer Monzani
Oreste Piccolo
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Publication of ITMI20001173A0 publication Critical patent/ITMI20001173A0/it
Priority to IT2000MI001173A priority Critical patent/IT1318539B1/it
Priority to CNB018099254A priority patent/CN100479856C/zh
Priority to YU88202A priority patent/YU88202A/sh
Priority to CZ20023772A priority patent/CZ302059B6/cs
Priority to RU2002135086/15A priority patent/RU2272615C2/ru
Priority to PL359601A priority patent/PL203354B1/pl
Priority to KR1020027015828A priority patent/KR100802625B1/ko
Priority to IL15301101A priority patent/IL153011A0/xx
Priority to PCT/EP2001/005949 priority patent/WO2001089479A2/en
Priority to HU0301921A priority patent/HU228926B1/hu
Priority to MXPA02011539A priority patent/MXPA02011539A/es
Priority to CA2409854A priority patent/CA2409854C/en
Priority to SI200130529T priority patent/SI1283700T1/sl
Priority to SK1655-2002A priority patent/SK16552002A3/sk
Priority to US10/258,616 priority patent/US7157099B2/en
Priority to DK01960242T priority patent/DK1283700T3/da
Priority to AU8178601A priority patent/AU8178601A/xx
Priority to EP01960242A priority patent/EP1283700B1/en
Priority to AU2001281786A priority patent/AU2001281786B8/en
Priority to PT01960242T priority patent/PT1283700E/pt
Priority to BR0111016-0 priority patent/BRPI0111016B8/pt
Priority to JP2001585724A priority patent/JP4954423B2/ja
Priority to AT01960242T priority patent/ATE321533T1/de
Priority to ES01960242T priority patent/ES2257428T3/es
Priority to DE60118395T priority patent/DE60118395T2/de
Publication of ITMI20001173A1 publication Critical patent/ITMI20001173A1/it
Priority to HR20020929A priority patent/HRP20020929A2/xx
Priority to NO20025621A priority patent/NO334880B1/no
Priority to ZA200209520A priority patent/ZA200209520B/en
Application granted granted Critical
Publication of IT1318539B1 publication Critical patent/IT1318539B1/it
Priority to CY20061100724T priority patent/CY1105262T1/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26Androgens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT2000MI001173A 2000-05-26 2000-05-26 Composizioni farmaceutiche a rilascio prolungato per lasomministrazione parenterale di sostanze idrofile biologicamente IT1318539B1 (it)

Priority Applications (29)

Application Number Priority Date Filing Date Title
IT2000MI001173A IT1318539B1 (it) 2000-05-26 2000-05-26 Composizioni farmaceutiche a rilascio prolungato per lasomministrazione parenterale di sostanze idrofile biologicamente
US10/258,616 US7157099B2 (en) 2000-05-26 2001-05-23 Sustained release pharmaceutical compositions for the parenteral administration of hydrophilic compounds
DK01960242T DK1283700T3 (da) 2000-05-26 2001-05-23 Farmaceutiske sustained release-præparater til parenteral administration af biologisk aktive hydrofile forbindelser
CZ20023772A CZ302059B6 (cs) 2000-05-26 2001-05-23 Stálá biologicky kompatibilní mikroemulze
RU2002135086/15A RU2272615C2 (ru) 2000-05-26 2001-05-23 Фармацевтические композиции устойчивого пролонгированного выделения для парентерального введения биологически активных гидрофильных веществ
PL359601A PL203354B1 (pl) 2000-05-26 2001-05-23 Trwała, biologicznie kompatybilna, dobrze tolerowana wodno-olejowa mikroemulsja, zawierająca środek powierzchniowo czynny, wodną fazę hydrofilową i olejową fazę hydrofobową i jej zastosowanie
KR1020027015828A KR100802625B1 (ko) 2000-05-26 2001-05-23 생물학적으로 활성인 친수성 화합물의 비경구적 투여를위한 서방성 약제학적 조성물
IL15301101A IL153011A0 (en) 2000-05-26 2001-05-23 Sustained release pharmaceutical compositions for parenteral administration of hydrophilic compounds
PCT/EP2001/005949 WO2001089479A2 (en) 2000-05-26 2001-05-23 Sustained release pharmaceutical compositions for parenteral administration of hydrophilic compounds
HU0301921A HU228926B1 (en) 2000-05-26 2001-05-23 Sustained release pharmaceutical compositions for paranteral administration of hydrophilic compounds
MXPA02011539A MXPA02011539A (es) 2000-05-26 2001-05-23 Composiciones farmaceuticas de liberacion sostenida para la administracion parenteral de compuestos hidrofilicos biologicamente activos.
