ATE277931T1 - Bicyclische stickstoffheteroaryl verbindungen - Google Patents
Bicyclische stickstoffheteroaryl verbindungenInfo
- Publication number
- ATE277931T1 ATE277931T1 AT99953796T AT99953796T ATE277931T1 AT E277931 T1 ATE277931 T1 AT E277931T1 AT 99953796 T AT99953796 T AT 99953796T AT 99953796 T AT99953796 T AT 99953796T AT E277931 T1 ATE277931 T1 AT E277931T1
- Authority
- AT
- Austria
- Prior art keywords
- lower alkyl
- heteroaryl
- aryl
- cycloalkyl
- alkyl
- Prior art date
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 2
- 150000001875 compounds Chemical class 0.000 title 1
- 229910052757 nitrogen Inorganic materials 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 12
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- -1 Amino-substituted dihydropyrimido[4,5-d]pyrimidinones Chemical class 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 206010012655 Diabetic complications Diseases 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000000771 oncological effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 239000003909 protein kinase inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Inorganic Insulating Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9823277.0A GB9823277D0 (en) | 1998-10-23 | 1998-10-23 | Bicycle nitrogen heterocycles |
| GBGB9920044.6A GB9920044D0 (en) | 1998-10-23 | 1999-08-24 | Biciclic nitrogen heterocycles |
| PCT/EP1999/007675 WO2000024744A1 (en) | 1998-10-23 | 1999-10-13 | Bicyclic nitrogen heterocycles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE277931T1 true ATE277931T1 (de) | 2004-10-15 |
Family
ID=26314565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99953796T ATE277931T1 (de) | 1998-10-23 | 1999-10-13 | Bicyclische stickstoffheteroaryl verbindungen |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6150373A (de) |
| EP (1) | EP1123295B1 (de) |
| JP (1) | JP3593035B2 (de) |
| CN (1) | CN1150195C (de) |
| AT (1) | ATE277931T1 (de) |
| AU (1) | AU769989B2 (de) |
| BR (1) | BR9914677A (de) |
| CA (1) | CA2347474C (de) |
| CZ (1) | CZ20011394A3 (de) |
| DE (1) | DE69920732T2 (de) |
| ES (1) | ES2228123T3 (de) |
| HK (1) | HK1041483B (de) |
| HR (1) | HRP20010274A2 (de) |
| HU (1) | HUP0104199A3 (de) |
| ID (1) | ID28276A (de) |
| MA (1) | MA27678A1 (de) |
| MY (1) | MY126478A (de) |
| NO (1) | NO318802B1 (de) |
| NZ (1) | NZ510760A (de) |
| PL (1) | PL347432A1 (de) |
| PT (1) | PT1123295E (de) |
| RU (1) | RU2256662C2 (de) |
| TR (1) | TR200101102T2 (de) |
| TW (1) | TWI227235B (de) |
| WO (1) | WO2000024744A1 (de) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW517055B (en) * | 1997-07-02 | 2003-01-11 | Smithkline Beecham Corp | Novel substituted imidazole compounds |
| EP1037639A4 (de) | 1997-12-19 | 2002-04-17 | Smithkline Beecham Corp | Heteroaryl-substituierte imidazol-verbindungen, deren pharmazeutische zusammensetzungen und verwendungen |
| US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US20040044012A1 (en) * | 1998-05-26 | 2004-03-04 | Dobrusin Ellen Myra | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
| EA003640B1 (ru) | 1998-05-26 | 2003-08-28 | Варнер-Ламберт Компани | Бициклические пиримидины и бициклические 3,4-дигидропиримидины как ингибиторы клеточной пролиферации |
| ES2221426T3 (es) | 1998-08-20 | 2004-12-16 | Smithkline Beecham Corporation | Nuevos compuestos de triazol sustituidos. |
| WO2000025791A1 (en) * | 1998-11-04 | 2000-05-11 | Smithkline Beecham Corporation | Pyridin-4-yl or pyrimidin-4-yl substituted pyrazines |
| ATE349447T1 (de) | 1999-10-21 | 2007-01-15 | Hoffmann La Roche | Alkylamino-substituierte bicyclische heterocyclen als p38 protein kinase inhibitoren |
