FR18C1031I1 - - Google Patents
Info
- Publication number
- FR18C1031I1 FR18C1031I1 FR18C1031C FR18C1031I1 FR 18C1031 I1 FR18C1031 I1 FR 18C1031I1 FR 18C1031 C FR18C1031 C FR 18C1031C FR 18C1031 I1 FR18C1031 I1 FR 18C1031I1
- Authority
- FR
- France
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Magnetically Actuated Valves (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010257022 | 2010-11-17 | ||
PCT/JP2011/076486 WO2012067176A1 (fr) | 2010-11-17 | 2011-11-17 | Molécule de liaison à un antigène multi-spécifique ayant une fonction alternative par rapport à la fonction du facteur viii de coagulation sanguine |
Publications (2)
Publication Number | Publication Date |
---|---|
FR18C1031I1 true FR18C1031I1 (fr) | 2018-08-31 |
FR18C1031I2 FR18C1031I2 (fr) | 2020-09-25 |
Family
ID=46084097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR18C1031C Active FR18C1031I2 (fr) | 2010-11-17 | 2018-07-19 | Molecule de liaison a un antigene multi-specifique ayant une fonction alternative par rapport a la fonction du facteur viii de coagulation sanguine |
Country Status (28)
Country | Link |
---|---|
US (11) | US9334331B2 (fr) |
EP (2) | EP3318633A1 (fr) |
JP (10) | JP6013915B2 (fr) |
KR (4) | KR101398290B1 (fr) |
CN (2) | CN103298937B (fr) |
AU (2) | AU2011330184B2 (fr) |
BR (1) | BR112013012213A2 (fr) |
CA (1) | CA2817964C (fr) |
DK (1) | DK2644698T3 (fr) |
ES (1) | ES2660151T3 (fr) |
FR (1) | FR18C1031I2 (fr) |
HR (1) | HRP20180421T1 (fr) |
HU (2) | HUE038305T2 (fr) |
LT (2) | LT2644698T (fr) |
LU (1) | LUC00076I2 (fr) |
MX (1) | MX355060B (fr) |
MY (1) | MY166429A (fr) |
NL (1) | NL300940I2 (fr) |
NO (3) | NO2644698T3 (fr) |
PH (2) | PH12013500974A1 (fr) |
PL (1) | PL2644698T3 (fr) |
PT (1) | PT2644698T (fr) |
RS (1) | RS57038B1 (fr) |
RU (3) | RU2620071C2 (fr) |
SI (1) | SI2644698T1 (fr) |
TR (1) | TR201802772T4 (fr) |
TW (4) | TWI452135B (fr) |
WO (1) | WO2012067176A1 (fr) |
Families Citing this family (173)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1578397B1 (fr) * | 2002-11-15 | 2012-12-26 | Genmab A/S | Anticorps monoclonaux humains contre cd25 |
TWI671403B (zh) | 2005-03-31 | 2019-09-11 | 中外製藥股份有限公司 | 控制組裝之多肽的製造方法 |
EP3056568B1 (fr) | 2006-03-31 | 2021-09-15 | Chugai Seiyaku Kabushiki Kaisha | Procédés pour le contrôle de la pharmacocinétique sanguine d'anticorps |
ES2654040T3 (es) | 2006-03-31 | 2018-02-12 | Chugai Seiyaku Kabushiki Kaisha | Método de modificación de anticuerpos para la purificación de anticuerpos biespecíficos |
LT3345607T (lt) * | 2006-12-29 | 2023-01-10 | Ossifi-Mab Llc | Kaulų augimo keitimo būdai, skiriant sost arba wise antagonistą ar agonistą |
HUE033472T2 (en) * | 2007-02-16 | 2017-12-28 | Merrimack Pharmaceuticals Inc | Antibodies to ErbB3 and their applications |
KR102339457B1 (ko) | 2007-09-26 | 2021-12-14 | 추가이 세이야쿠 가부시키가이샤 | 항체 정상영역 개변체 |
JP5334319B2 (ja) | 2007-09-26 | 2013-11-06 | 中外製薬株式会社 | Cdrのアミノ酸置換により抗体の等電点を改変する方法 |