CA2409854A CA2409854C (en) 2000-05-26 2001-05-23 Sustained release pharmaceutical compositions for the parenteral administration of biologically active hydrophilic compounds
SI200130529T SI1283700T1 (sl) 2000-05-26 2001-05-23 Farmacevtski sestavki s podaljsanim sproscanjem za parenteralno dajanje hidrofilnih spojin
SK1655-2002A SK16552002A3 (sk) 2000-05-26 2001-05-23 Stála, biologicky zlúčiteľná, dobre znášateľná mikroemulzia voda v oleji a jej použitie
CNB018099254A CN100479856C (zh) 2000-05-26 2001-05-23 用于亲水性化合物非肠道给药的缓释药物组合物
AU8178601A AU8178601A (en) 2000-05-26 2001-05-23 Sustained release pharmaceutical compositions for the parenteral administration of biologically active hydrophilic compounds
PT01960242T PT1283700E (pt) 2000-05-26 2001-05-23 Composicoes farmaceuticas de libertacao prolongada destinadas a administracao por via parental de compostos hidrofilos biologicamente activos
YU88202A YU88202A (sh) 2000-05-26 2001-05-23 Farmaceutski preparati sa odloženim oslobađanjem za parenteralno davanje biološki aktivnih hidrofilnih jedinjenja
AU2001281786A AU2001281786B8 (en) 2000-05-26 2001-05-23 Sustained release pharmaceutical compositions for parenteral administration of hydrophilic compounds
EP01960242A EP1283700B1 (en) 2000-05-26 2001-05-23 Sustained release pharmaceutical compositions for parenteral administration of hydrophilic compounds
BR0111016-0 BRPI0111016B8 (pt) 2000-05-26 2001-05-23 microemulsão água em óleo estavel, biologicamente compatível, bem tolerada e uso da mesma
JP2001585724A JP4954423B2 (ja) 2000-05-26 2001-05-23 生物学的に活性な親水性化合物を非経口的に投与するための徐放性薬剤組成物
AT01960242T ATE321533T1 (de) 2000-05-26 2001-05-23 Pharmazeutische zusammensetzungen mit verzögerter freisetzung für die parenterale applikation von hydrophilen wirkstoffen
ES01960242T ES2257428T3 (es) 2000-05-26 2001-05-23 Composiciones farmaceuticas de liberacion sostenida para administracion parenteral de compuestos hidrofilos.
DE60118395T DE60118395T2 (de) 2000-05-26 2001-05-23 Pharmazeutische zusammensetzungen mit verzögerter freisetzung für die parenterale applikation von hydrophilen wirkstoffen
HR20020929A HRP20020929A2 (en) 2000-05-26 2002-11-22 Sustained release pharmaceutical cmpositions for parenteral administration of hydrophilic compounds
NO20025621A NO334880B1 (no) 2000-05-26 2002-11-22 Farmasøytisk sammensetning med vedvarende frigjøring for parenteral administrasjon av hydrofile forbindelser
ZA200209520A ZA200209520B (en) 2000-05-26 2002-11-22 Sustained release pharmaceutical compositions for parenteral administration of hydrophilic compounds.
