[go: up one dir, main page]

GT199900216A - Polimorfos de acido 2-(3-ciano-4-isobutiloxifenil)-4-metil-5-tiazol carboxilico y metodo de produccion de los mismos. - Google Patents

Polimorfos de acido 2-(3-ciano-4-isobutiloxifenil)-4-metil-5-tiazol carboxilico y metodo de produccion de los mismos.

Info

Publication number
GT199900216A
GT199900216A GT199900216A GT199900216A GT199900216A GT 199900216 A GT199900216 A GT 199900216A GT 199900216 A GT199900216 A GT 199900216A GT 199900216 A GT199900216 A GT 199900216A GT 199900216 A GT199900216 A GT 199900216A
Authority
GT
Guatemala
Prior art keywords
polymorphes
acid
isobutiloxifenil
tiazol
ciano
Prior art date
Application number
GT199900216A
Other languages
English (en)
Inventor
Matsumoto Koichi
Watanabe Kenzo
Hiramatsu Toshiyuki
Kitamura Mitsutaka
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15953825&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT199900216(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teijin Ltd filed Critical Teijin Ltd
Publication of GT199900216A publication Critical patent/GT199900216A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCION PROVEE UNA TECNICA PARA PRODUCIR SELECTIVAMENTE UN POLIMORFO DESEADO DE ACIDO 2(CIANO4ISOBUTILOXIFENIL)4METIL5TIAZOL CARBOXILICO (VER FÒRMULA I). ESTA PROVEE TAMBIEN UN METODO PARA PRODUCIR VARIOS POLIMORFOS, QUE COMPRENDE CRISTALIZAR BAJO LAS CONDICIONES DEFINIDAS POR UNA TEMPERATURA ESPECIFICA Y UNA COMPOSICION DE UN SOLVENTE MIXTO DE METANOL Y AGUA, Y LOS POLIMORFOS OBTENIDOS POR EL MEODO.
GT199900216A 1998-06-19 1999-12-16 Polimorfos de acido 2-(3-ciano-4-isobutiloxifenil)-4-metil-5-tiazol carboxilico y metodo de produccion de los mismos. GT199900216A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17307998 1998-06-19

Publications (1)

Publication Number Publication Date
GT199900216A true GT199900216A (es) 2001-06-08

Family

ID=15953825

Family Applications (1)

Application Number Title Priority Date Filing Date
GT199900216A GT199900216A (es) 1998-06-19 1999-12-16 Polimorfos de acido 2-(3-ciano-4-isobutiloxifenil)-4-metil-5-tiazol carboxilico y metodo de produccion de los mismos.

Country Status (39)