EP2409991B1 (fr) | 2009-03-19 | 2017-05-03 | Chugai Seiyaku Kabushiki Kaisha | Variant d'une région constante d'anticorps |
WO2010107109A1 (fr) | 2009-03-19 | 2010-09-23 | 中外製薬株式会社 | Variant d'une région constante d'anticorps |
JP6087054B2 (ja) * | 2009-12-25 | 2017-03-01 | 中外製薬株式会社 | ポリペプチド多量体を精製するためのポリペプチドの改変方法 |
AR080428A1 (es) | 2010-01-20 | 2012-04-11 | Chugai Pharmaceutical Co Ltd | Formulaciones liquidas estabilizadas contentivas de anticuerpos |
EP2543730B1 (fr) | 2010-03-04 | 2018-10-31 | Chugai Seiyaku Kabushiki Kaisha | Variante de région constante d'anticorps |
SMT202000095T1 (it) * | 2010-05-14 | 2020-03-13 | Amgen Inc | Formulazioni di anticorpi anti-sclerostina ad alta concentrazione |
KR20130098279A (ko) | 2010-06-18 | 2013-09-04 | 엑스바이오테크, 인크. | 관절염 치료 |
BR112013012213A2 (pt) | 2010-11-17 | 2020-09-01 | Chugai Seiyaku Kabushiki Kaisha | moléculas de ligação a antígeno mul tlespecíficas tendo função alternativa à função dos fatores viii, ix e x de coagulação sanguínea, e anticorpo bies- 5 pecífico, seus usos na prevenção ou tratamento de hemorragia, ácido nucleico, vetor, célula, método para produzir as referidas moléculas de ligação, composição farmacêutica e kit |
EP4279512A3 (fr) | 2010-11-30 | 2024-02-28 | Chugai Seiyaku Kabushiki Kaisha | Agent thérapeutique inducteur de cytotoxicité |
WO2012126013A2 (fr) | 2011-03-17 | 2012-09-20 | Minerva Biotechnologies Corporation | Procédé d'obtention de cellules souches pluripotentes |
US8790651B2 (en) | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
CA2853230C (fr) | 2011-10-31 | 2021-11-23 | Chugai Seiyaku Kabushiki Kaisha | Molecule de liaison a un antigene a conjugaison regulee entre une chaine lourde et une chaine legere |
CA3202536A1 (fr) | 2012-05-10 | 2013-11-14 | Bioatla, Llc | Anticorps monoclonaux multi-specifiques |
EP2900263B1 (fr) * | 2012-09-26 | 2019-06-05 | Julius-Maximilians-Universität Würzburg | Anticorps monoclonaux dirigés contre le facteur de croissance et de différenciation 15 (gdf-15) |
RU2683933C2 (ru) | 2012-09-28 | 2019-04-03 | Чугаи Сейяку Кабусики Кайся | Способ для оценки реакции коагуляции крови |
EA038645B1 (ru) * | 2012-12-21 | 2021-09-28 | Авео Фармасьютикалз, Инк. | Антитела к gdf15 |
HK1216850A1 (zh) * | 2012-12-21 | 2016-12-09 | Seattle Genetics, Inc. | 抗ntb-a抗體及相關的組合物和方法 |
TWI682781B (zh) | 2013-07-11 | 2020-01-21 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法 |
PT3406633T (pt) * | 2013-07-25 | 2022-05-04 | Cytomx Therapeutics Inc | Anticorpos multi-específicos, anticorpos ativáveis multi-específicos e métodos de utilização dos mesmos |
CA2925256C (fr) | 2013-09-27 | 2023-08-15 | Chugai Seiyaku Kabushiki Kaisha | Procede de production d'un heteromultimere polypeptidique |
LT3065774T (lt) * | 2013-11-06 | 2021-09-10 | Janssen Biotech, Inc. | Anti-ccl17 antikūnai |
US11072647B2 (en) * | 2013-12-19 | 2021-07-27 | Onsejo Nacional DE Investigation Cientiticay Tecnica | TGF-receptor II isoform, fusion peptide, methods of treatment and methods in vitro |