| AU776250B2 (en) * | 1999-10-21 | 2004-09-02 | F. Hoffmann-La Roche Ag | Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of P38 protein kinase |
| JP2003514899A (ja) | 1999-11-23 | 2003-04-22 | スミスクライン・ビーチャム・コーポレイション | ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４‐ジヒドロ−（１Ｈ）−キナゾリン−２−オン化合物 |
| AU1782301A (en) | 1999-11-23 | 2001-06-04 | Smithkline Beecham Corporation | 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p39 kinase inhibitors |
| US6759410B1 (en) * | 1999-11-23 | 2004-07-06 | Smithline Beecham Corporation | 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors |
| AU1783201A (en) | 1999-11-23 | 2001-06-04 | Smithkline Beecham Corporation | 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors |
| US7101869B2 (en) | 1999-11-30 | 2006-09-05 | Pfizer Inc. | 2,4-diaminopyrimidine compounds useful as immunosuppressants |
| AR030053A1 (es) * | 2000-03-02 | 2003-08-13 | Smithkline Beecham Corp | 1h-pirimido [4,5-d] pirimidin-2-onas y sales, composiciones farmaceuticas, uso para la fabricacion de un medicamento y procedimiento para producirlas |
| US7235551B2 (en) * | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
| BR0114829A (pt) | 2000-10-23 | 2003-09-23 | Smithkline Beecham Corp | Novos compostos |
| EP1368028B1 (de) | 2001-03-12 | 2007-08-15 | Avanir Pharmaceuticals | Benzimidazolderivate zur ige-modulierung und zellproliferationshemmung |
| US7119111B2 (en) * | 2002-05-29 | 2006-10-10 | Amgen, Inc. | 2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use |
| US7196090B2 (en) * | 2002-07-25 | 2007-03-27 | Warner-Lambert Company | Kinase inhibitors |
| DE10235312A1 (de) * | 2002-08-01 | 2004-02-12 | Basf Ag | Verfahren zur Herstellung von Aminoalkoxybenzylaminen und Aminoalkoxybenzonitrilen als Zwischenprodukte |
| US7084270B2 (en) | 2002-08-14 | 2006-08-01 | Hoffman-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| WO2004024655A2 (en) | 2002-09-12 | 2004-03-25 | Avanir Pharmaceuticals | Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation |
| TW200413381A (en) | 2002-11-04 | 2004-08-01 | Hoffmann La Roche | Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents |
| US7112676B2 (en) | 2002-11-04 | 2006-09-26 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| US7098332B2 (en) | 2002-12-20 | 2006-08-29 | Hoffmann-La Roche Inc. | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones |
| RU2350617C2 (ru) * | 2003-04-10 | 2009-03-27 | Ф.Хоффманн-Ля Рош Аг | Пиримидиновые соединения, обладающие свойствами селективного ингибирования активности кдр и фрфр |
| ATE452121T1 (de) * | 2003-04-23 | 2010-01-15 | Japan Tobacco Inc | Casr-antagonist |
| BRPI0413005A (pt) | 2003-07-29 | 2006-09-26 | Irm Llc | compostos e composições como inibidores da proteìna cinase |
| WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
| KR100853975B1 (ko) * | 2004-08-31 | 2008-08-25 | 에프. 호프만-라 로슈 아게 | 3-페닐 디히드로피리미도[4,5-ｄ]피리미디논의 아미드유도체, 이의 제조 방법 및 약제로서의 용도 |
| US7494993B2 (en) | 2004-08-31 | 2009-02-24 | Hoffmann-La Roche Inc. | Amide derivatives of 7-amino-3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents |
| TWI389690B (zh) | 2005-03-25 | 2013-03-21 | Glaxo Group Ltd | 新穎化合物（一） |
| US8058283B2 (en) | 2006-01-31 | 2011-11-15 | Hoffmann-La Roche Inc. | 7H-pyrido[3,4-D]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors |
| US7897762B2 (en) * | 2006-09-14 | 2011-03-01 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of proliferative diseases |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| CN102816162B (zh) * | 2011-06-10 | 2016-04-27 | 中国科学院广州生物医药与健康研究院 | 嘧啶并嘧啶酮类化合物及其药用组合物和应用 |
| GB201204384D0 (en) | 2012-03-13 | 2012-04-25 | Univ Dundee | Anti-flammatory agents |