Country Link
US (1) US6225474B1 (es)
EP (4) EP1020454B2 (es)
JP (1) JP3547707B2 (es)
KR (1) KR100511183B1 (es)
CN (3) CN1275126A (es)
AT (2) ATE522512T2 (es)
AU (1) AU748026B2 (es)
BE (1) BE2010C024I2 (es)
BG (1) BG64734B1 (es)
BR (1) BR9906539A (es)
CA (2) CA2566652C (es)
CY (3) CY1109720T1 (es)
CZ (1) CZ298170B6 (es)
DE (2) DE69941672D1 (es)
DK (3) DK1956015T4 (es)
ES (3) ES2336287T5 (es)
FR (1) FR10C0022I2 (es)
GT (1) GT199900216A (es)
HK (2) HK1029788A1 (es)
HR (2) HRP20000092C1 (es)
HU (2) HU230799B1 (es)
ID (1) ID25775A (es)
IL (1) IL134594A (es)
IN (1) IN191537B (es)
IS (4) IS9020A (es)
LT (1) LT1956014T (es)
LU (1) LU91682I2 (es)
NO (1) NO321308B1 (es)
NZ (1) NZ503326A (es)
PL (1) PL200710B1 (es)
PT (3) PT1956014T (es)
RU (1) RU2198169C3 (es)
SI (3) SI1956015T2 (es)
SK (2) SK287928B6 (es)
TR (1) TR200000458T1 (es)
TW (1) TWI248439B (es)
UA (1) UA57611C2 (es)
WO (1) WO1999065885A1 (es)
ZA (1) ZA200000737B (es)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69941672D1 (de) 1998-06-19 2010-01-07 Teijin Ltd Polymorphe modifikationen der 2-(3-cyano-4-isobutylphenyl)-4-methyl-5-thiazol-carbonsäure und verfahren zu ihrer herstellung
BR0211061A (pt) * 2001-07-10 2004-07-20 Upjohn Co Cristais de tiazina oxazolidinonas e processos para isolar tais cristais
CN100364991C (zh) 2001-08-15 2008-01-30 法玛西雅厄普约翰美国公司 2,4-二甲基-1h-吡咯-3-甲酰胺衍生物的苹果酸盐的晶体、其制备方法和其组合物
AU2003223158B2 (en) * 2002-01-09 2008-01-17 Emisphere Technologies, Inc. Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate
JP2003261548A (ja) * 2002-03-07 2003-09-19 Teijin Ltd ２−（３−シアノ−４−イソブチルオキシフェニル）−４−メチル−５−チアゾールカルボン酸の結晶多形体の製造方法
US7361676B2 (en) * 2002-03-28 2008-04-22 Teijin Limited Solid preparation containing single crystal form
CA2607953A1 (en) * 2005-05-09 2006-11-16 Tap Pharmaceutical Products, Inc. Methods for treating nephrolithiasis
CN100430055C (zh) * 2005-11-11 2008-11-05 天津泰普药品科技发展有限公司 2-(3-氰基-4-异丁氧基苯基)-4-甲基-5-噻唑甲酸和聚乙烯吡咯烷酮玻璃态固溶体及其制备方法
US8148542B2 (en) 2006-06-23 2012-04-03 Teijin Pharma Limited Method for producing crystal polymorphs of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid
CN101139325B (zh) * 2006-09-07 2010-05-12 上海医药工业研究院 2-(3-氰基-4-异丁氧基苯基)-4-甲基-5-噻唑甲酸晶型及其制备方法
CN101812035B (zh) * 2006-09-07 2012-03-21 上海医药工业研究院 2-(3-氰基-4-异丁氧基苯基)-4-甲基-5-噻唑甲酸晶型及其制备方法
US20080269226A1 (en) * 2006-11-13 2008-10-30 Christopher Lademacher Methods for Preserving Renal Function Using Xanthine Oxidoreductase Inhibitors
US20090124623A1 (en) * 2006-11-13 2009-05-14 Christopher Lademacher Methods for preserving and/or increasing renal function using xanthine oxidoreductase inhibitors
CN102093309B (zh) * 2006-12-07 2012-07-04 重庆医药工业研究院有限责任公司 非布司他的晶型及其制备方法
CN102093308B (zh) * 2006-12-07 2012-08-29 重庆医药工业研究院有限责任公司 非布司他的晶型及其制备方法