RU2769133C2 (ru) * | 2013-12-30 | 2022-03-28 | Эпимаб Биотерапьютикс Инк. | Иммуноглобулин с тандемным расположением fab-фрагментов и его применение |
WO2015120138A2 (fr) * | 2014-02-05 | 2015-08-13 | Dana-Farber Cancer Institute, Inc. | Agents modulant la signalisation rgmb-neogénine-bmp et leurs procédés d'utilisation |
CA2943694A1 (fr) * | 2014-03-26 | 2015-10-01 | Julius-Maximilians-Universitat Wurzburg | Anticorps monoclonaux au facteur de croissance et de differenciation 15 (gdf-15), et utilisations de ces derniers pour traiter la cachexie du cancer et le cancer |
CN105294857B (zh) * | 2014-06-18 | 2019-02-19 | 上海交通大学 | 基于fix的抗原表位及其应用 |
TWI831106B (zh) * | 2014-06-20 | 2024-02-01 | 日商中外製藥股份有限公司 | 用於因第viii凝血因子及/或活化的第viii凝血因子的活性降低或欠缺而發病及/或進展的疾病之預防及/或治療之醫藥組成物 |
EP3157952B1 (fr) * | 2014-06-20 | 2021-12-22 | Aveo Pharmaceuticals, Inc. | Traitement de l'insuffisance cardiaque congestive et d'autres dysfonctionnements cardiaques à l'aide d'un modulateur gdf15 |
US9212225B1 (en) * | 2014-07-01 | 2015-12-15 | Amphivena Therapeutics, Inc. | Bispecific CD33 and CD3 binding proteins |
CN106999577B (zh) * | 2014-07-16 | 2021-12-21 | 特兰斯吉恩股份有限公司 | 溶瘤病毒和免疫检查点调节因子组合 |
JP6858559B2 (ja) | 2014-08-20 | 2021-04-14 | 中外製薬株式会社 | 蛋白質溶液の粘度測定方法 |
TWI700300B (zh) * | 2014-09-26 | 2020-08-01 | 日商中外製藥股份有限公司 | 中和具有第viii凝血因子(fviii)機能替代活性的物質之抗體 |
TWI701435B (zh) | 2014-09-26 | 2020-08-11 | 日商中外製藥股份有限公司 | 測定fviii的反應性之方法 |
EP3218394A1 (fr) * | 2014-11-12 | 2017-09-20 | Rinat Neuroscience Corp. | Récepteurs antigéniques chimériques inhibiteurs |
US10849862B2 (en) * | 2014-12-26 | 2020-12-01 | Theravalues Corporation | Formulation of curcumin and anti-PD-1 antibody |
IL298086B2 (en) | 2015-01-02 | 2024-11-01 | Takeda Pharmaceuticals Co | Bispecific antibodies against plasma kallikrein and factor xii |
TWI774028B (zh) | 2015-01-30 | 2022-08-11 | 學校法人埼玉醫科大學 | 抗alk2抗體及其用途 |
EP3253778A1 (fr) | 2015-02-05 | 2017-12-13 | Chugai Seiyaku Kabushiki Kaisha | Anticorps comprenant un domaine se liant à l'antigène dépendant de la concentration d'ions, variants de la région fc, anticorps se liant à l'il-8, et leurs utilisations |
KR20180016972A (ko) * | 2015-02-22 | 2018-02-20 | 소렌토 쎄라퓨틱스, 인코포레이티드 | Cd137에 결합하는 항체 치료제 |
RS61438B1 (sr) * | 2015-03-31 | 2021-03-31 | Medimmune Ltd | Novi oblik il33, mutirani oblici il33, antitela, testovi i postupci za njihovu upotrebu |
WO2016159213A1 (fr) | 2015-04-01 | 2016-10-06 | 中外製薬株式会社 | Procédé pour la production d'un hétéro-oligomère polypeptidique |
BR112017016952A2 (pt) * | 2015-04-17 | 2018-04-03 | F. Hoffmann-La Roche Ag | terapia de combinação com fatores de coagulação e anticorpos multiespecíficos |
WO2016170944A1 (fr) * | 2015-04-24 | 2016-10-27 | 公立大学法人奈良県立医科大学 | Procédé d'évaluation de capacité de coagulation d'échantillon sanguin, et réactif, trousse de réactifs et dispositif à utiliser en son sein |
