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HK1156348A1 - 抑制運甲狀腺素蛋白表達的組合物和方法 - Google Patents

抑制運甲狀腺素蛋白表達的組合物和方法

Info

Publication number
HK1156348A1
HK1156348A1 HK11110470.5A HK11110470A HK1156348A1 HK 1156348 A1 HK1156348 A1 HK 1156348A1 HK 11110470 A HK11110470 A HK 11110470A HK 1156348 A1 HK1156348 A1 HK 1156348A1
Authority
HK
Hong Kong
Prior art keywords
transthyretin
compositions
methods
inhibiting expression
inhibiting
Prior art date
Application number
HK11110470.5A
Other languages
English (en)
Inventor
Dinah Wen-Yee Sah
Gregory Hinkle
Rene Alvarez
Stuart Milstein
Qingmin Chen
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of HK1156348A1 publication Critical patent/HK1156348A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/30—Chemical structure
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HK11110470.5A 2008-10-20 2011-10-04 抑制運甲狀腺素蛋白表達的組合物和方法 HK1156348A1 (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US10695608P 2008-10-20 2008-10-20
US11573808P 2008-11-18 2008-11-18
US15667009P 2009-03-02 2009-03-02
US18554509P 2009-06-09 2009-06-09
US24278309P 2009-09-15 2009-09-15
US24479409P 2009-09-22 2009-09-22
PCT/US2009/061381 WO2010048228A2 (en) 2008-10-20 2009-10-20 Compositions and methods for inhibiting expression of transthyretin

Publications (1)

Publication Number Publication Date
HK1156348A1 true HK1156348A1 (zh) 2012-06-08

Family

ID=42062316

Family Applications (3)

Application Number Title Priority Date Filing Date
HK11110470.5A HK1156348A1 (zh) 2008-10-20 2011-10-04 抑制運甲狀腺素蛋白表達的組合物和方法
HK16104672.9A HK1216652A1 (zh) 2008-10-20 2016-04-22 抑制運甲狀腺素蛋白表達的組合物和方法
HK19101330.6A HK1258859A1 (zh) 2008-10-20 2019-01-25 抑制運甲狀腺素蛋白表達的組合物和方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK16104672.9A HK1216652A1 (zh) 2008-10-20 2016-04-22 抑制運甲狀腺素蛋白表達的組合物和方法
HK19101330.6A HK1258859A1 (zh) 2008-10-20 2019-01-25 抑制運甲狀腺素蛋白表達的組合物和方法

Country Status (28)

Country Link
US (8) US8168775B2 (zh)
EP (4) EP2344639B1 (zh)
JP (7) JP5791505B2 (zh)
KR (6) KR102031027B1 (zh)
CN (3) CN103937793B (zh)
AU (1) AU2009307677C1 (zh)
CA (3) CA2739895C (zh)
CY (3) CY1116944T1 (zh)
DK (2) DK2937418T3 (zh)
EA (3) EA029762B1 (zh)
ES (2) ES2543004T3 (zh)
HK (3) HK1156348A1 (zh)
HR (2) HRP20150796T1 (zh)
HU (3) HUE037875T2 (zh)
IL (5) IL302142B2 (zh)
LT (2) LT2937418T (zh)
LU (1) LUC00098I2 (zh)
MX (4) MX2011004268A (zh)
NL (1) NL300965I2 (zh)
NO (2) NO2937418T3 (zh)
NZ (2) NZ592867A (zh)
PL (2) PL2937418T3 (zh)
PT (2) PT2344639E (zh)
SG (3) SG10201912276XA (zh)
SI (2) SI2344639T1 (zh)
SM (2) SMT201800027T1 (zh)
WO (1) WO2010048228A2 (zh)
ZA (1) ZA201102876B (zh)

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