CN1970547B (zh) * 2006-12-07 2011-04-06 重庆医药工业研究院有限责任公司 非布司他的晶型及其制备方法
BRPI0806608A2 (pt) * 2007-01-19 2011-09-06 Takeda Pharmaceuticals North America Inc métodos para prevenir ou reduzir o número de surtos agudos de gota utilizando inibidores xantina oxidoredutase e agentes anti-inflamatórios
CN101412700B (zh) * 2007-10-19 2011-06-08 上海医药工业研究院 非布司他的晶型及其制备方法
CN101386605B (zh) * 2008-10-23 2010-09-08 中国科学院上海药物研究所 非布司他新型晶体及其制备方法
CN101759656B (zh) * 2008-12-12 2013-04-03 重庆医药工业研究院有限责任公司 非布司他新晶型及其制备方法
CN101768150B (zh) * 2009-01-05 2014-08-06 常州市第四制药厂有限公司 2-[3-氰基-4-异丁氧基苯基]-4-甲基噻唑-5-甲酸晶型及其制备方法
US20100311756A1 (en) * 2009-01-22 2010-12-09 Takeda Pharmaceuticals North America, Inc. Methods for delaying the progression of at least one of cardiac hypertrophy, cardiac remodeling or left ventricular function or the onset of heart failure in subjects in need of treatment thereof
CN101891702B (zh) * 2009-05-22 2012-07-04 重庆圣华曦药业股份有限公司 非布司他的晶体、制备方法及在药物中的应用
US8415481B2 (en) * 2009-06-10 2013-04-09 Teva Pharmaceuticals Usa, Inc. Crystalline form of febuxostat
JP5519201B2 (ja) * 2009-07-15 2014-06-11 光孝 北村 ２−（３−シアノ−４−イソブチルオキシフェニル）−４−メチル−５−チアゾールカルボン酸の結晶多形体の製造方法
TWI516480B (zh) * 2009-07-15 2016-01-11 Teijin Pharma Ltd A method for producing a crystalline polymorph of 2- (3-cyano-4-isobutyloxyphenyl) -4-methyl-5-thiazolecarboxylic acid by a poor solvent addition method
CN103936689B (zh) * 2009-07-17 2016-08-17 北京利乐生制药科技有限公司 2-[3-氰基-4-异丁氧基苯基]-4-甲基噻唑-5-甲酸晶型及其制备方法
WO2011080651A2 (en) 2009-12-31 2011-07-07 Ranbaxy Laboratories Limited Polymorphic forms of febuxostat
US20130190366A1 (en) 2010-02-19 2013-07-25 Cadila Healthcare Limited Substantially pure salts of febuxostat and processes for preparation thereof
EP2542540A1 (en) 2010-03-04 2013-01-09 Ranbaxy Laboratories Limited Polymorph of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid
WO2011134101A1 (zh) * 2010-04-27 2011-11-03 上海凯米侬医药科技有限公司 一种非布索坦的新晶型n及其制备方法
CN101824005B (zh) * 2010-04-27 2012-06-27 上海凯米侬医药科技有限公司 一种非布索坦的晶型q及其制备方法
EP2563768A4 (en) * 2010-04-29 2013-07-31 Reddys Lab Ltd Dr MANUFACTURE OF FEBUXOSTAT
IT1400310B1 (it) 2010-05-10 2013-05-24 Menarini Int Operations Lu Sa Associazione di inibitori della xantina ossidasi e statine e loro uso.
IT1400609B1 (it) 2010-05-10 2013-06-14 Menarini Int Operations Lu Sa Associazione di inibitori della xantina ossidasi e metformina e loro uso.
IT1400309B1 (it) 2010-05-10 2013-05-24 Menarini Int Operations Lu Sa Associazione di inibitori della xantina ossidasi e calcio antagonisti e loro uso.
IT1400311B1 (it) 2010-05-10 2013-05-24 Menarini Int Operations Lu Sa Associazione di inibitori della xantina ossidasi e antagonisti del recettore dell'angiotensina ii e loro uso.
PL2399911T3 (pl) 2010-06-25 2016-01-29 Sandoz Ag Polimorfy febuksostatu