CY20061100724T CY1105262T1 (el) 2000-05-26 2006-06-05 Φαρμακευτικες συνθεσεις παρατεταμενης απελευθερωσης για την παρεντepικη χορηγηση βιολογικως δραστικων υδροφιλων ενωσεων

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000MI001173A IT1318539B1 (it) 2000-05-26 2000-05-26 Composizioni farmaceutiche a rilascio prolungato per lasomministrazione parenterale di sostanze idrofile biologicamente

Publications (3)

Publication Number Publication Date
ITMI20001173A0 ITMI20001173A0 (it) 2000-05-26
ITMI20001173A1 ITMI20001173A1 (it) 2001-11-26
IT1318539B1 true IT1318539B1 (it) 2003-08-27

Family

ID=11445131

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2000MI001173A IT1318539B1 (it) 2000-05-26 2000-05-26 Composizioni farmaceutiche a rilascio prolungato per lasomministrazione parenterale di sostanze idrofile biologicamente

Country Status (28)

Country Link
US (1) US7157099B2 (it)
EP (1) EP1283700B1 (it)
JP (1) JP4954423B2 (it)
KR (1) KR100802625B1 (it)
CN (1) CN100479856C (it)
AT (1) ATE321533T1 (it)
AU (2) AU2001281786B8 (it)
BR (1) BRPI0111016B8 (it)
CA (1) CA2409854C (it)
CY (1) CY1105262T1 (it)
CZ (1) CZ302059B6 (it)
DE (1) DE60118395T2 (it)
DK (1) DK1283700T3 (it)
ES (1) ES2257428T3 (it)
HR (1) HRP20020929A2 (it)
HU (1) HU228926B1 (it)
IL (1) IL153011A0 (it)
IT (1) IT1318539B1 (it)
MX (1) MXPA02011539A (it)
NO (1) NO334880B1 (it)
PL (1) PL203354B1 (it)
PT (1) PT1283700E (it)
RU (1) RU2272615C2 (it)
SI (1) SI1283700T1 (it)
SK (1) SK16552002A3 (it)
WO (1) WO2001089479A2 (it)
YU (1) YU88202A (it)
ZA (1) ZA200209520B (it)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
US8119159B2 (en) 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
PT1787658E (pt) 2005-11-10 2012-06-22 Chemi Spa Formulações de libertação sustentada de análogos de somatostatina inibidores da hormona do crescimento
EP2007397B1 (en) 2006-04-07 2013-07-24 Merrion Research III Limited Solid oral dosage form containing an enhancer
KR100816065B1 (ko) * 2006-11-27 2008-03-24 동국제약 주식회사 초기 방출억제 특성이 우수한 서방출성 마이크로캡슐의제조방법 및 이에 의해 제조되는 마이크로캡슐
RU2362544C2 (ru) * 2007-04-09 2009-07-27 Закрытое акционерное общество "Санкт-Петербургский институт фармации" Наноэмульсия с биологически активными веществами
CN101888781A (zh) * 2007-10-04 2010-11-17 因斯蒂尔医学技术有限公司 用于配制和无菌充注液体产品的设备和方法
BRPI0912384A2 (pt) 2008-05-07 2015-10-13 Merrion Res Iii Ltd composição, e, método para preparar uma composição
TWI536999B (zh) 2010-01-13 2016-06-11 艾普森藥品公司 製備持續釋放生長激素抑制素類似物之醫藥組成物之方法
WO2011120033A1 (en) 2010-03-26 2011-09-29 Merrion Research Iii Limited Pharmaceutical compositions of selective factor xa inhibitors for oral administration
AU2011237630B2 (en) 2010-04-06 2016-01-21 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of CD274/PD-L1 gene
EP2576579B1 (en) 2010-06-02 2018-08-08 Alnylam Pharmaceuticals, Inc. Compositions and methods directed to treating liver fibrosis
ES2426603T3 (es) 2010-09-03 2013-10-24 Novagali Pharma S.A. Una emulsión de tipo agua en aceite para tratar una enfermedad de los ojos
US9107822B2 (en) 2010-09-03 2015-08-18 Santen Sas Water-in oil type emulsion for treating a disease of the eye
