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HUP0104199A2 - Szubsztituált pirimido-pirimidinon-származékok, ezeket tartalmazó gyógyszerkészítmények, eljárás előállításukra, valamint intermedierek - Google Patents

Szubsztituált pirimido-pirimidinon-származékok, ezeket tartalmazó gyógyszerkészítmények, eljárás előállításukra, valamint intermedierek

Info

Publication number
HUP0104199A2
HUP0104199A2 HU0104199A HUP0104199A HUP0104199A2 HU P0104199 A2 HUP0104199 A2 HU P0104199A2 HU 0104199 A HU0104199 A HU 0104199A HU P0104199 A HUP0104199 A HU P0104199A HU P0104199 A2 HUP0104199 A2 HU P0104199A2
Authority
HU
Hungary
Prior art keywords
alkyl
heteroaryl
aryl
intermediates
preparation
Prior art date
Application number
HU0104199A
Other languages
English (en)
Inventor
William Harris
Christopher Huw Hill
Ian Edward David Smith
Original Assignee
F.Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26314565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0104199(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9823277.0A external-priority patent/GB9823277D0/en
Application filed by F.Hoffmann-La Roche Ag. filed Critical F.Hoffmann-La Roche Ag.
Publication of HUP0104199A2 publication Critical patent/HUP0104199A2/hu
Publication of HUP0104199A3 publication Critical patent/HUP0104199A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Inorganic Insulating Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

(I) ltal nos képletű vegyületek[mely képletben R1 jelentésehidrogénatom, alkil-, aril-, aril-, alkil-, heteroaril-, heteroaril-,alkil-, cikloalkil- vagy cikloalkil-alkilcsoport; R2 jelentése alkil-,aril-, aril-, alkil-, heteroaril-, heteroaril- ,alkil-, cikloalkil-vagy cikloalkil-alkilcsoport; és R3 jelentése hidrogénatom, alkil-,aril-, aril-, alkil-, heteroaril-, heteroaril, alkil-, cikloalkil-,cikloalkenil- vagy cikloalkil-alkilcsoport; a gyógy szatban gyulladsos, immunológiai, onkológiai, bronchopulmon ris, dermatológiai éskardiovaszkul ris rendellenességek kezelésére vagy megelőzésére;asztma, k"zponti idegrendszeri rendellenességek vagy diabéteszeskomplik ciók kezelésére; vagy transzplant ciós sebészeti beavatkoz stk"vető graft kil"kődés megelőzésére alkalmazhatók. A tal lm ny t rgy tképezik teh t a fenti vegyületek, az ezeket tartalmazógyógyszerkészítmények, elj r s ezek elő llít s ra, valamint avegyületek elő llít sakor hasznos intermedierek. Ó
HU0104199A 1998-10-23 1999-10-13 Substituted pyrimido pyrimidinone derivatives, pharmaceutical compositions containing the same, process for the preparation thereof and intermediates HUP0104199A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9823277.0A GB9823277D0 (en) 1998-10-23 1998-10-23 Bicycle nitrogen heterocycles
GBGB9920044.6A GB9920044D0 (en) 1998-10-23 1999-08-24 Biciclic nitrogen heterocycles
PCT/EP1999/007675 WO2000024744A1 (en) 1998-10-23 1999-10-13 Bicyclic nitrogen heterocycles

Publications (2)

Publication Number Publication Date
HUP0104199A2 true HUP0104199A2 (hu) 2002-04-29
HUP0104199A3 HUP0104199A3 (en) 2002-12-28

Family

ID=26314565

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0104199A HUP0104199A3 (en) 1998-10-23 1999-10-13 Substituted pyrimido pyrimidinone derivatives, pharmaceutical compositions containing the same, process for the preparation thereof and intermediates

Country Status (25)

Country Link
US (1) US6150373A (hu)
EP (1) EP1123295B1 (hu)
JP (1) JP3593035B2 (hu)
CN (1) CN1150195C (hu)
AT (1) ATE277931T1 (hu)
AU (1) AU769989B2 (hu)
BR (1) BR9914677A (hu)
CA (1) CA2347474C (hu)
CZ (1) CZ20011394A3 (hu)
DE (1) DE69920732T2 (hu)
ES (1) ES2228123T3 (hu)
HK (1) HK1041483B (hu)
HR (1) HRP20010274A2 (hu)
HU (1) HUP0104199A3 (hu)
ID (1) ID28276A (hu)
MA (1) MA27678A1 (hu)
MY (1) MY126478A (hu)
NO (1) NO318802B1 (hu)
NZ (1) NZ510760A (hu)
PL (1) PL347432A1 (hu)
PT (1) PT1123295E (hu)
RU (1) RU2256662C2 (hu)
TR (1) TR200101102T2 (hu)
TW (1) TWI227235B (hu)
WO (1) WO2000024744A1 (hu)

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Also Published As

Publication number Publication date
JP3593035B2 (ja) 2004-11-24
EP1123295B1 (en) 2004-09-29
RU2256662C2 (ru) 2005-07-20
WO2000024744A1 (en) 2000-05-04
CA2347474A1 (en) 2000-05-04
CN1324360A (zh) 2001-11-28
MA27678A1 (fr) 2006-01-02
CN1150195C (zh) 2004-05-19
NO20011929L (no) 2001-04-19
AU769989B2 (en) 2004-02-12
HUP0104199A3 (en) 2002-12-28
HK1041483B (zh) 2004-12-24
PT1123295E (pt) 2005-01-31
DE69920732D1 (de) 2004-11-04
JP2002528455A (ja) 2002-09-03
TWI227235B (en) 2005-02-01
HRP20010274A2 (en) 2002-06-30
US6150373A (en) 2000-11-21
DE69920732T2 (de) 2006-02-23
AU1036300A (en) 2000-05-15
NO20011929D0 (no) 2001-04-19
CA2347474C (en) 2008-08-26
NZ510760A (en) 2003-08-29
ES2228123T3 (es) 2005-04-01
ATE277931T1 (de) 2004-10-15
MY126478A (en) 2006-10-31
ID28276A (id) 2001-05-10
BR9914677A (pt) 2001-07-17
CZ20011394A3 (cs) 2001-12-12
HK1041483A1 (en) 2002-07-12
PL347432A1 (en) 2002-04-08
EP1123295A1 (en) 2001-08-16
TR200101102T2 (tr) 2002-01-21
NO318802B1 (no) 2005-05-09

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