TW201217347A (en) 2010-07-13 2012-05-01 Interquim Sa Process for preparing the crystalline form a of febuxostat
WO2012020272A2 (en) 2010-08-13 2012-02-16 EGIS GYÓGYSZERGYÁR Nyilvánosan Müködö Részvénytársaság New salts, polymorphs and solvates of a pharmaceutical active ingredient
CN103298466B (zh) 2010-09-10 2015-11-25 武田制药美国有限公司 茶碱和非布索坦的联合治疗方法
EP2619191A4 (en) * 2010-09-24 2014-03-26 Hetero Research Foundation NEW POLYMORPHS OF FEBUXOSTAT
CN102442971B (zh) * 2010-10-13 2014-06-18 欣凯医药化工中间体（上海）有限公司 非布司他的晶型及其制备方法
WO2012048861A1 (en) 2010-10-14 2012-04-19 Gador S.A. A novel febuxostat crystalline form and the process for the preparation thereof
EP2632270A1 (en) * 2010-10-28 2013-09-04 Mapi Pharma Limited Polymorphs of febuxostat
TWI520732B (zh) * 2011-01-18 2016-02-11 輝瑞有限公司 固體分子分散液
CN102127033A (zh) * 2011-01-21 2011-07-20 北京虹湾医药技术有限公司 非布索坦晶型及其工业化制备方法
EP2502920A1 (en) 2011-03-25 2012-09-26 Sandoz Ag Crystallization process of Febuxostat from A
WO2012131590A1 (en) 2011-03-31 2012-10-04 Sandoz Ag An improved process for preparation of febuxostat and its polymorphic crystalline form c thereof
US20150031732A1 (en) 2011-04-15 2015-01-29 Ranbaxy Laboratories Limited Febuxostat solid dispersion
WO2012153313A1 (en) 2011-05-11 2012-11-15 Ranbaxy Laboratories Limited Pharmaceutical composition of febuxostat
WO2012168948A2 (en) * 2011-06-06 2012-12-13 Hetero Research Foundation Process for febuxostat
WO2012172461A1 (en) 2011-06-13 2012-12-20 Ranbaxy Laboratories Limited Pharmaceutical compositions of febuxostat
CN104114545B (zh) 2011-11-15 2018-06-01 迈兰实验室有限公司 用于制备非布索坦多晶型物的方法
WO2013088449A1 (en) * 2011-12-16 2013-06-20 Natco Pharma Limited Stable crystal form of febuxostat and process for the preparation thereof
EP2925306A1 (en) 2012-07-12 2015-10-07 Alembic Pharmaceuticals Limited Pharmaceutical composition of febuxostat
EP2692342A1 (en) 2012-07-30 2014-02-05 Interquim, S.A. Process for the preparation of pharmaceutical compositions comprising febuxostat in the form of tablets
WO2014057461A1 (en) 2012-10-11 2014-04-17 Ranbaxy Laboratories Limited Process for the preparation of crystalline form g of febuxostat
CN103936688A (zh) * 2013-01-21 2014-07-23 上海华拓医药科技发展股份有限公司 2-(3-氰基-4-(2-甲基丙氧基)苯基)-4-甲基-5-噻唑甲酸a晶的制备方法
DK2980085T3 (en) * 2013-03-29 2018-05-22 Teijin Pharma Ltd pyrazole
CN103396378B (zh) * 2013-07-29 2015-06-10 杭州朱养心药业有限公司 非布司他结晶
CN103588724B (zh) * 2013-09-10 2015-05-20 杭州华东医药集团新药研究院有限公司 一种非布司他晶型a及其制备方法
RU2016119523A (ru) * 2013-10-22 2017-11-28 Ниппон Кемифар Ко., Лтд. Мелкие кристаллы 2-[3-циано-4-(2-метилпропокси)фенил]-4-метилтиазол-5-карбоновой кислоты, продукт их тонкого измельчения и содержащие их твердые препараты
EP2881116A1 (en) 2013-12-05 2015-06-10 Ranbaxy Laboratories Limited Febuxostat composition
