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HK1041483B - 雙環氮雜環 - Google Patents

雙環氮雜環

Info

Publication number
HK1041483B
HK1041483B HK02103084.9A HK02103084A HK1041483B HK 1041483 B HK1041483 B HK 1041483B HK 02103084 A HK02103084 A HK 02103084A HK 1041483 B HK1041483 B HK 1041483B
Authority
HK
Hong Kong
Prior art keywords
lower alkyl
heteroaryl
aryl
cycloalkyl
alkyl
Prior art date
Application number
HK02103084.9A
Other languages
English (en)
Other versions
HK1041483A1 (en
Inventor
威廉‧哈里斯
克里斯托弗‧胡韋‧希爾
伊恩‧愛德華‧戴維‧史密斯
Original Assignee
霍夫曼-拉羅奇有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26314565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1041483(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9823277.0A external-priority patent/GB9823277D0/en
Application filed by 霍夫曼-拉羅奇有限公司 filed Critical 霍夫曼-拉羅奇有限公司
Publication of HK1041483A1 publication Critical patent/HK1041483A1/xx
Publication of HK1041483B publication Critical patent/HK1041483B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Inorganic Insulating Materials (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK02103084.9A 1998-10-23 2002-04-24 雙環氮雜環 HK1041483B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9823277.0A GB9823277D0 (en) 1998-10-23 1998-10-23 Bicycle nitrogen heterocycles
GBGB9920044.6A GB9920044D0 (en) 1998-10-23 1999-08-24 Biciclic nitrogen heterocycles
PCT/EP1999/007675 WO2000024744A1 (en) 1998-10-23 1999-10-13 Bicyclic nitrogen heterocycles

Publications (2)

Publication Number Publication Date
HK1041483A1 HK1041483A1 (en) 2002-07-12
HK1041483B true HK1041483B (zh) 2004-12-24

Family

ID=26314565

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02103084.9A HK1041483B (zh) 1998-10-23 2002-04-24 雙環氮雜環

Country Status (25)

Country Link
US (1) US6150373A (zh)
EP (1) EP1123295B1 (zh)
JP (1) JP3593035B2 (zh)
CN (1) CN1150195C (zh)
AT (1) ATE277931T1 (zh)
AU (1) AU769989B2 (zh)
BR (1) BR9914677A (zh)
CA (1) CA2347474C (zh)
CZ (1) CZ20011394A3 (zh)
DE (1) DE69920732T2 (zh)
ES (1) ES2228123T3 (zh)
HK (1) HK1041483B (zh)
HR (1) HRP20010274A2 (zh)
HU (1) HUP0104199A3 (zh)
ID (1) ID28276A (zh)
MA (1) MA27678A1 (zh)
MY (1) MY126478A (zh)
NO (1) NO318802B1 (zh)
NZ (1) NZ510760A (zh)
PL (1) PL347432A1 (zh)
PT (1) PT1123295E (zh)
RU (1) RU2256662C2 (zh)
TR (1) TR200101102T2 (zh)
TW (1) TWI227235B (zh)
WO (1) WO2000024744A1 (zh)

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DE69939168D1 (de) 1998-05-26 2008-09-04 Warner Lambert Co Bicyclische pyrimidine und bicyclische 3,4-dihydropyrimidine als inhibitoren der zellvermehrung
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ES2221426T3 (es) 1998-08-20 2004-12-16 Smithkline Beecham Corporation Nuevos compuestos de triazol sustituidos.
JP2002528506A (ja) 1998-11-04 2002-09-03 スミスクライン・ビーチャム・コーポレイション ピリジン−４−イルまたはピリミジン−４−イル置換ピラジン
CN1156477C (zh) 1999-10-21 2004-07-07 霍夫曼-拉罗奇有限公司 作为p38蛋白激酶的抑制剂的烷基氨基-取代的双环氮杂环类化合物
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EP1233950B1 (en) 1999-11-23 2005-10-05 Smithkline Beecham Corporation 3,4-DIHYDRO-(1H)QUINAZOLIN-2-ONE COMPOUNDS AS CSBP/P39 kINASE INHIBITORS
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US7235551B2 (en) * 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
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ATE439361T1 (de) 2006-01-31 2009-08-15 Hoffmann La Roche 7h-pyridoä3,4-düpyrimidin-8-one, ihre herstellung und ihre verwendung als proteinkinaseinhibitoren
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US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
ES2751669T3 (es) 2015-02-20 2020-04-01 Incyte Corp Heterociclos bicíclicos como inhibidores FGFR
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
WO2017031116A1 (en) * 2015-08-18 2017-02-23 The Arizona Board Of Regents On Behalf Of The University Of Arizona Small molecule inhibitors of ku70/80 and uses thereof
CN110225914A (zh) * 2016-07-05 2019-09-10 布罗德研究所股份有限公司 双环脲激酶抑制剂及其用途
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US11685729B2 (en) 2018-01-19 2023-06-27 Idorsia Pharmaceuticals Ltd. C5a receptor modulators
CA3087886A1 (en) 2018-01-19 2019-07-25 Idorsia Pharmaceuticals Ltd C5a receptor modulators
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JP2021523121A (ja) 2018-05-04 2021-09-02 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ｆｇｆｒ阻害剤の固体形態及びその調製プロセス
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CA3124569A1 (en) 2018-12-28 2020-07-02 Spv Therapeutics Inc. Cyclin-dependent kinase inhibitors
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WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
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US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
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EP4143191A2 (en) * 2020-04-28 2023-03-08 iOmx Therapeutics AG Bicyclic kinase inhibitors and uses thereof
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DE69939168D1 (de) * 1998-05-26 2008-09-04 Warner Lambert Co Bicyclische pyrimidine und bicyclische 3,4-dihydropyrimidine als inhibitoren der zellvermehrung

Also Published As

Publication number Publication date
ES2228123T3 (es) 2005-04-01
DE69920732T2 (de) 2006-02-23
NZ510760A (en) 2003-08-29
TR200101102T2 (tr) 2002-01-21
EP1123295B1 (en) 2004-09-29
EP1123295A1 (en) 2001-08-16
CN1150195C (zh) 2004-05-19
JP2002528455A (ja) 2002-09-03
RU2256662C2 (ru) 2005-07-20
ID28276A (id) 2001-05-10
CZ20011394A3 (cs) 2001-12-12
NO20011929D0 (no) 2001-04-19
CN1324360A (zh) 2001-11-28
US6150373A (en) 2000-11-21
PL347432A1 (en) 2002-04-08
AU769989B2 (en) 2004-02-12
AU1036300A (en) 2000-05-15
CA2347474C (en) 2008-08-26
NO318802B1 (no) 2005-05-09
JP3593035B2 (ja) 2004-11-24
HRP20010274A2 (en) 2002-06-30
TWI227235B (en) 2005-02-01
BR9914677A (pt) 2001-07-17
PT1123295E (pt) 2005-01-31
MY126478A (en) 2006-10-31
MA27678A1 (fr) 2006-01-02
HUP0104199A2 (hu) 2002-04-29
NO20011929L (no) 2001-04-19
HUP0104199A3 (en) 2002-12-28
WO2000024744A1 (en) 2000-05-04
HK1041483A1 (en) 2002-07-12
CA2347474A1 (en) 2000-05-04
DE69920732D1 (de) 2004-11-04
ATE277931T1 (de) 2004-10-15

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20081013