SG188272A1 (en) 2010-09-03 2013-04-30 Novagali Pharma Sa A water-in-oil type emulsion for treating a disease of the eye
US9193973B2 (en) 2010-12-10 2015-11-24 Alynylam Pharmaceuticals, Inc. Compositions and methods for increasing erythropoietin (EPO) production
WO2012079046A2 (en) 2010-12-10 2012-06-14 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of klf-1 and bcl11a genes
CN103476419A (zh) 2011-01-07 2013-12-25 梅里翁第三研究有限公司 口服投药的含铁药物组合物
CA2831284C (en) 2011-03-29 2023-12-12 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of tmprss6 gene
SG10201805199RA (en) 2011-06-02 2018-07-30 Harvard College Methods and Uses for Ex Vivo Tissue Culture Systems
SG10201913683WA (en) 2011-06-21 2020-03-30 Alnylam Pharmaceuticals Inc Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof
WO2012177906A1 (en) 2011-06-21 2012-12-27 Alnylam Pharmaceuticals, Inc. Assays and methods for determining activity of a therapeutic agent in a subject
EP4134433A1 (en) 2011-06-23 2023-02-15 Alnylam Pharmaceuticals, Inc. Serpina1 sirnas: compositions of matter and methods of treatment
EP2724156B1 (en) 2011-06-27 2017-08-16 The Jackson Laboratory Methods and compositions for treatment of cancer and autoimmune disease
WO2013019857A2 (en) 2011-08-01 2013-02-07 Alnylam Pharmaceuticals, Inc. Method for improving the success rate of hematopoietic stem cell transplants
CN102552187B (zh) * 2012-02-28 2015-10-28 大连医科大学 口服羟丝肽纳米粒及其制备方法
CN102552138A (zh) * 2012-02-28 2012-07-11 大连医科大学 口服羟丝肽w/o微乳制剂及其制备方法
AU2013230085B2 (en) * 2012-03-05 2016-04-28 Archer Daniels Midland Company Microemulsions and uses thereof as delivery systems
US9133461B2 (en) 2012-04-10 2015-09-15 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the ALAS1 gene
US9127274B2 (en) 2012-04-26 2015-09-08 Alnylam Pharmaceuticals, Inc. Serpinc1 iRNA compositions and methods of use thereof
EP3336187A1 (en) 2012-12-05 2018-06-20 Alnylam Pharmaceuticals, Inc. Pcsk9 irna compositions and methods of use thereof
EP3312281A3 (en) 2013-03-14 2018-06-27 Alnylam Pharmaceuticals, Inc. Complement component c5 irna compositions and methods of use thereof
WO2014160871A2 (en) 2013-03-27 2014-10-02 The General Hospital Corporation Methods and agents for treating alzheimer's disease
WO2014182661A2 (en) 2013-05-06 2014-11-13 Alnylam Pharmaceuticals, Inc Dosages and methods for delivering lipid formulated nucleic acid molecules
JP6495250B2 (ja) 2013-05-22 2019-04-03 アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. SERPINA1 iRNA組成物およびその使用方法
EP3587578A1 (en) 2013-05-22 2020-01-01 Alnylam Pharmaceuticals, Inc. Tmprss6 irna compositions and methods of use thereof
AU2014278011B2 (en) 2013-06-14 2020-03-19 Alyssum Therapeutics, Inc. Lipid-based platinum compounds and nanoparticles
EP2823808A1 (en) * 2013-07-09 2015-01-14 Ipsen Pharma S.A.S. Pharmaceutical composition for a sustained release of lanreotide
EP2832361A1 (en) * 2013-07-29 2015-02-04 Ipsen Pharma S.A.S. Aqueous sustained release compositions of LHRH analogs
MX385871B (es) 2013-10-02 2025-03-18 Alnylam Pharmaceuticals Inc Composiciones y metodos para inhibir la expresion del gen lect2.