EP2902016A1 (en) 2014-01-30 2015-08-05 Alfred E. Tiefenbacher (GmbH & Co. KG) Febuxostat tablet
CN103739568B (zh) * 2014-02-07 2015-09-16 浙江普洛康裕制药有限公司 2-(3-氰基-4-异丁氧基苯基)-4-甲基噻唑-5-甲酸a晶型的制备方法
CA2956553C (en) 2014-07-30 2023-03-21 Teijin Pharma Limited A 1h-1,2,3,4-tetrazole benzene derivative, crystalline forms thereof, and its use as a xanthine oxidase inhibitor
EP3002006A1 (en) 2014-10-01 2016-04-06 Bluepharma - Industria Farmacêutica, S.A. Pharmaceutical composition capable for the incorporation Febuxostat in the crystalline modifications F10, II, G and A
CZ27857U1 (cs) 2014-12-12 2015-02-23 Zentiva, K.S. Formulace obsahující tuhý roztok febuxostatu
JP2016150917A (ja) * 2015-02-17 2016-08-22 株式会社トクヤマ バルサルタンの結晶の製造方法
WO2016171254A1 (ja) * 2015-04-22 2016-10-27 日本ケミファ株式会社 ２－［３－シアノ－４－（２－メチルプロポキシ）フェニル］－４－メチルチアゾール－５－カルボン酸の結晶、その製造方法、及びそれらの利用
EP3153158A1 (de) 2015-10-09 2017-04-12 Stada Arzneimittel Ag Orale febuxostat-tablette
CN107540630A (zh) * 2016-06-29 2018-01-05 康普药业股份有限公司 一种非布司他化合物及制备方法
GR1009119B (el) 2016-06-30 2017-09-18 "Φαρματεν Α.Β.Ε.Ε." Φαρμακευτικο σκευασμα περιεχον ενα μη πουρινικο επιλεκτικο αναστολεα της οξειδασης της ξανθινης και μεθοδος παρασκευης αυτου
KR20180013563A (ko) * 2016-07-29 2018-02-07 한미정밀화학주식회사 고순도 결정형 페북소스타트의 개선된 제조 방법
CN106565627B (zh) * 2016-10-10 2020-01-10 扬子江药业集团有限公司 一种非布司他药用晶型的制备方法
GR1009659B (el) 2018-09-07 2019-11-28 Φαρματεν Α.Β.Ε.Ε. Φαρμακευτικο σκευασμα που περιλαμβανει ενα συμπλοκο αλατος της φεβουξοστατης με οξειδιο του μαγνησιου και μεθοδος για την παρασκευη αυτου
CN113166017B (zh) * 2018-09-28 2024-03-29 株式会社钟化 稳定性优异的还原型辅酶q10结晶的制造方法
CN112390766B (zh) * 2019-08-13 2022-09-06 浙江天宇药业股份有限公司 一种非布司他a晶型的制备方法
CN111004191A (zh) * 2019-10-24 2020-04-14 武汉光谷亚太医药研究院有限公司 一种大粒径非布司他a晶的制备方法
JP7506475B2 (ja) * 2019-12-26 2024-06-26 東和薬品株式会社 フェブキソスタット製剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8506572D0 (en) † 1985-03-14 1985-04-17 Appointrose Ltd Fire-resistant enclosures
EP0237608B1 (de) 1986-03-21 1992-01-29 HEUMANN PHARMA GMBH & CO Kristalline, wasserfreie Sigma -Form von 2-[4-(2-Furoyl-(2-piperazin)-1-yl]-4-amino-6,7-dimethoxychinazolinhydrochlorid und Verfahren zu ihrer Herstellung
US5015646A (en) 1987-08-28 1991-05-14 Bristol-Myers Squibb Co. Pharmaceutically useful polymorphic modification of buspirone
KR100221041B1 (ko) * 1990-11-30 1999-09-15 야스이 쇼사꾸 2-아릴티아졸 유도체 및 그의 약제학적 조성물
JP2706037B2 (ja) * 1993-04-13 1998-01-28 帝人株式会社 シアノ化合物およびその製造方法
JP3202607B2 (ja) * 1996-08-01 2001-08-27 帝人株式会社 ２−（４−アルコキシ−３−シアノフェニル）チアゾール誘導体の製造法
DE69941672D1 (de) 1998-06-19 2010-01-07 Teijin Ltd Polymorphe modifikationen der 2-(3-cyano-4-isobutylphenyl)-4-methyl-5-thiazol-carbonsäure und verfahren zu ihrer herstellung
US7361676B2 (en) 2002-03-28 2008-04-22 Teijin Limited Solid preparation containing single crystal form