JP2018123055A (ja) * | 2015-04-24 | 2018-08-09 | 公立大学法人奈良県立医科大学 | 血液凝固第viii因子(fviii)の機能を代替する多重特異性抗原結合分子を含有する、血液凝固第xi因子(fxi)異常症の予防および/または治療に用いられる医薬組成物 |
US10738118B2 (en) | 2015-05-29 | 2020-08-11 | Amphivena Therapeutics, Inc. | Methods of using bispecific CD33 and CD3 binding proteins |
FR3038517B1 (fr) | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
US10858391B2 (en) | 2015-07-31 | 2020-12-08 | Chugai Seiyaku Kabushiki Kaisha | Method for purifying composition comprising antibodies with anionic polymer |
AR105634A1 (es) | 2015-09-18 | 2017-10-25 | Chugai Pharmaceutical Co Ltd | Anticuerpos que se unen a il 8 y sus usos |
TWI752920B (zh) | 2015-10-12 | 2022-01-21 | 美商再生元醫藥公司 | 活化瘦素受體的抗原結合蛋白 |
CN107614529B (zh) * | 2015-11-17 | 2019-11-12 | 苏州盛迪亚生物医药有限公司 | Pd-l1抗体、其抗原结合片段及其医药用途 |
US20200270363A1 (en) * | 2015-12-25 | 2020-08-27 | Chugai Seiyaku Kabushiki Kaisha | Antibody having enhanced activity, and method for modifying same |
SG11201803989WA (en) * | 2015-12-28 | 2018-06-28 | Chugai Pharmaceutical Co Ltd | Method for promoting efficiency of purification of fc region-containing polypeptide |
EP3402516A4 (fr) * | 2016-01-12 | 2020-01-08 | Palleon Pharmaceuticals Inc. | Utilisation d'anticorps dirigés contre siglec-7 ou siglec-9 dans le traitement du cancer |
MA44780A (fr) | 2016-04-28 | 2019-03-06 | Chugai Pharmaceutical Co Ltd | Préparation contenant un anticorps |
CN113372446A (zh) * | 2016-06-08 | 2021-09-10 | 苏州康乃德生物医药有限公司 | 用于结合白细胞介素4受体的抗体 |
JP7231411B2 (ja) * | 2016-06-15 | 2023-03-01 | ノバルティス アーゲー | 骨形成タンパク質6(bmp6)の阻害剤を使用して疾患を処置する方法 |
CA3029627A1 (fr) | 2016-07-01 | 2018-01-04 | Resolve Therapeutics, Llc | Fusions de binuclease optimisees |
ES3005961T3 (en) | 2016-07-14 | 2025-03-17 | Bristol Myers Squibb Co | Antibodies against tim3 and uses thereof |
JP7050677B2 (ja) * | 2016-07-29 | 2022-04-08 | 中外製薬株式会社 | 増強されたfviii補因子機能代替活性を有する二重特異性抗体 |
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EP3509637B1 (fr) | 2016-09-06 | 2024-11-27 | Chugai Seiyaku Kabushiki Kaisha | Procédés d'utilisation d'un anticorps bispécifique qui reconnaît le facteur de coagulation ix et/ou le facteur de coagulation ix activé et le facteur de coagulation x et/ou le facteur de coagulation x activé |
JP7069177B2 (ja) * | 2016-09-21 | 2022-05-17 | ネクストキュア インコーポレイテッド | シグレック-15に対する抗体及びその使用方法 |
CA3034105A1 (fr) * | 2016-09-23 | 2018-03-29 | Csl Limited | Proteines de liaison au facteur de coagulation et leurs utilisations |
KR20250044934A (ko) * | 2016-10-19 | 2025-04-01 | 인벤라 인코포레이티드 | 항체 구조물 |
MX2019005397A (es) | 2016-11-08 | 2019-10-09 | Regeneron Pharma | Proteinas de union a antigeno que antagonizan el receptor de leptina. |
CN110662770A (zh) * | 2016-11-23 | 2020-01-07 | 比奥维拉迪维治疗股份有限公司 | 结合凝血因子ix和凝血因子x的双特异性抗体 |
CN117442720A (zh) * | 2016-12-21 | 2024-01-26 | 美莱奥生物制药第三有限公司 | 抗硬化蛋白抗体在治疗成骨不全症中的用途 |
US11680101B2 (en) * | 2017-01-27 | 2023-06-20 | Kymab Limited | Anti-OPG antibodies |
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