KR20220159478A (ko) 2013-10-04 2022-12-02 알닐람 파마슈티칼스 인코포레이티드 Alas1 유전자의 발현을 억제하기 위한 조성물 및 방법
IL314045A (en) 2013-12-12 2024-09-01 Alnylam Pharmaceuticals Inc Complement component irna compositions and methods of use thereof
CN118845818A (zh) 2014-02-11 2024-10-29 阿尔尼拉姆医药品有限公司 己酮糖激酶(KHK)iRNA组合物及其使用方法
WO2015175510A1 (en) 2014-05-12 2015-11-19 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating a serpinc1-associated disorder
SG11201609376SA (en) 2014-05-22 2016-12-29 Alnylam Pharmaceuticals Inc Angiotensinogen (agt) irna compositions and methods of use thereof
KR101686986B1 (ko) 2014-07-28 2016-12-16 에스케이케미칼주식회사 류프로라이드를 포함하는 속효성과 지속성을 동시에 갖는 약제학적 조성물
WO2016040589A1 (en) 2014-09-12 2016-03-17 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting complement component c5 and methods of use thereof
JOP20200115A1 (ar) 2014-10-10 2017-06-16 Alnylam Pharmaceuticals Inc تركيبات وطرق لتثبيط التعبير الجيني عن hao1 (حمض أوكسيداز هيدروكسيلي 1 (أوكسيداز جليكولات))
EP3207138B1 (en) 2014-10-17 2020-07-15 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
EP3212794B1 (en) 2014-10-30 2021-04-07 Genzyme Corporation Polynucleotide agents targeting serpinc1 (at3) and methods of use thereof
JOP20200092A1 (ar) 2014-11-10 2017-06-16 Alnylam Pharmaceuticals Inc تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها
WO2016081444A1 (en) 2014-11-17 2016-05-26 Alnylam Pharmaceuticals, Inc. Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
TW201702218A (zh) 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
WO2016118476A1 (en) 2015-01-20 2016-07-28 The Children's Medical Center Corporation Anti-net compounds for treating and preventing fibrosis and for facilitating wound healing
ES2975708T3 (es) 2015-01-29 2024-07-12 Novo Nordisk As Comprimidos que comprenden agonista del GLP-1 y recubrimiento entérico
CA2976445A1 (en) 2015-02-13 2016-08-18 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
MX2017012610A (es) 2015-04-08 2018-03-16 Alnylam Pharmaceuticals Inc Composiciones y metodos para inhibir la expresion del gen lect2.
TWI723986B (zh) 2015-04-13 2021-04-11 美商阿尼拉製藥公司 類血管生成素3(ANGPTL3)iRNA組成物及其用途方法
CA2984636A1 (en) 2015-05-06 2016-11-10 Alnylam Pharmaceuticals, Inc. Factor xii (hageman factor) (f12), kallikrein b, plasma (fletcher factor) 1 (klkb1), and kininogen 1 (kng1) irna compositions and methods of use thereof
EP3307316A1 (en) 2015-06-12 2018-04-18 Alnylam Pharmaceuticals, Inc. Complement component c5 irna compositions and methods of use thereof
WO2016205323A1 (en) 2015-06-18 2016-12-22 Alnylam Pharmaceuticals, Inc. Polynucleotde agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
WO2016209862A1 (en) 2015-06-23 2016-12-29 Alnylam Pharmaceuticals, Inc. Glucokinase (gck) irna compositions and methods of use thereof
US10494632B2 (en) 2015-07-10 2019-12-03 Alnylam Pharmaceuticals, Inc. Insulin-like growth factor binding protein, acid labile subunit (IGFALS) compositions and methods of use thereof
JP7028764B2 (ja) 2015-09-02 2022-03-02 アルナイラム ファーマシューティカルズ, インコーポレイテッド プログラム細胞死1リガンド1(PD-L1)iRNA組成物およびその使用方法
WO2017048620A1 (en) 2015-09-14 2017-03-23 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting patatin-like phospholipase domain containing 3 (pnpla3) and methods of use thereof
WO2017048843A1 (en) 2015-09-14 2017-03-23 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the alas1 gene