Also Published As

Publication number Publication date
SI1956015T2 (sl) 2018-12-31
BG104159A (en) 2000-08-31
ES2336287T5 (es) 2013-04-02
IN191537B (es) 2003-12-06
DK1956015T4 (en) 2019-02-11
SI1956014T1 (sl) 2019-02-28
US6225474B1 (en) 2001-05-01
ATE522512T2 (de) 2011-09-15
CZ298170B6 (cs) 2007-07-11
IL134594A0 (en) 2001-04-30
EP1020454B2 (en) 2013-01-23
AU748026B2 (en) 2002-05-30
EP2404910A3 (en) 2014-10-29
IS5377A (is) 2000-02-17
DK1020454T3 (da) 2010-01-04
HK1118293A1 (es) 2009-02-06
BE2010C024I2 (en) 2018-08-24
DK1956014T3 (en) 2019-04-15
CZ2000582A3 (cs) 2000-07-12
ES2371786T5 (es) 2019-04-22
BG64734B1 (bg) 2006-01-31
ID25775A (id) 2000-11-02
HRPK20000092B1 (en) 2001-10-31
HU230799B1 (hu) 2018-06-28
ES2718467T3 (es) 2019-07-02
CA2566652C (en) 2008-10-21
BR9906539A (pt) 2000-08-15
PT1020454E (pt) 2009-12-21
TWI248439B (en) 2006-02-01
KR20010023061A (ko) 2001-03-26
DK1956015T3 (da) 2011-09-26
SI1956015T1 (sl) 2011-10-28
UA57611C2 (uk) 2003-06-16
EP1956015B2 (en) 2018-11-14
IS3002B (is) 2018-09-15
SI1020454T2 (sl) 2013-03-29
EP1956014A3 (en) 2008-08-20
CN1275126A (zh) 2000-11-29
FR10C0022I1 (es) 2010-05-14
EP1956014A2 (en) 2008-08-13
SK287928B6 (sk) 2012-04-03
SI1020454T1 (sl) 2010-02-26
HRP20000092C1 (en) 2012-04-30
NO321308B1 (no) 2006-04-24
HRP20000092A2 (en) 2000-08-31
LU91682I2 (fr) 2010-06-22
LT1956014T (lt) 2019-03-25
EP1956015B1 (en) 2011-08-31
PT1956015E (pt) 2011-11-02
WO1999065885A1 (en) 1999-12-23
NO20000789L (no) 2000-02-17
CA2566652A1 (en) 1999-12-23
CY2010006I1 (el) 2012-01-25
IS9021A (is) 2013-01-25
CN102020617B (zh) 2019-04-23
TR200000458T1 (tr) 2000-10-23
IS9022A (is) 2013-01-25
HUP0004325A3 (en) 2001-12-28
CA2301863A1 (en) 1999-12-23
RU2198169C3 (ru) 2017-07-20
PT1956014T (pt) 2019-04-24
EP1020454A4 (en) 2002-05-15
JP3547707B2 (ja) 2004-07-28
PL200710B1 (pl) 2009-01-30
HRP20120217B1 (hr) 2019-04-05
CN102020617A (zh) 2011-04-20
EP1020454A1 (en) 2000-07-19
DE69941672D1 (de) 2010-01-07
EP1956015A3 (en) 2008-09-17
CA2301863C (en) 2009-01-27
ATE449765T1 (de) 2009-12-15
DK1020454T4 (da) 2013-11-25
CY2010006I2 (el) 2012-01-25
IS2886B (is) 2014-07-15
HUP0004325A2 (hu) 2001-10-28
HK1029788A1 (en) 2001-04-12
KR100511183B1 (ko) 2005-08-30
PL338780A1 (en) 2000-11-20
SK287946B6 (sk) 2012-06-04
DE122010000013I1 (de) 2010-07-08
IS9020A (is) 2013-01-25
EP2404910A2 (en) 2012-01-11
SK2202000A3 (en) 2000-11-07
ES2336287T3 (es) 2010-04-09
EP1956014B1 (en) 2019-01-16
AU4289299A (en) 2000-01-05
EP1956015A2 (en) 2008-08-13
NZ503326A (en) 2002-02-01
RU2198169C2 (ru) 2003-02-10
NO20000789D0 (no) 2000-02-17
IL134594A (en) 2004-12-15
ZA200000737B (en) 2000-09-08
HRP20120217A2 (hr) 2012-05-31
LU91682I9 (es) 2019-01-09
EP1020454B1 (en) 2009-11-25
CY1109720T1 (el) 2012-01-25
CN102659712A (zh) 2012-09-12
CY1111841T1 (el) 2015-10-07
FR10C0022I2 (fr) 2013-08-16
HU229405B1 (en) 2013-12-30
ES2371786T3 (es) 2012-01-10