| SI2861595T1 (sl) | 2012-06-13 | 2017-04-26 | Incyte Holdings Corporation | Substituirane triciklične spojine kot inhibitorji fgfr |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| SG11201507478VA (en) | 2013-03-15 | 2015-10-29 | Celgene Avilomics Res Inc | Heteroaryl compounds and uses thereof |
| US9321786B2 (en) | 2013-03-15 | 2016-04-26 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| CA2907243C (en) | 2013-03-15 | 2021-12-28 | Celgene Avilomics Research, Inc. | Substituted dihydropyrimidopyrimidinone compounds and pharmaceutical compositions thereof use fgfr4 inhibitor |
| ES2657451T3 (es) | 2013-04-19 | 2018-03-05 | Incyte Holdings Corporation | Heterocíclicos bicíclicos como inhibidores del FGFR |
| CA2954187C (en) | 2014-07-21 | 2022-08-16 | Dana-Farber Cancer Institute, Inc. | Macrocyclic kinase inhibitors and uses thereof |
| CA2954186A1 (en) | 2014-07-21 | 2016-01-28 | Dana-Farber Cancer Institute, Inc. | Imidazolyl kinase inhibitors and uses thereof |
| CA2955082A1 (en) | 2014-08-08 | 2016-02-11 | Dana-Farber Cancer Institute, Inc. | Uses of salt-inducible kinase (sik) inhibitors |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| CA2976790C (en) | 2015-02-20 | 2024-02-27 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2017031116A1 (en) * | 2015-08-18 | 2017-02-23 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Small molecule inhibitors of ku70/80 and uses thereof |
| ES2920823T3 (es) * | 2016-07-05 | 2022-08-10 | Broad Inst Inc | Inhibidores bicíclicos de la urea quinasa y usos de los mismos |
| US11241435B2 (en) | 2016-09-16 | 2022-02-08 | The General Hospital Corporation | Uses of salt-inducible kinase (SIK) inhibitors for treating osteoporosis |
| CN111163771B (zh) | 2017-02-28 | 2023-07-14 | 通用医疗公司 | 嘧啶并嘧啶酮类作为sik抑制剂的用途 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| CA3087886A1 (en) | 2018-01-19 | 2019-07-25 | Idorsia Pharmaceuticals Ltd | C5a receptor modulators |
| CN111683937A (zh) * | 2018-01-19 | 2020-09-18 | 爱杜西亚药品有限公司 | C5a受体调节剂 |
| MX2020011639A (es) | 2018-05-04 | 2021-02-15 | Incyte Corp | Sales de un inhibidor de receptores de factor de crecimiento de fibroblastos (fgfr). |
| KR20210018265A (ko) | 2018-05-04 | 2021-02-17 | 인사이트 코포레이션 | Fgfr 억제제의 고체 형태 및 이의 제조 방법 |
| TW202039489A (zh) * | 2018-12-27 | 2020-11-01 | 美商阿吉歐斯製藥公司 | Mat2a之雜雙環抑制劑及用於治療癌症之使用方法 |
| US20230048132A1 (en) * | 2018-12-28 | 2023-02-16 | Spv Therapeutics Inc. | Cyclin-dependent kinase inhibitors |
| US20230065740A1 (en) | 2018-12-28 | 2023-03-02 | Spv Therapeutics Inc. | Cyclin-dependent kinase inhibitors |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021011778A1 (en) * | 2019-07-16 | 2021-01-21 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Small molecule inhibitors of ku70/80 and uses thereof |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| JP7675711B2 (ja) | 2019-10-14 | 2025-05-13 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤としての二環式複素環 |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| GB201915828D0 (en) | 2019-10-31 | 2019-12-18 | Cancer Research Tech Ltd | Compounds, compositions and therapeutic uses thereof |
| CR20220285A (es) | 2019-12-04 | 2022-10-27 | Incyte Corp | Derivados de un inhibidor de fgfr |
| WO2021113479A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US20230192701A1 (en) * | 2020-04-28 | 2023-06-22 | Iomx Therapeutics Ag | Bicyclic kinase inhibitors and uses thereof |
| JP2024513575A (ja) | 2021-04-12 | 2024-03-26 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤及びネクチン－４標的化剤を含む併用療法 |
| AR126102A1 (es) | 2021-06-09 | 2023-09-13 | Incyte Corp | Heterociclos tricíclicos como inhibidores de fgfr |
| EP4352060A1 (de) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclische heterocyclen als fgfr-inhibitoren |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69031337T2 (de) * | 1989-02-27 | 1998-03-05 | Biocryst | 9-substituierte-8-unsubstituierte-9-deazaguanine |