WO2017064657A1 (en) 2015-10-16 2017-04-20 Invictus Oncology Pvt. Ltd. Fluorescent anticancer platinum drugs
EP3386518A1 (en) 2015-12-07 2018-10-17 Genzyme Corporation Methods and compositions for treating a serpinc1-associated disorder
WO2017100542A1 (en) 2015-12-10 2017-06-15 Alnylam Pharmaceuticals, Inc. Sterol regulatory element binding protein (srebp) chaperone (scap) irna compositions and methods of use thereof
MA45295A (fr) 2016-04-19 2019-02-27 Alnylam Pharmaceuticals Inc Composition d'arni de protéine de liaison de lipoprotéines haute densité (hdlbp/vigiline) et procédés pour les utiliser
JP2019518028A (ja) 2016-06-10 2019-06-27 アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. 補体成分C5iRNA組成物及び発作性夜間血色素尿症(PNH)を処置するためのその使用方法
TW202313978A (zh) 2016-11-23 2023-04-01 美商阿尼拉製藥公司 絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法
WO2018112320A1 (en) 2016-12-16 2018-06-21 Alnylam Pharmaceuticals, Inc. Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions
JP7277432B2 (ja) 2017-07-13 2023-05-19 アルナイラム ファーマシューティカルズ, インコーポレイテッド 乳酸脱水素酵素A(LDHA)iRNA組成物及びその使用方法
SG11202002940QA (en) 2017-11-01 2020-04-29 Alnylam Pharmaceuticals Inc Complement component c3 irna compositions and methods of use thereof
US20200385719A1 (en) 2017-11-16 2020-12-10 Alnylam Pharmaceuticals, Inc. Kisspeptin 1 (kiss1) irna compositions and methods of use thereof
WO2019100039A1 (en) 2017-11-20 2019-05-23 Alnylam Pharmaceuticals, Inc. Serum amyloid p component (apcs) irna compositions and methods of use thereof
CN111727252A (zh) 2017-12-18 2020-09-29 阿尔尼拉姆医药品有限公司 高速泳动族盒-1(HMGB1)iRNA组合物及其使用方法
US11987792B2 (en) 2018-08-16 2024-05-21 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the LECT2 gene
CN118667811A (zh) 2018-09-18 2024-09-20 阿尔尼拉姆医药品有限公司 己酮糖激酶(KHK)iRNA组合物及其使用方法
US10913951B2 (en) 2018-10-31 2021-02-09 University of Pittsburgh—of the Commonwealth System of Higher Education Silencing of HNF4A-P2 isoforms with siRNA to improve hepatocyte function in liver failure
EP4013870A1 (en) 2019-08-13 2022-06-22 Alnylam Pharmaceuticals, Inc. Small ribosomal protein subunit 25 (rps25) irna agent compositions and methods of use thereof
BR112022003860A2 (pt) 2019-09-03 2022-08-16 Alnylam Pharmaceuticals Inc Composições e métodos para inibir a expressão do gene lect2
EP4038189A1 (en) 2019-10-04 2022-08-10 Alnylam Pharmaceuticals, Inc. Compositions and methods for silencing ugt1a1 gene expression
WO2021087325A1 (en) 2019-11-01 2021-05-06 Alnylam Pharmaceuticals, Inc. Compositions and methods for silencing dnajb1-prkaca fusion gene expression
CN114728018B (zh) 2019-11-01 2024-07-19 阿尔尼拉姆医药品有限公司 亨廷顿(HTT)iRNA药剂组合物及其使用方法
MX2022006433A (es) 2019-12-13 2022-06-23 Alnylam Pharmaceuticals Inc Composiciones de agentes de acido ribonucleico de interferencia (arni) del marco de lectura abierto 72 del cromosoma 9 humano (c9orf72) y metodos de uso de los mismos.
WO2021154941A1 (en) 2020-01-31 2021-08-05 Alnylam Pharmaceuticals, Inc. Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als)
EP4103714A1 (en) 2020-02-10 2022-12-21 Alnylam Pharmaceuticals, Inc. Compositions and methods for silencing vegf-a expression
EP4114947A1 (en) 2020-03-05 2023-01-11 Alnylam Pharmaceuticals, Inc. Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases
EP4121534A1 (en) 2020-03-18 2023-01-25 Alnylam Pharmaceuticals, Inc. Compositions and methods for treating subjects having a heterozygous alanine-glyoxylate aminotransferase gene (agxt) variant