Similar Documents

Publication Publication Date Title
GT199900216A (es) Polimorfos de acido 2-(3-ciano-4-isobutiloxifenil)-4-metil-5-tiazol carboxilico y metodo de produccion de los mismos.
PT1249461E (pt) Catalisadores de amina bloqueados por acido para a producao de poliuretanos
DK1781683T3 (da) Fremgangsmåde til fremstilling af 17-vinyl-triflater som halvfabrikata
CO5271720A1 (es) Proceso para fabricar selectivamente hemipentahidrato y monopentahidrato de acido 3-piridil-12hidroxi-etiliden-1, 1-bisfofosnico sodio y composicion farmacetica que las contiene
AR008527A1 (es) Procedimiento para preparar eteres mixtos
ES8606879A1 (es) Un procedimiento para la preparacion de derivados esteroida-les
PE20000477A1 (es) Procedimiento para la preparacion de (s,s)-bencil-2,8-diazabiciclo[4.3.0)nonano
ES8305718A1 (es) "procedimiento para la preparacion de nuevos derivados de acidos 2-amino-carboxilicos".
BR0315112A (pt) Sal de adição ácido, e, processo para a preparação de um composto
ES8506707A1 (es) Un derivado de acido tiazolilacetico
AR070008A1 (es) Proceso e intermediarios para la sintesis de compuestos de 3,4- dioxo-1- ciclobuteno 1,2- sustituidos
AR041356A1 (es) Un procedimiento para la sintesis industrial del diester metilico del acido 5- amino-3-carboximetil -4-ciano-2- tiofencarboxilico y aplicacion del mismo a la produccion industrial de sales bivalentes de acido ranelico y sus hidratos
ES2222399T3 (es) Metodo para la produccion de acido tioctico racemico.
AR024518A1 (es) Metodo para la preparacion de citalopram
ES2163316T3 (es) Procedimiento para la alquilacion de sulfonamidas impedidas.
AR021668A1 (es) Polimorfos de acido 2-(3-ciano-4-isobutiloxi fenil)-4-metil-5-tiazol carboxilico y metodo de produccion de los mismos
UY25863A1 (es) Polimorfos de acido 2-(3-ciano-4-isobutiloxi fenil)4-metil 5 - tiazol carboxilico y metodo de produccion de los mismos.
AR036018A1 (es) Proceso para aislar monohidrato de imipenem cristalino puro
AR008526A1 (es) Procedimiento para preparar eteres bencilicos.
EP1582513A4 (en) PROCESS FOR REDUCING DESHALOGENATION
ES2246274T3 (es) Procedimiento de isomerizacion de los 6-beta-fluoesteroides en los derivados 6-alfa correspondientes.
DE602004020050D1 (de) Verfahren zur herstellung substituierter imidazolderivate und in dem verfahren verwendete zwischenprodukte
BR0302681A (pt) Método para a produção de um composto de éter
EP1466896A4 (en) PROCESS FOR PRODUCING A CRYSTAL OF A BENZENESULFONAMIDE DERIVATIVE, AND A NEW CRYSTAL OF AN INTERMEDIATE PRODUCT OF SAID DERIVATIVE AND METHOD FOR PRODUCING THE SAME
ITMI992534A1 (it) Procedimento per la preparazione di eteri derivati da acidididrossibenzoici