| US5679683A (en) * | 1994-01-25 | 1997-10-21 | Warner-Lambert Company | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| IL117923A (en) * | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| GB9619284D0 (en) * | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
| WO1998028281A1 (en) * | 1996-12-23 | 1998-07-02 | Celltech Therapeutics Limited | Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors |
| EA003640B1 (ru) * | 1998-05-26 | 2003-08-28 | Варнер-Ламберт Компани | Бициклические пиримидины и бициклические 3,4-дигидропиримидины как ингибиторы клеточной пролиферации |
-
1999
- 1999-10-13 AT AT99953796T patent/ATE277931T1/de not_active IP Right Cessation
- 1999-10-13 RU RU2001113444/04A patent/RU2256662C2/ru not_active IP Right Cessation
- 1999-10-13 HK HK02103084.9A patent/HK1041483B/zh not_active IP Right Cessation
- 1999-10-13 BR BR9914677-0A patent/BR9914677A/pt not_active IP Right Cessation
- 1999-10-13 ES ES99953796T patent/ES2228123T3/es not_active Expired - Lifetime
- 1999-10-13 PT PT99953796T patent/PT1123295E/pt unknown
- 1999-10-13 JP JP2000578314A patent/JP3593035B2/ja not_active Expired - Fee Related
- 1999-10-13 NZ NZ510760A patent/NZ510760A/en unknown
- 1999-10-13 HU HU0104199A patent/HUP0104199A3/hu unknown
- 1999-10-13 CA CA002347474A patent/CA2347474C/en not_active Expired - Fee Related
- 1999-10-13 AU AU10363/00A patent/AU769989B2/en not_active Ceased
- 1999-10-13 ID IDW20010903A patent/ID28276A/id unknown
- 1999-10-13 CN CNB998124702A patent/CN1150195C/zh not_active Expired - Fee Related
- 1999-10-13 DE DE69920732T patent/DE69920732T2/de not_active Expired - Fee Related
- 1999-10-13 CZ CZ20011394A patent/CZ20011394A3/cs unknown
- 1999-10-13 WO PCT/EP1999/007675 patent/WO2000024744A1/en not_active Ceased
- 1999-10-13 EP EP99953796A patent/EP1123295B1/de not_active Expired - Lifetime
- 1999-10-13 PL PL99347432A patent/PL347432A1/xx not_active Application Discontinuation
- 1999-10-13 TR TR2001/01102T patent/TR200101102T2/xx unknown
- 1999-10-13 HR HR20010274A patent/HRP20010274A2/hr not_active Application Discontinuation
- 1999-10-21 MY MYPI99004545A patent/MY126478A/en unknown
- 1999-10-21 US US09/422,451 patent/US6150373A/en not_active Expired - Fee Related
- 1999-11-03 TW TW088119157A patent/TWI227235B/zh active
-
2001
- 2001-04-19 NO NO20011929A patent/NO318802B1/no unknown
- 2001-04-20 MA MA26172A patent/MA27678A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0104199A3 (en) | 2002-12-28 |
| CZ20011394A3 (cs) | 2001-12-12 |
| MA27678A1 (fr) | 2006-01-02 |
| ES2228123T3 (es) | 2005-04-01 |
| CA2347474A1 (en) | 2000-05-04 |
| CN1324360A (zh) | 2001-11-28 |
| AU769989B2 (en) | 2004-02-12 |
| DE69920732T2 (de) | 2006-02-23 |
| WO2000024744A1 (en) | 2000-05-04 |
| PL347432A1 (en) | 2002-04-08 |
| EP1123295B1 (de) | 2004-09-29 |
| US6150373A (en) | 2000-11-21 |
| BR9914677A (pt) | 2001-07-17 |
| TR200101102T2 (tr) | 2002-01-21 |
| EP1123295A1 (de) | 2001-08-16 |
| JP3593035B2 (ja) | 2004-11-24 |
| NO20011929D0 (no) | 2001-04-19 |
| TWI227235B (en) | 2005-02-01 |
| JP2002528455A (ja) | 2002-09-03 |
| DE69920732D1 (de) | 2004-11-04 |
| ID28276A (id) | 2001-05-10 |
| HK1041483A1 (en) | 2002-07-12 |
| NZ510760A (en) | 2003-08-29 |
| HUP0104199A2 (hu) | 2002-04-29 |
| PT1123295E (pt) | 2005-01-31 |
| NO20011929L (no) | 2001-04-19 |
| CA2347474C (en) | 2008-08-26 |
| CN1150195C (zh) | 2004-05-19 |
| RU2256662C2 (ru) | 2005-07-20 |
| HK1041483B (zh) | 2004-12-24 |
| NO318802B1 (no) | 2005-05-09 |
| HRP20010274A2 (en) | 2002-06-30 |
| AU1036300A (en) | 2000-05-15 |
| MY126478A (en) | 2006-10-31 |
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