WO2021195307A1 (en) 2020-03-26 2021-09-30 Alnylam Pharmaceuticals, Inc. Coronavirus irna compositions and methods of use thereof
US20230190785A1 (en) 2020-03-30 2023-06-22 Alnylam Pharmaceuticals, Inc. Compositions and methods for silencing dnajc15 gene expression
JP2023520582A (ja) 2020-04-06 2023-05-17 アルナイラム ファーマシューティカルズ, インコーポレイテッド Myoc発現をサイレンシングするための組成物および方法
EP4133076A1 (en) 2020-04-07 2023-02-15 Alnylam Pharmaceuticals, Inc. Angiotensin-converting enzyme 2 (ace2) irna compositions and methods of use thereof
EP4133077A1 (en) 2020-04-07 2023-02-15 Alnylam Pharmaceuticals, Inc. Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof
US20230159933A1 (en) 2020-04-07 2023-05-25 Alnylam Pharmaceuticals, Inc. Compositions and methods for silencing scn9a expression
WO2021222065A1 (en) 2020-04-27 2021-11-04 Alnylam Pharmaceuticals, Inc. Apolipoprotein e (apoe) irna agent compositions and methods of use thereof
US20230183707A1 (en) 2020-05-21 2023-06-15 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting marc1 gene expression
WO2021252557A1 (en) 2020-06-09 2021-12-16 Alnylam Pharmaceuticals, Inc. Rnai compositions and methods of use thereof for delivery by inhalation
EP4217489A1 (en) 2020-09-24 2023-08-02 Alnylam Pharmaceuticals, Inc. Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof
EP4225917A1 (en) 2020-10-05 2023-08-16 Alnylam Pharmaceuticals, Inc. G protein-coupled receptor 75 (gpr75) irna compositions and methods of use thereof
CA3198823A1 (en) 2020-10-21 2022-04-28 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating primary hyperoxaluria
WO2022087329A1 (en) 2020-10-23 2022-04-28 Alnylam Pharmaceuticals, Inc. Mucin 5b (muc5b) irna compositions and methods of use thereof
TW202237150A (zh) 2020-12-01 2022-10-01 美商艾拉倫製藥股份有限公司 用於抑制hao1(羥基酸氧化酶1(乙醇酸氧化酶))基因表現的方法及組成物
KR20230146048A (ko) 2021-02-12 2023-10-18 알닐람 파마슈티칼스 인코포레이티드 슈퍼옥사이드 디스뮤타제 1(sod1) irna 조성물 및 슈퍼옥사이드 디스뮤타제 1- (sod1-) 관련 신경퇴행성 질환을 치료하거나 예방하기 위한 이의 사용 방법
EP4298220A1 (en) 2021-02-25 2024-01-03 Alnylam Pharmaceuticals, Inc. Prion protein (prnp) irna compositions and methods of use thereof
WO2022192519A1 (en) 2021-03-12 2022-09-15 Alnylam Pharmaceuticals, Inc. Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof
BR112023019981A2 (pt) 2021-03-29 2023-12-12 Alnylam Pharmaceuticals Inc Composições do agente irna de huntingtina (htt) e métodos de uso das mesmas
EP4321152A1 (en) * 2021-04-08 2024-02-14 Tionlab Therapeutics Sustained-release lipid pre-concentrate
JP2024522068A (ja) 2021-05-18 2024-06-11 アルナイラム ファーマシューティカルズ, インコーポレイテッド ナトリウム-グルコース共輸送体2(sglt2)irna組成物およびその使用方法
EP4347822A2 (en) 2021-06-04 2024-04-10 Alnylam Pharmaceuticals, Inc. Human chromosome 9 open reading frame 72 (c9orf72) irna agent compositions and methods of use thereof
TW202333748A (zh) 2021-07-19 2023-09-01 美商艾拉倫製藥股份有限公司 用於處置具有或有風險發展非原發性高草酸鹽尿疾病或病症的個體的方法及組成物
JP2024541974A (ja) 2021-10-29 2024-11-13 アルナイラム ファーマシューティカルズ, インコーポレイテッド ハンチンチン(HTT)iRNA剤組成物およびその使用方法
EP4469575A2 (en) 2022-01-24 2024-12-04 Alnylam Pharmaceuticals, Inc. Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof
TW202424193A (zh) 2022-09-15 2024-06-16 美商艾拉倫製藥股份有限公司 第13型17β-羥基類固醇去氫酶(HSD17B13)iRNA組成物及其使用方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08505367A (ja) * 1992-10-16 1996-06-11 スミスクライン・ビーチャム・コーポレイション 医薬用エマルジョン組成物
SE512663C2 (sv) * 1997-10-23 2000-04-17 Biogram Ab Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
AU1198599A (en) 1997-10-24 1999-05-17 Neorx Corporation Delivery vehicles for bioactive agents and uses thereof

Also Published As

Publication number Publication date
NO20025621D0 (no) 2002-11-22
CN100479856C (zh) 2009-04-22
US20030171299A1 (en) 2003-09-11
DE60118395D1 (de) 2006-05-18
PT1283700E (pt) 2006-07-31
HUP0301921A2 (hu) 2003-09-29
BRPI0111016B1 (pt) 2017-11-21
YU88202A (sh) 2006-01-16
CN1430502A (zh) 2003-07-16
KR20030011856A (ko) 2003-02-11
DK1283700T3 (da) 2006-07-24
KR100802625B1 (ko) 2008-02-13
IL153011A0 (en) 2003-06-24
ITMI20001173A0 (it) 2000-05-26
DE60118395T2 (de) 2006-12-07
PL359601A1 (en) 2004-08-23
HUP0301921A3 (en) 2005-11-28
WO2001089479A3 (en) 2002-03-28
EP1283700A2 (en) 2003-02-19
ATE321533T1 (de) 2006-04-15
JP2003534265A (ja) 2003-11-18
SI1283700T1 (sl) 2006-08-31
ES2257428T3 (es) 2006-08-01
JP4954423B2 (ja) 2012-06-13
BRPI0111016B8 (pt) 2021-05-25
HRP20020929A2 (en) 2004-02-29
HU228926B1 (en) 2013-06-28
BR0111016A (pt) 2003-04-15
AU2001281786B8 (en) 2005-11-17
NO334880B1 (no) 2014-06-30
RU2272615C2 (ru) 2006-03-27
SK16552002A3 (sk) 2003-05-02
US7157099B2 (en) 2007-01-02
CY1105262T1 (el) 2010-03-03
PL203354B1 (pl) 2009-09-30
AU8178601A (en) 2001-12-03
CA2409854A1 (en) 2001-11-29
CZ302059B6 (cs) 2010-09-22
ITMI20001173A1 (it) 2001-11-26
ZA200209520B (en) 2003-11-24
EP1283700B1 (en) 2006-03-29
AU2001281786B2 (en) 2005-07-21
CZ20023772A3 (cs) 2003-02-12
WO2001089479A2 (en) 2001-11-29
MXPA02011539A (es) 2004-08-12
NO20025621L (no) 2003-01-27
CA2409854C (en) 2011-02-08

Similar Documents

Publication Publication Date Title
IT1318539B1 (it) Composizioni farmaceutiche a rilascio prolungato per lasomministrazione parenterale di sostanze idrofile biologicamente
BR0212921A (pt) Composição farmacêutica com base em fondant
DK0703786T3 (da) Anvendelse af nona- og dekapeptider til fremstilling af et lægemiddel til behandling af AIDS
AU2001296865A1 (en) (5-(2-hydroxy-4-chlorobenzoyl) aminovaleric acid and salts thereof and compositions containing the same for delivering active agents
ATE309007T1 (de) Transplantate für die wiederherstellung von osteochondralen schäden
ATE332918T1 (de) Neoglycoproteine
ATE270544T1 (de) Halbfeste arzneizubereitung enthaltend isotretinoin
BR0112962B1 (pt) Composições farmacêuticas compreendendo ácido hialurônico, ácido glicirretínico e polivinilpirrolidona, e uso desses compostos na preparação de medicamentos
CA2420874A1 (en) Active ingredient combinations with insecticidal and acaricidal properties
ATE291908T1 (de) Ibuprofen-wirkstoffzubereitung
DE69819145D1 (de) Bioabbaubare mikropartikeln mit verzögerter wirkstofffreisetzung
HK1060691A1 (en) Ion-strength independent sustained release pharmaceutical formulation
DE60102590T2 (de) Darreichungsformen zur behandlung von oralen mykosen
ATE464878T1 (de) Pharmazeutische zusammensetzung zur nasalen anwendung von fentanyl
YU46503A (sh) Farmaceutski oblik dronedarona za parenteralnu upotrebu
SE0001916D0 (sv) Novel formulation
DE60004204D1 (de) Pharmazeutische zusammensetzungen, bestimmt zur oralen verabreichung von phloroglucinol sowie deren herstellung
BR0111018A (pt) Formulações estáveis lìquidas e sólidas
EP1629845A3 (en) Use of cortisol-sequestering agents for the treatment of hypercortisolaemia related disorders
BR0202759A (pt) Composição farmacêutica de liberação modificada contendo bupropiona como substância ativa